LOCUS       NM_006756               2777 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens transcription elongation factor A1 (TCEA1), transcript
            variant 1, mRNA.
ACCESSION   NM_006756 XM_001127192
VERSION     NM_006756.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2777)
  AUTHORS   Duardo,R.C., Marinello,J., Russo,M., Morelli,S., Pepe,S.,
            Guerra,F., Gomez-Gonzalez,B., Aguilera,A. and Capranico,G.
  TITLE     Human DNA topoisomerase I poisoning causes R loop-mediated genome
            instability attenuated by transcription factor IIS
  JOURNAL   Sci Adv 10 (21), eadm8196 (2024)
   PUBMED   38787953
  REMARK    GeneRIF: Human DNA topoisomerase I poisoning causes R loop-mediated
            genome instability attenuated by transcription factor IIS.
REFERENCE   2  (bases 1 to 2777)
  AUTHORS   Cermakova,K., Demeulemeester,J., Lux,V., Nedomova,M., Goldman,S.R.,
            Smith,E.A., Srb,P., Hexnerova,R., Fabry,M., Madlikova,M.,
            Horejsi,M., De Rijck,J., Debyser,Z., Adelman,K., Hodges,H.C. and
            Veverka,V.
  TITLE     A ubiquitous disordered protein interaction module orchestrates
            transcription elongation
  JOURNAL   Science 374 (6571), 1113-1121 (2021)
   PUBMED   34822292
  REMARK    GeneRIF: A ubiquitous disordered protein interaction module
            orchestrates transcription elongation.
REFERENCE   3  (bases 1 to 2777)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2777)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2777)
  AUTHORS   Zatreanu,D., Han,Z., Mitter,R., Tumini,E., Williams,H.,
            Gregersen,L., Dirac-Svejstrup,A.B., Roma,S., Stewart,A.,
            Aguilera,A. and Svejstrup,J.Q.
  TITLE     Elongation Factor TFIIS Prevents Transcription Stress and R-Loop
            Accumulation to Maintain Genome Stability
  JOURNAL   Mol Cell 76 (1), 57-69 (2019)
   PUBMED   31519522
  REMARK    GeneRIF: A mutant form of TFIIS increased RNAPII pausing and
            backtracking results in R-loop formation and genome instability.
REFERENCE   6  (bases 1 to 2777)
  AUTHORS   Qian,X., Jeon,C., Yoon,H., Agarwal,K. and Weiss,M.A.
  TITLE     Structure of a new nucleic-acid-binding motif in eukaryotic
            transcriptional elongation factor TFIIS
  JOURNAL   Nature 365 (6443), 277-279 (1993)
   PUBMED   7626141
  REMARK    Erratum:[Nature 1995 Jul 20;376(6537):279]
REFERENCE   7  (bases 1 to 2777)
  AUTHORS   Chen,H.C., England,L. and Kane,C.M.
  TITLE     Characterization of a HeLa cDNA clone encoding the human SII
            protein, an elongation factor for RNA polymerase II
  JOURNAL   Gene 116 (2), 253-258 (1992)
   PUBMED   1378807
REFERENCE   8  (bases 1 to 2777)
  AUTHORS   Kato,H., Sumimoto,H., Pognonec,P., Chen,C.H., Rosen,C.A. and
            Roeder,R.G.
  TITLE     HIV-1 Tat acts as a processivity factor in vitro in conjunction
            with cellular elongation factors
  JOURNAL   Genes Dev 6 (4), 655-666 (1992)
   PUBMED   1559613
REFERENCE   9  (bases 1 to 2777)
  AUTHORS   Yoo,O.J., Yoon,H.S., Baek,K.H., Jeon,C.J., Miyamoto,K., Ueno,A. and
            Agarwal,K.
  TITLE     Cloning, expression and characterization of the human transcription
            elongation factor, TFIIS
  JOURNAL   Nucleic Acids Res 19 (5), 1073-1079 (1991)
   PUBMED   1708494
REFERENCE   10 (bases 1 to 2777)
  AUTHORS   Reines,D., Chamberlin,M.J. and Kane,C.M.
