LOCUS       NM_003202               3288 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens transcription factor 7 (TCF7), transcript variant 1,
            mRNA.
ACCESSION   NM_003202
VERSION     NM_003202.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3288)
  AUTHORS   Kidani,Y., Kitagawa,Y., Hagiwara,M., Kawashima,A., Kanazawa,T.,
            Wada,H., Uemura,M., Nonomura,N., Motooka,D., Nakamura,S., Ohkura,N.
            and Sakaguchi,S.
  TITLE     Downregulation of TCF7 and LEF1 is a key determinant of
            tumor-infiltrating regulatory T-cell function
  JOURNAL   Int Immunol 36 (4), 167-182 (2024)
   PUBMED   38169425
  REMARK    GeneRIF: Downregulation of TCF7 and LEF1 is a key determinant of
            tumor-infiltrating regulatory T-cell function.
REFERENCE   2  (bases 1 to 3288)
  AUTHORS   Yakou,M.H., Ghilas,S., Tran,K., Liao,Y., Afshar-Sterle,S.,
            Kumari,A., Schmid,K., Dijkstra,C., Inguanti,C., Ostrouska,S.,
            Wilcox,J., Smith,M., Parathan,P., Allam,A., Xue,H.H., Belz,G.T.,
            Mariadason,J.M., Behren,A., Drummond,G.R., Ruscher,R.,
            Williams,D.S., Pal,B., Shi,W., Ernst,M., Raghu,D. and Mielke,L.A.
  TITLE     TCF-1 limits intraepithelial lymphocyte antitumor immunity in
            colorectal carcinoma
  JOURNAL   Sci Immunol 8 (88), eadf2163 (2023)
   PUBMED   37801516
  REMARK    GeneRIF: TCF-1 limits intraepithelial lymphocyte antitumor immunity
            in colorectal carcinoma.
REFERENCE   3  (bases 1 to 3288)
  AUTHORS   Jiang,K., Liu,S., Chen,Y., Xu,Z., Xu,Z., Qian,B., Ding,Q., Cui,H.,
            Sui,Y., Cao,D., Xu,W. and Shen,M.
  TITLE     Characterization of TCF-1 and its relationship between CD8+ TIL
            densities and immune checkpoints and their joint influences on
            prognoses of lung adenocarcinoma patients
  JOURNAL   Thorac Cancer 14 (27), 2745-2753 (2023)
   PUBMED   37536668
  REMARK    GeneRIF: Characterization of TCF-1 and its relationship between
            CD8+ TIL densities and immune checkpoints and their joint
            influences on prognoses of lung adenocarcinoma patients.
REFERENCE   4  (bases 1 to 3288)
  AUTHORS   Hrckulak,D., Kolar,M., Strnad,H. and Korinek,V.
  TITLE     TCF/LEF Transcription Factors: An Update from the Internet
            Resources
  JOURNAL   Cancers (Basel) 8 (7), 70 (2016)
   PUBMED   27447672
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3288)
  AUTHORS   Korinek,V., Barker,N., Willert,K., Molenaar,M., Roose,J.,
            Wagenaar,G., Markman,M., Lamers,W., Destree,O. and Clevers,H.
  TITLE     Two members of the Tcf family implicated in Wnt/beta-catenin
            signaling during embryogenesis in the mouse
  JOURNAL   Mol Cell Biol 18 (3), 1248-1256 (1998)
   PUBMED   9488439
REFERENCE   6  (bases 1 to 3288)
  AUTHORS   Van de Wetering,M., Castrop,J., Korinek,V. and Clevers,H.
  TITLE     Extensive alternative splicing and dual promoter usage generate
            Tcf-1 protein isoforms with differential transcription control
            properties
  JOURNAL   Mol Cell Biol 16 (3), 745-752 (1996)
   PUBMED   8622675
REFERENCE   7  (bases 1 to 3288)
  AUTHORS   Castrop,J., van Wichen,D., Koomans-Bitter,M., van de Wetering,M.,
            de Weger,R., van Dongen,J. and Clevers,H.
