LOCUS       NM_003200               4735 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens transcription factor 3 (TCF3), transcript variant 1,
            mRNA.
ACCESSION   NM_003200
VERSION     NM_003200.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4735)
  AUTHORS   Collinson,R.J., Wilson,L., Boey,D., Ng,Z.Y., Mirzai,B., Chuah,H.S.,
            Howman,R., Grove,C.S., Malherbe,J.A.J., Leahy,M.F., Linden,M.D.,
            Fuller,K.A., Erber,W.N. and Guo,B.B.
  TITLE     Transcription factor 3 is dysregulated in megakaryocytes in
            myelofibrosis
  JOURNAL   Platelets 35 (1), 2304173 (2024)
   PUBMED   38303515
  REMARK    GeneRIF: Transcription factor 3 is dysregulated in megakaryocytes
            in myelofibrosis.
REFERENCE   2  (bases 1 to 4735)
  AUTHORS   Xie,W., Liu,W., Wang,L., Li,S., Liao,Z., Xu,H., Li,Y., Jiang,X. and
            Ren,C.
  TITLE     Embryonic stem cell related gene regulates alternative splicing of
            transcription factor 3 to maintain human embryonic stem cells'
            self-renewal and pluripotency
  JOURNAL   Stem Cells 42 (6), 540-553 (2024)
   PUBMED   38393342
  REMARK    GeneRIF: Embryonic stem cell related gene regulates alternative
            splicing of transcription factor 3 to maintain human embryonic stem
            cells' self-renewal and pluripotency.
REFERENCE   3  (bases 1 to 4735)
  AUTHORS   Li,Y., Li,R., Li,Y., Li,G., Zhao,Y., Mou,H., Chen,Y., Xiao,L. and
            Gong,K.
  TITLE     Transcription Factor TCF3 Promotes Macrophage-Mediated Inflammation
            and MMP Secretion in Abdominal Aortic Aneurysm by Regulating
            miR-143-5p /CCL20
  JOURNAL   J Cardiovasc Pharmacol 82 (6), 458-469 (2023)
   PUBMED   37721971
  REMARK    GeneRIF: Transcription Factor TCF3 Promotes Macrophage-Mediated
            Inflammation and MMP Secretion in Abdominal Aortic Aneurysm by
            Regulating miR-143-5p /CCL20.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4735)
  AUTHORS   Zhang,W., Nowotny,H., Theodoropoulou,M., Simon,J., Hemmer,C.M.,
            Bidlingmaier,M., Auer,M.K., Reincke,M., Uhlenhaut,H. and Reisch,N.
  TITLE     E47 as a novel glucocorticoid-dependent gene mediating lipid
            metabolism in patients with endogenous glucocorticoid excess
  JOURNAL   Front Endocrinol (Lausanne) 14, 1249863 (2023)
   PUBMED   38047107
  REMARK    GeneRIF: E47 as a novel glucocorticoid-dependent gene mediating
            lipid metabolism in patients with endogenous glucocorticoid excess.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4735)
  AUTHORS   Burmeister,T., Groger,D., Gokbuget,N., Spriewald,B., Starck,M.,
            Elmaagacli,A., Hoelzer,D., Keller,U. and Schwartz,S.
  TITLE     Molecular characterization of TCF3::PBX1 chromosomal breakpoints in
            acute lymphoblastic leukemia and their use for measurable residual
            disease assessment
  JOURNAL   Sci Rep 13 (1), 15167 (2023)
   PUBMED   37704696
  REMARK    GeneRIF: Molecular characterization of TCF3::PBX1 chromosomal
            breakpoints in acute lymphoblastic leukemia and their use for
            measurable residual disease assessment.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4735)
  AUTHORS   Chakraborty,T., Martin,J.F. and Olson,E.N.
  TITLE     Analysis of the oligomerization of myogenin and E2A products in
            vivo using a two-hybrid assay system
  JOURNAL   J Biol Chem 267 (25), 17498-17501 (1992)
   PUBMED   1325437
REFERENCE   7  (bases 1 to 4735)
  AUTHORS   Inaba,T., Roberts,W.M., Shapiro,L.H., Jolly,K.W., Raimondi,S.C.,
            Smith,S.D. and Look,A.T.
