LOCUS       NM_001006935            1264 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens transcription elongation factor A like 4 (TCEAL4),
            transcript variant 2, mRNA.
ACCESSION   NM_001006935
VERSION     NM_001006935.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1264)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1264)
  AUTHORS   Akaishi,J., Onda,M., Okamoto,J., Miyamoto,S., Nagahama,M., Ito,K.,
            Yoshida,A. and Shimizu,K.
  TITLE     Down-regulation of transcription elogation factor A (SII) like 4
            (TCEAL4) in anaplastic thyroid cancer
  JOURNAL   BMC Cancer 6, 260 (2006)
   PUBMED   17076909
  REMARK    GeneRIF: Expression of TCEAL4 was down-regulated in all anaplastic
            thyroid carcinomas studied. Loss of TCEAL4 expression might be
            associated with development of ATC from pre-existing
            diffferentiated TC.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1264)
  AUTHORS   Winter,E.E. and Ponting,C.P.
  TITLE     Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism
            sustained by gene conversion events
  JOURNAL   BMC Evol Biol 5, 54 (2005)
   PUBMED   16221301
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1264)
  AUTHORS   Ohira,M., Morohashi,A., Inuzuka,H., Shishikura,T., Kawamoto,T.,
            Kageyama,H., Nakamura,Y., Isogai,E., Takayasu,H., Sakiyama,S.,
            Suzuki,Y., Sugano,S., Goto,T., Sato,S. and Nakagawara,A.
  TITLE     Expression profiling and characterization of 4200 genes cloned from
            primary neuroblastomas: identification of 305 genes differentially
            expressed between favorable and unfavorable subsets
  JOURNAL   Oncogene 22 (35), 5525-5536 (2003)
   PUBMED   12934113
REFERENCE   5  (bases 1 to 1264)
  AUTHORS   Lu,X.W., Yin,J.Y. and Cui,L.X.
  TITLE     [Cloning of human B lymphocyte activation-related novel gene]
  JOURNAL   Zhongguo Yi Xue Ke Xue Yuan Xue Bao 23 (1), 27-31 (2001)
   PUBMED   12905813
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF271783.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 21, 2020 this sequence version replaced NM_001006935.2.
            
            Summary: This gene encodes a member of the transcription elongation
            factor A (SII)-like (TCEAL) gene family. This family is comprised
            of nuclear phosphoproteins that modulate transcription in a
            promoter context-dependent manner. Multiple family members are
            located on the X chromosome. Alternatively splicing results in
            multiple transcript variants. There is a pseudogene for this gene
            on chromosome 13. [provided by RefSeq, Apr 2015].
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 5' UTR compared to variant 1. Variants 1, 2, 4, 6, 7, and 8
            encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF271783.1, SRR5189658.124919.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000472484.6/ ENSP00000421156.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1264              AF271783.1         3-1266
FEATURES             Location/Qualifiers
     source          1..1264
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.2"
     gene            1..1264
                     /gene="TCEAL4"
                     /gene_synonym="NPD017; WEX7"
                     /note="transcription elongation factor A like 4"
                     /db_xref="GeneID:79921"
                     /db_xref="HGNC:HGNC:26121"
     exon            1..110
                     /gene="TCEAL4"
                     /gene_synonym="NPD017; WEX7"
                     /inference="alignment:Splign:2.1.0"
     exon            111..183
