LOCUS       NM_001382548            4684 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens transcription elongation regulator 1 (TCERG1),
            transcript variant 3, mRNA.
ACCESSION   NM_001382548 XM_005268365
VERSION     NM_001382548.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4684)
  AUTHORS   Moreno-Castro,C., Prieto-Sanchez,S., Sanchez-Hernandez,N.,
            Hernandez-Munain,C. and Sune,C.
  TITLE     Role for the splicing factor TCERG1 in Cajal body integrity and
            snRNP assembly
  JOURNAL   J Cell Sci 132 (22) (2019)
   PUBMED   31636114
  REMARK    GeneRIF: Results of this study suggest that TCERG1 plays an
            important role in Cajal body formation and snRNP biogenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4684)
  AUTHORS   Munoz-Cobo,J.P., Sanchez-Hernandez,N., Gutierrez,S., El Yousfi,Y.,
            Montes,M., Gallego,C., Hernandez-Munain,C. and Sune,C.
  TITLE     Transcriptional Elongation Regulator 1 Affects Transcription and
            Splicing of Genes Associated with Cellular Morphology and
            Cytoskeleton Dynamics and Is Required for Neurite Outgrowth in
            Neuroblastoma Cells and Primary Neuronal Cultures
  JOURNAL   Mol Neurobiol 54 (10), 7808-7823 (2017)
   PUBMED   27844289
  REMARK    GeneRIF: TCERG1 affects expression of multiple mRNAs involved in
            neuron projection development.
REFERENCE   3  (bases 1 to 4684)
  AUTHORS   Sanchez-Hernandez,N., Boireau,S., Schmidt,U., Munoz-Cobo,J.P.,
            Hernandez-Munain,C., Bertrand,E. and Sune,C.
  TITLE     The in vivo dynamics of TCERG1, a factor that couples
            transcriptional elongation with splicing
  JOURNAL   RNA 22 (4), 571-582 (2016)
   PUBMED   26873599
  REMARK    GeneRIF: TCERG1 binds independently to elongation and splicing
            complexes, thus performing their coupling by transient interactions
            rather than by stable association with one or the other complexes.
REFERENCE   4  (bases 1 to 4684)
  AUTHORS   Miller,N.J., Schick,K., Timchenko,N., Harrison,E. and Roesler,W.J.
  TITLE     The Glutamine-Alanine Repeat Domain of TCERG1 is Required for the
            Inhibition of the Growth Arrest Activity of C/EBPalpha
  JOURNAL   J Cell Biochem 117 (3), 612-620 (2016)
   PUBMED   26264132
  REMARK    GeneRIF: The QA repeat domain of TCERG1 is required for
            relocalization of CEBPalpha.
REFERENCE   5  (bases 1 to 4684)
  AUTHORS   Montes,M., Coiras,M., Becerra,S., Moreno-Castro,C., Mateos,E.,
            Majuelos,J., Oliver,F.J., Hernandez-Munain,C., Alcami,J. and
            Sune,C.
  TITLE     Functional Consequences for Apoptosis by Transcription Elongation
            Regulator 1 (TCERG1)-Mediated Bcl-x and Fas/CD95 Alternative
            Splicing
  JOURNAL   PLoS One 10 (10), e0139812 (2015)
   PUBMED   26462236
  REMARK    GeneRIF: TCERG1 sensitizes a cell to apoptotic agents, thus
            promoting apoptosis by regulating the alternative splicing of both
            the Bcl-x and Fas/CD95 genes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4684)
  AUTHORS   Bohne,J., Cole,S.E., Sune,C., Lindman,B.R., Ko,V.D., Vogt,T.F. and
            Garcia-Blanco,M.A.
  TITLE     Expression analysis and mapping of the mouse and human
            transcriptional regulator CA150
  JOURNAL   Mamm Genome 11 (10), 930-933 (2000)
   PUBMED   11003711
REFERENCE   7  (bases 1 to 4684)
  AUTHORS   Carty,S.M., Goldstrohm,A.C., Sune,C., Garcia-Blanco,M.A. and
            Greenleaf,A.L.
