LOCUS       NM_080390               1110 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens transcription elongation factor A like 2 (TCEAL2),
            mRNA.
ACCESSION   NM_080390
VERSION     NM_080390.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1110)
  AUTHORS   Winter,E.E. and Ponting,C.P.
  TITLE     Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism
            sustained by gene conversion events
  JOURNAL   BMC Evol Biol 5, 54 (2005)
   PUBMED   16221301
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1110)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   3  (bases 1 to 1110)
  AUTHORS   Pillutla,R.C., Shimamoto,A., Furuichi,Y. and Shatkin,A.J.
  TITLE     Genomic structure and chromosomal localization of TCEAL1, a human
            gene encoding the nuclear phosphoprotein p21/SIIR
  JOURNAL   Genomics 56 (2), 217-220 (1999)
   PUBMED   10051408
  REMARK    GeneRIF: Characterizes TCEAL1, another member of the human TCEAL
            gene family.
REFERENCE   4  (bases 1 to 1110)
  AUTHORS   Bussow,K., Cahill,D., Nietfeld,W., Bancroft,D., Scherzinger,E.,
            Lehrach,H. and Walter,G.
  TITLE     A method for global protein expression and antibody screening on
            high-density filters of an arrayed cDNA library
  JOURNAL   Nucleic Acids Res 26 (21), 5007-5008 (1998)
   PUBMED   9776767
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL035214.2, CD580311.2,
            AF325115.1 and BM699243.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_080390.3.
            
            Summary: This gene encodes a member of the transcription elongation
            factor A (SII)-like (TCEAL) gene family. Members of this family
            contain TFA domains and may function as nuclear phosphoproteins
            that modulate transcription in a promoter context-dependent manner.
            Multiple family members are located on the X chromosome. [provided
            by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.384939.1,
                                           SRR3476690.1050666.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372780.6/ ENSP00000361866.1
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AL035214.2         20868-20876
            10-98               CD580311.2         32-120
            99-1107             AF325115.1         35-1043
            1108-1110           BM699243.1         475-477
FEATURES             Location/Qualifiers
     source          1..1110
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.1"
     gene            1..1110
                     /gene="TCEAL2"
                     /gene_synonym="my048; MY0876G05; WEX1"
                     /note="transcription elongation factor A like 2"
                     /db_xref="GeneID:140597"
                     /db_xref="HGNC:HGNC:29818"
     exon            1..128
                     /gene="TCEAL2"
                     /gene_synonym="my048; MY0876G05; WEX1"
                     /inference="alignment:Splign:2.1.0"
     exon            129..201
                     /gene="TCEAL2"
                     /gene_synonym="my048; MY0876G05; WEX1"
                     /inference="alignment:Splign:2.1.0"
     exon            202..1110
                     /gene="TCEAL2"
                     /gene_synonym="my048; MY0876G05; WEX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..912
                     /gene="TCEAL2"
                     /gene_synonym="my048; MY0876G05; WEX1"
                     /note="TCEA-like protein 2; transcription elongation
                     factor S-II protein-like 2; transcription elongation
                     factor A (SII)-like 2"
                     /codon_start=1
                     /product="transcription elongation factor A protein-like
                     2"
                     /protein_id="NP_525129.1"
                     /db_xref="CCDS:CCDS14496.1"
                     /db_xref="GeneID:140597"
                     /db_xref="HGNC:HGNC:29818"
                     /translation="MEKLFNENEGMPSNQGKIDNEEQPPHEGKPEVACILEDKKLENE
                     GNTENTGKRVEEPLKDKEKPESAGKAKGEGKSERKGKSEMQGGSKTEGKPERGGRAEG
                     EGEPDSEREPESEGEPESETRAAGKRPAEDDIPRKAKRKTNKGLAQYLKQYKEAIHDM
                     NFSNEDMIREFDNMARVEDKRRKSKQKLGAFLWMQRNLQDPFYPRGPREFRGGCRAPR
                     RDTEDIPYV"
     regulatory      1089..1094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCEAL2"
                     /gene_synonym="my048; MY0876G05; WEX1"
                     /note="hexamer: AATAAA"
     polyA_site      1110
                     /gene="TCEAL2"
                     /gene_synonym="my048; MY0876G05; WEX1"
                     /note="major polyA site"
ORIGIN      
        1 agcccgccca gcggtcgggt ccgggcgccc gcgcagaatc agctgtctga gctgcccagg
       61 cggcggggga gcagcgagcg ggcttcagcg agccgcagga ggcacaggcc tgtcctgggt
      121 ccccgcaggt ctgcgcgtct gttgttccca gcgctctgag aggcctgaaa aggaagagca
      181 acctgtccag aatccccgca ggaaaggaaa aggaggggaa atctcgacat ggaaaaactc
      241 ttcaatgaaa atgaaggaat gccttcgaat caaggaaaga tagacaatga agaacagcca
      301 ccgcacgagg gaaagccaga agtagcttgt attctggaag acaagaagtt agaaaacgag
      361 ggaaacacag aaaacacggg caagagagtt gaggaaccgt taaaggataa agaaaagcca
      421 gagagtgcgg gaaaggcaaa aggagaagga aagtcagaga ggaagggaaa gtcagagatg
      481 cagggaggat caaagacaga gggaaagcca gagagagggg gaagggcaga gggtgaagga
      541 gagccagaca gtgaaagaga gccagagagt gagggagagc cagaaagtga aacaagggct
      601 gcaggaaagc gcccagctga ggatgatata cccaggaaag ccaaaagaaa aaccaacaag
      661 gggctggctc agtacctcaa gcaatataag gaagccatac atgatatgaa tttcagcaat
      721 gaggacatga taagagaatt tgacaacatg gctagggtgg aggataaaag gagaaaaagc
      781 aaacagaaat tgggggcgtt tttgtggatg caaagaaatt tacaggaccc cttctatcct
      841 aggggtccaa gggaattcag gggtggctgc agggccccac gaagggacac tgaagacatt
      901 ccttatgtgt agtgtccctg gcaggcattt gtcaggccat atgttttaac cttatggtaa
      961 tactttgctt tagtcgttcc tcctgctacc agtagcgttt tgacccacct gccagtgttt
     1021 gcttgctcta tgtttcagta gcagattttc acacatgtgc attgcagaga cgtcatgatt
     1081 cgtggaaaaa taaagcagct tataatatca
//