  TITLE     The human TCF-1 gene encodes a nuclear DNA-binding protein uniquely
            expressed in normal and neoplastic T-lineage lymphocytes
  JOURNAL   Blood 86 (8), 3050-3059 (1995)
   PUBMED   7579399
REFERENCE   8  (bases 1 to 3288)
  AUTHORS   Mayer,K., Wolff,E., Clevers,H. and Ballhausen,W.G.
  TITLE     The human high mobility group (HMG)-box transcription factor TCF-1:
            novel isoforms due to alternative splicing and usage of a new exon
            IXA
  JOURNAL   Biochim Biophys Acta 1263 (2), 169-172 (1995)
   PUBMED   7640309
REFERENCE   9  (bases 1 to 3288)
  AUTHORS   van de Wetering,M., Oosterwegel,M., Holstege,F., Dooyes,D.,
            Suijkerbuijk,R., Geurts van Kessel,A. and Clevers,H.
  TITLE     The human T cell transcription factor-1 gene. Structure,
            localization, and promoter characterization
  JOURNAL   J Biol Chem 267 (12), 8530-8536 (1992)
   PUBMED   1569101
REFERENCE   10 (bases 1 to 3288)
  AUTHORS   van de Wetering,M., Oosterwegel,M., Dooijes,D. and Clevers,H.
  TITLE     Identification and cloning of TCF-1, a T lymphocyte-specific
            transcription factor containing a sequence-specific HMG box
  JOURNAL   EMBO J 10 (1), 123-132 (1991)
   PUBMED   1989880
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008608.7, BC048769.1,
            AC011336.5, AK057580.1, AL832816.1 and X59870.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003202.4.
            
            Summary: This gene encodes a member of the T-cell factor/lymphoid
            enhancer-binding factor family of high mobility group (HMG) box
            transcriptional activators. This gene is expressed predominantly in
            T-cells and plays a critical role in natural killer cell and innate
            lymphoid cell development. The encoded protein forms a complex with
            beta-catenin and activates transcription through a Wnt/beta-catenin
            signaling pathway. Mice with a knockout of this gene are viable and
            fertile, but display a block in T-lymphocyte differentiation.
            Alternative splicing results in multiple transcript variants.
            Naturally-occurring isoforms lacking the N-terminal beta-catenin
            interaction domain may act as dominant negative regulators of Wnt
            signaling. [provided by RefSeq, Oct 2016].
            
            Transcript Variant: This variant (1) encodes isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048769.1, AL832816.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342854.10/ ENSP00000340347.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AC008608.7         142563-142592
            31-1734             BC048769.1         1-1704
            1735-1735           AC011336.5         16994-16994
            1736-2105           AK057580.1         1498-1867
            2106-3071           AL832816.1         1795-2760
            3072-3075           AC011336.5         18331-18334
            3076-3288           X59870.1           2577-2789
FEATURES             Location/Qualifiers
     source          1..3288
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.1"
     gene            1..3288
                     /gene="TCF7"
                     /gene_synonym="TCF-1"
                     /note="transcription factor 7"
                     /db_xref="GeneID:6932"
                     /db_xref="HGNC:HGNC:11639"
                     /db_xref="MIM:189908"
     exon            1..475
                     /gene="TCF7"
