LOCUS       NM_152278               1134 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens transcription elongation factor A like 7 (TCEAL7),
            transcript variant 1, mRNA.
ACCESSION   NM_152278
VERSION     NM_152278.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1134)
  AUTHORS   Yu,L., Luan,W., Feng,Z., Jia,J., Wu,Z., Wang,M., Li,F. and Li,Z.
  TITLE     Long non-coding RNA HAND2-AS1 inhibits gastric cancer progression
            by suppressing TCEAL7 expression via targeting miR-769-5p
  JOURNAL   Dig Liver Dis 53 (2), 238-244 (2021)
   PUBMED   32952069
  REMARK    GeneRIF: Long non-coding RNA HAND2-AS1 inhibits gastric cancer
            progression by suppressing TCEAL7 expression via targeting
            miR-769-5p.
REFERENCE   2  (bases 1 to 1134)
  AUTHORS   Yue,X., Lan,F. and Xia,T.
  TITLE     Hypoxic Glioma Cell-Secreted Exosomal miR-301a Activates
            Wnt/beta-catenin Signaling and Promotes Radiation Resistance by
            Targeting TCEAL7
  JOURNAL   Mol Ther 27 (11), 1939-1949 (2019)
   PUBMED   31402274
  REMARK    GeneRIF: These results suggest that miR-301a promotes radiation
            resistance by repressing anti-oncogene TCEAL7 expression and then
            activity of the Wnt/beta-catenin-signaling pathway.
REFERENCE   3  (bases 1 to 1134)
  AUTHORS   Orhan,C., Bulut,P., Dalay,N., Ersen,E. and Buyru,N.
  TITLE     Downregulation of TCEAL7 expression induces CCND1 expression in
            non-small cell lung cancer
  JOURNAL   Mol Biol Rep 46 (5), 5251-5256 (2019)
   PUBMED   31321645
  REMARK    GeneRIF: Findings show that TCEAL7 expression is down-regulated in
            non-small cell lung cancer (NSCLC) like in other human cancers.
            This down-regulation was also associated with CCND1 over-expression
            in lung tumors.
REFERENCE   4  (bases 1 to 1134)
  AUTHORS   Huang,C.Y., Chen,Y.M., Zhao,J.J., Chen,Y.B., Jiang,S.S., Yan,S.M.,
            Zhao,B.W., Pan,K., Wang,D.D., Lv,L., Li,Y.F., Wang,W., Zhou,Z.W.
            and Xia,J.C.
  TITLE     Decreased expression of transcription elongation factor A-like 7 is
            associated with gastric adenocarcinoma prognosis
  JOURNAL   PLoS One 8 (1), e54671 (2013)
   PUBMED   23372750
  REMARK    GeneRIF: Our study suggests that TCEAL7 might serve as a candidate
            tumor suppressor and a potential prognostic biomarker in gastric
            carcinogenesis.
REFERENCE   5  (bases 1 to 1134)
  AUTHORS   Lafferty-Whyte,K., Bilsland,A., Hoare,S.F., Burns,S., Zaffaroni,N.,
            Cairney,C.J. and Keith,W.N.
  TITLE     TCEAL7 inhibition of c-Myc activity in alternative lengthening of
            telomeres regulates hTERT expression
  JOURNAL   Neoplasia 12 (5), 405-414 (2010)
   PUBMED   20454512
  REMARK    GeneRIF: alteration of TCEAL7 expression levels in
            recombination-based alternative lengthening of telomeres and
            telomerase-positive cells affects hTERT expression
REFERENCE   6  (bases 1 to 1134)
  AUTHORS   Chien,J., Narita,K., Rattan,R., Giri,S., Shridhar,R., Staub,J.,
            Beleford,D., Lai,J., Roberts,L.R., Molina,J., Kaufmann,S.H.,
            Prendergast,G.C. and Shridhar,V.
  TITLE     A role for candidate tumor-suppressor gene TCEAL7 in the regulation
            of c-Myc activity, cyclin D1 levels and cellular transformation
  JOURNAL   Oncogene 27 (58), 7223-7234 (2008)
   PUBMED   18806825
  REMARK    GeneRIF: A role for candidate tumor-suppressor gene TCEAL7 in the
            regulation of c-Myc activity, cyclin D1 levels and cellular
            transformation is reported.
REFERENCE   7  (bases 1 to 1134)
  AUTHORS   Winter,E.E. and Ponting,C.P.
  TITLE     Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism
            sustained by gene conversion events
  JOURNAL   BMC Evol Biol 5, 54 (2005)
   PUBMED   16221301
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1134)
  AUTHORS   Chien,J., Staub,J., Avula,R., Zhang,H., Liu,W., Hartmann,L.C.,
            Kaufmann,S.H., Smith,D.I. and Shridhar,V.
  TITLE     Epigenetic silencing of TCEAL7 (Bex4) in ovarian cancer
  JOURNAL   Oncogene 24 (32), 5089-5100 (2005)
   PUBMED   15870691
  REMARK    GeneRIF: TCEAL7 is a cell death regulatory protein that is
            frequently inactivated in ovarian cancers, and may function as a
            tumor suppressor.
