LOCUS       NM_153333               1174 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens transcription elongation factor A like 8 (TCEAL8),
            transcript variant 1, mRNA.
ACCESSION   NM_153333
VERSION     NM_153333.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1174)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1174)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1174)
  AUTHORS   Winter,E.E. and Ponting,C.P.
  TITLE     Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism
            sustained by gene conversion events
  JOURNAL   BMC Evol Biol 5, 54 (2005)
   PUBMED   16221301
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1174)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   5  (bases 1 to 1174)
  AUTHORS   Pillutla,R.C., Shimamoto,A., Furuichi,Y. and Shatkin,A.J.
  TITLE     Genomic structure and chromosomal localization of TCEAL1, a human
            gene encoding the nuclear phosphoprotein p21/SIIR
  JOURNAL   Genomics 56 (2), 217-220 (1999)
   PUBMED   10051408
  REMARK    GeneRIF: Characterizes TCEAL1, another member of the human TCEAL
            gene family.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU932815.1, BC035573.1 and
            AK026349.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_153333.2.
            
            Summary: This gene encodes a member of the transcription elongation
            factor A (SII)-like (TCEAL) gene family. Members of this family
            contain TFA domains and may function as nuclear phosphoproteins
            that modulate transcription in a promoter context-dependent manner.
            Multiple family members are located on the X chromosome.
            Alternative splicing results in multiple transcript variants
            encoding a single isoform. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK026349.1, SRR1163655.124765.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372685.8/ ENSP00000361770.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                BU932815.1         51-128
            79-1172             BC035573.1         134-1227
            1173-1174           AK026349.1         1188-1189
FEATURES             Location/Qualifiers
     source          1..1174
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.1"
     gene            1..1174
                     /gene="TCEAL8"
                     /gene_synonym="WEX3"
                     /note="transcription elongation factor A like 8"
                     /db_xref="GeneID:90843"
                     /db_xref="HGNC:HGNC:28683"
     exon            1..78
                     /gene="TCEAL8"
                     /gene_synonym="WEX3"
                     /inference="alignment:Splign:2.1.0"
     exon            79..151
                     /gene="TCEAL8"
                     /gene_synonym="WEX3"
                     /inference="alignment:Splign:2.1.0"
     exon            152..1174
                     /gene="TCEAL8"
                     /gene_synonym="WEX3"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..543
                     /gene="TCEAL8"
                     /gene_synonym="WEX3"
                     /note="TCEA-like protein 8; transcription elongation
                     factor S-II protein-like 8; transcription elongation
                     factor A (SII)-like 8"
                     /codon_start=1
                     /product="transcription elongation factor A protein-like
                     8"
                     /protein_id="NP_699164.1"
                     /db_xref="CCDS:CCDS14504.1"
                     /db_xref="GeneID:90843"
                     /db_xref="HGNC:HGNC:28683"
                     /translation="MQKSCEENEGKPQNMPKAEEDRPLEDVPQEAEGNPQPSEEGVSQ
                     EAEGNPRGGPNQPGQGFKEDTPVRHLDPEEMIRGVDELERLREEIRRVRNKFVMMHWK
                     QRHSRSRPYPVCFRP"
     regulatory      1150..1155
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCEAL8"
                     /gene_synonym="WEX3"
                     /note="hexamer: AATAAA"
     polyA_site      1174
                     /gene="TCEAL8"
                     /gene_synonym="WEX3"
                     /note="major polyA site"
ORIGIN      
        1 ccttatagtc cagggcctgt ttccctgtag cagctcctta ttgctggaga aggagaaaag
       61 tgcccaagat cctttcagga tatttggttt tttgggcgcg acacaaatcg aggtgaggga
      121 agagagagga aaatcccctg aatccctgca ggattaattt attcaaaaag gaaataaaaa
      181 atactcaata tgcaaaagtc ttgtgaagaa aatgagggaa aaccacagaa catgccaaag
      241 gccgaggaag atcgcccttt ggaggatgta ccacaggagg cagaaggaaa tcctcaacct
      301 tccgaagaag gcgtaagcca ggaagcagaa ggaaacccca gaggagggcc gaatcagcct
      361 ggccagggat ttaaagagga cacacccgtt aggcatttgg accctgaaga aatgataaga
      421 ggagtagatg agcttgaaag gcttagggaa gagataagaa gagtaagaaa caagtttgtg
      481 atgatgcatt ggaagcaaag acattcacgc agccgtcctt atcctgtgtg ctttaggcct
      541 tgaattcatt tttgcctaat attaaaatct ggccccagct ttctttctgt tagcattttc
      601 tgatgtatct ttgacctcca ttttactttt aatcatctga tgaaattttg ttttaggtaa
      661 tttccttggt accagcatct cattggattt tggattttga cccattttcc aggtctattt
      721 ttcaattgga aactttcaca catttgcatg ggaatatgtt cattccatgt tgtaaagtaa
      781 aacataacag gttatggcaa agcagcatat ttaatatcag ctcacatatg taggataaaa
      841 ttccaaactt tgtgtgtgtg cgtgtgtgta tacatacatc catataacat atatcacaaa
      901 cttaaccaag cttatttctg tgtggtgtga aattttattt gttttcttct ttttgttctt
      961 tttgcttata tgtacttttt aatgaacacg tgtctcacac acaaaaagaa ttaaggattt
     1021 tttttacaag taagagtcaa ataatttgca accagcttat gagggcaatg ggggcaccta
     1081 aactcttgat gaaagaactt taaaaagaaa tgtaaacctc aaattacctc tggatctctt
     1141 agccagagga ataaactggc aattattaca gata
//