                     /gene_synonym="TCF-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..1381
                     /gene="TCF7"
                     /gene_synonym="TCF-1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     T-cell-specific transcription factor 1; transcription
                     factor 7 (T-cell specific, HMG-box); T-cell-factor-7"
                     /codon_start=1
                     /product="transcription factor 7 isoform 1"
                     /protein_id="NP_003193.2"
                     /db_xref="CCDS:CCDS4169.1"
                     /db_xref="GeneID:6932"
                     /db_xref="HGNC:HGNC:11639"
                     /db_xref="MIM:189908"
                     /translation="MPQLDSGGGGAGGGDDLGAPDELLAFQDEGEEQDDKSRDSAAGP
                     ERDLAELKSSLVNESEGAAGGAGIPGVPGAGAGARGEAEALGREHAAQRLFPDKLPEP
                     LEDGLKAPECTSGMYKETVYSAFNLLMHYPPPSGAGQHPQPQPPLHKANQPPHGVPQL
                     SLYEHFNSPHPTPAPADISQKQVHRPLQTPDLSGFYSLTSGSMGQLPHTVSWFTHPSL
                     MLGSGVPGHPAAIPHPAIVPPSGKQELQPFDRNLKTQAESKAEKEAKKPTIKKPLNAF
                     MLYMKEMRAKVIAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYP
                     GWSARDNYGKKKRRSREKHQESTTGGKRNAFGTYPEKAAAPAPFLPMTVL"
     exon            476..542
                     /gene="TCF7"
                     /gene_synonym="TCF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            543..667
                     /gene="TCF7"
                     /gene_synonym="TCF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            668..773
                     /gene="TCF7"
                     /gene_synonym="TCF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            774..861
                     /gene="TCF7"
                     /gene_synonym="TCF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            862..981
                     /gene="TCF7"
                     /gene_synonym="TCF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1144
                     /gene="TCF7"
                     /gene_synonym="TCF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1252
                     /gene="TCF7"
                     /gene_synonym="TCF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1301
                     /gene="TCF7"
                     /gene_synonym="TCF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..3288
                     /gene="TCF7"
                     /gene_synonym="TCF-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3267..3272
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCF7"
                     /gene_synonym="TCF-1"
                     /note="hexamer: AATAAA"
     polyA_site      3288
                     /gene="TCF7"
                     /gene_synonym="TCF-1"
                     /note="major polyA site"
ORIGIN      
        1 actcggccgg cggcgccttt gatgttccga cccgccagct cgcggagccg ctctgccccg
       61 cgccctagcc cgcgcctgca gcccgcccag gcggagtcag cccgcgctcc gcccgccgcg
      121 atccgagctc ggaggttcgg actccgggct cgccgccccc cgggccggct ccgcgccccg
      181 cactcccggc gcccagcgcc ccgcgccccg gcgggcggag cgcaccatgc cgcagctgga
      241 ctccggcggg ggcggcgcgg gcggcggcga cgacctcggc gcgccggacg agctgctggc
      301 cttccaggat gaaggcgagg agcaggacga caagagccgc gacagcgccg ccggtcccga
      361 gcgcgacctg gccgagctca agtcgtcgct cgtgaacgag tccgagggcg cggccggcgg
      421 cgcagggatc ccgggggtcc cgggggccgg cgccggggcc cgcggcgagg ccgaggctct
      481 cgggcgggaa cacgctgcgc agagactctt cccggacaaa cttccagagc ccctggagga
