LOCUS       NM_175769               4882 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens transcription factor 23 (TCF23), mRNA.
ACCESSION   NM_175769
VERSION     NM_175769.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4882)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4882)
  AUTHORS   Kommagani,R., Szwarc,M.M., Kovanci,E., Creighton,C.J.,
            O'Malley,B.W., Demayo,F.J. and Lydon,J.P.
  TITLE     A murine uterine transcriptome, responsive to steroid receptor
            coactivator-2, reveals transcription factor 23 as essential for
            decidualization of human endometrial stromal cells
  JOURNAL   Biol Reprod 90 (4), 75 (2014)
   PUBMED   24571987
  REMARK    GeneRIF: Transcription factor 23 (Tcf23), a basic-helix-loop-helix
            transcription factor, is a new progesterone-induced target gene
            that requires SRC-2 for full induction.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4882)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   4  (bases 1 to 4882)
  AUTHORS   McLellan,A.S., Langlands,K. and Kealey,T.
  TITLE     Exhaustive identification of human class II basic helix-loop-helix
            proteins by virtual library screening
  JOURNAL   Mech Dev 119 Suppl 1, S285-S291 (2002)
   PUBMED   14516699
REFERENCE   5  (bases 1 to 4882)
  AUTHORS   Tachibana,M., Narumi,O., Muguruma,K., Yamamoto,I., Shinkai,Y. and
            Yokota,Y.
  TITLE     Genomic organization and chromosomal mapping of the basic
            helix-loop-helix factor OUT (Tcf23/TCF23)
  JOURNAL   Cytogenet Cell Genet 94 (1-2), 23-25 (2001)
   PUBMED   11701948
REFERENCE   6  (bases 1 to 4882)
  AUTHORS   Narumi,O., Mori,S., Boku,S., Tsuji,Y., Hashimoto,N., Nishikawa,S.
            and Yokota,Y.
  TITLE     OUT, a novel basic helix-loop-helix transcription factor with an
            Id-like inhibitory activity
  JOURNAL   J Biol Chem 275 (5), 3510-3521 (2000)
   PUBMED   10652346
  REMARK    GeneRIF: Study of the orthologous gene in mouse shows the encoded
            protein does not bind DNA but may negatively regulate other basic
            helix-loop-helix factors via the formation of a functionally
            inactive heterodimeric complex.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC013403.9 and BC137191.1.
            
            On Nov 22, 2018 this sequence version replaced NM_175769.2.
            
            Summary: The gene encodes a member of the basic helix-loop-helix
            transcription factor family. Studies of the orthologous gene in
            mouse have shown the encoded protein does not bind DNA but may
            negatively regulate other basic helix-loop-helix factors via the
            formation of a functionally inactive heterodimeric complex.
            [provided by RefSeq, May 2010].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC137191.1, DY654546.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296096.6/ ENSP00000296096.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AC013403.9         89704-89776
            74-859              BC137191.1         1-786
            860-4882            AC013403.9         93652-97674
FEATURES             Location/Qualifiers
     source          1..4882
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..4882
                     /gene="TCF23"
                     /gene_synonym="bHLHa24; OUT; TCF-23"
                     /note="transcription factor 23"
                     /db_xref="GeneID:150921"
                     /db_xref="HGNC:HGNC:18602"
                     /db_xref="MIM:609635"
     exon            1..352
                     /gene="TCF23"
                     /gene_synonym="bHLHa24; OUT; TCF-23"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..775
                     /gene="TCF23"
                     /gene_synonym="bHLHa24; OUT; TCF-23"
