LOCUS       NM_004609               1006 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens transcription factor 15 (TCF15), mRNA.
ACCESSION   NM_004609
VERSION     NM_004609.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1006)
  AUTHORS   Yang,W.Y., Petit,T., Thijs,L., Zhang,Z.Y., Jacobs,L., Hara,A.,
            Wei,F.F., Salvi,E., Citterio,L., Delli Carpini,S., Gu,Y.M.,
            Knez,J., Cauwenberghs,N., Barcella,M., Barlassina,C., Manunta,P.,
            Coppiello,G., Aranguren,X.L., Kuznetsova,T., Cusi,D., Verhamme,P.,
            Luttun,A. and Staessen,J.A.
  TITLE     Coronary risk in relation to genetic variation in MEOX2 and TCF15
            in a Flemish population
  JOURNAL   BMC Genet 16, 116 (2015)
   PUBMED   26428460
  REMARK    GeneRIF: Genetic variation in MEOX2, but not TCF15, is a strong
            predictor of CHD. Further experimental studies should elucidate the
            underlying molecular mechanisms.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1006)
  AUTHORS   Coppiello,G., Collantes,M., Sirerol-Piquer,M.S.,
            Vandenwijngaert,S., Schoors,S., Swinnen,M., Vandersmissen,I.,
            Herijgers,P., Topal,B., van Loon,J., Goffin,J., Prosper,F.,
            Carmeliet,P., Garcia-Verdugo,J.M., Janssens,S., Penuelas,I.,
            Aranguren,X.L. and Luttun,A.
  TITLE     Meox2/Tcf15 heterodimers program the heart capillary endothelium
            for cardiac fatty acid uptake
  JOURNAL   Circulation 131 (9), 815-826 (2015)
   PUBMED   25561514
  REMARK    GeneRIF: Microarray profiling on freshly isolated ECs had a genetic
            signature for microvascular heart ECs and identified Meox2/Tcf15
            heterodimers as novel transcriptional determinants. This signature
            was similar in skeletal muscle and adipose tissue endothelium.
REFERENCE   3  (bases 1 to 1006)
  AUTHORS   Guo,P., Zhao,K.W., Dong,X.Y., Sun,X. and Dong,J.T.
  TITLE     Acetylation of KLF5 alters the assembly of p15 transcription
            factors in transforming growth factor-beta-mediated induction in
            epithelial cells
  JOURNAL   J Biol Chem 284 (27), 18184-18193 (2009)
   PUBMED   19419955
  REMARK    GeneRIF: Activation of TGFbeta recruits p300 to the KLF5-Smad
            complex to acetylate KLF5, and the complex with acetylated KLF5
            binds to the Smad binding element and alters the binding of other
            factors to p15 promoter to induce its transcription
REFERENCE   4  (bases 1 to 1006)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   5  (bases 1 to 1006)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   6  (bases 1 to 1006)
  AUTHORS   Hidai,H., Quertermous,E.E., Espinosa,R. 3rd, LeBeau,M.M. and
            Quertermous,T.
  TITLE     Genomic organization and chromosomal localization of the gene TCF15
            encoding the early mesodermal basic helix-loop-helix factor
            bHLH-EC2
  JOURNAL   Genomics 30 (3), 598-601 (1995)
   PUBMED   8825648
REFERENCE   7  (bases 1 to 1006)
  AUTHORS   Quertermous,E.E., Hidai,H., Blanar,M.A. and Quertermous,T.
  TITLE     Cloning and characterization of a basic helix-loop-helix protein
            expressed in early mesoderm and the developing somites
  JOURNAL   Proc Natl Acad Sci U S A 91 (15), 7066-7070 (1994)
   PUBMED   8041747
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL133231.15.
            
            On Nov 18, 2020 this sequence version replaced NM_004609.3.
