LOCUS       NM_207037               6114 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens transcription factor 12 (TCF12), transcript variant 2,
            mRNA.
ACCESSION   NM_207037
VERSION     NM_207037.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6114)
  AUTHORS   Wang,G., Wu,Y., Su,Y., Qu,N., Chen,B., Zhou,D., Yuan,L., Yin,M.,
            Liu,M. and Zhou,W.
  TITLE     TCF12-regulated GRB7 facilitates the HER2+ breast cancer
            progression by activating Notch1 signaling pathway
  JOURNAL   J Transl Med 22 (1), 745 (2024)
   PUBMED   39113057
  REMARK    GeneRIF: TCF12-regulated GRB7 facilitates the HER2+ breast cancer
            progression by activating Notch1 signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6114)
  AUTHORS   Yan,S., Yuan,M., Yang,X., Huang,X., Wu,D., Wang,N., Sun,X., Qin,Y.,
            Fei,Y., Zhao,Z. and Wang,Q.
  TITLE     Lncrna CASC15 Activated By TCF12 Promote Colorectal Cancer
            Progression via EMT
  JOURNAL   Comb Chem High Throughput Screen 27 (8), 1222-1230 (2024)
   PUBMED   37680149
  REMARK    GeneRIF: Lncrna CASC15 Activated By TCF12 Promote Colorectal Cancer
            Progression via EMT.
REFERENCE   3  (bases 1 to 6114)
  AUTHORS   Geng,N., Yu,Z., Zeng,X., Xu,D., Gao,H., Yang,M. and Huang,X.
  TITLE     Nuclear Tubulin Enhances CXCR4 Transcription and Promotes
            Chemotaxis Through TCF12 Transcription Factor in human
            Hematopoietic Stem Cells
  JOURNAL   Stem Cell Rev Rep 19 (5), 1328-1339 (2023)
   PUBMED   37067645
  REMARK    GeneRIF: Nuclear Tubulin Enhances CXCR4 Transcription and Promotes
            Chemotaxis Through TCF12 Transcription Factor in human
            Hematopoietic Stem Cells.
REFERENCE   4  (bases 1 to 6114)
  AUTHORS   Liu,L., Zhou,X., Cheng,S., Ge,Y., Chen,B., Shi,J., Li,H., Li,S.,
            Li,Y., Yuan,J., Wu,A., Liu,X., Huang,S., Xu,Z. and Dong,J.
  TITLE     RNA-binding protein DHX9 promotes glioma growth and
            tumor-associated macrophages infiltration via TCF12
  JOURNAL   CNS Neurosci Ther 29 (4), 988-999 (2023)
   PUBMED   36377508
  REMARK    GeneRIF: RNA-binding protein DHX9 promotes glioma growth and
            tumor-associated macrophages infiltration via TCF12.
REFERENCE   5  (bases 1 to 6114)
  AUTHORS   Li,X.P., Jia,Y.L., Duan,Y.Q., Zhao,Y., Yin,X.L., Zhen,S.M.,
            Zhang,Y. and Liu,L.H.
  TITLE     Circular RNA hsa_circ_0002938 (circCRIM1) promotes the progression
            of esophageal squamous cell carcinoma by upregulating transcription
            factor 12
  JOURNAL   Neoplasma 70 (1), 145-157 (2023)
   PUBMED   36916930
  REMARK    GeneRIF: Circular RNA hsa_circ_0002938 (circCRIM1) promotes the
            progression of esophageal squamous cell carcinoma by upregulating
            transcription factor 12.
REFERENCE   6  (bases 1 to 6114)
  AUTHORS   Zhang,Y., Doyle,K. and Bina,M.
  TITLE     Interactions of HTF4 with E-box motifs in the long terminal repeat
            of human immunodeficiency virus type 1
  JOURNAL   J Virol 66 (9), 5631-5634 (1992)
   PUBMED   1501295
REFERENCE   7  (bases 1 to 6114)
  AUTHORS   Hu,J.S., Olson,E.N. and Kingston,R.E.
