LOCUS       NM_016303               1028 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens transcription elongation factor A like 9 (TCEAL9),
            transcript variant 1, mRNA.
ACCESSION   NM_016303
VERSION     NM_016303.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1028)
  AUTHORS   Ward,C., Cauchy,P., Garcia,P., Frampton,J., Esteban,M.A. and
            Volpe,G.
  TITLE     High WBP5 expression correlates with elevation of HOX genes levels
            and is associated with inferior survival in patients with acute
            myeloid leukaemia
  JOURNAL   Sci Rep 10 (1), 3505 (2020)
   PUBMED   32103106
  REMARK    GeneRIF: High WBP5 expression correlates with elevation of HOX
            genes levels and is associated with inferior survival in patients
            with acute myeloid leukaemia.
            Erratum:[Sci Rep. 2020 Jul 30;10(1):13109. doi:
            10.1038/s41598-020-70049-3.. PMID: 32733008]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1028)
  AUTHORS   Tang,R., Lei,Y., Hu,B., Yang,J., Fang,S., Wang,Q., Li,M. and Guo,L.
  TITLE     WW domain binding protein 5 induces multidrug resistance of small
            cell lung cancer under the regulation of miR-335 through the Hippo
            pathway
  JOURNAL   Br J Cancer 115 (2), 243-251 (2016)
   PUBMED   27336605
  REMARK    GeneRIF: WW domain binding protein 5 can modulate MDR through the
            Hippo pathway under the regulation of miR-335. WW domain binding
            protein 5 may be a prognostic predictor and a potential target for
            interfering with MDR in SCLC.
REFERENCE   3  (bases 1 to 1028)
  AUTHORS   Winter,E.E. and Ponting,C.P.
  TITLE     Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism
            sustained by gene conversion events
  JOURNAL   BMC Evol Biol 5, 54 (2005)
   PUBMED   16221301
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1028)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   5  (bases 1 to 1028)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
REFERENCE   6  (bases 1 to 1028)
  AUTHORS   Bedford,M.T., Chan,D.C. and Leder,P.
  TITLE     FBP WW domains and the Abl SH3 domain bind to a specific class of
            proline-rich ligands
  JOURNAL   EMBO J 16 (9), 2376-2383 (1997)
   PUBMED   9171351
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG400091.1 and BC023544.2.
            
            On Nov 22, 2018 this sequence version replaced NM_016303.2.
            
            Summary: The globular WW domain is composed of 38 to 40
            semiconserved amino acids shared by proteins of diverse functions
            including structural, regulatory, and signaling proteins. The
            domain is involved in mediating protein-protein interactions
            through the binding of polyproline ligands. This gene encodes a WW
            domain binding protein. This gene also encodes a domain with
            similarity to the transcription elongation factor A, SII-related
            family. Alternative splicing results in multiple transcript
            variants encoding a single isoform. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1 through 4 encode the same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023544.2, SRR3476690.162727.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372661.6/ ENSP00000361745.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BG400091.1         56-70
            16-1028             BC023544.2         21-1033
FEATURES             Location/Qualifiers
     source          1..1028
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.2"
     gene            1..1028
                     /gene="TCEAL9"
                     /gene_synonym="WBP5; WEX6"
                     /note="transcription elongation factor A like 9"
                     /db_xref="GeneID:51186"
                     /db_xref="HGNC:HGNC:30084"
     exon            1..101
                     /gene="TCEAL9"
                     /gene_synonym="WBP5; WEX6"
                     /inference="alignment:Splign:2.1.0"
     exon            102..180
                     /gene="TCEAL9"
                     /gene_synonym="WBP5; WEX6"
                     /inference="alignment:Splign:2.1.0"
     exon            181..1028
                     /gene="TCEAL9"
                     /gene_synonym="WBP5; WEX6"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..565
                     /gene="TCEAL9"
                     /gene_synonym="WBP5; WEX6"
                     /note="pp21 homolog; WW domain binding protein 1; WW
                     domain-binding protein 5; WBP-5; TCEA-like protein 9;
                     transcription elongation factor S-II protein-like 9"
                     /codon_start=1
                     /product="transcription elongation factor A protein-like
                     9"
                     /protein_id="NP_057387.1"
                     /db_xref="CCDS:CCDS14507.1"
                     /db_xref="GeneID:51186"
                     /db_xref="HGNC:HGNC:30084"
                     /translation="MKSCQKMEGKPENESEPKHEEEPKPEEKPEEEEKLEEEAKAKGT
                     FRERLIQSLQEFKEDIHNRHLSNEDMFREVDEIDEIRRVRNKLIVMRWKVNRNHPYPY
                     LM"
     regulatory      1006..1011
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCEAL9"
                     /gene_synonym="WBP5; WEX6"
                     /note="hexamer: AATAAA"
     polyA_site      1028
                     /gene="TCEAL9"
                     /gene_synonym="WBP5; WEX6"
                     /note="major polyA site"
ORIGIN      
        1 aatctggtcc ttgttcccgt ctggatacca gcttccttca gcagcgcagg cggtggtccc
       61 tgaggcccgt ggaaggagtc aaacttgcgg gaattttgca gtttatctgc agggctgttg
      121 tttccagcaa gacccaaagc tagaaaagga ggaggaagaa actgacccga tcagtgccag
      181 aagtcattgt attcaaagaa gaataagcaa gaaagaaaag aaggaaggaa gagaggtaga
      241 cagatacaag atgaaatcct gtcaaaaaat ggaaggaaaa ccagaaaatg agagtgaacc
      301 aaagcatgag gaagagccaa agcctgagga aaagccagaa gaggaggaga agctagagga
      361 ggaggccaaa gcaaaaggaa cttttagaga aaggctgatt caatctctcc aggagtttaa
      421 agaagatata cacaacaggc atttaagcaa tgaagatatg tttagagaag tggatgaaat
      481 agatgagata aggagagtca gaaacaaact tatagtgatg cgttggaagg ttaatcgaaa
      541 ccatccttac ccctatttaa tgtagtttac cttgattttt atctgatatt aacaatacca
      601 tatagcttgc tttttattag catttcctga tattcctttg tccatatttc tacttataac
      661 ctgttgctat taatggtttt agatgtatct cttgttatct gcatctcatt gtttattgta
      721 ttttgaacca atctacaagt ctctgtcttt taataaaaga actttacaca tttgtaaaaa
      781 agaggttctt ggtaagatat aaaatggaaa aaggctaagt aatatgtgaa tatcatattt
      841 ttgaaaggta aaaagtacat ttgtatatta catatatgga cataacttgt gaaggatgaa
      901 agaaagtaca gcctctcggt ggtgggatta tgaatgattt ttctcctttt gcttgtttgt
      961 attttctata ttcctaaaat taacacacat tattattgct agaataataa aagttttata
     1021 aaaaagaa
//
