LOCUS       NM_001346450            2924 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens transcription factor 7 (TCF7), transcript variant 9,
            mRNA.
ACCESSION   NM_001346450
VERSION     NM_001346450.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2924)
  AUTHORS   Kidani,Y., Kitagawa,Y., Hagiwara,M., Kawashima,A., Kanazawa,T.,
            Wada,H., Uemura,M., Nonomura,N., Motooka,D., Nakamura,S., Ohkura,N.
            and Sakaguchi,S.
  TITLE     Downregulation of TCF7 and LEF1 is a key determinant of
            tumor-infiltrating regulatory T-cell function
  JOURNAL   Int Immunol 36 (4), 167-182 (2024)
   PUBMED   38169425
  REMARK    GeneRIF: Downregulation of TCF7 and LEF1 is a key determinant of
            tumor-infiltrating regulatory T-cell function.
REFERENCE   2  (bases 1 to 2924)
  AUTHORS   Yakou,M.H., Ghilas,S., Tran,K., Liao,Y., Afshar-Sterle,S.,
            Kumari,A., Schmid,K., Dijkstra,C., Inguanti,C., Ostrouska,S.,
            Wilcox,J., Smith,M., Parathan,P., Allam,A., Xue,H.H., Belz,G.T.,
            Mariadason,J.M., Behren,A., Drummond,G.R., Ruscher,R.,
            Williams,D.S., Pal,B., Shi,W., Ernst,M., Raghu,D. and Mielke,L.A.
  TITLE     TCF-1 limits intraepithelial lymphocyte antitumor immunity in
            colorectal carcinoma
  JOURNAL   Sci Immunol 8 (88), eadf2163 (2023)
   PUBMED   37801516
  REMARK    GeneRIF: TCF-1 limits intraepithelial lymphocyte antitumor immunity
            in colorectal carcinoma.
REFERENCE   3  (bases 1 to 2924)
  AUTHORS   Jiang,K., Liu,S., Chen,Y., Xu,Z., Xu,Z., Qian,B., Ding,Q., Cui,H.,
            Sui,Y., Cao,D., Xu,W. and Shen,M.
  TITLE     Characterization of TCF-1 and its relationship between CD8+ TIL
            densities and immune checkpoints and their joint influences on
            prognoses of lung adenocarcinoma patients
  JOURNAL   Thorac Cancer 14 (27), 2745-2753 (2023)
   PUBMED   37536668
  REMARK    GeneRIF: Characterization of TCF-1 and its relationship between
            CD8+ TIL densities and immune checkpoints and their joint
            influences on prognoses of lung adenocarcinoma patients.
REFERENCE   4  (bases 1 to 2924)
  AUTHORS   Hrckulak,D., Kolar,M., Strnad,H. and Korinek,V.
  TITLE     TCF/LEF Transcription Factors: An Update from the Internet
            Resources
  JOURNAL   Cancers (Basel) 8 (7), 70 (2016)
   PUBMED   27447672
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2924)
  AUTHORS   Korinek,V., Barker,N., Willert,K., Molenaar,M., Roose,J.,
            Wagenaar,G., Markman,M., Lamers,W., Destree,O. and Clevers,H.
  TITLE     Two members of the Tcf family implicated in Wnt/beta-catenin
            signaling during embryogenesis in the mouse
  JOURNAL   Mol Cell Biol 18 (3), 1248-1256 (1998)
   PUBMED   9488439
REFERENCE   6  (bases 1 to 2924)
  AUTHORS   Van de Wetering,M., Castrop,J., Korinek,V. and Clevers,H.
  TITLE     Extensive alternative splicing and dual promoter usage generate
            Tcf-1 protein isoforms with differential transcription control
            properties
  JOURNAL   Mol Cell Biol 16 (3), 745-752 (1996)
   PUBMED   8622675
REFERENCE   7  (bases 1 to 2924)
  AUTHORS   Castrop,J., van Wichen,D., Koomans-Bitter,M., van de Wetering,M.,
            de Weger,R., van Dongen,J. and Clevers,H.
  TITLE     The human TCF-1 gene encodes a nuclear DNA-binding protein uniquely
            expressed in normal and neoplastic T-lineage lymphocytes
  JOURNAL   Blood 86 (8), 3050-3059 (1995)
   PUBMED   7579399
REFERENCE   8  (bases 1 to 2924)
  AUTHORS   Mayer,K., Wolff,E., Clevers,H. and Ballhausen,W.G.
  TITLE     The human high mobility group (HMG)-box transcription factor TCF-1:
            novel isoforms due to alternative splicing and usage of a new exon
            IXA
  JOURNAL   Biochim Biophys Acta 1263 (2), 169-172 (1995)
   PUBMED   7640309
REFERENCE   9  (bases 1 to 2924)
  AUTHORS   van de Wetering,M., Oosterwegel,M., Holstege,F., Dooyes,D.,
            Suijkerbuijk,R., Geurts van Kessel,A. and Clevers,H.