  TITLE     HEB, a helix-loop-helix protein related to E2A and ITF2 that can
            modulate the DNA-binding ability of myogenic regulatory factors
  JOURNAL   Mol Cell Biol 12 (3), 1031-1042 (1992)
   PUBMED   1312219
REFERENCE   8  (bases 1 to 6114)
  AUTHORS   Zhang,Y. and Bina,M.
  TITLE     The nucleotide sequence of the human transcription factor HTF4a
            cDNA
  JOURNAL   DNA Seq 2 (6), 397-403 (1992)
   PUBMED   1446075
REFERENCE   9  (bases 1 to 6114)
  AUTHORS   Sommer,L., Hagenbuchle,O., Wellauer,P.K. and Strubin,M.
  TITLE     Nuclear targeting of the transcription factor PTF1 is mediated by a
            protein subunit that does not bind to the PTF1 cognate sequence
  JOURNAL   Cell 67 (5), 987-994 (1991)
   PUBMED   1720355
REFERENCE   10 (bases 1 to 6114)
  AUTHORS   Zhang,Y., Babin,J., Feldhaus,A.L., Singh,H., Sharp,P.A. and Bina,M.
  TITLE     HTF4: a new human helix-loop-helix protein
  JOURNAL   Nucleic Acids Res 19 (16), 4555 (1991)
   PUBMED   1886779
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU178185.1, BC050556.1,
            BK001049.1 and AC016525.11.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_207037.1.
            
            Summary: The protein encoded by this gene is a member of the basic
            helix-loop-helix (bHLH) E-protein family that recognizes the
            consensus binding site (E-box) CANNTG. This encoded protein is
            expressed in many tissues, among them skeletal muscle, thymus, B-
            and T-cells, and may participate in regulating lineage-specific
            gene expression through the formation of heterodimers with other
            bHLH E-proteins. Several alternatively spliced transcript variants
            of this gene have been described, but the full-length nature of
            some of these variants has not been determined. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.42839.1,
                                           SRR1803617.48022.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333725.10/ ENSP00000331057.6
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-675               BU178185.1         21-695
            676-4769            BC050556.1         626-4719
            4770-4779           BK001049.1         4781-4790
            4780-6114           AC016525.11        85322-86656
FEATURES             Location/Qualifiers
     source          1..6114
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.3"
     gene            1..6114
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /note="transcription factor 12"
                     /db_xref="GeneID:6938"
                     /db_xref="HGNC:HGNC:11623"
                     /db_xref="MIM:600480"
     exon            1..263
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            264..360
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..2406
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /note="isoform a is encoded by transcript variant 2;
                     helix-loop-helix transcription factor 4; E-box-binding
                     protein; DNA-binding protein HTF4; transcription factor
                     HTF-4; class B basic helix-loop-helix protein 20"
                     /codon_start=1
                     /product="transcription factor 12 isoform a"
                     /protein_id="NP_996920.1"
                     /db_xref="CCDS:CCDS10160.1"
                     /db_xref="GeneID:6938"
                     /db_xref="HGNC:HGNC:11623"
                     /db_xref="MIM:600480"