  TITLE     Protein-interaction modules that organize nuclear function: FF
            domains of CA150 bind the phosphoCTD of RNA polymerase II
  JOURNAL   Proc Natl Acad Sci U S A 97 (16), 9015-9020 (2000)
   PUBMED   10908677
REFERENCE   8  (bases 1 to 4684)
  AUTHORS   Sune,C. and Garcia-Blanco,M.A.
  TITLE     Transcriptional cofactor CA150 regulates RNA polymerase II
            elongation in a TATA-box-dependent manner
  JOURNAL   Mol Cell Biol 19 (7), 4719-4728 (1999)
   PUBMED   10373521
REFERENCE   9  (bases 1 to 4684)
  AUTHORS   Neubauer,G., King,A., Rappsilber,J., Calvio,C., Watson,M., Ajuh,P.,
            Sleeman,J., Lamond,A. and Mann,M.
  TITLE     Mass spectrometry and EST-database searching allows
            characterization of the multi-protein spliceosome complex
  JOURNAL   Nat Genet 20 (1), 46-50 (1998)
   PUBMED   9731529
REFERENCE   10 (bases 1 to 4684)
  AUTHORS   Sune,C., Hayashi,T., Liu,Y., Lane,W.S., Young,R.A. and
            Garcia-Blanco,M.A.
  TITLE     CA150, a nuclear protein associated with the RNA polymerase II
            holoenzyme, is involved in Tat-activated human immunodeficiency
            virus type 1 transcription
  JOURNAL   Mol Cell Biol 17 (10), 6029-6039 (1997)
   PUBMED   9315662
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011375.5.
            
            On May 14, 2020 this sequence version replaced XM_005268365.3.
            
            Summary: This gene encodes a nuclear protein that regulates
            transcriptional elongation and pre-mRNA splicing. The encoded
            protein interacts with the hyperphosphorylated C-terminal domain of
            RNA polymerase II via multiple FF domains, and with the pre-mRNA
            splicing factor SF1 via a WW domain. Alternative splicing results
            in multiple transcripts variants encoding different isoforms.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) encodes the longest isoform
            (3).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.306788.1,
                                           SRR14038193.2028000.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000679501.2/ ENSP00000505217.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AC011375.5         73656-73731         c
            77-302              AC011375.5         65783-66008         c
            303-455             AC011375.5         63729-63881         c
            456-909             AC011375.5         61727-62180         c
            910-1152            AC011375.5         57271-57513         c
            1153-1215           AC011375.5         52661-52723         c
            1216-1416           AC011375.5         51320-51520         c
            1417-1529           AC011375.5         50316-50428         c
            1530-1618           AC011375.5         49488-49576         c
            1619-1779           AC011375.5         42411-42571         c
            1780-1836           AC011375.5         41153-41209         c
            1837-1903           AC011375.5         40970-41036         c
            1904-1954           AC011375.5         39864-39914         c
            1955-2090           AC011375.5         38337-38472         c
            2091-2180           AC011375.5         37435-37524         c
            2181-2299           AC011375.5         28026-28144         c