  TITLE     Fusion of the leucine zipper gene HLF to the E2A gene in human
            acute B-lineage leukemia
  JOURNAL   Science 257 (5069), 531-534 (1992)
   PUBMED   1386162
REFERENCE   8  (bases 1 to 4735)
  AUTHORS   Sommer,L., Hagenbuchle,O., Wellauer,P.K. and Strubin,M.
  TITLE     Nuclear targeting of the transcription factor PTF1 is mediated by a
            protein subunit that does not bind to the PTF1 cognate sequence
  JOURNAL   Cell 67 (5), 987-994 (1991)
   PUBMED   1720355
REFERENCE   9  (bases 1 to 4735)
  AUTHORS   Lassar,A.B., Davis,R.L., Wright,W.E., Kadesch,T., Murre,C.,
            Voronova,A., Baltimore,D. and Weintraub,H.
  TITLE     Functional activity of myogenic HLH proteins requires
            hetero-oligomerization with E12/E47-like proteins in vivo
  JOURNAL   Cell 66 (2), 305-315 (1991)
   PUBMED   1649701
REFERENCE   10 (bases 1 to 4735)
  AUTHORS   Hunger,S.P., Galili,N., Carroll,A.J., Crist,W.M., Link,M.P. and
            Cleary,M.L.
  TITLE     The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1
            coding sequences in acute lymphoblastic leukemias
  JOURNAL   Blood 77 (4), 687-693 (1991)
   PUBMED   1671560
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006274.1, M31222.1,
            AC005321.1 and KC877695.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 5, 2018 this sequence version replaced NM_003200.4.
            
            Summary: This gene encodes a member of the E protein (class I)
            family of helix-loop-helix transcription factors. E proteins
            activate transcription by binding to regulatory E-box sequences on
            target genes as heterodimers or homodimers, and are inhibited by
            heterodimerization with inhibitor of DNA-binding (class IV)
            helix-loop-helix proteins. E proteins play a critical role in
            lymphopoiesis, and the encoded protein is required for B and T
            lymphocyte development. Deletion of this gene or diminished
            activity of the encoded protein may play a role in lymphoid
            malignancies. This gene is also involved in several chromosomal
            translocations that are associated with lymphoid malignancies
            including pre-B-cell acute lymphoblastic leukemia (t(1;19), with
            PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia
            (t(12;19), with ZNF384). Alternatively spliced transcript variants
            encoding multiple isoforms have been observed for this gene, and a
            pseudogene of this gene is located on the short arm of chromosome
            9. [provided by RefSeq, Sep 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (E12). This isoform is
            also known as Pan-2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M31222.1, SRR14038193.1259148.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262965.12/ ENSP00000262965.5
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-286               AC006274.1         14645-14930         c
            287-2349            M31222.1           1-2063
            2350-4481           AC005321.1         8168-10299          c
            4482-4735           KC877695.1         301-554             c
FEATURES             Location/Qualifiers
     source          1..4735
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..4735
                     /gene="TCF3"