                     /translation="MNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSS
                     QFSGSGIDERGGTTSWGTSGQPSPSYDSSRGFTDSPHYSDHLNDSRLGAHEGLSPTPF
                     MNSNLMGKTSERGSFSLYSRDTGLPGCQSSLLRQDLGLGSPAQLSSSGKPGTAYYSFS
                     ATSSRRRPLHDSAALDPLQAKKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPT
                     SMFASTFFMQDGTHNSSDLWSSSNGMSQPGFGGILGTSTSHMSQSSSYGNLHSHDRLS
                     YPPHSVSPTDINTSLPPMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGSSQ
                     TGDALGKALASIYSPDHTSSSFPSNPSTPVGSPSPLTGTSQWPRPGGQAPSSPSYENS
                     LHSLKNRVEQQLHEHLQDAMSFLKDVCEQSRMEDRLDRLDDAIHVLRNHAVGPSTSLP
                     AGHSDIHSLLGPSHNAPIGSLNSNYGGSSLVASSRSASMVGTHREDSVSLNGNHSVLS
                     STVTTSSTDLNHKTQENYRGGLQSQSGTVVTTEIKTENKEKDENLHEPPSSDDMKSDD
                     ESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINEAFKEL
                     GRMCQLHLKSEKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSAVS
                     AEPPTTLPGTHPGLSETTNPMGHM"
     exon            361..433
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            434..507
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            508..610
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            611..675
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            676..811
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            812..864
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            865..970
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1110
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1255
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1320
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1399
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1473
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1545
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1752
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1867
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2030
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2263
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2264..2417
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..6114
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4745..4750
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /note="hexamer: AATAAA"
     regulatory      4773..4778
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /note="hexamer: AGTAAA"
     polyA_site      4779
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /note="major polyA site"
     polyA_site      4813
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
     regulatory      6098..6103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /note="hexamer: AATAAT"
     polyA_site      6114
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
ORIGIN      
        1 gagccgagcg cggtggtgag gccgcctcag cgaaaaaaat gtccgcctga agagacccac
       61 aagttctatt cggggggacc gacagcccgc cccgggagga aggggcggcc aggcccgaaa
      121 gccgcctccc cctcccagac ccgagagctc gtgcggggca aagtgaaccg agccgctggg
      181 cggtgcaagg ggaagcccaa gcccgttctc ccggccaaag tgaactttaa tcggggtggt
      241 tggatgcgga gacggggcgg caggacctgc tagaagtggc cgaagatgaa tccccagcaa
      301 caacgcatgg ccgctatagg gaccgacaag gagctgagcg acctactgga cttcagtgcg
      361 atgttttccc cacctgttaa tagtgggaaa actagaccaa ctacactggg aagcagtcaa
      421 ttcagtggat caggtattga tgaaagagga ggtacaacat cttggggaac aagtggtcaa
      481 ccaagtcctt cctatgattc atctagaggt tttacagaca gccctcatta cagtgatcac
