LOCUS       NM_001322156            6176 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens transcription factor 12 (TCF12), transcript variant
            11, mRNA.
ACCESSION   NM_001322156 XM_005254613
VERSION     NM_001322156.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6176)
  AUTHORS   Wang,G., Wu,Y., Su,Y., Qu,N., Chen,B., Zhou,D., Yuan,L., Yin,M.,
            Liu,M. and Zhou,W.
  TITLE     TCF12-regulated GRB7 facilitates the HER2+ breast cancer
            progression by activating Notch1 signaling pathway
  JOURNAL   J Transl Med 22 (1), 745 (2024)
   PUBMED   39113057
  REMARK    GeneRIF: TCF12-regulated GRB7 facilitates the HER2+ breast cancer
            progression by activating Notch1 signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6176)
  AUTHORS   Yan,S., Yuan,M., Yang,X., Huang,X., Wu,D., Wang,N., Sun,X., Qin,Y.,
            Fei,Y., Zhao,Z. and Wang,Q.
  TITLE     Lncrna CASC15 Activated By TCF12 Promote Colorectal Cancer
            Progression via EMT
  JOURNAL   Comb Chem High Throughput Screen 27 (8), 1222-1230 (2024)
   PUBMED   37680149
  REMARK    GeneRIF: Lncrna CASC15 Activated By TCF12 Promote Colorectal Cancer
            Progression via EMT.
REFERENCE   3  (bases 1 to 6176)
  AUTHORS   Geng,N., Yu,Z., Zeng,X., Xu,D., Gao,H., Yang,M. and Huang,X.
  TITLE     Nuclear Tubulin Enhances CXCR4 Transcription and Promotes
            Chemotaxis Through TCF12 Transcription Factor in human
            Hematopoietic Stem Cells
  JOURNAL   Stem Cell Rev Rep 19 (5), 1328-1339 (2023)
   PUBMED   37067645
  REMARK    GeneRIF: Nuclear Tubulin Enhances CXCR4 Transcription and Promotes
            Chemotaxis Through TCF12 Transcription Factor in human
            Hematopoietic Stem Cells.
REFERENCE   4  (bases 1 to 6176)
  AUTHORS   Liu,L., Zhou,X., Cheng,S., Ge,Y., Chen,B., Shi,J., Li,H., Li,S.,
            Li,Y., Yuan,J., Wu,A., Liu,X., Huang,S., Xu,Z. and Dong,J.
  TITLE     RNA-binding protein DHX9 promotes glioma growth and
            tumor-associated macrophages infiltration via TCF12
  JOURNAL   CNS Neurosci Ther 29 (4), 988-999 (2023)
   PUBMED   36377508
  REMARK    GeneRIF: RNA-binding protein DHX9 promotes glioma growth and
            tumor-associated macrophages infiltration via TCF12.
REFERENCE   5  (bases 1 to 6176)
  AUTHORS   Li,X.P., Jia,Y.L., Duan,Y.Q., Zhao,Y., Yin,X.L., Zhen,S.M.,
            Zhang,Y. and Liu,L.H.
  TITLE     Circular RNA hsa_circ_0002938 (circCRIM1) promotes the progression
            of esophageal squamous cell carcinoma by upregulating transcription
            factor 12
  JOURNAL   Neoplasma 70 (1), 145-157 (2023)
   PUBMED   36916930
  REMARK    GeneRIF: Circular RNA hsa_circ_0002938 (circCRIM1) promotes the
            progression of esophageal squamous cell carcinoma by upregulating
            transcription factor 12.
REFERENCE   6  (bases 1 to 6176)
  AUTHORS   Zhang,Y., Doyle,K. and Bina,M.
  TITLE     Interactions of HTF4 with E-box motifs in the long terminal repeat
            of human immunodeficiency virus type 1
  JOURNAL   J Virol 66 (9), 5631-5634 (1992)
   PUBMED   1501295
REFERENCE   7  (bases 1 to 6176)
  AUTHORS   Hu,J.S., Olson,E.N. and Kingston,R.E.
  TITLE     HEB, a helix-loop-helix protein related to E2A and ITF2 that can
            modulate the DNA-binding ability of myogenic regulatory factors
  JOURNAL   Mol Cell Biol 12 (3), 1031-1042 (1992)
   PUBMED   1312219
REFERENCE   8  (bases 1 to 6176)
  AUTHORS   Zhang,Y. and Bina,M.