  TITLE     The human T cell transcription factor-1 gene. Structure,
            localization, and promoter characterization
  JOURNAL   J Biol Chem 267 (12), 8530-8536 (1992)
   PUBMED   1569101
REFERENCE   10 (bases 1 to 2924)
  AUTHORS   van de Wetering,M., Oosterwegel,M., Dooijes,D. and Clevers,H.
  TITLE     Identification and cloning of TCF-1, a T lymphocyte-specific
            transcription factor containing a sequence-specific HMG box
  JOURNAL   EMBO J 10 (1), 123-132 (1991)
   PUBMED   1989880
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB128524.1, AC011336.5,
            CN274309.1 and X59871.1.
            
            On May 31, 2019 this sequence version replaced NM_001346450.1.
            
            Summary: This gene encodes a member of the T-cell factor/lymphoid
            enhancer-binding factor family of high mobility group (HMG) box
            transcriptional activators. This gene is expressed predominantly in
            T-cells and plays a critical role in natural killer cell and innate
            lymphoid cell development. The encoded protein forms a complex with
            beta-catenin and activates transcription through a Wnt/beta-catenin
            signaling pathway. Mice with a knockout of this gene are viable and
            fertile, but display a block in T-lymphocyte differentiation.
            Alternative splicing results in multiple transcript variants.
            Naturally-occurring isoforms lacking the N-terminal beta-catenin
            interaction domain may act as dominant negative regulators of Wnt
            signaling. [provided by RefSeq, Oct 2016].
            
            Transcript Variant: This variant (9) differs in the 5' UTR, has
            multiple coding region differences, and uses a downstream start
            codon, compared to variant 1. The resulting isoform (7) is shorter
            at the N-terminus and has a distinct C-terminus, compared to
            isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279825.5681.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-551               DB128524.1         7-557
            552-567             AC011336.5         12599-12614
            568-1245            CN274309.1         1-678
            1246-2711           AC011336.5         16869-18334
            2712-2924           X59871.1           2673-2885
FEATURES             Location/Qualifiers
     source          1..2924
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.1"
     gene            1..2924
                     /gene="TCF7"
                     /gene_synonym="TCF-1"
                     /note="transcription factor 7"
                     /db_xref="GeneID:6932"
                     /db_xref="HGNC:HGNC:11639"
                     /db_xref="MIM:189908"
     exon            1..62
                     /gene="TCF7"
                     /gene_synonym="TCF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            63..187
                     /gene="TCF7"
                     /gene_synonym="TCF-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..937
                     /gene="TCF7"
                     /gene_synonym="TCF-1"
                     /note="isoform 7 is encoded by transcript variant 9;
                     T-cell-specific transcription factor 1; transcription
                     factor 7 (T-cell specific, HMG-box); T-cell-factor-7"
                     /codon_start=1
                     /product="transcription factor 7 isoform 7"
                     /protein_id="NP_001333379.1"
                     /db_xref="GeneID:6932"
                     /db_xref="HGNC:HGNC:11639"
                     /db_xref="MIM:189908"
                     /translation="MYKETVYSAFNLLMHYPPPSGAGQHPQPQPPLHKANQPPHGVPQ
                     LSLYEHFNSPHPTPAPADISQKQVHRPLQTPDLSGFYSLTSGSMGQLPHTVSWPSPPL
                     YPLSPSCGYRQHFPAPTAAPGAPYPRFTHPSLMLGSGVPGHPAAIPHPAIVPPSGKQE
                     LQPFDRNLKTQAESKAEKEAKKPTIKKPLNAFMLYMKEMRAKVIAECTLKESAAINQI
                     LGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKRRSREKHQESTTDN
                     SLHYS"
     exon            188..293
                     /gene="TCF7"
                     /gene_synonym="TCF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            294..381
                     /gene="TCF7"
                     /gene_synonym="TCF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            382..474
                     /gene="TCF7"
                     /gene_synonym="TCF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            475..594
                     /gene="TCF7"
