LOCUS       NM_014972               2248 bp    mRNA    linear   PRI 01-DEC-2024
DEFINITION  Homo sapiens TCF25 ribosome quality control complex subunit
            (TCF25), mRNA.
ACCESSION   NM_014972
VERSION     NM_014972.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2248)
  AUTHORS   Dos Santos,O.A.L., Carneiro,R.L., Requiao,R.D., Ribeiro-Alves,M.,
            Domitrovic,T. and Palhano,F.L.
  TITLE     Transcriptional profile of ribosome-associated quality control
            components and their associated phenotypes in mammalian cells
  JOURNAL   Sci Rep 14 (1), 1439 (2024)
   PUBMED   38228636
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2248)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 2248)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2248)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 2248)
  AUTHORS   Zhang,X., Lei,F., Wang,X.M., Deng,K.Q., Ji,Y.X., Zhang,Y., Li,H.,
            Zhang,X.D., Lu,Z. and Zhang,P.
  TITLE     NULP1 Alleviates Cardiac Hypertrophy by Suppressing NFAT3
            Transcriptional Activity
  JOURNAL   J Am Heart Assoc 9 (16), e016419 (2020)
   PUBMED   32805187
  REMARK    GeneRIF: NULP1 Alleviates Cardiac Hypertrophy by Suppressing NFAT3
            Transcriptional Activity.
REFERENCE   6  (bases 1 to 2248)
  AUTHORS   Oguri,M., Kato,K., Yokoi,K., Yoshida,T., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Assessment of a polymorphism of SDK1 with hypertension in Japanese
            Individuals
  JOURNAL   Am J Hypertens 23 (1), 70-77 (2010)
   PUBMED   19851296
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2248)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
REFERENCE   8  (bases 1 to 2248)
  AUTHORS   Steen,H. and Lindholm,D.
  TITLE     Nuclear localized protein-1 (Nulp1) increases cell death of human
            osteosarcoma cells and binds the X-linked inhibitor of apoptosis
            protein
  JOURNAL   Biochem Biophys Res Commun 366 (2), 432-437 (2008)
   PUBMED   18068114
  REMARK    GeneRIF: These results indicate that Nulp1 plays a role in cell
            death control and may influence tumor growth.
REFERENCE   9  (bases 1 to 2248)
  AUTHORS   Cai,Z., Wang,Y., Yu,W., Xiao,J., Li,Y., Liu,L., Zhu,C., Tan,K.,
            Deng,Y., Yuan,W., Liu,M. and Wu,X.
  TITLE     hnulp1, a basic helix-loop-helix protein with a novel
            transcriptional repressive domain, inhibits transcriptional
            activity of serum response factor
  JOURNAL   Biochem Biophys Res Commun 343 (3), 973-981 (2006)
   PUBMED   16574069
  REMARK    GeneRIF: hnulp1 may act as a novel transcriptional repressor in
            serum response factor signaling pathways.
REFERENCE   10 (bases 1 to 2248)
  AUTHORS   Olsson,M., Durbeej,M., Ekblom,P. and Hjalt,T.
  TITLE     Nulp1, a novel basic helix-loop-helix protein expressed broadly
            during early embryonic organogenesis and prominently in developing
            dorsal root ganglia
  JOURNAL   Cell Tissue Res 308 (3), 361-370 (2002)
   PUBMED   12107429
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI913551.1 and BC011884.2.
            
            On Nov 22, 2018 this sequence version replaced NM_014972.2.