  TITLE     The nucleotide sequence of the human transcription factor HTF4a
            cDNA
  JOURNAL   DNA Seq 2 (6), 397-403 (1992)
   PUBMED   1446075
REFERENCE   9  (bases 1 to 6176)
  AUTHORS   Sommer,L., Hagenbuchle,O., Wellauer,P.K. and Strubin,M.
  TITLE     Nuclear targeting of the transcription factor PTF1 is mediated by a
            protein subunit that does not bind to the PTF1 cognate sequence
  JOURNAL   Cell 67 (5), 987-994 (1991)
   PUBMED   1720355
REFERENCE   10 (bases 1 to 6176)
  AUTHORS   Zhang,Y., Babin,J., Feldhaus,A.L., Singh,H., Sharp,P.A. and Bina,M.
  TITLE     HTF4: a new human helix-loop-helix protein
  JOURNAL   Nucleic Acids Res 19 (16), 4555 (1991)
   PUBMED   1886779
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010999.6, AC090511.3,
            AC090532.1 and AC016525.11.
            
            On Jun 2, 2019 this sequence version replaced NM_001322156.1.
            
            Summary: The protein encoded by this gene is a member of the basic
            helix-loop-helix (bHLH) E-protein family that recognizes the
            consensus binding site (E-box) CANNTG. This encoded protein is
            expressed in many tissues, among them skeletal muscle, thymus, B-
            and T-cells, and may participate in regulating lineage-specific
            gene expression through the formation of heterodimers with other
            bHLH E-proteins. Several alternatively spliced transcript variants
            of this gene have been described, but the full-length nature of
            some of these variants has not been determined. [provided by
            RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.164725.1,
                                           SRR1660805.144209.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-263               AC010999.6         96906-97168
            264-360             AC010999.6         98154-98250
            361-433             AC010999.6         99288-99360
            434-507             AC090511.3         45620-45693
            508-569             AC090511.3         54523-54584
            570-672             AC090511.3         73659-73761
            673-737             AC090532.1         74921-74985
            738-873             AC090532.1         100677-100812
            874-926             AC090532.1         106292-106344
            927-1032            AC090532.1         139671-139776
            1033-1172           AC090532.1         140810-140949
            1173-1317           AC090532.1         141231-141375
            1318-1382           AC090532.1         142562-142626
            1383-1461           AC090532.1         151991-152069
            1462-1535           AC090532.1         159869-159942
            1536-1607           AC090532.1         160940-161011
            1608-1814           AC090532.1         161781-161987
            1815-1929           AC016525.11        58897-59011
            1930-2092           AC016525.11        59915-60077
            2093-2325           AC016525.11        69833-70065
            2326-2479           AC016525.11        79248-79401
            2480-6176           AC016525.11        82960-86656
FEATURES             Location/Qualifiers
     source          1..6176
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.3"
     gene            1..6176
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /note="transcription factor 12"
                     /db_xref="GeneID:6938"
                     /db_xref="HGNC:HGNC:11623"
                     /db_xref="MIM:600480"
     exon            1..263
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            264..360
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            361..433
