LOCUS       NM_001006938            3056 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens transcription elongation factor A like 6 (TCEAL6),
            transcript variant 2, mRNA.
ACCESSION   NM_001006938
VERSION     NM_001006938.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3056)
  AUTHORS   Sui,X., Wang,Y. and Liu,H.
  TITLE     hsa_circ_0101119 facilitates the progression of cervical cancer via
            an interaction with EIF4A3 to inhibit TCEAL6 expression
  JOURNAL   Mol Med Rep 24 (3) (2021)
   PUBMED   34278492
  REMARK    GeneRIF: hsa_circ_0101119 facilitates the progression of cervical
            cancer via an interaction with EIF4A3 to inhibit TCEAL6 expression.
REFERENCE   2  (bases 1 to 3056)
  AUTHORS   Winter,E.E. and Ponting,C.P.
  TITLE     Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism
            sustained by gene conversion events
  JOURNAL   BMC Evol Biol 5, 54 (2005)
   PUBMED   16221301
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3056)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Z70719.1.
            
            On Mar 29, 2019 this sequence version replaced NM_001006938.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.66475.1,
                                           SRR1803615.191659.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               Z70719.1           31240-31368
            130-202             Z70719.1           31935-32007
            203-3056            Z70719.1           32366-35219
FEATURES             Location/Qualifiers
     source          1..3056
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.1"
     gene            1..3056
                     /gene="TCEAL6"
                     /gene_synonym="Tceal3; WEX2"
                     /note="transcription elongation factor A like 6"
                     /db_xref="GeneID:158931"
                     /db_xref="HGNC:HGNC:24553"
     exon            1..129
                     /gene="TCEAL6"
                     /gene_synonym="Tceal3; WEX2"
                     /inference="alignment:Splign:2.1.0"
     exon            130..202
                     /gene="TCEAL6"
                     /gene_synonym="Tceal3; WEX2"
                     /inference="alignment:Splign:2.1.0"
     exon            203..3056
                     /gene="TCEAL6"
                     /gene_synonym="Tceal3; WEX2"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..778
                     /gene="TCEAL6"
                     /gene_synonym="Tceal3; WEX2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     transcription elongation factor A protein-like 6;
                     TCEA-like protein 6; transcription elongation factor S-II
                     protein-like 6; transcription elongation factor A
                     (SII)-like 3; transcription elongation factor A (SII)-like
                     6"
                     /codon_start=1
                     /product="transcription elongation factor A protein-like 6
                     isoform 2"
                     /protein_id="NP_001006939.2"
                     /db_xref="GeneID:158931"
                     /db_xref="HGNC:HGNC:24553"
                     /translation="MEKPYNKNEGNLENEGKPEDEVEPDDEGKSDEEEKPDAEGKTEC
                     EGKRKAEGEPGDEGQLEDKGSQEKQGKSEGEGKPQGEGKPASQAKPEGQPRAAEKRPA
                     GDYVPRKAKRKTDRGTDDSPKDSQEDLQERHLSSEEMMRECGDVSRAQEELRKKQKMG
                     GFHWMQRDVQDPFAQGDNGVSGE"
     polyA_site      1053
                     /gene="TCEAL6"
                     /gene_synonym="Tceal3; WEX2"
                     /note="major polyA site"
     regulatory      1060..1065
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCEAL6"
                     /gene_synonym="Tceal3; WEX2"
                     /note="hexamer: AATAAA"
     polyA_site      1087
                     /gene="TCEAL6"
                     /gene_synonym="Tceal3; WEX2"
                     /note="major polyA site"
     regulatory      1442..1447
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCEAL6"
                     /gene_synonym="Tceal3; WEX2"
                     /note="hexamer: AATAAA"
     regulatory      1453..1458
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCEAL6"
                     /gene_synonym="Tceal3; WEX2"
                     /note="hexamer: AATACA"
     polyA_site      1463