            
            Summary: TCF25 is a member of the basic helix-loop-helix (bHLH)
            family of transcription factors that are important in embryonic
            development (Steen and Lindholm, 2008 [PubMed 18068114]).[supplied
            by OMIM, Sep 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1091791.1,
                                           SRR1660809.32437.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263346.13/ ENSP00000263346.8
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BI913551.1         7-26
            21-2248             BC011884.2         1-2228
FEATURES             Location/Qualifiers
     source          1..2248
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.3"
     gene            1..2248
                     /gene="TCF25"
                     /gene_synonym="FKSG26; hKIAA1049; Hulp1; NULP1; PRO2620"
                     /note="TCF25 ribosome quality control complex subunit"
                     /db_xref="GeneID:22980"
                     /db_xref="HGNC:HGNC:29181"
                     /db_xref="MIM:612326"
     exon            1..268
                     /gene="TCF25"
                     /gene_synonym="FKSG26; hKIAA1049; Hulp1; NULP1; PRO2620"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..2107
                     /gene="TCF25"
                     /gene_synonym="FKSG26; hKIAA1049; Hulp1; NULP1; PRO2620"
                     /note="TCF-25; nuclear localized protein 1; transcription
                     factor 25 (basic helix-loop-helix)"
                     /codon_start=1
                     /product="ribosome quality control complex subunit TCF25"
                     /protein_id="NP_055787.1"
                     /db_xref="CCDS:CCDS10987.1"
                     /db_xref="GeneID:22980"
                     /db_xref="HGNC:HGNC:29181"
                     /db_xref="MIM:612326"
                     /translation="MSRRALRRLRGEQRGQEPLGPGALHFDLRDDDDAEEEGPKRELG
                     VRRPGGAGKEGVRVNNRFELINIDDLEDDPVVNGERSGCALTDAVAPGNKGRGQRGNT
                     ESKTDGDDTETVPSEQSHASGKLRKKKKKQKNKKSSTGEASENGLEDIDRILERIEDS
                     TGLNRPGPAPLSSRKHVLYVEHRHLNPDTELKRYFGARAILGEQRPRQRQRVYPKCTW
                     LTTPKSTWPRYSKPGLSMRLLESKKGLSFFAFEHSEEYQQAQHKFLVAVESMEPNNIV
                     VLLQTSPYHVDSLLQLSDACRFQEDQEMARDLVERALYSMECAFHPLFSLTSGACRLD
                     YRRPENRSFYLALYKQMSFLEKRGCPRTALEYCKLILSLEPDEDPLCMLLLIDHLALR
                     ARNYEYLIRLFQEWEAHRNLSQLPNFAFSVPLAYFLLSQQTDLPECEQSSARQKASLL
                     IQQALTMFPGVLLPLLESCSVRPDASVSSHRFFGPNAEISQPPALSQLVNLYLGRSHF
                     LWKEPATMSWLEENVHEVLQAVDAGDPAVEACENRRKVLYQRAPRNIHRHVILSEIKE
                     AVAALPPDVTTQSVMGFDPLPPSDTIYSYVRPERLSPISHGNTIALFFRSLLPNYTME
                     GERPEEGVAGGLNRNQGLNRLMLAVRDMMANFHLNDLEAPHEDDAEGEGEWD"
     exon            269..430
                     /gene="TCF25"
                     /gene_synonym="FKSG26; hKIAA1049; Hulp1; NULP1; PRO2620"
                     /inference="alignment:Splign:2.1.0"
     exon            431..505
                     /gene="TCF25"
                     /gene_synonym="FKSG26; hKIAA1049; Hulp1; NULP1; PRO2620"
                     /inference="alignment:Splign:2.1.0"
     exon            506..624
                     /gene="TCF25"
                     /gene_synonym="FKSG26; hKIAA1049; Hulp1; NULP1; PRO2620"
                     /inference="alignment:Splign:2.1.0"
     exon            625..690
                     /gene="TCF25"
                     /gene_synonym="FKSG26; hKIAA1049; Hulp1; NULP1; PRO2620"
                     /inference="alignment:Splign:2.1.0"
     exon            691..773
                     /gene="TCF25"
                     /gene_synonym="FKSG26; hKIAA1049; Hulp1; NULP1; PRO2620"
                     /inference="alignment:Splign:2.1.0"
     exon            774..904
                     /gene="TCF25"
                     /gene_synonym="FKSG26; hKIAA1049; Hulp1; NULP1; PRO2620"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1004
                     /gene="TCF25"
                     /gene_synonym="FKSG26; hKIAA1049; Hulp1; NULP1; PRO2620"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1098
                     /gene="TCF25"
                     /gene_synonym="FKSG26; hKIAA1049; Hulp1; NULP1; PRO2620"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1191
                     /gene="TCF25"
                     /gene_synonym="FKSG26; hKIAA1049; Hulp1; NULP1; PRO2620"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1297
                     /gene="TCF25"
