LOCUS       NM_001012979            1046 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens transcription elongation factor A like 5 (TCEAL5),
            mRNA.
ACCESSION   NM_001012979 XM_291334
VERSION     NM_001012979.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1046)
  AUTHORS   Miyamoto-Sato,E., Fujimori,S., Ishizaka,M., Hirai,N., Masuoka,K.,
            Saito,R., Ozawa,Y., Hino,K., Washio,T., Tomita,M., Yamashita,T.,
            Oshikubo,T., Akasaka,H., Sugiyama,J., Matsumoto,Y. and Yanagawa,H.
  TITLE     A comprehensive resource of interacting protein regions for
            refining human transcription factor networks
  JOURNAL   PLoS One 5 (2), e9289 (2010)
   PUBMED   20195357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1046)
  AUTHORS   Winter,E.E. and Ponting,C.P.
  TITLE     Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism
            sustained by gene conversion events
  JOURNAL   BMC Evol Biol 5, 54 (2005)
   PUBMED   16221301
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1046)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM725918.1, BC132924.1 and
            Z68694.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001012979.2.
            
            Summary: This gene, which is located on the X chromosome, encodes a
            protein which contains a BEX (brain expressed X-liked like family)
            domain. This domain is found in proteins encoded by the TCEAL
            elongation factor (transcription elongation factor A (SII)-like)
            gene family also located on the X chromosome. The coding region for
            this gene is located entirely in the terminal exon. [provided by
            RefSeq, Sep 2011].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1103294.1,
                                           SRR3476690.716689.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372680.2/ ENSP00000361765.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BM725918.1         120-123
            5-854               BC132924.1         1-850
            855-1046            Z68694.1           5063-5254
FEATURES             Location/Qualifiers
     source          1..1046
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.1"
     gene            1..1046
                     /gene="TCEAL5"
                     /gene_synonym="WEX4"
                     /note="transcription elongation factor A like 5"
                     /db_xref="GeneID:340543"
                     /db_xref="HGNC:HGNC:22282"
     exon            1..78
                     /gene="TCEAL5"
                     /gene_synonym="WEX4"
                     /inference="alignment:Splign:2.1.0"
     exon            79..146
                     /gene="TCEAL5"
                     /gene_synonym="WEX4"
                     /inference="alignment:Splign:2.1.0"
     exon            147..1046
                     /gene="TCEAL5"
                     /gene_synonym="WEX4"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..794
                     /gene="TCEAL5"
                     /gene_synonym="WEX4"
                     /note="TCEA-like protein 5; transcription elongation
                     factor S-II protein-like 5; transcription elongation
                     factor A (SII)-like 5"
                     /codon_start=1
                     /product="transcription elongation factor A protein-like
                     5"
                     /protein_id="NP_001012997.1"
                     /db_xref="CCDS:CCDS35356.1"
                     /db_xref="GeneID:340543"
                     /db_xref="HGNC:HGNC:22282"
                     /translation="MEKLYKENEGKPENERNLESEGKPEDEGSTEDEGKSDEEEKPDM
                     EGKTECEGKREDEGEPGDEGQLEDEGNQEKQGKSEGEDKPQSEGKPASQAKPESQPRA
                     AEKRPAEDYVPRKAKRKTDRGTDDSPKDSQEDLQERHLSSEEMMRECGDVSRAQEELR
                     KKQKMGGFHWMQRDVQDPFAPRGQRGVRGVRGGGRGQKDLEDVPYV"
     regulatory      1021..1026
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCEAL5"
                     /gene_synonym="WEX4"
                     /note="hexamer: AATAAA"
     polyA_site      1046
                     /gene="TCEAL5"
                     /gene_synonym="WEX4"
                     /note="major polyA site"
ORIGIN      
        1 accagatccc tgtttccgtg gaggaaggca gacttcagac tgaaggacag agaaggcaac
       61 tgccctacag ccctgcaggt cttcaagtct gtggttgtgg gcactaaccc agacaagaaa
      121 aggaaagacc tgcagtatcg gtgcaggaaa ggcaaagaag ggaacatctc aacatggaaa
      181 agctctacaa agaaaatgaa ggaaagccag agaatgaaag aaacctagaa agtgagggaa
      241 agccagagga tgagggaagt acagaagatg aaggaaagtc agacgaggaa gaaaagccgg
      301 acatggaggg gaagacagaa tgcgagggaa agcgagagga tgagggagag ccaggtgatg
      361 agggacaact ggaagatgag ggaaaccagg aaaagcaggg caagtctgaa ggtgaggaca
      421 agccacaaag tgagggcaag ccagcctccc aggccaagcc agagagccag ccgcgggccg
      481 ccgaaaagcg cccggctgaa gattatgtgc cccggaaagc aaaaagaaaa accgacaggg
      541 ggacggacga ttcccccaag gactctcagg aggacttaca agaaaggcat ctgagcagtg
      601 aggagatgat gagagaatgt ggagatgtgt caagggctca ggaggagcta aggaaaaaac
      661 agaaaatggg tggttttcat tggatgcaaa gagatgtaca ggatccattc gccccaaggg
      721 gccaacgggg tgtgagggga gtgaggggcg gaggtagggg ccagaaagac ttagaagatg
      781 tcccatatgt ttaatgtctt tggcctttaa ttctgatttc tctgatggga atattgccag
      841 tcctgctttt cctggcaggc atttgccggc ctatgtgctt taaccttaag ctgatacttt
      901 cctttaggtg tcactcttgt taccagcaga cttttgaccc aactacagtg ctctgtcttt
      961 tagtagagga ttttcaccca tgtgcatgga ataaatgttc atggtacatt gtaaaataac
     1021 aataaaaaag agttttcaga accatg
//