                     /gene_synonym="AGM8; AGM8A; AGM8B; bHLHb21; E2A; E47;
                     ITF1; p75; TCF-3; VDIR"
                     /note="transcription factor 3"
                     /db_xref="GeneID:6929"
                     /db_xref="HGNC:HGNC:11633"
                     /db_xref="MIM:147141"
     exon            1..316
                     /gene="TCF3"
                     /gene_synonym="AGM8; AGM8A; AGM8B; bHLHb21; E2A; E47;
                     ITF1; p75; TCF-3; VDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            317..427
                     /gene="TCF3"
                     /gene_synonym="AGM8; AGM8A; AGM8B; bHLHb21; E2A; E47;
                     ITF1; p75; TCF-3; VDIR"
                     /inference="alignment:Splign:2.1.0"
     CDS             356..2320
                     /gene="TCF3"
                     /gene_synonym="AGM8; AGM8A; AGM8B; bHLHb21; E2A; E47;
                     ITF1; p75; TCF-3; VDIR"
                     /note="isoform E12 is encoded by transcript variant 1; VDR
                     interacting repressor; transcription factor E2-alpha;
                     immunoglobulin transcription factor 1; kappa-E2-binding
                     factor; transcription factor ITF-1; E2A-HLF fusion
                     transcript protein; class B basic helix-loop-helix protein
                     21; vitamin D receptor-interacting repressor; negative
                     vitamin D response element-binding protein;
                     helix-loop-helix protein HE47; transcription factor 3 (E2A
                     immunoglobulin enhancer binding factors E12/E47);
                     NOL1-TCF3 fusion"
                     /codon_start=1
                     /product="transcription factor E2-alpha isoform E12"
                     /protein_id="NP_003191.1"
                     /db_xref="CCDS:CCDS12074.1"
                     /db_xref="GeneID:6929"
                     /db_xref="HGNC:HGNC:11633"
                     /db_xref="MIM:147141"
                     /translation="MNQPQRMAPVGTDKELSDLLDFSMMFPLPVTNGKGRPASLAGAQ
                     FGGSGLEDRPSSGSWGSGDQSSSSFDPSRTFSEGTHFTESHSSLSSSTFLGPGLGGKS
                     GERGAYASFGRDAGVGGLTQAGFLSGELALNSPGPLSPSGMKGTSQYYPSYSGSSRRR
                     AADGSLDTQPKKVRKVPPGLPSSVYPPSSGEDYGRDATAYPSAKTPSSTYPAPFYVAD
                     GSLHPSAELWSPPGQAGFGPMLGGGSSPLPLPPGSGPVGSSGSSSTFGGLHQHERMGY
                     QLHGAEVNGGLPSASSFSSAPGATYGGVSSHTPPVSGADSLLGSRGTTAGSSGDALGK
                     ALASIYSPDHSSNNFSSSPSTPVGSPQGLAGTSQWPRAGAPGALSPSYDGGLHGLQSK
                     IEDHLDEAIHVLRSHAVGTAGDMHTLLPGHGALASGFTGPMSLGGRHAGLVGGSHPED
                     GLAGSTSLMHNHAALPSQPGTLPDLSRPPDSYSGLGRAGATAAASEIKREEKEDEENT
                     SAADHSEEEKKELKAPRARTSPDEDEDDLLPPEQKAEREKERRVANNARERLRVRDIN
                     EAFKELGRMCQLHLNSEKPQTKLLILHQAVSVILNLEQQVRERNLNPKAACLKRREEE
                     KVSGVVGDPQMVLSAPHPGLSEAHNPAGHM"
     exon            428..500
                     /gene="TCF3"
                     /gene_synonym="AGM8; AGM8A; AGM8B; bHLHb21; E2A; E47;
                     ITF1; p75; TCF-3; VDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            501..574
                     /gene="TCF3"
                     /gene_synonym="AGM8; AGM8A; AGM8B; bHLHb21; E2A; E47;
                     ITF1; p75; TCF-3; VDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            575..653
