LOCUS       NM_003196               1719 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens transcription elongation factor A3 (TCEA3), mRNA.
ACCESSION   NM_003196 XM_114075
VERSION     NM_003196.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1719)
  AUTHORS   Wu,F., Chai,B., Qi,P., Han,Y., Gu,Z., Pan,W., Zhang,H., Wang,X.,
            Liu,X., Zou,H., Liang,C., Li,Y., Fang,W. and Ma,Z.
  TITLE     Oncogenic tRNA-derived fragment tRF-Leu-CAG promotes tumorigenesis
            of lung cancer via targeting TCEA3 and increasing autophagy
  JOURNAL   J Gene Med 26 (9), e3737 (2024)
   PUBMED   39198937
  REMARK    GeneRIF: Oncogenic tRNA-derived fragment tRF-Leu-CAG promotes
            tumorigenesis of lung cancer via targeting TCEA3 and increasing
            autophagy.
REFERENCE   2  (bases 1 to 1719)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1719)
  AUTHORS   Kazim,N., Adhikari,A., Oh,T.J. and Davie,J.
  TITLE     The transcription elongation factor TCEA3 induces apoptosis in
            rhabdomyosarcoma
  JOURNAL   Cell Death Dis 11 (1), 67 (2020)
   PUBMED   31988307
  REMARK    GeneRIF: The transcription elongation factor TCEA3 induces
            apoptosis in rhabdomyosarcoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1719)
  AUTHORS   Liao,J.M., Cao,B., Deng,J., Zhou,X., Strong,M., Zeng,S., Xiong,J.,
            Flemington,E. and Lu,H.
  TITLE     TFIIS.h, a new target of p53, regulates transcription efficiency of
            pro-apoptotic bax gene
  JOURNAL   Sci Rep 6, 23542 (2016)
   PUBMED   27005522
  REMARK    GeneRIF: Findings reveal a novel mechanism by which p53 utilizes
            TFIIS.h to selectively promote the transcriptional elongation of
            the bax gene, upsurging cell death in response to severe DNA
            damage.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1719)
  AUTHORS   Li,J., Jin,Y., Pan,S., Chen,Y., Wang,K., Lin,C., Jin,S. and Wu,J.
  TITLE     TCEA3 Attenuates Gastric Cancer Growth by Apoptosis Induction
  JOURNAL   Med Sci Monit 21, 3241-3246 (2015)
   PUBMED   26498664
  REMARK    GeneRIF: TCEA3 attenuates the proliferation and induces apoptosis
            of gastric cancer cells
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1719)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   7  (bases 1 to 1719)
  AUTHORS   Kim,J., Guermah,M. and Roeder,R.G.
  TITLE     The human PAF1 complex acts in chromatin transcription elongation
            both independently and cooperatively with SII/TFIIS
  JOURNAL   Cell 140 (4), 491-503 (2010)
   PUBMED   20178742
  REMARK    GeneRIF: Study demonstrates a strong synergy between hPAF1C and
            elongation factor SII/TFIIS and an underlying mechanism involving
            direct hPAF1C-SII interactions and cooperative binding to RNA
            polymerase II.
REFERENCE   8  (bases 1 to 1719)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 1719)
  AUTHORS   Toulza,E., Mattiuzzo,N.R., Galliano,M.F., Jonca,N., Dossat,C.,
            Jacob,D., de Daruvar,A., Wincker,P., Serre,G. and Guerrin,M.
  TITLE     Large-scale identification of human genes implicated in epidermal
            barrier function
  JOURNAL   Genome Biol 8 (6), R107 (2007)
   PUBMED   17562024
REFERENCE   10 (bases 1 to 1719)
  AUTHORS   Labhart,P. and Morgan,G.T.
  TITLE     Identification of novel genes encoding transcription elongation
            factor TFIIS (TCEA) in vertebrates: conservation of three distinct
            TFIIS isoforms in frog, mouse, and human
  JOURNAL   Genomics 52 (3), 278-288 (1998)
   PUBMED   9790746
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY070786.1, AK300707.1, AK290272.1, BQ003897.1, BE880226.1,
            AA873235.1, CU449151.1, AL109936.11 and BI835458.1.