      541 ttgaatgaca gtcgattagg agcccatgaa ggcttgtccc caacaccttt catgaactca
      601 aatctgatgg gaaaaacatc agagagaggc tcattttccc tgtacagcag agatactgga
      661 ttaccaggct gtcaatctag tctcctgaga caagatctgg ggcttgggag cccagcacag
      721 ctatcttctt caggaaaacc tgggacagca tactattcat tctctgctac aagttccagg
      781 aggagaccac tccatgactc tgcagcgctt gatcccttgc aagcaaaaaa agtcagaaag
      841 gtgcctcctg gtttgccttc ttctgtatat gcaccatccc caaattcaga tgatttcaac
      901 cgtgaatctc ctagttatcc atctcctaag ccaccaacca gtatgttcgc tagcactttc
      961 tttatgcaag atgggaccca caattcttct gacctttgga gttcatcaaa tgggatgagc
     1021 cagcctggtt ttggtggaat tctggggacc tccacttccc acatgtctca atccagtagt
     1081 tatggcaacc ttcattcaca tgaccgcttg agttatcctc cacactcagt ttcaccaaca
     1141 gacataaaca cgagtcttcc accaatgtcc agctttcatc gcggcagtac cagcagttca
     1201 ccttacgttg ctgcctcaca cactcctccc atcaatggat cagacagcat tctaggaacc
     1261 agagggaatg ctgctggaag ctcacagaca ggtgatgcac ttggaaaggc tttggcatct
     1321 atttattctc ctgaccatac cagcagtagt tttccgtcaa atccatcaac accagttgga
     1381 tcaccttcac ctctcacagg taccagtcag tggccaagac ctggagggca agcaccttca
     1441 tccccaagct atgaaaactc actccactcc ctgaaaaatc gagttgagca gcaacttcac
     1501 gagcatttgc aagatgcaat gtccttctta aaggatgtct gtgagcagtc tcgaatggag
     1561 gatcgtttag acagactgga tgatgcaatc catgtgctgc ggaaccatgc tgtgggacct
     1621 tccaccagtt tgcctgctgg tcacagtgat atacatagtt tattgggacc atcccataat
     1681 gcaccaattg gaagcctcaa ttcaaactat ggaggatcaa gccttgttgc aagcagtcga
     1741 tcagcttcaa tggttggaac tcatcgggaa gactctgtca gtctcaatgg caatcattca
     1801 gtcctgtcta gtacagtcac tacttcaagc acagacctga accataaaac acaagaaaat
     1861 tatagaggtg gcttgcaaag tcagtctgga actgttgtta caacagaaat caagactgaa
     1921 aacaaagaaa aggatgaaaa ccttcatgaa cctccttcat cagatgacat gaagtcagat
     1981 gatgaatcct cccaaaaaga tatcaaggtt tcatctagag gcagaacaag cagtactaat
     2041 gaagatgagg atttgaaccc tgaacagaag atagaaaggg agaaggagag gcggatggct
     2101 aacaatgcca gagaacgctt acgcgtgcgg gatattaatg aagcattcaa agagcttggc
     2161 cgaatgtgtc agcttcactt gaagagtgaa aaaccccaaa caaaactcct tattcttcat
     2221 caagccgtgg cagtcatcct tagtctagaa cagcaagtca gagagaggaa ccttaacccc
     2281 aaagcagcct gccttaagag aagggaagaa gaaaaagttt ctgccgtatc ggcagagccg
     2341 ccaaccacac tgccaggaac ccatcctggg cttagtgaaa ctaccaaccc tatgggtcat
     2401 atgtaaacat cagccagttc cagagttatc agtaggctag atagaaggtg acctctcctc
     2461 ataaggactt ggacaactca gattatctga agacacaaac ctgacaggag ggagaagaaa
     2521 aaacaaaaca cttgaaccaa gaaactcaaa tgtaatccta cgatcaaagc aactggtcaa
     2581 cacttccatc agaagtgaag ataggaagct catcagatag aacatcagcc catgagatgt
     2641 ttgcaacaaa tcttttgttg caagcagtgt gtcgcttctg cacaatcaga gactgtctcg
     2701 atctctccac tcaccgtgga agttgccttg tgcctaaact gaattgacaa atgcattgta
     2761 actacaaatt ttatttattg ttatgaaact gtaaggtcta catataaagg gaaaaagtta
     2821 atgtggaaag ctgatctaca ctcagctgat gccagcatac attaaagcgg ttcacgtgca
     2881 gagaacaaag cagtgacaac cattggccct tagcattccc ggcataccta ttagtgtctt
     2941 aaaaaggaag ggaaaagtct tttgttgccc tctcctatcc tcttgccata tgaatagcgt
     3001 tttccatgaa ataggaaaat attacttggt atagcatttc tcttgctctc attttttgat
     3061 ttatttttat tttctctttg tgggtgttat atttgatctc taaatctgaa cagtttatgg
     3121 tcacagtcca gcctcctccg tgcagccctg tgtgctttgc acatttacct tacagtggta
     3181 agcagagacc atctgtgacc atagcctagc tagcatttta aaaggggaaa ttttgttctc
     3241 taggttttcc cccaaataaa cattgcttta tttctaataa taaccaagac ttttcaagct