            
            Summary: The protein encoded by this gene is found in the nucleus
            and may be involved in the early transcriptional regulation of
            patterning of the mesoderm. The encoded basic helix-loop-helix
            protein requires dimerization with another basic helix-loop-helix
            protein for efficient DNA binding. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067836.1, U08336.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000246080.4/ ENSP00000246080.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-597               AL133231.15        44231-44827         c
            598-1006            AL133231.15        38775-39183         c
FEATURES             Location/Qualifiers
     source          1..1006
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..1006
                     /gene="TCF15"
                     /gene_synonym="bHLHa40; EC2; PARAXIS"
                     /note="transcription factor 15"
                     /db_xref="GeneID:6939"
                     /db_xref="HGNC:HGNC:11627"
                     /db_xref="MIM:601010"
     exon            1..597
                     /gene="TCF15"
                     /gene_synonym="bHLHa40; EC2; PARAXIS"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..672
                     /gene="TCF15"
                     /gene_synonym="bHLHa40; EC2; PARAXIS"
                     /note="basic helix-loop-helix transcription factor 15;
                     TCF-15; protein bHLH-EC2; class A basic helix-loop-helix
                     protein 40; transcription factor 15 (basic
                     helix-loop-helix)"
                     /codon_start=1
                     /product="transcription factor 15"
                     /protein_id="NP_004600.3"
                     /db_xref="CCDS:CCDS33432.1"
                     /db_xref="GeneID:6939"
                     /db_xref="HGNC:HGNC:11627"
                     /db_xref="MIM:601010"
                     /translation="MAFALLRPVGAHVLYPDVRLLSEDEENRSESDASDQSFGCCEGP
                     EAARRGPGPGGGRRAGGGGGAGPVVVVRQRQAANARERDRTQSVNTAFTALRTLIPTE
                     PVDRKLSKIETVRLASSYIAHLANVLLLGDSADDGQPCFRAAGSAKGAVPAAADGGRQ
                     PRSICTFCLSNQRKGGGRRDLGGSCLKVRGVAPLRGPRR"
     exon            598..1006
                     /gene="TCF15"
                     /gene_synonym="bHLHa40; EC2; PARAXIS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      983..988
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCF15"
                     /gene_synonym="bHLHa40; EC2; PARAXIS"
                     /note="hexamer: AATAAA"
     polyA_site      1006
                     /gene="TCF15"
                     /gene_synonym="bHLHa40; EC2; PARAXIS"
                     /note="major polyA site"
ORIGIN      
        1 agcgcgcggg agcgcacggc ggggcgcggc cgacgctggg acgcggcgca cggagggacg
       61 cggccggcgc ccatggcgtt cgcgctgctg cggcccgtcg gcgcgcacgt gctgtacccg
      121 gacgtgcggc tgctgagcga ggacgaggag aaccgcagcg agagcgacgc gtcggaccag
      181 tcgttcggct gctgcgaggg cccggaggcg gcgcggcgcg gcccgggccc cgggggcggg
      241 cggcgggcgg gcggcggcgg cggcgcgggc cccgtggtgg tggtgcgaca gcggcaggcg
      301 gccaacgcgc gggagcggga ccgcactcag agcgtgaaca cggccttcac ggcgctgcgc
      361 acgctcatcc ccaccgagcc ggtggaccgc aagctgtcca agatcgagac cgtgcgcctg
      421 gcgtccagct acatcgcgca cctggccaac gtgctgctgc tgggcgactc ggccgacgac
      481 gggcagccgt gcttccgtgc cgcgggcagt gccaagggcg ccgtccccgc cgccgccgac
      541 ggcggccgcc agccgcgctc catctgcacc ttctgcctca gcaaccagcg caaggggggt
      601 ggccgtcgtg acctgggggg cagctgcttg aaggtgaggg gggtggcccc ccttcgaggg
      661 ccacggagat gagcctggac cctggagaag gaggccagga gccagccact ggctggacag
      721 ggaagaagac cccaggagcc aagcccaccc cttctttgtg tagggaccgg gggaccatgg
      781 cctgttccgg gacactctgg gcagggccct cgggacatct ccacccgatc ctggagagct
      841 gtgaggatcc attcagcctg cccagctctg gctggtcaga gacaaggcag aacttttgga
      901 aaaacaaaga ctgttggtga cagggtgtgt gtgtatctgt gcgtgagtgt gagtgtgtgt
      961 gagagagaat tggtgagttt aaaataaaag ctatttttaa ataaaa
//