REFERENCE   9  (bases 1 to 1134)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   10 (bases 1 to 1134)
  AUTHORS   Jia,L., Young,M.F., Powell,J., Yang,L., Ho,N.C., Hotchkiss,R.,
            Robey,P.G. and Francomano,C.A.
  TITLE     Gene expression profile of human bone marrow stromal cells:
            high-throughput expressed sequence tag sequencing analysis
  JOURNAL   Genomics 79 (1), 7-17 (2002)
   PUBMED   11827452
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA142141.1, DB481725.1, BC016786.1 and AI753521.1.
            
            On Nov 22, 2018 this sequence version replaced NM_152278.4.
            
            Transcript Variant: This variant (1) encodes the longer transcript.
            Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.985170.1,
                                           SRR5189652.121273.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332431.5/ ENSP00000329794.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                DA142141.1         71-136
            67-167              DB481725.1         120-220
            168-1131            BC016786.1         172-1135
            1132-1134           AI753521.1         20-22               c
FEATURES             Location/Qualifiers
     source          1..1134
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.2"
     gene            1..1134
                     /gene="TCEAL7"
                     /gene_synonym="WEX5"
                     /note="transcription elongation factor A like 7"
                     /db_xref="GeneID:56849"
                     /db_xref="HGNC:HGNC:28336"
                     /db_xref="MIM:300771"
     exon            1..66
                     /gene="TCEAL7"
                     /gene_synonym="WEX5"
                     /inference="alignment:Splign:2.1.0"
     exon            67..184
                     /gene="TCEAL7"
                     /gene_synonym="WEX5"
                     /inference="alignment:Splign:2.1.0"
     exon            185..1134
                     /gene="TCEAL7"
                     /gene_synonym="WEX5"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..514
                     /gene="TCEAL7"
                     /gene_synonym="WEX5"
                     /note="TCEA-like protein 7; transcription elongation
                     factor S-II protein-like 7; transcription elongation
                     factor A (SII)-like 7"
                     /codon_start=1
                     /product="transcription elongation factor A protein-like
                     7"
                     /protein_id="NP_689491.1"
                     /db_xref="CCDS:CCDS14506.1"
                     /db_xref="GeneID:56849"
                     /db_xref="HGNC:HGNC:28336"
                     /db_xref="MIM:300771"
                     /translation="MQKPCKENEGKPKCSVPKREEKRPYGEFERQQTEGNFRQRLLQS
                     LEEFKEDIDYRHFKDEEMTREGDEMERCLEEIRGLRKKFRALHSNHRHSRDRPYPI"
     regulatory      848..853
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCEAL7"
                     /gene_synonym="WEX5"
                     /note="hexamer: ATTATA"
     polyA_site      873
                     /gene="TCEAL7"
                     /gene_synonym="WEX5"
                     /note="major polyA site"
     regulatory      1110..1115
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCEAL7"
                     /gene_synonym="WEX5"
                     /note="hexamer: AATAAA"
     polyA_site      1134
                     /gene="TCEAL7"
                     /gene_synonym="WEX5"
                     /note="major polyA site"
ORIGIN      
        1 gtaccagctc cttactgccc tgcagacaag cgtgccgtgc gtgcttgtgg ccaagggaag
       61 gaagagctgg ttgatccaca gatagctcct tcctccccgc cccttccttt ttgtttggag
      121 gtcccaggat ctgtgttcac agacatctgg gggaagaaaa ggagcaggaa actaccccgc
      181 acagagttaa gcaggaaaca acaacaacat catgcaaaaa ccctgcaaag aaaacgaagg
      241 aaagccaaag tgcagcgtgc caaagaggga ggaaaaacgc ccgtatggag aatttgaacg
      301 ccagcaaaca gaagggaatt ttagacagag gctgcttcag tctctcgaag aatttaaaga
      361 ggacatagac tataggcatt ttaaagatga agaaatgaca agggagggag atgagatgga
      421 aaggtgtttg gaagagataa ggggtctgag aaagaaattt agggctctgc attctaacca
      481 taggcattct cgggaccgtc cttatcccat ttaattaatt tctctgacaa ttcaattatt
      541 ttctgttatt aatgttgcca ctgctttctg tttgtctgca ctttcttgat aaatatttgc
      601 tatcgtttta ctccagtcat tcgatgttgc tgagatttac atatgactct tgtcaacatc
      661 tcatcttttg acccaatctt attcatttaa taagaggtct cattcatttg catggaaaaa
      721 tgctcattgt atattgcaaa gtgaaaataa cgagttgcaa aacagtgtat acatatatgt
      781 gtgtatatat gtacacttta tttgtacatt tctatgtgac ataatgcaaa ggaaagtgtc
      841 tgattttatt atacaccaaa ggttaacagt gaatctctgt gtgatctctt tttttttctt
      901 tttgcctatc tgcatcttct cacttgccaa aaaatgaata tatgtttatg tgtgtatatt
      961 acttgtgtca caaaaaaccc taaagtagac agtaaaagaa cttgtcaatc gcctttggaa
     1021 ggcaatgaaa cacttaataa actctcaata acagaagcgt aaaaatgaaa tgtaaacctc
     1081 caattacctc tggatctctt agccagagta ataaactggt aattattaca gata
//