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            434..507
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            508..569
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     CDS             522..2468
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /note="isoform h is encoded by transcript variant 11;
                     helix-loop-helix transcription factor 4; E-box-binding
                     protein; DNA-binding protein HTF4; transcription factor
                     HTF-4; class B basic helix-loop-helix protein 20"
                     /codon_start=1
                     /product="transcription factor 12 isoform h"
                     /protein_id="NP_001309085.1"
                     /db_xref="GeneID:6938"
                     /db_xref="HGNC:HGNC:11623"
                     /db_xref="MIM:600480"
                     /translation="MKQLNSKARQKGQRIKGFTDSPHYSDHLNDSRLGAHEGLSPTPF
                     MNSNLMGKTSERGSFSLYSRDTGLPGCQSSLLRQDLGLGSPAQLSSSGKPGTAYYSFS
                     ATSSRRRPLHDSAALDPLQAKKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPT
                     SMFASTFFMQDGTHNSSDLWSSSNGMSQPGFGGILGTSTSHMSQSSSYGNLHSHDRLS
                     YPPHSVSPTDINTSLPPMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGSSQ
                     TGDALGKALASIYSPDHTSSSFPSNPSTPVGSPSPLTGTSQWPRPGGQAPSSPSYENS
                     LHSLKNRVEQQLHEHLQDAMSFLKDVCEQSRMEDRLDRLDDAIHVLRNHAVGPSTSLP
                     AGHSDIHSLLGPSHNAPIGSLNSNYGGSSLVASSRSASMVGTHREDSVSLNGNHSVLS
                     STVTTSSTDLNHKTQENYRGGLQSQSGTVVTTEIKTENKEKDENLHEPPSSDDMKSDD
                     ESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINEAFKEL
                     GRMCQLHLKSEKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSAVS
                     AEPPTTLPGTHPGLSETTNPMGHM"
     exon            570..672
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            673..737
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            738..873
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            874..926
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1032
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1172
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1317
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1382
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1461
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1535
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1607
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1814
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1929
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2092
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2325
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2326..2479
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2480..6176
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4807..4812
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /note="hexamer: AATAAA"
     regulatory      4835..4840
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /note="hexamer: AGTAAA"
     polyA_site      4841
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /note="major polyA site"
     polyA_site      4875
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
     regulatory      6160..6165
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /note="hexamer: AATAAT"
     polyA_site      6176
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
ORIGIN      
        1 gagccgagcg cggtggtgag gccgcctcag cgaaaaaaat gtccgcctga agagacccac
       61 aagttctatt cggggggacc gacagcccgc cccgggagga aggggcggcc aggcccgaaa
      121 gccgcctccc cctcccagac ccgagagctc gtgcggggca aagtgaaccg agccgctggg
      181 cggtgcaagg ggaagcccaa gcccgttctc ccggccaaag tgaactttaa tcggggtggt