     3301 tctagatctc ataggaaagc ttgtaatagc aaaattgtaa attacaaggg aagaatctac
     3361 tttttagaaa tcgctttgtt ttccaagcag taagtactac atacagtact tgtaaagtgt
     3421 tagctgtaag taagcacaaa atacatttaa aatacaaaga cgattttttc aggctgtgat
     3481 tatggtgaac ataacaaaac ccagtagtca ccaaggcagg tagtgtgata aatgaacaca
     3541 ccactctgag gctaattacc taatggaata caagagcaat ggtcacccgt atttccttat
     3601 cctagccttt atttctctgt catttggatg gctggtcaat ggggaagaat tgagtgggtg
     3661 atttaatcaa ctgcaaacca tctgcccctg tcccaaaatg atgagccaga ttagcattaa
     3721 accagtactt gtcagtccat cttaatactg ttcattaagg cactctctgt ctctaatcct
     3781 taggagttgt tttaaaagac ataatcactt tgaacttcca tgaaacctgt cttccaccac
     3841 aacaaccctg ggagagaaaa acatgctaaa ggaggtatct tggcttaata attccttata
     3901 gccaatatca acagtggcaa tcagcacaca gaggaaagga cccaaatcac tatgtagctt
     3961 aaagatttct gttaatttga aagaacaaaa acaagacaga acttctggta ctctaatcag
     4021 gatgattcct aacaagtcag tcatttgtga acttagtgga ctttttggtt actttaattt
     4081 gcatatattc tccagttaca tcggactcta tctgtggcct tgttcttcat ttcagtgtta
     4141 atcagctaaa cagaagttgt tgcttatgat gtgtgagtga acatatgcca ctgcctggcc
     4201 tttttttctt cagagcttgt tgtctttttc gctatattag actttgcagt atgcccagaa
     4261 gctttccttc ataaaataga aagaaaaaaa catttggctt atttttcact gtagctagtc
     4321 ttttatacaa taatcttgta agaaaatttc ttgaattcta aatattactc tttctagatt
     4381 tttgaaatca aaaagttttc agtaaaaagt ttcttacttt attttattat attaggtagt
     4441 aaaaaatgta gggttattta ccataacctg ttcattaata tcagaaattt acaatagcat
     4501 tttaagacca tagtaggatt ctagcatacc gtgtagtacc tatggagtat tgtaagagct
     4561 aattgttgga gatgaattgc ttctcatctt gttctccagt ttccattgtt ggtttattgc
     4621 agatttgtat cctgtgtcaa attcaaggta ttattgataa accttttcaa ccagcagcaa
     4681 gaagttcaaa tttttttctg tcactgtaac agaaaacaca atatgtatat aacatttatg
     4741 tagcaataaa tgtgccatct tttttttaac acagtaaaat agtgagtttt ttacatttct
     4801 ctttctcaaa taataatgta ttttgtttta ttttctccat ctcattcgtc ccagaaacac
     4861 tcacactgct tttcctaact gcattaccga cattatctgg gaaacccttc aggacagaat
     4921 caggcttgtg gagctaagtt ggcaatctgg tctagagctt ctctagcttg tgcttttctc
     4981 ctcttgccct cactactgac ggtggccttt taaccttttc ctaaagattg accaaacagc
     5041 aactagtagt tatagaaaat ctactcattt gtagatacag agaaaaatga agaagatgga
     5101 aaaagactca aaagaggctt tttaagttat tcttcaaagc acttttcaca tttccccata
     5161 ccctttctca caaaaaaagt gtcataatta agtaatggta ttgtttactg tttaaaagtt
     5221 aaaagatcaa aaatttgctt ttatcccagt ttttaaccac aaaaaaaagc gtagggatta
     5281 tccatgagga cttcatgcca agcaagaacc tcaaacaaac tagacaaact ttttttttga
     5341 cagtgaatga ctttttgtag gacctgtgcg tgcgaaaccc atggcaattg tcacatcctc
     5401 ttggtatgct ggcagattgc ttctcttggt gaattatgaa atccactgtt cacattgggt
     5461 gcctaacaga acattttgct tcttgtggga tttagtgaaa actattaaac ttgttaagtt
     5521 gattttatac aaaacgataa ataaaaagct ctaagaagaa aatgtataat cttagagctg
     5581 aaataaaata tagagaccat ctagtaaatg acctcattaa tatatctgtg aaaactgaga
     5641 ctcagattgt atgtctctaa gaacacataa ttagtaacag atcaagacac ttaaaacttt
     5701 ccctacaaaa cctccctgcc ttgactttct ctttctcttt gcagatttct aggccgcttc
     5761 tgctcagtgt cttcattttc ttccatattt gttttatttc atttttcttt tctatagttc
     5821 atgttttctt tttccttgga aactcaaaat ttaaacacac gtcgtgtgtg tgtgtgtgtg
     5881 tgtgtctgtg tgtgtgtgac ttaaagaatc ttaagctttg gcattaaata gtcctcgatt
     5941 caaatctaag ctcaacatct gattaacttc attttcctat ctgaaaaatg gagataacat
     6001 tagaattgtg taagtattga atgaaacaat gtatggaaag ctcttatggt tcttgtcacc
     6061 taagaagtac ttaataaatg ataaatattt ttaaataaat aatattataa ccaa
//