                     /gene_synonym="TCF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            595..757
                     /gene="TCF7"
                     /gene_synonym="TCF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            758..865
                     /gene="TCF7"
                     /gene_synonym="TCF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            866..914
                     /gene="TCF7"
                     /gene_synonym="TCF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            915..2924
                     /gene="TCF7"
                     /gene_synonym="TCF-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2903..2908
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCF7"
                     /gene_synonym="TCF-1"
                     /note="hexamer: AATAAA"
     polyA_site      2924
                     /gene="TCF7"
                     /gene_synonym="TCF-1"
                     /note="major polyA site"
ORIGIN      
        1 gcctcccctc ctgcccaggt gactgactaa tccgccgcct tcaggagaca gaattggcca
       61 aggcctgaag gccccggagt gcaccagcgg catgtacaaa gagaccgtct actccgcctt
      121 caatctgctc atgcattacc cacccccctc gggagcaggg cagcaccccc agccgcagcc
      181 cccgctgcac aaggccaatc agccccccca cggtgtcccc caactctctc tctacgaaca
      241 tttcaacagc ccacatccca cccctgcacc tgcggacatc agccagaagc aagttcacag
      301 gcctctgcag acccctgacc tctctggctt ctactccctg acctcaggca gcatggggca
      361 gctcccccac actgtgagct ggcccagccc tcctctctac cccctgtccc cttcctgcgg
      421 atatagacag cacttccctg cccccactgc agcccctggc gccccctacc ccaggttcac
      481 ccacccatcc ttgatgctag gttctggtgt acctggtcac ccagcagcca tcccccaccc
      541 ggccattgtg cccccctcag ggaagcagga gctgcagccc ttcgaccgca acctgaagac
      601 acaagcagag tccaaggcag agaaggaggc caagaagcca accatcaaga agcccctcaa
      661 tgccttcatg ctgtacatga aggagatgag agccaaggtc attgcagagt gcacacttaa
      721 ggagagcgct gccatcaacc agatcctggg ccgcaggtgg cacgcgctgt cgcgagaaga
      781 gcaggccaag tactatgagc tggcccgcaa ggagaggcag ctgcacatgc agctataccc
      841 aggctggtca gcgcgggaca actacgggaa gaagaagagg cggtcgaggg aaaagcacca
      901 agaatccacc acagataact ctcttcacta ttcctaggag gaaaaagaaa tgcattcggt
      961 acttacccgg agaaggccgc tgccccagcc ccgttccttc cgatgacagt gctctaggct
     1021 gccccgggtc cccagctccc caggactcac cctcatacca tctgctgccc cgcttcccca
     1081 cagaactgct tactagccct gcggagccgg cacctacatc cccaggtctc tccactgctc
     1141 tcagcctccc aaccccaggg cccccacagg ccccccgcag caccctgcag agcacacagg
     1201 tacagcaaca ggaatctcag agacaggtgg cctagcaggc acaggacacc tggccgcctc
     1261 caggagccta ccccctgaaa gtgacagaga cccagatctc atggaaactg gccaggggtc
     1321 ctgttaacgt catctcaggg tccagaccct gaagatttca gaggctgcag gacttctgcc
     1381 tgaacctggg gtcatcgatt caaactgctc caagtggtgg gaatcagatc tgtcttgatg
     1441 tgtcatctaa ttaagggaat cccttgtacc tatggctgcc tgcatctatt ctttgtacca
     1501 tctgtcttgc cagccagaag cctctgcctc cctagctttt ctgctatagg tcagagatgg
     1561 gctgaactga gcctagctac cttctctacc catctccccc atcccccact gccacaccct
     1621 ccccattcag acacttcatg gaccaagaat gagctggttt gtcaaacaac atgtgagcat
     1681 ggtcacaagc acaaagctca agatgacagc tcttctaagg aaatggagaa gctctgttta
     1741 taaaaacaaa aacaaaacca gctgctactc ataagttgga ccagaggaag ccccttacta
     1801 tgatctcagg agcttgcaag aagcaggaag gggaatggaa taggttaagt ttaggcctat
     1861 caacctaagc aacagaaata atctgacact accttatcag gcaaattggg gaggggaggg
     1921 tgtatctagc tctagttcaa attatttgga agtgttccct gagaaaccca ccagcctaag
     1981 aagctctggc cccaggcttg tcactagcag ctgcagtcaa cagttcaaag aagtcatggc
     2041 ccaaatccag tgtgcacccc tccccattca cagagccttt ttcacaattc catttccagt
     2101 tcatctatgg cagtccagcc agctcctggg cagcttgaga gggcaaaccc aaaacctcat
     2161 gacagccaga gcctgtcttt cagcattcag tccgcctggc cggctccagt ttccccatgg
     2221 ggctgcggga cagaggacca ttacaactag atcaaggagc ccagaaaacc tccagtagtg
     2281 gacaacaggt tttcaccata gcctacgtta acccattttt gagccaagct tcaaccctca
     2341 gccttgaaaa acaagtcttt aatttaattt ttgttttttg cctaaatcca aagaaaaagg
     2401 gctgccgggc caggcgcggt ggctcacgcc tgtaatccca gcactttggc aggccgaggc
     2461 aggtggatca cctgacgtca gtagtttgag accagcctgg ccaacatggt gaaaccctgt
     2521 atctactaaa aatacaaaaa ttagccggac gtggtggtgc gcgcatgtaa tcccagctac
     2581 tcgggaggct gaggcggaag aatcacttga acccgggagg cggaggttcc agtgagccga
     2641 gatggcgcta ttgcactcca gtctgggtaa cagggagact gcatctcaaa aaaaaaaaaa
     2701 aaaaaaaaaa agggctgtcc atgtattcac acacccctca aaaaaagcct ttagttccta
     2761 ctttagccac tggtttctca gaatccaaag atcacatatt ctagtgtaac actgcaagaa
     2821 gtcttgagaa aaagattatt gtagtgttca aaatattttt gtattgttaa tgcatcatca
     2881 tagaaaaact tttaaacatg agaataaaga tactttttac tggg
//