            2300-2450           AC011375.5         22378-22528         c
            2451-2615           AC011375.5         17525-17689         c
            2616-2798           AC011375.5         17058-17240         c
            2799-2978           AC011375.5         13857-14036         c
            2979-3062           AC011375.5         13108-13191         c
            3063-3163           AC011375.5         11819-11919         c
            3164-4684           AC011375.5         9103-10623          c
FEATURES             Location/Qualifiers
     source          1..4684
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q32"
     gene            1..4684
                     /gene="TCERG1"
                     /gene_synonym="CA150; TAF2S; Urn1"
                     /note="transcription elongation regulator 1"
                     /db_xref="GeneID:10915"
                     /db_xref="HGNC:HGNC:15630"
                     /db_xref="MIM:605409"
     exon            1..76
                     /gene="TCERG1"
                     /gene_synonym="CA150; TAF2S; Urn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..3365
                     /gene="TCERG1"
                     /gene_synonym="CA150; TAF2S; Urn1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     transcription factor CA150; TATA box binding protein
                     (TBP)-associated factor, RNA polymerase II, S, 150kD; TATA
                     box-binding protein-associated factor 2S; co-activator of
                     150 kDa"
                     /codon_start=1
                     /product="transcription elongation regulator 1 isoform 3"
                     /protein_id="NP_001369477.1"
                     /db_xref="CCDS:CCDS93799.1"
                     /db_xref="GeneID:10915"
                     /db_xref="HGNC:HGNC:15630"
                     /db_xref="MIM:605409"
                     /translation="MAERGGDGGESERFNPGELRMAQQQALRFRGPAPPPNAVMRGPP
                     PLMRPPPPFGMMRGPPPPPRPPFGRPPFDPNMPPMPPPGGIPPPMGPPHLQRPPFMPP
                     PMSSMPPPPGMMFPPGMPPVTAPGTPALPPTEEIWVENKTPDGKVYYYNARTRESAWT
                     KPDGVKVIQQSELTPMLAAQAQVQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQ
                     AQAQAQAQAQAQAQAQAQAQAQAQVQAQVQAQVQAQAVGASTPTTSSPAPAVSTSTSS
                     STPSSTTSTTTTATSVAQTVSTPTTQDQTPSSAVSVATPTVSVSTPAPTATPVQTVPQ
                     PHPQTLPPAVPHSVPQPTTAIPAFPPVMVPPFRVPLPGMPIPLPGVAMMQIVSCPYVK
                     TVATTKTGVLPGMAPPIVPMIHPQVAIAASPATLAGATAVSEWTEYKTADGKTYYYNN
                     RTLESTWEKPQELKEKEKLEEKIKEPIKEPSEEPLPMETEEEDPKEEPIKEIKEEPKE
                     EEMTEEEKAAQKAKPVATAPIPGTPWCVVWTGDERVFFYNPTTRLSMWDRPDDLIGRA
                     DVDKIIQEPPHKKGMEELKKLRHPTPTMLSIQKWQFSMSAIKEEQELMEEINEDEPVK
                     AKKRKRMSKKSFMWIARASLFRRDDNKDIDSEKEAAMEAEIKAARERAIVPLEARMKQ
                     FKDMLLERGVSAFSTWEKELHKIVFDPRYLLLNPKERKQVFDQYVKTRAEEERREKKN
                     KIMQAKEDFKKMMEEAKFNPRATFSEFAAKHAKDSRFKAIEKMKDREALFNEFVAAAR
                     KKEKEDSKTRGEKIKSDFFELLSNHHLDSQSRWSKVKDKVESDPRYKAVDSSSMREDL
                     FKQYIEKIAKNLDSEKEKELERQARIEASLREREREVQKARSEQTKEIDREREQHKRE
                     EAIQNFKALLSDMVRSSDVSWSDTRRTLRKDHRWESGSLLEREEKEKLFNEHIEALTK
                     KKREHFRQLLDETSAITLTSTWKEVKKIIKEDPRCIKFSSSDRKKQREFEEYIRDKYI
