LOCUS       NM_174937               2618 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens transcription elongation regulator 1 like (TCERG1L),
            mRNA.
ACCESSION   NM_174937
VERSION     NM_174937.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2618)
  AUTHORS   Chen,G., Bentley,A., Adeyemo,A., Shriner,D., Zhou,J., Doumatey,A.,
            Huang,H., Ramos,E., Erdos,M., Gerry,N., Herbert,A., Christman,M.
            and Rotimi,C.
  TITLE     Genome-wide association study identifies novel loci association
            with fasting insulin and insulin resistance in African Americans
  JOURNAL   Hum Mol Genet 21 (20), 4530-4536 (2012)
   PUBMED   22791750
  REMARK    GeneRIF: TCERG1L is associated with plasma adiponectin, a key
            modulator of obesity, inflammation, IR and diabetes.
REFERENCE   2  (bases 1 to 2618)
  AUTHORS   Service,S.K., Verweij,K.J., Lahti,J., Congdon,E., Ekelund,J.,
            Hintsanen,M., Raikkonen,K., Lehtimaki,T., Kahonen,M., Widen,E.,
            Taanila,A., Veijola,J., Heath,A.C., Madden,P.A., Montgomery,G.W.,
            Sabatti,C., Jarvelin,M.R., Palotie,A., Raitakari,O., Viikari,J.,
            Martin,N.G., Eriksson,J.G., Keltikangas-Jarvinen,L., Wray,N.R. and
            Freimer,N.B.
  TITLE     A genome-wide meta-analysis of association studies of Cloninger's
            Temperament Scales
  JOURNAL   Transl Psychiatry 2 (5), e116 (2012)
   PUBMED   22832960
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2618)
  AUTHORS   Kenny,E.E., Pe'er,I., Karban,A., Ozelius,L., Mitchell,A.A.,
            Ng,S.M., Erazo,M., Ostrer,H., Abraham,C., Abreu,M.T., Atzmon,G.,
            Barzilai,N., Brant,S.R., Bressman,S., Burns,E.R., Chowers,Y.,
            Clark,L.N., Darvasi,A., Doheny,D., Duerr,R.H., Eliakim,R.,
            Giladi,N., Gregersen,P.K., Hakonarson,H., Jones,M.R., Marder,K.,
            McGovern,D.P., Mulle,J., Orr-Urtreger,A., Proctor,D.D., Pulver,A.,
            Rotter,J.I., Silverberg,M.S., Ullman,T., Warren,S.T., Waterman,M.,
            Zhang,W., Bergman,A., Mayer,L., Katz,S., Desnick,R.J., Cho,J.H. and
            Peter,I.
  TITLE     A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests
            novel susceptibility loci
  JOURNAL   PLoS Genet 8 (3), e1002559 (2012)
   PUBMED   22412388
REFERENCE   4  (bases 1 to 2618)
  AUTHORS   Sim,X., Ong,R.T., Suo,C., Tay,W.T., Liu,J., Ng,D.P., Boehnke,M.,
            Chia,K.S., Wong,T.Y., Seielstad,M., Teo,Y.Y. and Tai,E.S.
  TITLE     Transferability of type 2 diabetes implicated loci in multi-ethnic
            cohorts from Southeast Asia
  JOURNAL   PLoS Genet 7 (4), e1001363 (2011)
   PUBMED   21490949
REFERENCE   5  (bases 1 to 2618)
  AUTHORS   Neale,B.M., Medland,S., Ripke,S., Anney,R.J., Asherson,P.,
            Buitelaar,J., Franke,B., Gill,M., Kent,L., Holmans,P.,
            Middleton,F., Thapar,A., Lesch,K.P., Faraone,S.V., Daly,M.,
            Nguyen,T.T., Schafer,H., Steinhausen,H.C., Reif,A., Renner,T.J.,
            Romanos,M., Romanos,J., Warnke,A., Walitza,S., Freitag,C.,
            Meyer,J., Palmason,H., Rothenberger,A., Hawi,Z., Sergeant,J.,
            Roeyers,H., Mick,E. and Biederman,J.
  CONSRTM   IMAGE II Consortium Group
  TITLE     Case-control genome-wide association study of
            attention-deficit/hyperactivity disorder
  JOURNAL   J Am Acad Child Adolesc Psychiatry 49 (9), 906-920 (2010)
   PUBMED   20732627
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   6  (bases 1 to 2618)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC042951.1, BC101535.1, BM689725.1 and AL390203.29.