      241 tggatgcgga gacggggcgg caggacctgc tagaagtggc cgaagatgaa tccccagcaa
      301 caacgcatgg ccgctatagg gaccgacaag gagctgagcg acctactgga cttcagtgcg
      361 atgttttccc cacctgttaa tagtgggaaa actagaccaa ctacactggg aagcagtcaa
      421 ttcagtggat caggtattga tgaaagagga ggtacaacat cttggggaac aagtggtcaa
      481 ccaagtcctt cctatgattc atctagagta caatacacga gatgaagcag ttaaatagca
      541 aagcaagaca gaagggtcag agaattaaag gttttacaga cagccctcat tacagtgatc
      601 acttgaatga cagtcgatta ggagcccatg aaggcttgtc cccaacacct ttcatgaact
      661 caaatctgat gggaaaaaca tcagagagag gctcattttc cctgtacagc agagatactg
      721 gattaccagg ctgtcaatct agtctcctga gacaagatct ggggcttggg agcccagcac
      781 agctatcttc ttcaggaaaa cctgggacag catactattc attctctgct acaagttcca
      841 ggaggagacc actccatgac tctgcagcgc ttgatccctt gcaagcaaaa aaagtcagaa
      901 aggtgcctcc tggtttgcct tcttctgtat atgcaccatc cccaaattca gatgatttca
      961 accgtgaatc tcctagttat ccatctccta agccaccaac cagtatgttc gctagcactt
     1021 tctttatgca agatgggacc cacaattctt ctgacctttg gagttcatca aatgggatga
     1081 gccagcctgg ttttggtgga attctgggga cctccacttc ccacatgtct caatccagta
     1141 gttatggcaa ccttcattca catgaccgct tgagttatcc tccacactca gtttcaccaa
     1201 cagacataaa cacgagtctt ccaccaatgt ccagctttca tcgcggcagt accagcagtt
     1261 caccttacgt tgctgcctca cacactcctc ccatcaatgg atcagacagc attctaggaa
     1321 ccagagggaa tgctgctgga agctcacaga caggtgatgc acttggaaag gctttggcat
     1381 ctatttattc tcctgaccat accagcagta gttttccgtc aaatccatca acaccagttg
     1441 gatcaccttc acctctcaca ggtaccagtc agtggccaag acctggaggg caagcacctt
     1501 catccccaag ctatgaaaac tcactccact ccctgaaaaa tcgagttgag cagcaacttc
     1561 acgagcattt gcaagatgca atgtccttct taaaggatgt ctgtgagcag tctcgaatgg
     1621 aggatcgttt agacagactg gatgatgcaa tccatgtgct gcggaaccat gctgtgggac
     1681 cttccaccag tttgcctgct ggtcacagtg atatacatag tttattggga ccatcccata
     1741 atgcaccaat tggaagcctc aattcaaact atggaggatc aagccttgtt gcaagcagtc
     1801 gatcagcttc aatggttgga actcatcggg aagactctgt cagtctcaat ggcaatcatt
     1861 cagtcctgtc tagtacagtc actacttcaa gcacagacct gaaccataaa acacaagaaa
     1921 attatagagg tggcttgcaa agtcagtctg gaactgttgt tacaacagaa atcaagactg
     1981 aaaacaaaga aaaggatgaa aaccttcatg aacctccttc atcagatgac atgaagtcag
     2041 atgatgaatc ctcccaaaaa gatatcaagg tttcatctag aggcagaaca agcagtacta
     2101 atgaagatga ggatttgaac cctgaacaga agatagaaag ggagaaggag aggcggatgg
     2161 ctaacaatgc cagagaacgc ttacgcgtgc gggatattaa tgaagcattc aaagagcttg
     2221 gccgaatgtg tcagcttcac ttgaagagtg aaaaacccca aacaaaactc cttattcttc
     2281 atcaagccgt ggcagtcatc cttagtctag aacagcaagt cagagagagg aaccttaacc
     2341 ccaaagcagc ctgccttaag agaagggaag aagaaaaagt ttctgccgta tcggcagagc
     2401 cgccaaccac actgccagga acccatcctg ggcttagtga aactaccaac cctatgggtc
     2461 atatgtaaac atcagccagt tccagagtta tcagtaggct agatagaagg tgacctctcc
     2521 tcataaggac ttggacaact cagattatct gaagacacaa acctgacagg agggagaaga
     2581 aaaaacaaaa cacttgaacc aagaaactca aatgtaatcc tacgatcaaa gcaactggtc
     2641 aacacttcca tcagaagtga agataggaag ctcatcagat agaacatcag cccatgagat
     2701 gtttgcaaca aatcttttgt tgcaagcagt gtgtcgcttc tgcacaatca gagactgtct
     2761 cgatctctcc actcaccgtg gaagttgcct tgtgcctaaa ctgaattgac aaatgcattg
     2821 taactacaaa ttttatttat tgttatgaaa ctgtaaggtc tacatataaa gggaaaaagt
     2881 taatgtggaa agctgatcta cactcagctg atgccagcat acattaaagc ggttcacgtg
     2941 cagagaacaa agcagtgaca accattggcc cttagcattc ccggcatacc tattagtgtc
     3001 ttaaaaagga agggaaaagt cttttgttgc cctctcctat cctcttgcca tatgaatagc
     3061 gttttccatg aaataggaaa atattacttg gtatagcatt tctcttgctc tcattttttg
     3121 atttattttt attttctctt tgtgggtgtt atatttgatc tctaaatctg aacagtttat
