LOCUS       NM_003206               1280 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens transcription factor 21 (TCF21), transcript variant 2,
            mRNA.
ACCESSION   NM_003206
VERSION     NM_003206.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1280)
  AUTHORS   Yu,T.H., Lee,T.L., Tsai,I.T., Hsuan,C.F., Wang,C.P., Lu,Y.C.,
            Tang,W.H., Wei,C.T., Chung,F.M., Lee,Y.J. and Wu,C.C.
  TITLE     Transcription factor 21 rs12190287 polymorphism is related to
            stable angina and ST elevation myocardial infarction in a Chinese
            Population
  JOURNAL   Int J Med Sci 21 (3), 483-491 (2024)
   PUBMED   38250610
  REMARK    GeneRIF: Transcription factor 21 rs12190287 polymorphism is related
            to stable angina and ST elevation myocardial infarction in a
            Chinese Population.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1280)
  AUTHORS   Santos,M.R., Mendonca,M.I., Temtem,M., Sa,D., Sousa,A.C.,
            Freitas,S., Rodrigues,M., Borges,S., Guerra,G., Ornelas,I.,
            Drumond,A. and Palma Dos Reis,R.
  TITLE     Transcription factor 21 gene and prognosis in a coronary population
  JOURNAL   Rev Port Cardiol 42 (11), 907-913 (2023)
   PUBMED   37391023
  REMARK    GeneRIF: Transcription factor 21 gene and prognosis in a coronary
            population.
REFERENCE   3  (bases 1 to 1280)
  AUTHORS   Wang,J.G., Jin,X.F., Huang,Y.M., Xu,Z.F., Huang,S.J., Zhu,Y., Ai,L.
            and Hang,T.
  TITLE     TCF21 rs2327429 and TCF21 rs12190287 are associated with colorectal
            cancer in a Chinese population
  JOURNAL   Biomark Med 17 (17), 693-699 (2023)
   PUBMED   38197316
  REMARK    GeneRIF: TCF21 rs2327429 and TCF21 rs12190287 are associated with
            colorectal cancer in a Chinese population.
REFERENCE   4  (bases 1 to 1280)
  AUTHORS   Zhao,X.K., Zhu,M.M., Wang,S.N., Zhang,T.T., Wei,X.N., Wang,C.Y.,
            Zheng,J., Zhu,W.Y., Jiang,M.X., Xu,S.W., Yang,X.X., Duan,Y.J.,
            Zhang,B.C., Han,J.H., Miao,Q.R., Hu,H. and Chen,Y.L.
  TITLE     Transcription factor 21 accelerates vascular calcification in mice
            by activating the IL-6/STAT3 signaling pathway and the interplay
            between VSMCs and ECs
  JOURNAL   Acta Pharmacol Sin 44 (8), 1625-1636 (2023)
   PUBMED   36997664
  REMARK    GeneRIF: Transcription factor 21 accelerates vascular calcification
            in mice by activating the IL-6/STAT3 signaling pathway and the
            interplay between VSMCs and ECs.
REFERENCE   5  (bases 1 to 1280)
  AUTHORS   Passaia,B.D.S., Kremer,J.L., Fragoso,M.C.V. and Lotfi,C.F.P.
  TITLE     N-type calcium channel v2.2 is a target of TCF21 in adrenocortical
            carcinomas
  JOURNAL   Neoplasma 69 (4), 899-908 (2022)
   PUBMED   35603952
  REMARK    GeneRIF: N-type calcium channel v2.2 is a target of TCF21 in
            adrenocortical carcinomas.
REFERENCE   6  (bases 1 to 1280)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
REFERENCE   7  (bases 1 to 1280)
  AUTHORS   Quaggin,S.E., Schwartz,L., Cui,S., Igarashi,P., Deimling,J.,
            Post,M. and Rossant,J.
  TITLE     The basic-helix-loop-helix protein pod1 is critically important for
            kidney and lung organogenesis
  JOURNAL   Development 126 (24), 5771-5783 (1999)
   PUBMED   10572052
REFERENCE   8  (bases 1 to 1280)
  AUTHORS   Robb,L., Mifsud,L., Hartley,L., Biben,C., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A. and Harvey,R.P.
  TITLE     epicardin: A novel basic helix-loop-helix transcription factor gene
            expressed in epicardium, branchial arch myoblasts, and mesenchyme
            of developing lung, gut, kidney, and gonads
  JOURNAL   Dev Dyn 213 (1), 105-113 (1998)
   PUBMED   9733105
REFERENCE   9  (bases 1 to 1280)
  AUTHORS   Hidai,H., Bardales,R., Goodwin,R., Quertermous,T. and
            Quertermous,E.E.
  TITLE     Cloning of capsulin, a basic helix-loop-helix factor expressed in
            progenitor cells of the pericardium and the coronary arteries
  JOURNAL   Mech Dev 73 (1), 33-43 (1998)
   PUBMED   9545526
REFERENCE   10 (bases 1 to 1280)
  AUTHORS   Quaggin,S.E., Vanden Heuvel,G.B. and Igarashi,P.