      541 cggcctgaag gccccggagt gcaccagcgg catgtacaaa gagaccgtct actccgcctt
      601 caatctgctc atgcattacc cacccccctc gggagcaggg cagcaccccc agccgcagcc
      661 cccgctgcac aaggccaatc agccccccca cggtgtcccc caactctctc tctacgaaca
      721 tttcaacagc ccacatccca cccctgcacc tgcggacatc agccagaagc aagttcacag
      781 gcctctgcag acccctgacc tctctggctt ctactccctg acctcaggca gcatggggca
      841 gctcccccac actgtgagct ggttcaccca cccatccttg atgctaggtt ctggtgtacc
      901 tggtcaccca gcagccatcc cccacccggc cattgtgccc ccctcaggga agcaggagct
      961 gcagcccttc gaccgcaacc tgaagacaca agcagagtcc aaggcagaga aggaggccaa
     1021 gaagccaacc atcaagaagc ccctcaatgc cttcatgctg tacatgaagg agatgagagc
     1081 caaggtcatt gcagagtgca cacttaagga gagcgctgcc atcaaccaga tcctgggccg
     1141 caggtggcac gcgctgtcgc gagaagagca ggccaagtac tatgagctgg cccgcaagga
     1201 gaggcagctg cacatgcagc tatacccagg ctggtcagcg cgggacaact acgggaagaa
     1261 gaagaggcgg tcgagggaaa agcaccaaga atccaccaca ggaggaaaaa gaaatgcatt
     1321 cggtacttac ccggagaagg ccgctgcccc agccccgttc cttccgatga cagtgctcta
     1381 ggctgccccg ggtccccagc tccccaggac tcaccctcat accatctgct gccccgcttc
     1441 cccacagaac tgcttactag ccctgcggag ccggcaccta catccccagg tctctccact
     1501 gctctcagcc tcccaacccc agggccccca caggcccccc gcagcaccct gcagagcaca
     1561 caggtacagc aacaggaatc tcagagacag gtggcctagc aggcacagga cacctggccg
     1621 cctccaggag cctaccccct gaaagtgaca gagacccaga tctcatggaa actggccagg
     1681 ggtcctgtta acgtcatctc agggtccaga ccctgaagat ttcagaggct gcaggacttc
     1741 tgcctgaacc tggggtcatc gattcaaact gctccaagtg gtgggaatca gatctgtctt
     1801 gatgtgtcat ctaattaagg gaatcccttg tacctatggc tgcctgcatc tattctttgt
     1861 accatctgtc ttgccagcca gaagcctctg cctccctagc ttttctgcta taggtcagag
     1921 atgggctgaa ctgagcctag ctaccttctc tacccatctc ccccatcccc cactgccaca
     1981 ccctccccat tcagacactt catggaccaa gaatgagctg gtttgtcaaa caacatgtga
     2041 gcatggtcac aagcacaaag ctcaagatga cagctcttct aaggaaatgg agaagctctg
     2101 tttataaaaa caaaaacaaa accagctgct actcataagt tggaccagag gaagcccctt
     2161 actatgatct caggagcttg caagaagcag gaaggggaat ggaataggtt aagtttaggc
     2221 ctatcaacct aagcaacaga aataatctga cactacctta tcaggcaaat tggggagggg
     2281 agggtgtatc tagctctagt tcaaattatt tggaagtgtt ccctgagaaa cccaccagcc
     2341 taagaagctc tggccccagg cttgtcacta gcagctgcag tcaacagttc aaagaagtca
     2401 tggcccaaat ccagtgtgca cccctcccca ttcacagagc ctttttcaca attccatttc
     2461 cagttcatct atggcagtcc agccagctcc tgggcagctt gagagggcaa acccaaaacc
     2521 tcatgacagc cagagcctgt ctttcagcat tcagtccgcc tggccggctc cagtttcccc
     2581 atggggctgc gggacagagg accattacaa ctagatcaag gagcccagaa aacctccagt
     2641 agtggacaac aggttttcac catagcctac gttaacccat ttttgagcca agcttcaacc
     2701 ctcagccttg aaaaacaagt ctttaattta atttttgttt tttgcctaaa tccaaagaaa
     2761 aagggctgcc gggccaggcg cggtggctca cgcctgtaat cccagcactt tggcaggccg
     2821 aggcaggtgg atcacctgac gtcagtagtt tgagaccagc ctggccaaca tggtgaaacc
     2881 ctgtatctac taaaaataca aaaattagcc ggacgtggtg gtgcgcgcat gtaatcccag
     2941 ctactcggga ggctgaggcg gaagaatcac ttgaacccgg gaggcggagg ttccagtgag
     3001 ccgagatggc gctattgcac tccagtctgg gtaacaggga gactgcatct caaaaaaaaa
     3061 aaaaaaaaaa aaaaagggct gtccatgtat tcacacaccc ctcaaaaaaa gcctttagtt
     3121 cctactttag ccactggttt ctcagaatcc aaagatcaca tattctagtg taacactgca
     3181 agaagtcttg agaaaaagat tattgtagtg ttcaaaatat ttttgtattg ttaatgcatc
     3241 atcatagaaa aacttttaaa catgagaata aagatacttt ttactggg
//