            
            On May 17, 2019 this sequence version replaced NM_003196.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.239695.1,
                                           SRR1660809.93669.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000450454.7/ ENSP00000406293.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               HY070786.1         33-133
            102-102             AK300707.1         130-130
            103-1172            AK290272.1         131-1200
            1173-1428           BQ003897.1         155-410             c
            1429-1484           BE880226.1         568-623
            1485-1567           AA873235.1         16-98               c
            1568-1604           CU449151.1         531-567
            1605-1605           AL109936.11        143538-143538       c
            1606-1712           CU449151.1         569-675
            1713-1719           BI835458.1         571-577
FEATURES             Location/Qualifiers
     source          1..1719
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.12"
     gene            1..1719
                     /gene="TCEA3"
                     /gene_synonym="TFIIS; TFIIS.H"
                     /note="transcription elongation factor A3"
                     /db_xref="GeneID:6920"
                     /db_xref="HGNC:HGNC:11615"
                     /db_xref="MIM:604128"
     exon            1..184
                     /gene="TCEA3"
                     /gene_synonym="TFIIS; TFIIS.H"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1162
                     /gene="TCEA3"
                     /gene_synonym="TFIIS; TFIIS.H"
                     /note="rhabdomyosarcoma antigen MU-RMS-40.22;
                     transcription elongation factor TFIIS.h; transcription
                     elongation factor S-II protein 3; transcription elongation
                     factor A (SII), 3"
                     /codon_start=1
                     /product="transcription elongation factor A protein 3"
                     /protein_id="NP_003187.1"
                     /db_xref="CCDS:CCDS44086.1"
                     /db_xref="GeneID:6920"
                     /db_xref="HGNC:HGNC:11615"
                     /db_xref="MIM:604128"
                     /translation="MGQEEELLRIAKKLEKMVARKNTEGALDLLKKLHSCQMSIQLLQ
                     TTRIGVAVNGVRKHCSDKEVVSLAKVLIKNWKRLLDSPGPPKGEKGEEREKAKKKEKG
                     LECSDWKPEAGLSPPRKKREDPKTRRDSVDSKSSASSSPKRPSVERSNSSKSKAESPK
                     TPSSPLTPTFASSMCLLAPCYLTGDSVRDKCVEMLSAALKADDDYKDYGVNCDKMASE
                     IEDHIYQELKSTDMKYRNRVRSRISNLKDPRNPGLRRNVLSGAISAGLIAKMTAEEMA
                     SDELRELRNAMTQEAIREHQMAKTGGTTTDLFQCSKCKKKNCTYNQVQTRSADEPMTT
                     FVLCNECGNRWKFC"
     exon            185..247
                     /gene="TCEA3"
                     /gene_synonym="TFIIS; TFIIS.H"
                     /inference="alignment:Splign:2.1.0"
     exon            248..353
                     /gene="TCEA3"
                     /gene_synonym="TFIIS; TFIIS.H"
                     /inference="alignment:Splign:2.1.0"
     exon            354..495
                     /gene="TCEA3"
                     /gene_synonym="TFIIS; TFIIS.H"
                     /inference="alignment:Splign:2.1.0"
     exon            496..558
                     /gene="TCEA3"
                     /gene_synonym="TFIIS; TFIIS.H"
                     /inference="alignment:Splign:2.1.0"
     exon            559..722
                     /gene="TCEA3"
                     /gene_synonym="TFIIS; TFIIS.H"
                     /inference="alignment:Splign:2.1.0"