                     TAKADFRTLLKETKFITYRSKKLIQESDQHLKDVEKILQNDKRYLVLDCVPEERRKLI
                     VAYVDDLDRRGPPPPPTASEPTRRSTK"
     exon            77..302
                     /gene="TCERG1"
                     /gene_synonym="CA150; TAF2S; Urn1"
                     /inference="alignment:Splign:2.1.0"
     exon            303..455
                     /gene="TCERG1"
                     /gene_synonym="CA150; TAF2S; Urn1"
                     /inference="alignment:Splign:2.1.0"
     exon            456..909
                     /gene="TCERG1"
                     /gene_synonym="CA150; TAF2S; Urn1"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1152
                     /gene="TCERG1"
                     /gene_synonym="CA150; TAF2S; Urn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1215
                     /gene="TCERG1"
                     /gene_synonym="CA150; TAF2S; Urn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1416
                     /gene="TCERG1"
                     /gene_synonym="CA150; TAF2S; Urn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1529
                     /gene="TCERG1"
                     /gene_synonym="CA150; TAF2S; Urn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1618
                     /gene="TCERG1"
                     /gene_synonym="CA150; TAF2S; Urn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1779
                     /gene="TCERG1"
                     /gene_synonym="CA150; TAF2S; Urn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1836
                     /gene="TCERG1"
                     /gene_synonym="CA150; TAF2S; Urn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1903
                     /gene="TCERG1"
                     /gene_synonym="CA150; TAF2S; Urn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..1954
                     /gene="TCERG1"
                     /gene_synonym="CA150; TAF2S; Urn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2090
                     /gene="TCERG1"
                     /gene_synonym="CA150; TAF2S; Urn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2180
                     /gene="TCERG1"
                     /gene_synonym="CA150; TAF2S; Urn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2299
                     /gene="TCERG1"
                     /gene_synonym="CA150; TAF2S; Urn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2450
                     /gene="TCERG1"
                     /gene_synonym="CA150; TAF2S; Urn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2615
                     /gene="TCERG1"
                     /gene_synonym="CA150; TAF2S; Urn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2616..2798
                     /gene="TCERG1"
                     /gene_synonym="CA150; TAF2S; Urn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2799..2978
                     /gene="TCERG1"
                     /gene_synonym="CA150; TAF2S; Urn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2979..3062
                     /gene="TCERG1"
                     /gene_synonym="CA150; TAF2S; Urn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3063..3163
                     /gene="TCERG1"
                     /gene_synonym="CA150; TAF2S; Urn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3164..4684
                     /gene="TCERG1"