                     /note="class II basic helix-loop-helix protein TCF23;
                     class A basic helix-loop-helix protein 24"
                     /codon_start=1
                     /product="transcription factor 23"
                     /protein_id="NP_786951.1"
                     /db_xref="CCDS:CCDS33163.1"
                     /db_xref="GeneID:150921"
                     /db_xref="HGNC:HGNC:18602"
                     /db_xref="MIM:609635"
                     /translation="MSQRKARGPPAMPGVGHSQTQAKARLLPGADRKRSRLSRTRQDP
                     WEERSWSNQRWSRATPGPRGTRAGGLALGRSEASPENAARERSRVRTLRQAFLALQAA
                     LPAVPPDTKLSKLDVLVLAASYIAHLTRTLGHELPGPAWPPFLRGLRYLHPLKKWPMR
                     SRLYAGGLGYSDLDSTTASTPSQRTRDAEVGSQVPGEADALLSTTPLSPALGDK"
     exon            353..595
                     /gene="TCF23"
                     /gene_synonym="bHLHa24; OUT; TCF-23"
                     /inference="alignment:Splign:2.1.0"
     exon            596..4882
                     /gene="TCF23"
                     /gene_synonym="bHLHa24; OUT; TCF-23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4855..4860
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCF23"
                     /gene_synonym="bHLHa24; OUT; TCF-23"
                     /note="hexamer: AATAAA"
     polyA_site      4882
                     /gene="TCF23"
                     /gene_synonym="bHLHa24; OUT; TCF-23"
                     /note="major polyA site"
ORIGIN      
        1 gagttggcgc cagcttcctc ggatgtagat attgctggct ggatgaccag ccacagccag
       61 ctagcttgag tccaaggcct cctcaggcac tgtgtttctg ctctgtgggc tgcagcccca
      121 gtggggtggc atgtcacaga ggaaggccag agggccacca gccatgccag gggtggggca
      181 tagccagact caggccaaag cacggttgct gccaggcgct gacaggaaga ggagccgcct
      241 cagcaggaca aggcaggacc cgtgggaaga aagaagctgg agcaaccaga gatggagcag
      301 agctacccct ggccctcgag ggaccagggc tgggggcctg gctcttggca ggagcgaggc
      361 cagtcctgag aatgccgcgc gggagcggag ccgggtcagg acgctgcgcc aggccttctt
      421 ggccttgcag gctgctctgc ctgccgtgcc gcccgacacc aagctctcca agttggacgt
      481 gctggtgctc gccgccagct acatagccca cctcacccgc acactcggcc acgagttgcc
      541 tggccctgcc tggccgccct tcctgcgtgg actccgctac ttgcaccctc tcaagaagtg
      601 gccgatgcga tctcgtctct atgctggagg cctggggtac tccgatcttg actccaccac
      661 agccagcacc cccagccaaa gaacaagaga tgcagaggtg gggtcccaag tccctggaga
      721 ggcagatgct ctcctttcca ccacaccact ctcaccagct cttggtgaca aataattatc
      781 acactcgccc ttttctccta gactgtgact catgcttatg ggcctggatt ttctaccagc
      841 ccccagattc tcagccatca gacttgactc agactcagct cccaagttcc agcatgcaga
      901 ccaagagaag cagtagcact tctgtgatgg acagtaccta gaggggcaca ggttggagag
      961 cctcctcctt ggtccccagg aggggacttc cccatggctc ttctgtgaca gctactggga
     1021 agtgggagag aaagaggtat aattgggctc aaagttgagg tagggaacca ccctagcttt
     1081 cttcccctaa ggtttctaca aaccctctgc agatagcaaa aaggcaggtg cagagggagg
     1141 ggcctgggat ggcaccagcc ccaggtgctg atgggaaagc caggtggccg gataggctcc
     1201 tggtagctcc aagtgtaaac agatctgggc tgggtcacac agccagaggg gaaactgaag
     1261 aaggaaatgt gctttctaac tgcatcatga gatgcttacc tgatgttaga gagatagtga
     1321 ggaattcagg attcctccct ctgtagtatg ggcctttcca gaagctgccc ctcaccacta
     1381 cattttctct ccctctcggc tcctgcactc ttccactctt ttcttttctt ttcttttctt
     1441 ttcgtttctt cttcttttta tgtagagatg ggggtcttga tatgttgccc aggctggcct
     1501 cgaacccctg gcctcaagtg atcctcccac ctcagcctcc taaagtgctg ggattacagg
     1561 catgagccac catgcccaac cccactgttt tcttgacatg agttatatct acaggttaag
     1621 ccatacatct tgcattgctt acattccagt ttccagagaa acttttagat agtcccagat
     1681 gcctagtttg agatcttaac cagaagcaat tctaccttaa ttgaaccaag cagcaactta
     1741 tggccttaaa tatgaaggat attgacagaa tcaattacat ccttgaagga ccttaagaga
     1801 agatcaggta tatagggggt gatcattaca gtcttctctt tccattatgt tagaaacctg