            
            On Nov 22, 2018 this sequence version replaced NM_174937.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC042951.1, SRR14038197.1477997.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144120, SAMEA2145240
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368642.4/ ENSP00000357631.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1101              BC042951.1         6-1106
            1102-1925           BC101535.1         951-1774
            1926-2245           BC042951.1         1931-2250
            2246-2616           BM689725.1         47-417
            2617-2617           BC042951.1         2622-2622
            2618-2618           AL390203.29        87941-87941         c
FEATURES             Location/Qualifiers
     source          1..2618
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.3"
     gene            1..2618
                     /gene="TCERG1L"
                     /note="transcription elongation regulator 1 like"
                     /db_xref="GeneID:256536"
                     /db_xref="HGNC:HGNC:23533"
                     /db_xref="MIM:620498"
     exon            1..428
                     /gene="TCERG1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1847
                     /gene="TCERG1L"
                     /note="5730476P14Rik"
                     /codon_start=1
                     /product="transcription elongation regulator 1-like
                     protein"
                     /protein_id="NP_777597.2"
                     /db_xref="CCDS:CCDS7662.2"
                     /db_xref="GeneID:256536"
                     /db_xref="HGNC:HGNC:23533"
                     /db_xref="MIM:620498"
                     /translation="MQAGARFQRRRRQLQQQQPRRRQPLLWPMDAEPPPPPPWVWMVP
                     GSAGLLRLSAGVVVPPVLLASAPPPAAPLLPGLPGWPAPSEPVLPLLPLPSAPDSAAA
                     AAAHPFPALHGQWLFGGHSPSLGLPPSSTVELVPVFPHLCPSALATPIGKSWIDKRIP
                     NCKIFFNNSFALDSTWIHPEESRFFHGHEKPRLLANQVAVSLSRPAPASRPLPTVVLA
                     PQPIPGGCHNSLKVTSSPAIAIATAAAAAMVSVDPENLRGPSPSSVQPRHFLTLAPIK
                     IPLRTSPVSDTRTERGRVARPPALMLRAQKSRDGDKEDKEPPPMLGGGEDSTARGNRP
                     VASTPVPGSPWCVVWTGDDRVFFFNPTMHLSVWEKPMDLKDRGDLNRIIEDPPHKRKL
                     EAPATDNSDGSSSEDNREDQDVKTKRNRTEGCGSPKPEEAKREDKGTRTPPPQILLPL
                     EERVTHFRDMLLERGVSAFSTWEKELHKIVFDPRYLLLNSEERKQIFEQFVKTRIKEE
                     YKEKKSKLLLAKEEFKKLLEESKVSPRTTFKEFAEKYGRDQRFRLVQKRKDQEHFFNQ
                     FILILKKRDKENRLRLRKMR"
     exon            429..575
                     /gene="TCERG1L"
                     /inference="alignment:Splign:2.1.0"
     exon            576..756
                     /gene="TCERG1L"
                     /inference="alignment:Splign:2.1.0"
     exon            757..942
                     /gene="TCERG1L"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1031
                     /gene="TCERG1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1120
                     /gene="TCERG1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1275
                     /gene="TCERG1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1345
                     /gene="TCERG1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1481
                     /gene="TCERG1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1571
                     /gene="TCERG1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1690
                     /gene="TCERG1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..2618
