LOCUS       NM_001306219            5411 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens transcription factor 12 (TCF12), transcript variant 6,
            mRNA.
ACCESSION   NM_001306219 XM_011521964
VERSION     NM_001306219.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5411)
  AUTHORS   Wang,G., Wu,Y., Su,Y., Qu,N., Chen,B., Zhou,D., Yuan,L., Yin,M.,
            Liu,M. and Zhou,W.
  TITLE     TCF12-regulated GRB7 facilitates the HER2+ breast cancer
            progression by activating Notch1 signaling pathway
  JOURNAL   J Transl Med 22 (1), 745 (2024)
   PUBMED   39113057
  REMARK    GeneRIF: TCF12-regulated GRB7 facilitates the HER2+ breast cancer
            progression by activating Notch1 signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5411)
  AUTHORS   Yan,S., Yuan,M., Yang,X., Huang,X., Wu,D., Wang,N., Sun,X., Qin,Y.,
            Fei,Y., Zhao,Z. and Wang,Q.
  TITLE     Lncrna CASC15 Activated By TCF12 Promote Colorectal Cancer
            Progression via EMT
  JOURNAL   Comb Chem High Throughput Screen 27 (8), 1222-1230 (2024)
   PUBMED   37680149
  REMARK    GeneRIF: Lncrna CASC15 Activated By TCF12 Promote Colorectal Cancer
            Progression via EMT.
REFERENCE   3  (bases 1 to 5411)
  AUTHORS   Geng,N., Yu,Z., Zeng,X., Xu,D., Gao,H., Yang,M. and Huang,X.
  TITLE     Nuclear Tubulin Enhances CXCR4 Transcription and Promotes
            Chemotaxis Through TCF12 Transcription Factor in human
            Hematopoietic Stem Cells
  JOURNAL   Stem Cell Rev Rep 19 (5), 1328-1339 (2023)
   PUBMED   37067645
  REMARK    GeneRIF: Nuclear Tubulin Enhances CXCR4 Transcription and Promotes
            Chemotaxis Through TCF12 Transcription Factor in human
            Hematopoietic Stem Cells.
REFERENCE   4  (bases 1 to 5411)
  AUTHORS   Liu,L., Zhou,X., Cheng,S., Ge,Y., Chen,B., Shi,J., Li,H., Li,S.,
            Li,Y., Yuan,J., Wu,A., Liu,X., Huang,S., Xu,Z. and Dong,J.
  TITLE     RNA-binding protein DHX9 promotes glioma growth and
            tumor-associated macrophages infiltration via TCF12
  JOURNAL   CNS Neurosci Ther 29 (4), 988-999 (2023)
   PUBMED   36377508
  REMARK    GeneRIF: RNA-binding protein DHX9 promotes glioma growth and
            tumor-associated macrophages infiltration via TCF12.
REFERENCE   5  (bases 1 to 5411)
  AUTHORS   Li,X.P., Jia,Y.L., Duan,Y.Q., Zhao,Y., Yin,X.L., Zhen,S.M.,
            Zhang,Y. and Liu,L.H.
  TITLE     Circular RNA hsa_circ_0002938 (circCRIM1) promotes the progression
            of esophageal squamous cell carcinoma by upregulating transcription
            factor 12
  JOURNAL   Neoplasma 70 (1), 145-157 (2023)
   PUBMED   36916930
  REMARK    GeneRIF: Circular RNA hsa_circ_0002938 (circCRIM1) promotes the
            progression of esophageal squamous cell carcinoma by upregulating
            transcription factor 12.
REFERENCE   6  (bases 1 to 5411)
  AUTHORS   Zhang,Y., Doyle,K. and Bina,M.
  TITLE     Interactions of HTF4 with E-box motifs in the long terminal repeat
            of human immunodeficiency virus type 1
  JOURNAL   J Virol 66 (9), 5631-5634 (1992)
   PUBMED   1501295
REFERENCE   7  (bases 1 to 5411)
  AUTHORS   Hu,J.S., Olson,E.N. and Kingston,R.E.