  TITLE     Pod-1, a mesoderm-specific basic-helix-loop-helix protein expressed
            in mesenchymal and glomerular epithelial cells in the developing
            kidney
  JOURNAL   Mech Dev 71 (1-2), 37-48 (1998)
   PUBMED   9507058
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL356109.8, AF035718.1 and
            BU688835.1.
            
            On Nov 21, 2019 this sequence version replaced NM_003206.3.
            
            Summary: TCF21 encodes a transcription factor of the basic
            helix-loop-helix family. The TCF21 product is mesoderm specific,
            and expressed in embryonic epicardium, mesenchyme-derived tissues
            of lung, gut, gonad, and both mesenchymal and glomerular epithelial
            cells in the kidney. Two transcript variants encoding the same
            protein have been found for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (2) differs in the 3' UTR compared
            to variant 1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF047419.1, BM975273.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367882.5/ ENSP00000356857.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-467               AL356109.8         12897-13363
            468-1279            AF035718.1         443-1254
            1280-1280           BU688835.1         15-15               c
FEATURES             Location/Qualifiers
     source          1..1280
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q23.2"
     gene            1..1280
                     /gene="TCF21"
                     /gene_synonym="bHLHa23; POD1"
                     /note="transcription factor 21"
                     /db_xref="GeneID:6943"
                     /db_xref="HGNC:HGNC:11632"
                     /db_xref="MIM:603306"
     exon            1..735
                     /gene="TCF21"
                     /gene_synonym="bHLHa23; POD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..825
                     /gene="TCF21"
                     /gene_synonym="bHLHa23; POD1"
                     /note="epicardin; capsulin; podocyte-expressed 1; pod-1;
                     class A basic helix-loop-helix protein 23"
                     /codon_start=1
                     /product="transcription factor 21"
                     /protein_id="NP_003197.2"
                     /db_xref="CCDS:CCDS5167.1"
                     /db_xref="GeneID:6943"
                     /db_xref="HGNC:HGNC:11632"
                     /db_xref="MIM:603306"
                     /translation="MSTGSLSDVEDLQEVEMLECDGLKMDSNKEFVTSNESTEESSNC
                     ENGSPQKGRGGLGKRRKAPTKKSPLSGVSQEGKQVQRNAANARERARMRVLSKAFSRL
                     KTTLPWVPPDTKLSKLDTLRLASSYIAHLRQILANDKYENGYIHPVNLTWPFMVAGKP
                     ESDLKEVVTASRLCGTTAS"
     exon            736..1280
                     /gene="TCF21"
                     /gene_synonym="bHLHa23; POD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1254..1259
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCF21"
                     /gene_synonym="bHLHa23; POD1"
                     /note="hexamer: AATAAA"
     polyA_site      1280
                     /gene="TCF21"
                     /gene_synonym="bHLHa23; POD1"
                     /note="major polyA site"
ORIGIN      
        1 agcgctcgct caccctcctc tacggccacg actctgggag tggggaaaca gagagccggt
       61 tcctctgctg cagaagtcct cggggttcct tctcacaact ctgcgaaggg gaaagggttg
      121 tgagacccaa ccagacccca actccagctc ccagcaggag gtggctgcgc cacactcggg
      181 aggcctcttg gtttcagggt ctctctgtct ctctctcacc ctcttcctcg ctttctctgt
      241 ctctctgtct ctctctctct ctctccctcg tccactcccc caaacatgtc caccggctcc
      301 ctcagcgatg tggaggacct tcaagaggtg gagatgttgg aatgtgacgg gttgaaaatg
      361 gattcgaaca aggaatttgt gacttccaac gagagcaccg aggagagctc caactgcgag
      421 aatgggtctc cccagaaggg ccgcggcggc ctgggcaaga ggaggaaggc gcccaccaag
      481 aagagccccc tgagcggggt cagccaggag gggaagcagg tccagcgcaa cgccgccaac
      541 gcgcgagagc gggcccgcat gcgagtgctg agcaaggcct tctccagact caagaccacc
      601 ctgccctggg tgccccccga caccaagctc tccaagctgg acacgctcag gctggcgtcc
      661 agctacatcg cccacttgag gcagatcctg gctaacgaca aatacgagaa cgggtacatt
      721 cacccggtca acctgacgtg gccctttatg gtggccggga aacccgagag tgacctgaaa
      781 gaagtggtga ccgcgagccg cttatgtgga accaccgcgt cctgaccttg gaggtgcgag
      841 tctgggaaag gcgcgctccc ggggggagcg ggccccggga aggcgacccc tgccctcagt
      901 gctctctgtc tctgcttccc cctcgcaatg ctcctctctc tgtcccaccc cgcgagaaca
      961 ctttacaacg acgaggagat tcgtttccaa accagaggag atcaattgta cttacaaaga
     1021 ttcccatcta tttaacttta ttaacttcta ccgtgaatga ctctgcaagc cttgctggtc
     1081 caagtgcaat atgtaattat aaatatataa atagataaga gcctatcaat gtatcttttg
     1141 tacaatatgt tgtaaaatgt agatcatagg atagctgact ttgacagtca catttataaa
     1201 gtaattcact taaagatata tatttttttc aaacaagttt tgctactttt gaaaataaat
     1261 ctttctttat attgctaaaa
//