     exon            723..779
                     /gene="TCEA3"
                     /gene_synonym="TFIIS; TFIIS.H"
                     /inference="alignment:Splign:2.1.0"
     exon            780..934
                     /gene="TCEA3"
                     /gene_synonym="TFIIS; TFIIS.H"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1081
                     /gene="TCEA3"
                     /gene_synonym="TFIIS; TFIIS.H"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1153
                     /gene="TCEA3"
                     /gene_synonym="TFIIS; TFIIS.H"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1719
                     /gene="TCEA3"
                     /gene_synonym="TFIIS; TFIIS.H"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1241..1246
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCEA3"
                     /gene_synonym="TFIIS; TFIIS.H"
                     /note="hexamer: ATTAAA"
     polyA_site      1257
                     /gene="TCEA3"
                     /gene_synonym="TFIIS; TFIIS.H"
                     /note="major polyA site"
     regulatory      1543..1548
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCEA3"
                     /gene_synonym="TFIIS; TFIIS.H"
                     /note="hexamer: AATAAA"
     polyA_site      1567
                     /gene="TCEA3"
                     /gene_synonym="TFIIS; TFIIS.H"
ORIGIN      
        1 gtcgtgtgtg tttggggccc gcgcgggttg cgcgccctcc gccttcgcgc ctcctgcccc
       61 cgaggcccta ctgctgcccc tgtgcccctc gccccgccgg gcgtcgcggg ccaacatggg
      121 ccaggaagag gagctgctga ggatcgccaa aaagctggag aagatggtgg ccaggaagaa
      181 cacggaaggg gccctggacc ttctgaagaa gctgcacagc tgccagatgt ccatccagct
      241 actacagaca accaggattg gagttgctgt taatggggtc cgcaagcact gctcagacaa
      301 ggaggtggtg tccttggcca aagtccttat caaaaactgg aagcggctgc tagactcccc
      361 tggaccccca aaaggagaaa aaggagagga aagagaaaag gcaaagaaga aggaaaaagg
      421 gcttgagtgt tcagactgga agccagaagc aggcctttct ccaccaagga aaaaacgaga
      481 agaccccaaa accaggagag actctgtgga ctccaagtct tctgcctcct cctctccaaa
      541 aagaccatcg gtggaaagat caaacagcag caaatcaaaa gcggagagcc ccaaaacacc
      601 tagcagcccc ttgaccccca cgtttgcctc ttccatgtgt ctcctggccc cctgctatct
      661 cacaggggac tctgtccggg acaagtgtgt ggagatgctg tcagcagccc tgaaggcgga
      721 cgatgattac aaggactatg gagtcaactg tgacaagatg gcatcagaaa tcgaagatca
      781 tatctaccaa gagctcaaga gcacggacat gaagtaccgg aaccgcgtgc gcagccgcat
      841 aagcaacctc aaggacccca ggaaccccgg cctgcggcgg aacgtgctca gtggggccat
      901 ctccgcaggg cttatagcca agatgacggc agaggaaatg gccagtgatg aactgaggga
      961 gttgaggaat gccatgaccc aggaggccat ccgtgagcac cagatggcca agactggcgg
     1021 caccaccact gacctcttcc agtgcagcaa atgcaagaag aagaactgca cctataacca
     1081 ggtgcagaca cgcagtgctg atgagcccat gactaccttt gtcttatgca atgaatgtgg
     1141 caatcgctgg aagttctgct gatggaacag ccagccatga acaaggtgag gaagaagaaa
     1201 gaggaagcgc tgaattatct gaactggaga agcaataaaa attaaagtga aggaaaatac
     1261 tgaactctgt ctgagtggga tggtatgagt tagaggaaga attctcttgc aaattaataa
     1321 tcggtcatta gaaacaattg gttaatgggg gagcctaatt ggagaatgat gctgagaatt
     1381 tgtattgatg aacctctttt agaaactgca gagggctggg cacggtggtt tatggctgta
     1441 atctgcaaac tctgggaggc tgaggtggga gaatcgctta accccagaag tttgagtcca
     1501 gcccaggcaa cacagcaaga ccccatctct ataaaaagaa aaaataaaga aactgcagcg
     1561 ccttagacct gaggtgtcat atctttgaca gtgggctggc agacgtttgc tttgagttcc
     1621 ttctctccca tctggatctc ccagcctttt ccaaattgaa aaatgccaga tcaacacaaa
     1681 ccttacccca cccccacctc cgagtcacac gtgcagaac
//