  TITLE     HEB, a helix-loop-helix protein related to E2A and ITF2 that can
            modulate the DNA-binding ability of myogenic regulatory factors
  JOURNAL   Mol Cell Biol 12 (3), 1031-1042 (1992)
   PUBMED   1312219
REFERENCE   8  (bases 1 to 5411)
  AUTHORS   Zhang,Y. and Bina,M.
  TITLE     The nucleotide sequence of the human transcription factor HTF4a
            cDNA
  JOURNAL   DNA Seq 2 (6), 397-403 (1992)
   PUBMED   1446075
REFERENCE   9  (bases 1 to 5411)
  AUTHORS   Sommer,L., Hagenbuchle,O., Wellauer,P.K. and Strubin,M.
  TITLE     Nuclear targeting of the transcription factor PTF1 is mediated by a
            protein subunit that does not bind to the PTF1 cognate sequence
  JOURNAL   Cell 67 (5), 987-994 (1991)
   PUBMED   1720355
REFERENCE   10 (bases 1 to 5411)
  AUTHORS   Zhang,Y., Babin,J., Feldhaus,A.L., Singh,H., Sharp,P.A. and Bina,M.
  TITLE     HTF4: a new human helix-loop-helix protein
  JOURNAL   Nucleic Acids Res 19 (16), 4555 (1991)
   PUBMED   1886779
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC090532.1 and AC016525.11.
            
            On Jun 2, 2019 this sequence version replaced NM_001306219.2.
            
            Summary: The protein encoded by this gene is a member of the basic
            helix-loop-helix (bHLH) E-protein family that recognizes the
            consensus binding site (E-box) CANNTG. This encoded protein is
            expressed in many tissues, among them skeletal muscle, thymus, B-
            and T-cells, and may participate in regulating lineage-specific
            gene expression through the formation of heterodimers with other
            bHLH E-proteins. Several alternatively spliced transcript variants
            of this gene have been described, but the full-length nature of
            some of these variants has not been determined. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (6) lacks multiple exon in the 5'
            UTR and 5' coding region and uses an alternate 5' most exon
            compared to variant 1. The encoded isoform (d) has a shorter and
            distinct N-terminus compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.168352.1,
                                           SRR1803616.17694.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               AC090532.1         127949-128109
            162-267             AC090532.1         139671-139776
            268-407             AC090532.1         140810-140949
            408-552             AC090532.1         141231-141375
            553-617             AC090532.1         142562-142626
            618-696             AC090532.1         151991-152069
            697-770             AC090532.1         159869-159942
            771-842             AC090532.1         160940-161011
            843-1049            AC090532.1         161781-161987
            1050-1164           AC016525.11        58897-59011
            1165-1327           AC016525.11        59915-60077
            1328-1560           AC016525.11        69833-70065
            1561-1714           AC016525.11        79248-79401
            1715-5411           AC016525.11        82960-86656
FEATURES             Location/Qualifiers
     source          1..5411
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.3"
     gene            1..5411