                     /gene_synonym="CA150; TAF2S; Urn1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4209..4214
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCERG1"
                     /gene_synonym="CA150; TAF2S; Urn1"
                     /note="hexamer: AATAAA"
     polyA_site      4231
                     /gene="TCERG1"
                     /gene_synonym="CA150; TAF2S; Urn1"
                     /note="major polyA site"
     regulatory      4666..4671
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCERG1"
                     /gene_synonym="CA150; TAF2S; Urn1"
                     /note="hexamer: AATAAA"
     polyA_site      4684
                     /gene="TCERG1"
                     /gene_synonym="CA150; TAF2S; Urn1"
ORIGIN      
        1 gaacgcggcc ctctgtaatg gcggagcgtg gcggggacgg gggcgagagt gaacgattca
       61 acccggggga gctcaggatg gcccaacagc aggccttgag gttccgaggt ccggctcccc
      121 caccaaatgc agtgatgcga ggcccaccac ctctgatgcg acctcctcca ccttttggta
      181 tgatgcgagg ccctcctcca ccaccacggc cgccctttgg acgtcctcct tttgatccta
      241 atatgccgcc aatgcctcct ccaggaggga tacctccacc tatgggccct ccacacctcc
      301 agagaccacc tttcatgcct cctcccatga gttccatgcc tcctcctccg ggtatgatgt
      361 ttccaccagg aatgcctcct gtgactgctc ctggtactcc agcactacct cctacggagg
      421 agatatgggt tgaaaataaa actccagatg ggaaggttta ttattataat gctcggacac
      481 gtgaatctgc atggaccaag ccagatggag ttaaggttat tcagcaatca gaactgacac
      541 ctatgcttgc agcccaggca caggttcagg ctcaggccca ggcgcaggct caggcccagg
      601 cgcaggctca ggcccaggca caagctcagg cccaggctca ggctcaggcc caggcccagg
      661 cccaggccca ggcccaggcc caagcccaag cccaggccca ggctcaggct caggcacaag
      721 ctcaggccca ggcccaggct caggtccagg cccaggtcca ggcacaagtg caagcacaag
      781 cagttggagc ttccacccct acgaccagta gcccagcacc tgcagtatcc acttcaacat
      841 catcatccac cccttcctct accacttcta ccacaacaac tgctacttca gttgcgcaga
      901 cagtatcaac acccacaaca caagatcaga ccccaagttc tgctgtttca gttgccacgc
      961 ctacagttag tgtttcaact cctgctccta cagccacacc tgtgcaaacc gttccccagc
     1021 cgcaccctca gacgttacct cctgctgttc ctcattcagt acctcagcca acaacagcaa
     1081 tacctgcttt tccaccagta atggtacctc cgtttcgtgt tccccttcct ggcatgccaa
     1141 ttccacttcc aggtgtagca atgatgcaaa tagtcagctg cccgtatgta aagacagtcg
     1201 ctaccaccaa gaccggtgta ttgccaggaa tggcccctcc tatcgtaccc atgatacatc
     1261 cccaggttgc tattgcagct tcacctgcta ccttagctgg agcaacagca gtttctgaat
     1321 ggactgaata taaaacagca gatgggaaga catattatta taataataga acattagaat
     1381 caacctggga aaaaccccaa gaactaaagg aaaaagaaaa gttagaagag aagattaaag
     1441 agccaattaa agaaccctct gaagagcctc tgccaatgga gacggaggag gaggatccta
     1501 aagaagagcc tataaaggag ataaaggagg agcccaaaga agaggagatg actgaagaag
     1561 aaaaggctgc ccagaaggca aagccagttg ctactgctcc tattcctggt actccatggt
     1621 gtgtcgtttg gactggtgat gagcgggtct tcttttataa tcccaccact cgtctttcta
     1681 tgtgggaccg acctgatgat ctgattggca gggcagatgt tgacaaaatt attcaggagc
     1741 cccctcataa aaaaggaatg gaggaattga agaaactaag gcacccaact ccgacaatgc
     1801 tgtcgatcca aaagtggcaa ttctctatga gtgcaattaa agaggaacaa gaattaatgg
     1861 aagaaattaa tgaagatgag cctgttaaag caaaaaaacg gaagagaatg tcaaagaagt
     1921 cctttatgtg gattgcccga gcttctctat ttaggagaga cgataataaa gacattgact
     1981 cagagaaaga agctgccatg gaagctgaaa ttaaagctgc ccgagaaagg gccattgtcc