                     /gene="TCF3"
                     /gene_synonym="AGM8; AGM8A; AGM8B; bHLHb21; E2A; E47;
                     ITF1; p75; TCF-3; VDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            654..721
                     /gene="TCF3"
                     /gene_synonym="AGM8; AGM8A; AGM8B; bHLHb21; E2A; E47;
                     ITF1; p75; TCF-3; VDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            722..854
                     /gene="TCF3"
                     /gene_synonym="AGM8; AGM8A; AGM8B; bHLHb21; E2A; E47;
                     ITF1; p75; TCF-3; VDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            855..904
                     /gene="TCF3"
                     /gene_synonym="AGM8; AGM8A; AGM8B; bHLHb21; E2A; E47;
                     ITF1; p75; TCF-3; VDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1007
                     /gene="TCF3"
                     /gene_synonym="AGM8; AGM8A; AGM8B; bHLHb21; E2A; E47;
                     ITF1; p75; TCF-3; VDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1177
                     /gene="TCF3"
                     /gene_synonym="AGM8; AGM8A; AGM8B; bHLHb21; E2A; E47;
                     ITF1; p75; TCF-3; VDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1310
                     /gene="TCF3"
                     /gene_synonym="AGM8; AGM8A; AGM8B; bHLHb21; E2A; E47;
                     ITF1; p75; TCF-3; VDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1369
                     /gene="TCF3"
                     /gene_synonym="AGM8; AGM8A; AGM8B; bHLHb21; E2A; E47;
                     ITF1; p75; TCF-3; VDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1448
                     /gene="TCF3"
                     /gene_synonym="AGM8; AGM8A; AGM8B; bHLHb21; E2A; E47;
                     ITF1; p75; TCF-3; VDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1522
                     /gene="TCF3"
                     /gene_synonym="AGM8; AGM8A; AGM8B; bHLHb21; E2A; E47;
                     ITF1; p75; TCF-3; VDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1681
                     /gene="TCF3"
                     /gene_synonym="AGM8; AGM8A; AGM8B; bHLHb21; E2A; E47;
                     ITF1; p75; TCF-3; VDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1805
                     /gene="TCF3"
                     /gene_synonym="AGM8; AGM8A; AGM8B; bHLHb21; E2A; E47;
                     ITF1; p75; TCF-3; VDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..1941
                     /gene="TCF3"
                     /gene_synonym="AGM8; AGM8A; AGM8B; bHLHb21; E2A; E47;
                     ITF1; p75; TCF-3; VDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2177
                     /gene="TCF3"
                     /gene_synonym="AGM8; AGM8A; AGM8B; bHLHb21; E2A; E47;
                     ITF1; p75; TCF-3; VDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..4735
                     /gene="TCF3"
                     /gene_synonym="AGM8; AGM8A; AGM8B; bHLHb21; E2A; E47;
                     ITF1; p75; TCF-3; VDIR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3041..3046
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCF3"
                     /gene_synonym="AGM8; AGM8A; AGM8B; bHLHb21; E2A; E47;
                     ITF1; p75; TCF-3; VDIR"