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /note="transcription factor 12"
                     /db_xref="GeneID:6938"
                     /db_xref="HGNC:HGNC:11623"
                     /db_xref="MIM:600480"
     exon            1..161
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1703
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /note="isoform d is encoded by transcript variant 6;
                     helix-loop-helix transcription factor 4; E-box-binding
                     protein; DNA-binding protein HTF4; transcription factor
                     HTF-4; class B basic helix-loop-helix protein 20"
                     /codon_start=1
                     /product="transcription factor 12 isoform d"
                     /protein_id="NP_001293148.1"
                     /db_xref="CCDS:CCDS76760.1"
                     /db_xref="GeneID:6938"
                     /db_xref="HGNC:HGNC:11623"
                     /db_xref="MIM:600480"
                     /translation="MYCAYPVPGMGSNSLMYYYNGKTVYAPSPNSDDFNRESPSYPSP
                     KPPTSMFASTFFMQDGTHNSSDLWSSSNGMSQPGFGGILGTSTSHMSQSSSYGNLHSH
                     DRLSYPPHSVSPTDINTSLPPMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAA
                     GSSQTGDALGKALASIYSPDHTSSSFPSNPSTPVGSPSPLTGTSQWPRPGGQAPSSPS
                     YENSLHSLKNRVEQQLHEHLQDAMSFLKDVCEQSRMEDRLDRLDDAIHVLRNHAVGPS
                     TSLPAGHSDIHSLLGPSHNAPIGSLNSNYGGSSLVASSRSASMVGTHREDSVSLNGNH
                     SVLSSTVTTSSTDLNHKTQENYRGGLQSQSGTVVTTEIKTENKEKDENLHEPPSSDDM
                     KSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINEA
                     FKELGRMCQLHLKSEKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKV
                     SAVSAEPPTTLPGTHPGLSETTNPMGHM"
     exon            162..267
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            268..407
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            408..552
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            553..617
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            618..696
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            697..770
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            771..842
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            843..1049
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1164
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1327
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1560
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1714
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..5411
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4042..4047
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /note="hexamer: AATAAA"
     regulatory      4070..4075
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /note="hexamer: AGTAAA"
     polyA_site      4076
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /note="major polyA site"
     polyA_site      4110
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
     regulatory      5395..5400
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /note="hexamer: AATAAT"
     polyA_site      5411
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
ORIGIN      
        1 actgaagact tactcccttt gcctgtgtgg atatatgtct tggagagagg ctgtgtgcat
       61 tagctacaaa tagtaacatt ttcaaaatca acatgtattg tgcttatcct gtccctggaa