     2041 ctctggaggc tcgaatgaag cagttcaagg acatgctgct agagagaggg gtgtctgctt
     2101 tttcaacgtg ggagaaggag ttgcacaaga tagtttttga tccccggtac ttacttctca
     2161 atcctaaaga gagaaaacag gtgtttgatc agtatgtaaa gaccagggca gaggaagaac
     2221 gcagggaaaa gaaaaataaa ataatgcaag ccaaggaaga tttcaaaaaa atgatggaag
     2281 aagcaaaatt taatccaaga gcaactttta gtgaatttgc agccaagcat gctaaagatt
     2341 caagattcaa agcaattgaa aagatgaaag accgagaagc cttgtttaat gagtttgtgg
     2401 ccgctgctag gaagaaagag aaagaagatt cgaagaccag aggtgagaag attaaatcgg
     2461 atttctttga actattatct aatcatcact tggacagtca gtctcgatgg agcaaagtaa
     2521 aagacaaagt agaaagtgat ccacgttaca aagcagtaga tagttcatca atgagagaag
     2581 accttttcaa acagtacatt gaaaaaatag ccaagaattt agactcagaa aaagaaaagg
     2641 agcttgaaag gcaagcccgc attgaggcaa gccttcgaga acgagaaagg gaggttcaaa
     2701 aggcccgttc agaacaaaca aaagaaatag atcgagagag agagcagcac aaacgagaag
     2761 aagctatcca gaatttcaaa gctcttctgt ctgacatggt acgttcttca gatgtgtcat
     2821 ggtctgatac tcgtaggacc ctccgaaaag atcaccgctg ggaatctgga tccttattgg
     2881 aaagagagga gaaagagaag ctttttaatg aacacattga agcacttacc aaaaaaaaga
     2941 gagagcactt taggcaactt ctggatgaaa cttctgcaat taccttaaca tccacgtgga
     3001 aagaagtaaa aaaaatcatt aaggaagatc ctcgatgtat taagttctcc tccagtgaca
     3061 ggaaaaaaca aagagaattt gaagaatata tcagagacaa atatatcaca gccaaagctg
     3121 acttcaggac gcttttgaaa gagaccaaat ttataacata tagatccaaa aaattaatcc
     3181 aagaatcaga tcagcacctg aaagatgtag aaaaaatttt acagaatgac aaacggtatc
     3241 tagtactgga ctgtgtgcca gaggagaggc gtaaactgat tgtggcatat gttgatgacc
     3301 tggatcgccg gggtccaccc ccacctccca cagcatcgga gcccacgaga cgatcaacaa
     3361 aataattcta aatactcttc cataggggca tctattcaaa atgcttgcat gagccaattt
     3421 tcaggttttt acatatatgt gcattagtca acctattgcg aaaccatctg acaaacagaa
     3481 ggagaagcat ttgtgaacag tttctgaaca gaacactttg gaaatattta tgcttttctt
     3541 tgtgtggcat gactgacata catactcaaa tataggctgt ctctagtaaa tcttaaaatc
     3601 ttgaagctaa aattcatcct tttatgaggt gtggaagtca gtgacttggt gacgttcttc
     3661 ctagcagtgt taatacatgc aagaagtaag agcatttgtg gcttgaactt gccagatgca
     3721 aataccacag actccaagaa aacccgagtt ggggtttgtt ttgttttgat tttttttttt
     3781 taaagcgggt aaaagagaaa acactgaaaa ttgaattctt atcttccaga ggctacaatt
     3841 attataatgg acaatacttt tacctttgtc tctaaagatc agattagttt tatttgttca
     3901 cttacgtgct ttgattatcc cctctgaatt atagaccgag tcttgttgtt tagcctaaga
     3961 gaagatttat gtagtaattt cttctcaggt atggaaccac ggtcataact aacatgttgg
     4021 ccagaataga accactggtt aaacatattt tattcaccat taagtgatct ttatcaatat
     4081 tctggattag acaacaaatt acctttctgg gtgtttcttg taaactatac tcctgtttga
     4141 atgttaaact ttgttgctaa agtttaattt taagatgttt gaatgttcag tttatgtatt
     4201 tgaactacaa taaaccaacc ctttttatat atctgtattg tatatgatta ttgttactta
     4261 atttttaaga gcttatttta acctgttttt aaaagcagca aatagaattt cccacaaagt
     4321 aagttgactc taaatcttaa gtattaccta gtttttaaag gtttgaatat aataatgcag
     4381 tatttgcagt ataaaaagga aggaatttgt agagaatcat tttggtgctc aagtctctta
     4441 gcagtgcctt attgcctcat agcaagaaga tgctggggtt ttttttgttt ttgtcctttg
     4501 tattaatgta tgatggtttg cgcctttttg gcattctttc aacatgtcgt gtacatcaca
     4561 ccatgaatca gttcctaatt gatatatcta gctttacctc ccgagttaaa aaaaaatctt
     4621 tttattttat gccttcatag gttgctcgtt tcagagtgcc acataaataa aatgtttaac
     4681 aaaa
//
