LOCUS       NM_001297563            3251 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens transcription elongation factor A N-terminal and
            central domain containing (TCEANC), transcript variant 2, mRNA.
ACCESSION   NM_001297563 XM_005274455
VERSION     NM_001297563.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3251)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 3251)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK291271.1, AC079383.17 and BC020095.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001297563.1.
            
            Transcript Variant: This variant (2) contains an additional exon in
            the 5' UTR which results in the use of a downstream AUG compared to
            variant 1. The encoded isoform (2) has a shorter N-terminus
            compared to isoform 1. Variants 2 and 3 encode the same isoform
            (2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.7663.1,
                                           SRR1660805.201383.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1968540,
                                           SAMEA1968968 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000696128.1/ ENSP00000512421.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-224               AK291271.1         36-259
            225-225             AC079383.17        112194-112194
            226-837             AK291271.1         261-872
            838-3210            AC079383.17        115447-117819
            3211-3251           BC020095.1         3091-3131
FEATURES             Location/Qualifiers
     source          1..3251
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.2"
     gene            1..3251
                     /gene="TCEANC"
                     /gene_synonym="TCEANC1"
                     /note="transcription elongation factor A N-terminal and
                     central domain containing"
                     /db_xref="GeneID:170082"
                     /db_xref="HGNC:HGNC:28277"
                     /db_xref="MIM:301084"
     exon            1..48
                     /gene="TCEANC"
                     /gene_synonym="TCEANC1"
                     /inference="alignment:Splign:2.1.0"
     exon            49..133
                     /gene="TCEANC"
                     /gene_synonym="TCEANC1"
                     /inference="alignment:Splign:2.1.0"
     exon            134..250
                     /gene="TCEANC"
                     /gene_synonym="TCEANC1"
                     /inference="alignment:Splign:2.1.0"
     exon            251..342
                     /gene="TCEANC"
                     /gene_synonym="TCEANC1"
                     /inference="alignment:Splign:2.1.0"
     exon            343..3251
                     /gene="TCEANC"
                     /gene_synonym="TCEANC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             351..1406
                     /gene="TCEANC"
                     /gene_synonym="TCEANC1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     TFS2-M domain-containing protein 1; transcription
                     elongation factor A N-terminal and central
                     domain-containing protein; TFIIS central domain-containing
                     protein 1; transcription elongation factor A (SII)
                     N-terminal and central domain containing"
                     /codon_start=1
                     /product="transcription elongation factor A N-terminal and
                     central domain-containing protein isoform 2"
                     /protein_id="NP_001284492.1"
                     /db_xref="CCDS:CCDS75954.1"
                     /db_xref="GeneID:170082"
                     /db_xref="HGNC:HGNC:28277"
                     /db_xref="MIM:301084"
                     /translation="MSDKNQIAARASLIEQLMSKRNFEDLGNHLTELETIYVTKEHLQ
                     ETDVVRAVYRVLKNCPSVALKKKAKCLLSKWKAVYKQTHSKARNSPKLFPVRGNKEEN
                     SGPSHDPSQNETLGICSSNSLSSQDVAKLSEMIVPENRAIQLKPKEEHFGDGDPESTG
                     KRSSELLDPTTPMRTKCIELLYAALTSSSTDQPKADLWQNFAREIEEHVFTLYSKNIK
                     KYKTCIRSKVANLKNPRNSHLQQNLLSGTTSPREFAEMTVMEMANKELKQLRASYTES
                     CIQEHYLPQVIDGTQTNKIKCRRCEKYNCKVTVIDRGTLFLPSWVRNSNPDEQMMTYV
                     ICNECGEQWYHSKWVCW"
     regulatory      2576..2581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCEANC"
                     /gene_synonym="TCEANC1"
                     /note="hexamer: AATGAA"
     polyA_site      2593
                     /gene="TCEANC"
                     /gene_synonym="TCEANC1"
                     /note="major polyA site"
     regulatory      3114..3119