      121 tgggcagcaa ttctttgatg tattactaca atgggaaaac ggtatatgca ccatccccaa
      181 attcagatga tttcaaccgt gaatctccta gttatccatc tcctaagcca ccaaccagta
      241 tgttcgctag cactttcttt atgcaagatg ggacccacaa ttcttctgac ctttggagtt
      301 catcaaatgg gatgagccag cctggttttg gtggaattct ggggacctcc acttcccaca
      361 tgtctcaatc cagtagttat ggcaaccttc attcacatga ccgcttgagt tatcctccac
      421 actcagtttc accaacagac ataaacacga gtcttccacc aatgtccagc tttcatcgcg
      481 gcagtaccag cagttcacct tacgttgctg cctcacacac tcctcccatc aatggatcag
      541 acagcattct aggaaccaga gggaatgctg ctggaagctc acagacaggt gatgcacttg
      601 gaaaggcttt ggcatctatt tattctcctg accataccag cagtagtttt ccgtcaaatc
      661 catcaacacc agttggatca ccttcacctc tcacaggtac cagtcagtgg ccaagacctg
      721 gagggcaagc accttcatcc ccaagctatg aaaactcact ccactccctg aaaaatcgag
      781 ttgagcagca acttcacgag catttgcaag atgcaatgtc cttcttaaag gatgtctgtg
      841 agcagtctcg aatggaggat cgtttagaca gactggatga tgcaatccat gtgctgcgga
      901 accatgctgt gggaccttcc accagtttgc ctgctggtca cagtgatata catagtttat
      961 tgggaccatc ccataatgca ccaattggaa gcctcaattc aaactatgga ggatcaagcc
     1021 ttgttgcaag cagtcgatca gcttcaatgg ttggaactca tcgggaagac tctgtcagtc
     1081 tcaatggcaa tcattcagtc ctgtctagta cagtcactac ttcaagcaca gacctgaacc
     1141 ataaaacaca agaaaattat agaggtggct tgcaaagtca gtctggaact gttgttacaa
     1201 cagaaatcaa gactgaaaac aaagaaaagg atgaaaacct tcatgaacct ccttcatcag
     1261 atgacatgaa gtcagatgat gaatcctccc aaaaagatat caaggtttca tctagaggca
     1321 gaacaagcag tactaatgaa gatgaggatt tgaaccctga acagaagata gaaagggaga
     1381 aggagaggcg gatggctaac aatgccagag aacgcttacg cgtgcgggat attaatgaag
     1441 cattcaaaga gcttggccga atgtgtcagc ttcacttgaa gagtgaaaaa ccccaaacaa
     1501 aactccttat tcttcatcaa gccgtggcag tcatccttag tctagaacag caagtcagag
     1561 agaggaacct taaccccaaa gcagcctgcc ttaagagaag ggaagaagaa aaagtttctg
     1621 ccgtatcggc agagccgcca accacactgc caggaaccca tcctgggctt agtgaaacta
     1681 ccaaccctat gggtcatatg taaacatcag ccagttccag agttatcagt aggctagata
     1741 gaaggtgacc tctcctcata aggacttgga caactcagat tatctgaaga cacaaacctg
     1801 acaggaggga gaagaaaaaa caaaacactt gaaccaagaa actcaaatgt aatcctacga
     1861 tcaaagcaac tggtcaacac ttccatcaga agtgaagata ggaagctcat cagatagaac
     1921 atcagcccat gagatgtttg caacaaatct tttgttgcaa gcagtgtgtc gcttctgcac
     1981 aatcagagac tgtctcgatc tctccactca ccgtggaagt tgccttgtgc ctaaactgaa
     2041 ttgacaaatg cattgtaact acaaatttta tttattgtta tgaaactgta aggtctacat
     2101 ataaagggaa aaagttaatg tggaaagctg atctacactc agctgatgcc agcatacatt
     2161 aaagcggttc acgtgcagag aacaaagcag tgacaaccat tggcccttag cattcccggc
     2221 atacctatta gtgtcttaaa aaggaaggga aaagtctttt gttgccctct cctatcctct
     2281 tgccatatga atagcgtttt ccatgaaata ggaaaatatt acttggtata gcatttctct
     2341 tgctctcatt ttttgattta tttttatttt ctctttgtgg gtgttatatt tgatctctaa
     2401 atctgaacag tttatggtca cagtccagcc tcctccgtgc agccctgtgt gctttgcaca
     2461 tttaccttac agtggtaagc agagaccatc tgtgaccata gcctagctag cattttaaaa
     2521 ggggaaattt tgttctctag gttttccccc aaataaacat tgctttattt ctaataataa
     2581 ccaagacttt tcaagcttct agatctcata ggaaagcttg taatagcaaa attgtaaatt
     2641 acaagggaag aatctacttt ttagaaatcg ctttgttttc caagcagtaa gtactacata
     2701 cagtacttgt aaagtgttag ctgtaagtaa gcacaaaata catttaaaat acaaagacga