                     /note="hexamer: ATTAAA"
     polyA_site      3062
                     /gene="TCF3"
                     /gene_synonym="AGM8; AGM8A; AGM8B; bHLHb21; E2A; E47;
                     ITF1; p75; TCF-3; VDIR"
                     /note="major polyA site"
     regulatory      4711..4716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCF3"
                     /gene_synonym="AGM8; AGM8A; AGM8B; bHLHb21; E2A; E47;
                     ITF1; p75; TCF-3; VDIR"
                     /note="hexamer: AATAAA"
     polyA_site      4735
                     /gene="TCF3"
                     /gene_synonym="AGM8; AGM8A; AGM8B; bHLHb21; E2A; E47;
                     ITF1; p75; TCF-3; VDIR"
                     /note="major polyA site"
ORIGIN      
        1 ggaacatgtc tcccgccgca ggaagatgag gcagcggcgg cggctgcggg cgtagcgggc
       61 cggagccgac gcggcggcgg gcaccgcggg caccgcgcac gccgctgccc caggggcgcc
      121 ccggccggcc gcgcgcacgg gccccgcggg acgggccacg cgggggtggg aggggcccgg
      181 gccacgcgcg ccgccgccgc cgcccacgcg cgaccctcgg gggcccggcc gcgacgcacc
      241 tttgtccggg ggggggcccc cccgcttcat gccgccgccc ccccccacgc gccgcgtgcc
      301 cggccgcgcc cagcagggtt tccaggcctg aggtgcccgc cctggcccca ggagaatgaa
      361 ccagccgcag aggatggcgc ctgtgggcac agacaaggag ctcagtgacc tcctggactt
      421 cagcatgatg ttcccgctgc ctgtcaccaa cgggaagggc cggcccgcct ccctggccgg
      481 ggcgcagttc ggaggttcag gtcttgagga ccggcccagc tcaggctcct ggggcagcgg
      541 cgaccagagc agctcctcct ttgaccccag ccggaccttc agcgagggca cccacttcac
      601 tgagtcgcac agcagcctct cttcatccac attcctggga ccgggactcg gaggcaagag
      661 cggtgagcgg ggcgcctatg cctccttcgg gagagacgca ggcgtgggcg gcctgactca
      721 ggctggcttc ctgtcaggcg agctggccct caacagcccc gggcccctgt ccccttcggg
      781 catgaagggg acctcccagt actacccctc ctactccggc agctcccggc ggagagcggc
      841 agacggcagc ctagacacgc agcccaagaa ggtccggaag gtcccgccgg gtcttccatc
      901 ctcggtgtac ccacccagct caggtgagga ctacggcagg gatgccaccg cctacccgtc
      961 cgccaagacc cccagcagca cctatcccgc ccccttctac gtggcagatg gcagcctgca
     1021 cccctcagcc gagctctgga gtcccccggg ccaggcgggc ttcgggccca tgctgggtgg
     1081 gggctcatcc ccgctgcccc tcccgcccgg tagcggcccg gtgggcagca gtggaagcag
     1141 cagcacgttt ggtggcctgc accagcacga gcgtatgggc taccagctgc atggagcaga
     1201 ggtgaacggt gggctcccat ctgcatcctc cttctcctca gcccccggag ccacgtacgg
     1261 cggcgtctcc agccacacgc cgcctgtcag cggggccgac agcctcctgg gctcccgagg
     1321 gaccacagct ggcagctccg gggatgccct cggcaaagca ctggcctcga tctactcccc
     1381 ggatcactca agcaataact tctcgtccag cccttctacc cccgtgggct ccccccaggg
     1441 cctggcagga acgtcacagt ggcctcgagc aggagccccc ggtgccttat cgcccagcta
     1501 cgacgggggt ctccacggcc tgcagagtaa gatagaagac cacctggacg aggccatcca
     1561 cgtgctccgc agccacgccg tgggcacagc cggcgacatg cacacgctgc tgcctggcca
     1621 cggggcgctg gcctcaggtt tcaccggccc catgtcactg ggcgggcggc acgcaggcct
     1681 ggttggaggc agccaccccg aggacggcct cgcaggcagc accagcctca tgcacaacca
     1741 cgcggccctc cccagccagc caggcaccct ccctgacctg tctcggcctc ccgactccta
     1801 cagtgggcta gggcgagcag gtgccacggc ggccgccagc gagatcaagc gggaggagaa
     1861 ggaggacgag gagaacacgt cagcggctga ccactcggag gaggagaaga aggagctgaa
     1921 ggccccccgg gcccggacca gcccagacga ggacgaggac gaccttctcc ccccagagca
     1981 gaaggccgag cgggagaagg agcgccgggt ggccaataac gcccgggagc ggctgcgggt