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCEANC"
                     /gene_synonym="TCEANC1"
                     /note="hexamer: CATAAA"
     polyA_site      3140
                     /gene="TCEANC"
                     /gene_synonym="TCEANC1"
     regulatory      3229..3234
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCEANC"
                     /gene_synonym="TCEANC1"
                     /note="hexamer: AATAAA"
     polyA_site      3251
                     /gene="TCEANC"
                     /gene_synonym="TCEANC1"
                     /note="major polyA site"
ORIGIN      
        1 gtgggcactg ggcggctgaa ggctccggaa ctgcgcctgc gcttttcgga gtattgtgag
       61 gattgagatg actggagtgt gtgtggcctg gagagttgct caataaatat atgttgcctt
      121 ccactgtgaa gagagtctcg ctctgtcgcc aggttggagt gcagtggcat gatctcggct
      181 caccgcaaac tctgcctccc gggttcaagc aattctcctg cctcggcctt ccgagtagct
      241 gggactacag agatggggtt tcaccatgtt agccaggatg gtctcgatct cctgacctcg
      301 tgatctgcct gcctcggcct cccaaagtgc tgggattaca ggctgtaaag atgtctgaca
      361 agaaccagat agctgccaga gcttctctta ttgagcaact gatgtccaaa aggaattttg
      421 aggatcttgg caaccacctt actgagctag aaacaattta tgtgactaag gagcatctcc
      481 aggagacaga tgtggtcaga gctgtgtaca gagtcctcaa aaactgcccc tctgtggctt
      541 tgaaaaagaa agccaagtgt ttgctatcaa agtggaaagc tgtttataag cagactcact
      601 ccaaagcgag gaacagccct aaattatttc ctgtgagggg taataaagaa gaaaattcag
      661 gaccttctca tgacccaagt cagaatgaga cactgggcat ctgcagctcg aattctctgt
      721 cttcccaaga cgttgcaaaa ctcagtgaaa tgattgtgcc tgaaaataga gccattcaat
      781 tgaaacctaa ggaagagcat tttggggatg gtgaccctga atccactggc aagagatcga
      841 gtgagttgct ggatcccaca acacccatga gaactaaatg catagagctt ctttacgcag
      901 ctttaactag ttcttccaca gatcaaccca aagctgattt gtggcaaaac tttgcaagag
      961 aaattgaaga gcatgttttt accctttatt caaagaacat caaaaaatat aaaacttgca
     1021 tcagaagcaa agttgccaat ttgaagaacc ccagaaattc tcatttacaa caaaacttgc
     1081 tctctgggac cacgtctcca cgagaatttg ctgaaatgac tgtcatggag atggcaaata
     1141 aggaactgaa gcagttgaga gcctcctaca cggaatcttg tatccaggaa cattaccttc
     1201 cccaagtaat tgatggcaca cagacaaata aaataaaatg cagacgctgt gagaaataca
     1261 attgcaaagt cactgtaatt gacagaggaa cacttttcct tcccagctgg gtgcggaatt
     1321 caaacccaga tgaacaaatg atgacttacg taatttgtaa cgaatgtggg gagcagtggt
     1381 accatagcaa gtgggtgtgc tggtaactgt aaatcagtgt tctcttaaca gataaccgga
     1441 gtgatacctt ttatttgtac aacccttttg tgcttttaaa aatcttatac acactactct
     1501 ctaaaacaga aaaaggagga aagaaagtcg ttagctgaag ctgccaccac catccctaaa
     1561 agttacagtt tggggagagg gagtggatga ctatttatat tgtgccttgt ggccatttag
     1621 taccttactg tagacagagt gtgggtgaga acagcccagc ataaactggg agactgtggg
     1681 aaatgcattc ccaggcctca caccattgaa tccgaatctg cattttgaca ggatccccag
     1741 gtaatcttcc aggataggat agtttgagaa gtgctacttt agcaataggc ctgtggctct
     1801 cagcagtggc tgcatattaa aatcatctgg gaagctttga aaacccactg gtgctgagac
     1861 cccaccctag aacaattcag ttggaaccta tgagatggga cccaggcatc aacatttctt
     1921 ttttcattcc tcaagttatt ttaagatgca gtcagagttg agaactactc agaaataggc
     1981 tctcatttga tcctttttac agctctaaga caagaatgtt attccaggca cttcacgaat
     2041 gaggaaacag gtccacagag gtgtggtgac atgtccaagt gacacaacca taaatagtac
     2101 caattctgac agatcccaga ttttctccct cctgactcac tgagactggc tcaatatcga
     2161 cttctgagaa atgtattcct ggaggtcggg gacaaaatga agaatgtgtt taaactccaa
     2221 cattgggtga ctagatcttc attcttttcc cctctctttt ctcatttata ggtctccctt
     2281 caaccacaaa agtcaccctg gaactcatcc cgcagttaga attttgtttg gagccctctt
     2341 gcttagttga aggagtttcg tagttgtttt ttgtttttgt ttttgttttt gttttttccc
     2401 cctgtgaaca ggtttttcgg gggtatgtaa actctaggat gtttagtttc tgatgtcagg
     2461 agtcttcatg ttctcaagga caagtgtcct tgagatggac attaatggtc attagtctgt
     2521 cagaggaagc ccatcacttt agcctttgaa tgtagtaaca gacgtttatc taataaatga
     2581 attgaagata aaattacctc tttgaggcct ttgcaaacag tgtttaacca gtttatataa
     2641 ttgtttgact acaacacgcc ttctatgtga ttatggctga ttttttttcc ttaaaaaact
     2701 catggaatgt tcaccgtttt atagttttaa aaagtttact ttggcggtct ctacaaacct
     2761 accatttcac tttctcacca gttcttttct cctaactctc ttcctttgtt ggagctctga
     2821 aggcctaact gtgtgtacac tttacctgcc tgacagaatt ctccaaaaca tgcataaaag
     2881 taaaatatgt tcgtattttc aaataatttg gaagagtcgg ctcaatgcca tcaagtgtaa
     2941 aatctatttt gatatacttg ctctccgtgt cttcccaggg ctgctttttg tgatgcaaca
     3001 tgtttagtcc ttaacttgca aggtcatcta aaacttgaag tttcacaaag tgtggtttca
     3061 tatgacttgg aataatctga aaaactattc agtggttacg aaagagcaca gcacataaaa
     3121 accaaatttg attagttcaa gtcggtgttt atgttttgct ttgggggttt gtgtgtatgt
     3181 gtgtagtttt tatttatatt ggaatttggc aaactaaatg ttcagacaaa taaaagtaat
     3241 taaaatggaa a
//