     2761 ttttttcagg ctgtgattat ggtgaacata acaaaaccca gtagtcacca aggcaggtag
     2821 tgtgataaat gaacacacca ctctgaggct aattacctaa tggaatacaa gagcaatggt
     2881 cacccgtatt tccttatcct agcctttatt tctctgtcat ttggatggct ggtcaatggg
     2941 gaagaattga gtgggtgatt taatcaactg caaaccatct gcccctgtcc caaaatgatg
     3001 agccagatta gcattaaacc agtacttgtc agtccatctt aatactgttc attaaggcac
     3061 tctctgtctc taatccttag gagttgtttt aaaagacata atcactttga acttccatga
     3121 aacctgtctt ccaccacaac aaccctggga gagaaaaaca tgctaaagga ggtatcttgg
     3181 cttaataatt ccttatagcc aatatcaaca gtggcaatca gcacacagag gaaaggaccc
     3241 aaatcactat gtagcttaaa gatttctgtt aatttgaaag aacaaaaaca agacagaact
     3301 tctggtactc taatcaggat gattcctaac aagtcagtca tttgtgaact tagtggactt
     3361 tttggttact ttaatttgca tatattctcc agttacatcg gactctatct gtggccttgt
     3421 tcttcatttc agtgttaatc agctaaacag aagttgttgc ttatgatgtg tgagtgaaca
     3481 tatgccactg cctggccttt ttttcttcag agcttgttgt ctttttcgct atattagact
     3541 ttgcagtatg cccagaagct ttccttcata aaatagaaag aaaaaaacat ttggcttatt
     3601 tttcactgta gctagtcttt tatacaataa tcttgtaaga aaatttcttg aattctaaat
     3661 attactcttt ctagattttt gaaatcaaaa agttttcagt aaaaagtttc ttactttatt
     3721 ttattatatt aggtagtaaa aaatgtaggg ttatttacca taacctgttc attaatatca
     3781 gaaatttaca atagcatttt aagaccatag taggattcta gcataccgtg tagtacctat
     3841 ggagtattgt aagagctaat tgttggagat gaattgcttc tcatcttgtt ctccagtttc
     3901 cattgttggt ttattgcaga tttgtatcct gtgtcaaatt caaggtatta ttgataaacc
     3961 ttttcaacca gcagcaagaa gttcaaattt ttttctgtca ctgtaacaga aaacacaata
     4021 tgtatataac atttatgtag caataaatgt gccatctttt ttttaacaca gtaaaatagt
     4081 gagtttttta catttctctt tctcaaataa taatgtattt tgttttattt tctccatctc
     4141 attcgtccca gaaacactca cactgctttt cctaactgca ttaccgacat tatctgggaa
     4201 acccttcagg acagaatcag gcttgtggag ctaagttggc aatctggtct agagcttctc
     4261 tagcttgtgc ttttctcctc ttgccctcac tactgacggt ggccttttaa ccttttccta
     4321 aagattgacc aaacagcaac tagtagttat agaaaatcta ctcatttgta gatacagaga
     4381 aaaatgaaga agatggaaaa agactcaaaa gaggcttttt aagttattct tcaaagcact
     4441 tttcacattt ccccataccc tttctcacaa aaaaagtgtc ataattaagt aatggtattg
     4501 tttactgttt aaaagttaaa agatcaaaaa tttgctttta tcccagtttt taaccacaaa
     4561 aaaaagcgta gggattatcc atgaggactt catgccaagc aagaacctca aacaaactag
     4621 acaaactttt tttttgacag tgaatgactt tttgtaggac ctgtgcgtgc gaaacccatg
     4681 gcaattgtca catcctcttg gtatgctggc agattgcttc tcttggtgaa ttatgaaatc
     4741 cactgttcac attgggtgcc taacagaaca ttttgcttct tgtgggattt agtgaaaact
     4801 attaaacttg ttaagttgat tttatacaaa acgataaata aaaagctcta agaagaaaat
     4861 gtataatctt agagctgaaa taaaatatag agaccatcta gtaaatgacc tcattaatat
     4921 atctgtgaaa actgagactc agattgtatg tctctaagaa cacataatta gtaacagatc
     4981 aagacactta aaactttccc tacaaaacct ccctgccttg actttctctt tctctttgca
     5041 gatttctagg ccgcttctgc tcagtgtctt cattttcttc catatttgtt ttatttcatt
     5101 tttcttttct atagttcatg ttttcttttt ccttggaaac tcaaaattta aacacacgtc
     5161 gtgtgtgtgt gtgtgtgtgt gtctgtgtgt gtgtgactta aagaatctta agctttggca
     5221 ttaaatagtc ctcgattcaa atctaagctc aacatctgat taacttcatt ttcctatctg
     5281 aaaaatggag ataacattag aattgtgtaa gtattgaatg aaacaatgta tggaaagctc
     5341 ttatggttct tgtcacctaa gaagtactta ataaatgata aatattttta aataaataat
     5401 attataacca a
//
