LOCUS       NM_032926               1056 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens transcription elongation factor A like 3 (TCEAL3),
            transcript variant 2, mRNA.
ACCESSION   NM_032926
VERSION     NM_032926.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1056)
  AUTHORS   Winter,E.E. and Ponting,C.P.
  TITLE     Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism
            sustained by gene conversion events
  JOURNAL   BMC Evol Biol 5, 54 (2005)
   PUBMED   16221301
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1056)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   3  (bases 1 to 1056)
  AUTHORS   Pillutla,R.C., Shimamoto,A., Furuichi,Y. and Shatkin,A.J.
  TITLE     Genomic structure and chromosomal localization of TCEAL1, a human
            gene encoding the nuclear phosphoprotein p21/SIIR
  JOURNAL   Genomics 56 (2), 217-220 (1999)
   PUBMED   10051408
  REMARK    GeneRIF: Characterizes TCEAL1, another member of the human TCEAL
            gene family.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC008703.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032926.2.
            
            Summary: This gene encodes a member of the transcription elongation
            factor A (SII)-like (TCEAL) gene family. Members of this family
            contain TFA domains and may function as nuclear phosphoproteins
            that modulate transcription in a promoter context-dependent manner.
            Multiple family members are located on the X chromosome.
            Alternative splicing results in multiple transcript variants
            encoding a single isoform. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008703.1, SRR1803617.326282.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372627.10/ ENSP00000361710.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1056              BC008703.1         58-1113
FEATURES             Location/Qualifiers
     source          1..1056
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.2"
     gene            1..1056
                     /gene="TCEAL3"
                     /gene_synonym="WEX8"
                     /note="transcription elongation factor A like 3"
                     /db_xref="GeneID:85012"
                     /db_xref="HGNC:HGNC:28247"
     exon            1..96
                     /gene="TCEAL3"
                     /gene_synonym="WEX8"
                     /inference="alignment:Splign:2.1.0"
     exon            97..166
                     /gene="TCEAL3"
                     /gene_synonym="WEX8"
                     /inference="alignment:Splign:2.1.0"
     exon            167..1056
                     /gene="TCEAL3"
                     /gene_synonym="WEX8"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..796
                     /gene="TCEAL3"
                     /gene_synonym="WEX8"
                     /note="TCEA-like protein 3; transcription elongation
                     factor S-II protein-like 3; transcription elongation
                     factor A (SII)-like 3"
                     /codon_start=1
                     /product="transcription elongation factor A protein-like
                     3"
                     /protein_id="NP_116315.1"
                     /db_xref="CCDS:CCDS14511.1"
                     /db_xref="GeneID:85012"
                     /db_xref="HGNC:HGNC:28247"
                     /translation="MEKPYNKNEGNLENEGKPEDEVEPDDEGKSDEEEKPDVEGKTEC
                     EGKREDEGEPGDEGQLEDEGSQEKQGRSEGEGKPQGEGKPASQAKPESQPRAAEKRPA
                     EDYVPRKAKRKTDRGTDDSPKDSQEDLQERHLSSEEMMRECGDVSRAQEELRKKQKMG
                     GFHWMQRDVQDPFAPRGQRGVRGVRGGGRGQRGLHDIPYL"
     regulatory      1032..1037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCEAL3"
                     /gene_synonym="WEX8"
                     /note="hexamer: ATTAAA"
     polyA_site      1056
                     /gene="TCEAL3"
                     /gene_synonym="WEX8"
                     /note="major polyA site"
ORIGIN      
        1 gcagaaccag ctgtctgagc tgcccgggca gcgggggagc agcgagcggg cttccgcgag
       61 ccggagaagg cacaggcctg tcccgggtcc cggcaggtct gcgcgtctgt tcccagcgct
      121 ctgcgaggcc taaaaaggag gagcaacctg tccagaatcc ctgcaggaca ggaaaaggag
      181 gggaaatctc gacatggaaa aaccctacaa taaaaatgaa ggaaacctgg aaaacgaggg
      241 aaagccagaa gatgaagtag agcctgatga tgaaggaaag tcagacgagg aagaaaagcc
      301 agacgtggag gggaagacag aatgcgaggg aaagagagag gatgagggag agccaggtga
      361 tgagggacaa ctggaagatg agggaagcca ggaaaagcag ggcaggtccg aaggtgaggg
      421 caagccacaa ggcgagggca agccagcctc ccaggcaaag ccagagagcc agccgcgggc
      481 cgccgaaaag cgcccggctg aagattatgt gccccggaaa gcaaaaagaa aaacggacag
      541 ggggacggac gattccccca aggactctca ggaggactta caggaaaggc atctgagcag
      601 tgaggagatg atgagagaat gtggagatgt gtcaagggct caagaggagc taaggaaaaa
      661 acagaaaatg ggtggttttc attggatgca aagagatgta caggatccat tcgccccaag
      721 gggacaacgg ggtgtcaggg gagtgagggg tggaggtagg ggccagaggg gcttacacga
      781 tatcccatac ctttaatgcc tttggccttc cattctgatt tctctgatga gaatattgct
      841 ggccctgctt tccctggtag gtatttgcca ggcccaatgc tttaacctta agctgatact
      901 ttgctttaga tgtcagtctc gttaccagca gccttttgac ccaactacgg cgctctatat
      961 tttagtagag gattttcacc catgtgcatg gaaaagatgt tcatggtaca ttgtaaaaaa
     1021 ataaaattaa aattaaaaaa agtttgcaga accgca
//