     2041 ccgtgacatc aacgaggcct ttaaggagct ggggcgcatg tgccaactgc acctcaacag
     2101 cgagaagccc cagaccaaac tgctcatcct gcaccaggct gtctcggtca tcctgaactt
     2161 ggagcagcaa gtgcgagagc ggaacctgaa tcccaaagca gcctgtttga aacggcgaga
     2221 agaggaaaag gtgtcaggtg tggttggaga cccccagatg gtgctttcag ctccccaccc
     2281 aggcctgagc gaagcccaca accccgccgg gcacatgtga aaggtatgcc tccgtgggac
     2341 gagccacccg ctttcagccc tgtgctctgg ccccagaacg gccactcgag accccgggct
     2401 tcatccacat ccacacctca cacacctgtt gtcagcatcg agccaacacc aacctgacaa
     2461 ggttcggagt gatgggggcg gccaaggtga cactgggtcc aggagctccc tggggccctg
     2521 gcctaccact cactggcctc gctccccctg tccccgaatc tcagccaccg tgtcactctg
     2581 tgacctgtcc catggatcct gaaactgcat cttggccctg ttgcctgggc tgacaggagc
     2641 attttttttt tttccagtaa acaaaacctg aaagcaagca acaaaacata cactttgtca
     2701 gagaagaaaa aaatgcctta actataaaaa gcggagaaat ggaaacatat cactcaaggg
     2761 ggatgctgtg gaaacctggc ttattcttct aaagccacca gcaaattgtg cctaagcgaa
     2821 atattttttt taaggaaaat aaaaacatta gttacaagat tttttttttc ttaatgtaga
     2881 tgaaaattag caaggatgct gcctttggtc tctggttttt ttaagctttt tttgcatatg
     2941 ttttgtaagc aacaaatttt tttgtataaa agtcccgtgt ctctcgctat ttctgctgct
     3001 gttcctagac tgagcattgc atttcttgat caaccagatg attaaacgtt gtattaaaaa
     3061 gaccccgtgt aaacctgagc ccccccgtcc cccccccccc ccggaagcca ctgcacacag
     3121 acagaacggg gacaggcggc gggtcttttg tttttttgat gttgggggtt ctcttggttt
     3181 tgtcatgtgg aaagtgatgc gtgggcgttc cctgatgaag gcaccttggg gcttccctgc
     3241 cgcatcctct cccctcagga aggggactga cctgggcttg ggggaaggga cgtcagcaag
     3301 gtggctctga ccctcccagg tgactctgcc aagcagctgt ggcccccagg gctaccctac
     3361 acaacgccct ccccaggccc ccctaagctg ctctcccttg gaacctgcac agctctctga
     3421 aatggggcat tttgttggga ccagtgaccc ctggcatggg gaccacaccc tggagcccgg
     3481 tgctggggac ctcctggaca ccctgtcctt cactcctttg ccccagggac ccaggctcat
     3541 gctctgaact ctggctgaga ggatgctgct caggagccag cacaggacac cccccacccc
     3601 accccaccat gtccccatta caccagaggg ccatcgtgac gtagacagga tgccaggggc
     3661 ctggccagcc tcccccaatg ctggggagca tccctgggcc tggggccaca cctgctgccc
     3721 tccctctgtg tggtccaagg gcaagagtgg ctggagccgg gggactgtgc tggtctgagc
     3781 cccacgaagg ccttgggctg tgcgtccgac cctgctgcag aaccagcagg gtgtcccctc
     3841 gggcccatct gtgtcccatg tcccagcacc caggcctctc tccaggtctc cttttctggt
     3901 cttttgccat gagggtaacc agctcttccc agctggctgg ggactgtctt gggtttaaaa
     3961 ctgcaagtct cctaccctgg gatcccatcc agttccacac gaactagggc agtggtcact
     4021 gtggcaccca ggtgtgggcc tggctagctg ggggccttca tgtgcccttc atgcccctcc
     4081 ctgcattgag gccttgtgga cccctgggct ggctgtgttc atccccgctg caggtcgggc
     4141 gtctcccccc gtgccactcc tgagactccc accgttaccc ccaggagatc ctggactgcc
     4201 tgactcccct ccccagactg gcttgggagc ctgggcccca tggtagatgc aagggaaacc
     4261 tcaaggccag ctcaatgcct ggtatctgcc cccagtccag gccaggcgga ggggaggggc
     4321 tgtccggctg cctctccctt ctcggtggct tcccctacgc cctgggagtt tgatctctta
     4381 agggaacttg cctctccctc ttgttttgct cctggccctg cccctaggtc tgggtgggca
     4441 gtggccccat agcctctgga actgtgcgtt ctgcatagaa ttcaaacgag attcacccag
     4501 cgcgaggagg aagaaacagc agttcctggg aaccacaatt atggggggtg gggggtgtga
     4561 tctgagtgcc tcaagatggt tttcaaaaaa atttttttaa agaaaataat tgtatacgtg
     4621 tcaacacagc tggctggatg attgggactt taaaacgacc ctctttcagg tggattcaga
     4681 gacctgtcct gtatataaca gcactgtagc aataaacgtg acattttata acgat
//