                     /gene_synonym="FKSG26; hKIAA1049; Hulp1; NULP1; PRO2620"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1457
                     /gene="TCF25"
                     /gene_synonym="FKSG26; hKIAA1049; Hulp1; NULP1; PRO2620"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1545
                     /gene="TCF25"
                     /gene_synonym="FKSG26; hKIAA1049; Hulp1; NULP1; PRO2620"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1704
                     /gene="TCF25"
                     /gene_synonym="FKSG26; hKIAA1049; Hulp1; NULP1; PRO2620"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1795
                     /gene="TCF25"
                     /gene_synonym="FKSG26; hKIAA1049; Hulp1; NULP1; PRO2620"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1875
                     /gene="TCF25"
                     /gene_synonym="FKSG26; hKIAA1049; Hulp1; NULP1; PRO2620"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..1948
                     /gene="TCF25"
                     /gene_synonym="FKSG26; hKIAA1049; Hulp1; NULP1; PRO2620"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2248
                     /gene="TCF25"
                     /gene_synonym="FKSG26; hKIAA1049; Hulp1; NULP1; PRO2620"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2230..2235
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCF25"
                     /gene_synonym="FKSG26; hKIAA1049; Hulp1; NULP1; PRO2620"
                     /note="hexamer: TATAAA"
     polyA_site      2248
                     /gene="TCF25"
                     /gene_synonym="FKSG26; hKIAA1049; Hulp1; NULP1; PRO2620"
                     /note="major polyA site"
ORIGIN      
        1 gtgcgcaggc gcgccgacag ccgagttttc tgcgcttcct tctccctctc tccagacgtc
       61 gtggtcgttc ggtcctatgt cgcgccgggc cctccggagg ctgagggggg aacagcgcgg
      121 ccaggagccc ctcgggcccg gcgccttgca tttcgatctc cgtgatgacg atgacgcgga
      181 agaagaaggg cccaagcggg agcttggtgt ccggcgtccc gggggcgcag ggaaggaggg
      241 cgtccgagtc aacaaccgct tcgagctgat aaacattgac gatcttgagg atgaccctgt
      301 ggtgaacggg gagaggtctg gctgtgcgct cacagacgct gtggcaccag ggaacaaagg
      361 aaggggtcag cgtggaaaca cagagagcaa gacggatgga gatgacaccg agacagtgcc
      421 ctcagagcag tctcatgcaa gtggcaaact ccggaagaag aaaaaaaaac agaaaaacaa
      481 gaaaagcagc acgggagaag catcggaaaa cggactagaa gatatcgatc gcatcctaga
      541 gaggattgag gacagcactg ggttgaaccg tcccggccca gctcccctga gctccaggaa
      601 gcacgttctc tacgtggagc acagacactt gaatccagac acagaactga aaaggtattt
      661 tggtgcccgg gcaatcctgg gggagcaaag gccacggcag agacaacgtg tgtaccccaa
      721 gtgcacatgg ctgaccaccc ctaaaagcac ctggccccgc tacagcaaac caggtctgtc
      781 catgcggctg ctggaatcaa aaaaaggcct ctccttcttt gcgtttgagc acagtgagga
      841 gtaccagcag gctcagcaca agttcctggt ggccgtggag tctatggagc cgaacaacat
      901 cgtggttctg ctccagacga gcccttacca cgttgactca ctcctgcagc tcagcgatgc
      961 ctgccgcttt caagaggatc aggagatggc tcgagacctc gtagagagag cgctgtacag
     1021 catggaatgt gcgttccacc ccctgttcag tctcaccagt ggggcctgcc ggctggatta
     1081 ccgcagaccc gagaacagga gcttctacct ggccctctac aagcagatga gcttcctgga
     1141 gaagcgaggc tgcccgcgca cggcgctgga gtactgcaag ctcatcctga gtctcgagcc
     1201 ggatgaggac cccctctgca tgctgctgct catcgaccac ctggccttgc gggcccggaa
     1261 ctacgagtac ctgatccgcc tcttccagga gtgggaggct catcggaacc tgtcccagct
     1321 ccctaatttt gccttctctg ttccactggc gtatttcctg ctgagccagc agacagacct
     1381 ccctgagtgt gagcagagct ctgccaggca gaaggcctct ctcctgatac agcaggcgct
     1441 caccatgttc cctggagtcc tcctgcccct gctcgagtct tgcagtgtgc ggcccgacgc
     1501 cagcgtttcc agtcaccgct tctttggacc caatgctgaa ataagccagc cccctgccct
     1561 gagccagctg gtgaacctgt accttgggag gtcacacttt ctctggaaag agcccgccac
     1621 catgagctgg ctggaggaga acgtccacga ggttctgcaa gcagtggacg ccggggaccc
     1681 agccgtggaa gcctgtgaga accggcggaa ggtgctctac cagcgtgcac ccaggaatat
     1741 ccaccgccat gtgatcctct ctgagatcaa ggaagccgtc gctgccctgc ccccggacgt
     1801 gaccacgcag tctgtgatgg ggtttgatcc tctgcctcct tcggacacaa tctactccta
     1861 cgtcaggcca gagaggctaa gtcctatcag ccatggaaac accattgctc tcttcttccg
     1921 gtcactgttg ccaaactata ccatggaggg ggagaggccc gaggaaggag tggctggggg
     1981 tctgaaccgc aaccagggcc tgaacaggct gatgctggct gtgcgcgaca tgatggccaa
     2041 cttccacctc aacgacctgg aggcgccgca cgaggacgac gctgaggggg agggggagtg
     2101 ggactgagcg tccgcagagg tgaccgaaaa gccgtatgat gatgttcccg atttctctgt
     2161 tggtcggagt cggccagttg cctgaagtag ggaagctgag tgtgtcgctc cctggtccac
     2221 tgtttctcct ataaatgtaa atgggtca
//