                     /gene="TCERG1L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2600..2605
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCERG1L"
                     /note="hexamer: AATAAA"
     polyA_site      2618
                     /gene="TCERG1L"
                     /note="major polyA site"
ORIGIN      
        1 gagttcgctc cggagccgcg ccgccgccgg cccagcatct cgggcgcccg ccgcccccgc
       61 cgccgccgtc agcgcgggga tgtaggatgc aggcgggcgc caggttccag cggcggcggc
      121 ggcagctgca gcagcagcag ccccggcggc ggcagcctct cctctggccg atggacgcag
      181 agccgccgcc gccgccgccc tgggtctgga tggtgccggg ctcggccggg ctgctccggc
      241 tcagcgcggg ggtcgtggtt cccccggtgc tgctcgcctc ggccccgccg cccgcggccc
      301 cgctgctccc cggtctcccc ggctggccgg ccccgagcga gccggtgctc ccgctgctgc
      361 cgctgccctc tgcgccagac tccgccgccg ccgccgccgc gcaccccttc cccgcgctcc
      421 acgggcagtg gctgtttggt ggccattctc cgtccctagg actgcccccc tcttccacag
      481 tggagctggt gcccgtcttc ccacatctct gcccttctgc tcttgcaacc cctattggga
      541 aaagttggat agacaaaagg attcctaact gtaagatctt ttttaataat tcctttgctc
      601 tggactcaac gtggatacat cctgaggagt caaggttttt ccatgggcat gaaaagcctc
      661 gtttgctggc aaatcaagta gctgtgtctc tgtccaggcc ggctcctgcc tccaggccgc
      721 tccccacggt ggtgttagca cctcagccca tcccaggtgg ctgccataac agccttaagg
      781 tgaccagcag ccccgccatt gccatcgcca ccgccgccgc cgctgccatg gtctccgtgg
      841 accctgagaa cctccggggc ccgtccccct ccagcgtgca gccgcgccac ttcctgacct
      901 tggcacccat caaaataccc ctccggacgt cccccgtctc agatacaagg acagagcggg
      961 gccgagtggc ccgccctcct gccctgatgc tgcgggccca gaagagccgg gatggagaca
     1021 aagaagacaa ggagcctcca ccgatgctgg ggggaggaga ggacagcaca gccagaggca
     1081 acaggccagt ggcctccacc ccggtgcccg gatccccctg gtgtgtggtc tggacgggcg
     1141 atgaccgagt tttcttcttc aacccaacga tgcacctgtc tgtctgggag aagcccatgg
     1201 acctgaagga ccgcggagac ctcaacagga tcattgagga cccgccccac aaacgcaagc
     1261 tggaggcacc agcaactgac aacagcgatg ggtccagttc tgaagacaac agggaagacc
     1321 aagatgtgaa aaccaagagg aaccggaccg aaggctgcgg gagtcccaag ccagaggagg
     1381 caaagagaga ggacaaaggc acaaggacgc cgcccccgca gatcctcctg cctctggagg
     1441 agcgtgtgac ccacttccga gacatgctgc tggagagagg ggtatcagca ttttctacct
     1501 gggagaaaga attacacaaa atcgtgtttg acccacgcta tctcctgctc aactctgagg
     1561 aacgaaagca gatatttgaa cagtttgtca agacaagaat aaaagaagaa tacaaggaaa
     1621 agaaaagtaa attgctgcta gccaaagaag aattcaagaa acttctagag gaatctaaag
     1681 tgtctcccag gaccacgttt aaggagtttg cagagaaata cggccgggat cagaggttcc
     1741 gacttgttca aaaaagaaag gaccaggagc attttttcaa ccaattcata cttattctta
     1801 agaaacggga caaggaaaac agactaaggc tgcggaaaat gagatgagtt tgtgaaaaaa
     1861 tgcaataagc ccgggggttg accctgggcg tgccgggggc gagggggtca cggtggagac
     1921 ggacacgggc gtggggcggc cgagacctgc acggcccagc gggcaccggc actgcggggt
     1981 cttcgttctc agaggattac tgtttcatat tgaagctctc tcttttgtac attcagagtt
     2041 tgatgcattt ctaatcaccg tgatacgtcg atcccttaat tgttttaatt atgcaaatta
     2101 cttgtaatat acacaaatta tcaatccact gcaggactgt ggggaagcag gaacgggagc
     2161 ctctgtaaca atctcaaggc atttgtgtca tcacctaaga cgattggcga aaacttttct
     2221 gaaaaccttt gtgaattact tcgtttctcc aggattcccg cagtgttgag gaattcctta
     2281 ctctgtccct aggtctcagt ctcgtttctg agtagcagca atagggtttt catcattcat
     2341 catagtgaca actgtgagca ttccacacct ggaccgtgga tcacttacag gtttccaagg
     2401 gtggccgcgc gttcctccca gaggggcgtc ccggcctgga gcagggagcc gtgttggttg
     2461 ccaccggtcc tacttcaaaa gaattatttt gtacaaaatc atcatattaa tatttgagtt
     2521 atttttattg tatgcccgga gtttgcatga gattttttct catcaccttt gtataaaaaa
     2581 tttttaattt tttttaatca ataaatattt taaaccag
//