     3181 ggtcacagtc cagcctcctc cgtgcagccc tgtgtgcttt gcacatttac cttacagtgg
     3241 taagcagaga ccatctgtga ccatagccta gctagcattt taaaagggga aattttgttc
     3301 tctaggtttt cccccaaata aacattgctt tatttctaat aataaccaag acttttcaag
     3361 cttctagatc tcataggaaa gcttgtaata gcaaaattgt aaattacaag ggaagaatct
     3421 actttttaga aatcgctttg ttttccaagc agtaagtact acatacagta cttgtaaagt
     3481 gttagctgta agtaagcaca aaatacattt aaaatacaaa gacgattttt tcaggctgtg
     3541 attatggtga acataacaaa acccagtagt caccaaggca ggtagtgtga taaatgaaca
     3601 caccactctg aggctaatta cctaatggaa tacaagagca atggtcaccc gtatttcctt
     3661 atcctagcct ttatttctct gtcatttgga tggctggtca atggggaaga attgagtggg
     3721 tgatttaatc aactgcaaac catctgcccc tgtcccaaaa tgatgagcca gattagcatt
     3781 aaaccagtac ttgtcagtcc atcttaatac tgttcattaa ggcactctct gtctctaatc
     3841 cttaggagtt gttttaaaag acataatcac tttgaacttc catgaaacct gtcttccacc
     3901 acaacaaccc tgggagagaa aaacatgcta aaggaggtat cttggcttaa taattcctta
     3961 tagccaatat caacagtggc aatcagcaca cagaggaaag gacccaaatc actatgtagc
     4021 ttaaagattt ctgttaattt gaaagaacaa aaacaagaca gaacttctgg tactctaatc
     4081 aggatgattc ctaacaagtc agtcatttgt gaacttagtg gactttttgg ttactttaat
     4141 ttgcatatat tctccagtta catcggactc tatctgtggc cttgttcttc atttcagtgt
     4201 taatcagcta aacagaagtt gttgcttatg atgtgtgagt gaacatatgc cactgcctgg
     4261 cctttttttc ttcagagctt gttgtctttt tcgctatatt agactttgca gtatgcccag
     4321 aagctttcct tcataaaata gaaagaaaaa aacatttggc ttatttttca ctgtagctag
     4381 tcttttatac aataatcttg taagaaaatt tcttgaattc taaatattac tctttctaga
     4441 tttttgaaat caaaaagttt tcagtaaaaa gtttcttact ttattttatt atattaggta
     4501 gtaaaaaatg tagggttatt taccataacc tgttcattaa tatcagaaat ttacaatagc
     4561 attttaagac catagtagga ttctagcata ccgtgtagta cctatggagt attgtaagag
     4621 ctaattgttg gagatgaatt gcttctcatc ttgttctcca gtttccattg ttggtttatt
     4681 gcagatttgt atcctgtgtc aaattcaagg tattattgat aaaccttttc aaccagcagc
     4741 aagaagttca aatttttttc tgtcactgta acagaaaaca caatatgtat ataacattta
     4801 tgtagcaata aatgtgccat ctttttttta acacagtaaa atagtgagtt ttttacattt
     4861 ctctttctca aataataatg tattttgttt tattttctcc atctcattcg tcccagaaac
     4921 actcacactg cttttcctaa ctgcattacc gacattatct gggaaaccct tcaggacaga
     4981 atcaggcttg tggagctaag ttggcaatct ggtctagagc ttctctagct tgtgcttttc
     5041 tcctcttgcc ctcactactg acggtggcct tttaaccttt tcctaaagat tgaccaaaca
     5101 gcaactagta gttatagaaa atctactcat ttgtagatac agagaaaaat gaagaagatg
     5161 gaaaaagact caaaagaggc tttttaagtt attcttcaaa gcacttttca catttcccca
     5221 taccctttct cacaaaaaaa gtgtcataat taagtaatgg tattgtttac tgtttaaaag
     5281 ttaaaagatc aaaaatttgc ttttatccca gtttttaacc acaaaaaaaa gcgtagggat
     5341 tatccatgag gacttcatgc caagcaagaa cctcaaacaa actagacaaa cttttttttt
     5401 gacagtgaat gactttttgt aggacctgtg cgtgcgaaac ccatggcaat tgtcacatcc
     5461 tcttggtatg ctggcagatt gcttctcttg gtgaattatg aaatccactg ttcacattgg
     5521 gtgcctaaca gaacattttg cttcttgtgg gatttagtga aaactattaa acttgttaag
     5581 ttgattttat acaaaacgat aaataaaaag ctctaagaag aaaatgtata atcttagagc
     5641 tgaaataaaa tatagagacc atctagtaaa tgacctcatt aatatatctg tgaaaactga
     5701 gactcagatt gtatgtctct aagaacacat aattagtaac agatcaagac acttaaaact
     5761 ttccctacaa aacctccctg ccttgacttt ctctttctct ttgcagattt ctaggccgct
     5821 tctgctcagt gtcttcattt tcttccatat ttgttttatt tcatttttct tttctatagt
     5881 tcatgttttc tttttccttg gaaactcaaa atttaaacac acgtcgtgtg tgtgtgtgtg
     5941 tgtgtgtctg tgtgtgtgtg acttaaagaa tcttaagctt tggcattaaa tagtcctcga
     6001 ttcaaatcta agctcaacat ctgattaact tcattttcct atctgaaaaa tggagataac
     6061 attagaattg tgtaagtatt gaatgaaaca atgtatggaa agctcttatg gttcttgtca
     6121 cctaagaagt acttaataaa tgataaatat ttttaaataa ataatattat aaccaa
//