                     /gene="TCEAL6"
                     /gene_synonym="Tceal3; WEX2"
     polyA_site      1473
                     /gene="TCEAL6"
                     /gene_synonym="Tceal3; WEX2"
     regulatory      3033..3038
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCEAL6"
                     /gene_synonym="Tceal3; WEX2"
                     /note="hexamer: AATAAA"
     polyA_site      3056
                     /gene="TCEAL6"
                     /gene_synonym="Tceal3; WEX2"
ORIGIN      
        1 ccgcccgccc agcggtccgg tccaggcgcc cgcgcagaat cagctgtctg agctgcccag
       61 gcggcggggg agcagcgagc gggcttcagc gagccgcagg aggcacaggc ctgtcctggg
      121 tccccgcagg tctgcgcgtc tgttgttccc agcgctcttg gaggcctgca aaggaagagc
      181 aacctgtcca gactccccgc aggacaggaa aaagagaaat ctcgacatgg aaaaacccta
      241 caataaaaat gaaggaaacc tggaaaacga gggaaagcca gaagatgaag tagagcctga
      301 tgatgaagga aagtcagacg aggaagaaaa gccagacgcg gaggggaaga cagaatgcga
      361 gggaaagcga aaggctgagg gagagccagg tgatgaggga caactggaag ataagggaag
      421 ccaggaaaag cagggcaagt ccgaaggtga gggcaagcca caaggcgagg gcaagccagc
      481 ctcccaggca aagccagagg gccagccgcg ggccgccgaa aagcgcccgg ctggagatta
      541 tgtgccccgg aaagcaaaaa gaaaaacaga cagggggacg gacgattccc ccaaggactc
      601 tcaggaggac ttacaggaaa ggcatctgag cagtgaggag atgatgagag aatgtggaga
      661 tgtgtcaagg gctcaggagg agctaaggaa aaaacagaaa atgggtggtt ttcattggat
      721 gcaaagagat gtacaggatc cattcgccca aggggacaac ggggtgtcag gggagtgagg
      781 ggtggaggta ggggccaaag aggcttacac gatatcccat acctttaatg cctttggcct
      841 tccattctga cttctctgat gagattattg tcaaccctgc tttccctggt agatatttgc
      901 caggcccaat gctttaacct taagctgata tttttgcttt agatgtcaat ctcgttacca
      961 gcagcctttt gacccaacta cagcgctcta tattttagta gaggattttc acccatgtgc
     1021 atggaaaaga tgttcatgac acattgtaaa aaataaataa ataaagaaca gtttgcagaa
     1081 cctcgtatac ggttatcagc caatatttat aaaaatgtaa atgtttgtat aatgcatttc
     1141 tgcgcaaaga aaaccctgaa agcatgtaca ctaaaaagca ggcaatggtt attcctgaag
     1201 ggtagccaag aataggtctc acctgtattc aaaaatgagt cctaccacct cttgtatgta
     1261 cctccatgat attcctctgc tgctgtgcac atccctatgt cttccctagg tcgagccagg
     1321 tcagtgggca ctgttgctag gtcctctatc atgttcctgg gtcttctaac atgagtgctg
     1381 ggtctgcata ctcagaccca tactaaaata taatactaaa tatttgtcat actgaaaaat
     1441 aaataaaagc tgaatacaat acatactaag aaattgaact gtttggtgcg cttacaaagg
     1501 caataaagac actcagaatt cctgttatca gaacataaga tgacaggtaa aattcatatt
     1561 atctctggga ctaaaagcta aaggaatcaa cctggaaatt ctaacagatc tattgctgta
     1621 agagtcaatc ttgtcatttg taaaataagg gtaatacttg cctcacagga ctgcctggtg
     1681 gatcagatga gatactaagt atgtgagctg tgttgtgacc tggtccccac taggcactca
     1741 ggggaggaat ggctcctaaa ctattcccat acagtggcag gaaagtcgat ggaatcagac
     1801 acattggagg aggactgagg gagttctcac catgtctagg aatatttcca ggcagctaag
     1861 aagtagatgc cactctctcc tggatacttc catgtctgct gggcactatg ccctttttcc
     1921 cgggtcctgc accctttact gatagaggat ttatggtgtc aaagccctgt cattttctct
     1981 ggagtcactg gtgagcaatg tccaccaacc catgaccccc gtagaagtgg ataaagccct
     2041 ctctccactt tatagttaca gtaaccaggt acacatggat atcaccttgg tgctgcttgg
     2101 gcctctcatt aatatcttcc aaattctttt tgccaaaata atcatttatg tgtattcctt
     2161 atttctttgt tttgcataca taaatattgt cctcacaaaa ctgagatatt gcaggctagg
     2221 ccaggaaaaa atacctgcat gatagtggtt gtgctgttct catgggttaa tatcttgtct
     2281 gcagatgctc ttttctctgt tgagttcact ctcaggaaac ttgtcaggta acactttagc
     2341 agttcggcag acccatcaat acatttgagt tttaaatcct ttgtaatgaa catgttgtgg
     2401 tccatgaaaa agctgcatag tcatcacctg gggaactaat tagaaacgca gaatctcagg
     2461 tcttgcctca gacctaataa gttagaatct tcattttaac aagatcccaa gaagattcct
     2521 atgcacattg aagtttgaga agcactggct tagaaagaga cccttcaggc tccccactcc
     2581 cacctttaca taaaatatgt gcctaaaaat ataaatatat gtgctatata agacacacat
     2641 cacagattat taaataagcc catgtttttc aaaatgaagt tgtccttccc ccatgaaaag
     2701 tagatcttga aatcaattca atgggtcaag ataggtaatt ttttaaaaat gaaataggat
     2761 agaatagact tgaatacagc caaacagaaa atatcaaata gcaaatagca ttgtaaatag
     2821 actgaatatt ttttgtgaaa tttgtgtttc agttacgtac gtatgtatgt gtgtgcacca
     2881 tgagttatga tgaaaataaa tttctgactg tgggctgcag caaaaaaatt gagaaagact
     2941 gcactggatt ctgcatctca aagtatggca tgtccatttt atatttgtat tgctagtgcc
     3001 caacacaagt aactgacaag tagtaagcac ttaataaaaa tgtaaataat aatgac
//