                     /gene="TCEAL4"
                     /gene_synonym="NPD017; WEX7"
                     /inference="alignment:Splign:2.1.0"
     exon            184..1264
                     /gene="TCEAL4"
                     /gene_synonym="NPD017; WEX7"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..858
                     /gene="TCEAL4"
                     /gene_synonym="NPD017; WEX7"
                     /note="isoform 1 is encoded by transcript variant 2;
                     transcription elongation factor A protein-like 4;
                     TCEA-like protein 4; transcription elongation factor S-II
                     protein-like 4; epididymis secretory sperm binding
                     protein; transcription elongation factor A (SII)-like 4"
                     /codon_start=1
                     /product="transcription elongation factor A protein-like 4
                     isoform 1"
                     /protein_id="NP_001006936.1"
                     /db_xref="CCDS:CCDS14510.2"
                     /db_xref="GeneID:79921"
                     /db_xref="HGNC:HGNC:26121"
                     /translation="MEKLYSENEGMASNQGKMENEEQPQDERKPEVTCTLEDKKLENE
                     GKTENKGKTGDEEMLKDKGKPESEGEAKEGKSEREGESEMEGGSEREGKPEIEGKPES
                     EGEPGSETRAAGKRPAEDDVPRKAKRKTNKGLAHYLKEYKEAIHDMNFSNEDMIREFD
                     NMAKVQDEKRKSKQKLGAFLWMQRNLQDPFYPRGPREFRGGCRAPRRDIEDIPYV"
     regulatory      1026..1031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCEAL4"
                     /gene_synonym="NPD017; WEX7"
                     /note="hexamer: ATTAAA"
     polyA_site      1053
                     /gene="TCEAL4"
                     /gene_synonym="NPD017; WEX7"
                     /note="major polyA site"
     regulatory      1248..1253
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCEAL4"
                     /gene_synonym="NPD017; WEX7"
                     /note="hexamer: TATAAA"
     polyA_site      1264
                     /gene="TCEAL4"
                     /gene_synonym="NPD017; WEX7"
ORIGIN      
        1 gcacgggcgc agatgtaggc accggtccga gtgcctgccc tctgtccccg cggctgggtc
       61 tcgtctgctc cggttcctgg gctcctaatt cttggtccag cttcttccag gtctgcgcgt
      121 ctgttgttcc cagcgctctg cgaagcctga aaaggaggag caacctgtcc agaatccccg
      181 caggacagga aaaggagggg aaatctcgac atggaaaaac tctacagtga aaatgaagga
      241 atggcttcaa accaaggaaa gatggaaaat gaagaacagc cacaagacga gagaaagcca
      301 gaagtaactt gtactctgga agacaagaag ttagaaaacg agggaaagac agaaaacaag
      361 ggcaaaacag gagatgagga aatgttaaag gataaaggaa agccagagag tgagggagag
      421 gcaaaagaag gaaagtcaga gagggaggga gagtcagaga tggagggagg atcagagaga
      481 gagggaaaac cagagataga gggaaagcca gagagtgaag gagagccagg gagtgaaaca
      541 agggctgcag gaaagcgccc agctgaggat gatgtaccca ggaaagccaa aagaaaaact
      601 aataaggggc tggctcatta cctcaaggag tataaagagg ccatacatga tatgaatttc
      661 agcaatgagg acatgataag agaatttgac aatatggcta aggtgcagga tgagaagaga
      721 aaaagcaaac agaaattggg ggcgtttttg tggatgcaaa gaaatttaca ggaccccttc
      781 taccctagag gtccaaggga attcaggggt ggctgcaggg ccccacgaag ggacattgaa
      841 gacattcctt atgtgtagtg tccctggcag gcatttacca ggccatgtgc tttaacgtta
      901 cggtaatact ttactttagg catccctcct gttgctagca gccttttgac ctatctgcaa
      961 tgcagtgttc tcagtaggaa atgttcatct gttacatgga aaaaatgttg atggtgcatt
     1021 gtaaaattaa aaaacacaac ttgcagaacc aaatatatgg catcagtaca tttttgtaaa
     1081 actacaaaga tacttaccta gtaatatagt atagaaaaca attctgaaag ctgtgtccac
     1141 taaaagatta acagtggtta tctctgggtg attttttctg ttcttttttg ttcatctgtc
     1201 catttttctc ctaaaaacag atttctttag tcataaaaat aataaaatat aaagtattgg
     1261 aaaa
//