     1861 ccctcaagca aaaacaagat aggcctgcct tcaactgctc aaccactcaa ttggctcctt
     1921 gtaaaatttg tgttcgaggc ttccctggct ctggagttat ttctatagtc tattagctcc
     1981 ctagggccgg ctccgcctca tggagatcgt ccttgggggc tttctctaag tcctaccatg
     2041 gggtgccaga aatgtgatat agcttcggtg aaactcatct ctggccctaa agaaataact
     2101 tgaggactaa tcatagaatc tacacacact gaaaataact ttccagatcg gatgtagcct
     2161 caaacctggc acctgaagtc cagatggaac aaattacctt tcggttaaat ttcagccctt
     2221 cagagtggga ggggacgggc atgaccaact agagtcccaa caaggttatc cttagacaca
     2281 caccattgtt gttatcatga atgtaagtga gctctgggca ggctgggaat ggttggggtc
     2341 tgggttctgg catgacagga ccctgtacct ccacagggct ggccagggca gagctgaaat
     2401 agggctgggg gtgcgactga gccagttgtg gtagaggtag aaaaagagac acagaacatc
     2461 ccagccccga gctgcctggg atgtgggaga acagctggaa tgtggatggg agccatgggg
     2521 agaaggcctc ggccaaggct gaactcgtaa atctgccttg aaccacgtct ctgcagaggg
     2581 accctgaaga gcttgtgcag agctgatgtg ggcagctgga cagggccagg caggggcaga
     2641 ggccaggtgt gggagggcat gagcacagtg ttcttcacaa gaccataaaa gtccagctag
     2701 aatgtactat ttttaaagcc aaacagcagt atcttcctgg ttgagttcac gggagtgcta
     2761 ggaagagaag cagatacatt tcctcctcag ttggtggcac actttcctgg ggatgaaggg
     2821 aaattggctt ggggtgtgtg tcggggtcct ctggatagca tggagcttct cctgataata
     2881 gagtagactt tgggttggag cttgccccac cctgtcctgc tcagactcag gcctttgcct
     2941 agtaacatta gagccctcag gggtgaccgc atggccctgg tgtagacaag gagggcacag
     3001 gaaggatgac gcaggtggag ggctgcagga ggcaggtccc atcgctacaa gtttctcagg
     3061 gtgtcttggg ccctttccag gcaaagctgt tctcctttgt gcccaggaca gtcgaggggg
     3121 gtggggcaga ggccatctcc tccagccaca gagacccagc cccgtcaggc cagcaagcaa
     3181 aggggcctgg cagggggcag ggtgagccaa gggaaggcct aggggatgga tgggaataac
     3241 cagaggatgg actgggccct ccctccctga caagcacagt aatgcccttg agacatgtca
     3301 ggacttggat gcgtgaatga accagaagta acccgctttg tctctgcaat gagaaagaaa
     3361 aacacagcca ggctcagtgg ctcatgcctg taatcccagc actttgggga gtcgaggcgg
     3421 gcggatcatg aggtcaggag ttcgagacca gcctcgccaa catgatgaaa ccccttcttt
     3481 actaaaaata caaaaattag ccagatgtcg tagtgggcac ctgtaatcct agctacttgg
     3541 gaggctgagg caggagaatt gcttgaacct aggaggcgga ggttgcagtg agccaagatc
     3601 acgccactgc actccagcct gggcgacaga gcaagacccc atctcgggaa aaaaaaatga
     3661 aagaaaaaaa aagaaaagaa aagaaataaa agaaaatatg gatgaaaaca tttgagcatg
     3721 gatgacaaat gacactaggg tggcctggct caggagttgg aggctcagct gctccatagg
     3781 ggattggcct ggcctacctg gtcttcctgc accacctgcc ccatccccag gacttgggat
     3841 tgggatggag gtggaggtgg ggaacaagac ttccctgctg gctccctcca cagagcatgt
     3901 gctttctgag gaacaggatg gcagggtgga ggcttagatg gggctgtggg gctgggtgtg
     3961 gtggctgatg cctgtaatcc cagcactttg ggaggccggg gtcgggggtg gatcatctga
     4021 ggtcaggagt tcaagaccag cctgaccaac atggtgaaac cctgtctcta ctaaaaatac
     4081 gaaattagct gggtgtggtg gcacatgcct ataaccccag ctacttggga ggctgaggca
     4141 ggagaattgc ttgatcccag gaggtggagt ttgcagtgag ctgagattgt gccattgcac
     4201 tccagcctgg gcaacaagag taaaactccg tctaaaaaaa aaaaaaaaat gcggctgtgg
     4261 gagaagcaga gctggcccag tgatttcttt ttttttgttt tttgagacag agtctcactc
     4321 tgtcaccgag gctggagcgc agtggcgtga tctcggctca ctgcaagctc cgcctcctgg
     4381 gttcacgcga ttctcctgcc tcagcctccc gagcagctgg gactacaggc acccgccaac
     4441 acgcccggct aatttttttt tttttttgta tttttagtag agacggggtt tcaccatgtt
     4501 agccaggatg gtcttgatct cctgacctcg tgatccgccc gcctcggcct cccaaagtgc
     4561 tgggattaca ggcatgagcc accgcacccg gctggcccag tgatttctaa gtaatacagt
     4621 ggacactgga ttttaccaaa ttgggaacta gagaagtaga ggatctagcc ttctctgaga
     4681 ctccttttct cttcctctgg gaggagcctg gctagggtga gtcagatggc actgtcctct
     4741 cccttttgtg gcatgagccc taaacccagg gcccctaaaa gcttattcta ttctagatca
     4801 aggtaggcaa actatggcca gtgggccaaa cccagccccc catgtatttt tgtaaataaa
     4861 gttttattgg aacacatcca ca
//