  TITLE     Transcription elongation factor SII (TFIIS) enables RNA polymerase
            II to elongate through a block to transcription in a human gene in
            vitro
  JOURNAL   J Biol Chem 264 (18), 10799-10809 (1989)
   PUBMED   2471707
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB091231.1, DA021678.1, X62585.1 and BQ016366.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006756.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.264479.1,
                                           SRR1660803.101043.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000521604.7/ ENSP00000428426.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               DB091231.1         9-179
            172-219             DA021678.1         172-219
            220-2656            X62585.1           1-2437
            2657-2777           BQ016366.1         20-140              c
FEATURES             Location/Qualifiers
     source          1..2777
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q11.23"
     gene            1..2777
                     /gene="TCEA1"
                     /gene_synonym="GTF2S; SII; TCEA; TF2S; TFIIS"
                     /note="transcription elongation factor A1"
                     /db_xref="GeneID:6917"
                     /db_xref="HGNC:HGNC:11612"
                     /db_xref="MIM:601425"
     exon            1..386
                     /gene="TCEA1"
                     /gene_synonym="GTF2S; SII; TCEA; TF2S; TFIIS"
                     /inference="alignment:Splign:2.1.0"
     CDS             324..1229
                     /gene="TCEA1"
                     /gene_synonym="GTF2S; SII; TCEA; TF2S; TFIIS"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription elongation factor A protein 1; transcription
                     elongation factor TFIIS.o; transcription elongation factor
                     S-II protein 1; transcription elongation factor A (SII),
                     1; transcription factor IIS; epididymis secretory sperm
                     binding protein"
                     /codon_start=1
                     /product="transcription elongation factor A protein 1
                     isoform 1"
                     /protein_id="NP_006747.1"
                     /db_xref="CCDS:CCDS47858.1"
                     /db_xref="GeneID:6917"
                     /db_xref="HGNC:HGNC:11612"
                     /db_xref="MIM:601425"
                     /translation="MEDEVVRFAKKMDKMVQKKNAAGALDLLKELKNIPMTLELLQST
                     RIGMSVNAIRKQSTDEEVTSLAKSLIKSWKKLLDGPSTEKDLDEKKKEPAITSQNSPE
                     AREESTSSGNVSNRKDETNARDTYVSSFPRAPSTSDSVRLKCREMLAAALRTGDDYIA
                     IGADEEELGSQIEEAIYQEIRNTDMKYKNRVRSRISNLKDAKNPNLRKNVLCGNIPPD
                     LFARMTAEEMASDELKEMRKNLTKEAIREHQMAKTGGTQTDLFTCGKCKKKNCTYTQV
                     QTRSADEPMTTFVVCNECGNRWKFC"
     exon            387..449
                     /gene="TCEA1"
                     /gene_synonym="GTF2S; SII; TCEA; TF2S; TFIIS"
                     /inference="alignment:Splign:2.1.0"
     exon            450..555
                     /gene="TCEA1"
                     /gene_synonym="GTF2S; SII; TCEA; TF2S; TFIIS"
                     /inference="alignment:Splign:2.1.0"
     exon            556..643
                     /gene="TCEA1"
                     /gene_synonym="GTF2S; SII; TCEA; TF2S; TFIIS"
                     /inference="alignment:Splign:2.1.0"
     exon            644..789
                     /gene="TCEA1"
                     /gene_synonym="GTF2S; SII; TCEA; TF2S; TFIIS"
                     /inference="alignment:Splign:2.1.0"
     exon            790..846
                     /gene="TCEA1"
                     /gene_synonym="GTF2S; SII; TCEA; TF2S; TFIIS"
                     /inference="alignment:Splign:2.1.0"
     exon            847..1001
                     /gene="TCEA1"
                     /gene_synonym="GTF2S; SII; TCEA; TF2S; TFIIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1148
                     /gene="TCEA1"
                     /gene_synonym="GTF2S; SII; TCEA; TF2S; TFIIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1220
                     /gene="TCEA1"
                     /gene_synonym="GTF2S; SII; TCEA; TF2S; TFIIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..2777
                     /gene="TCEA1"
                     /gene_synonym="GTF2S; SII; TCEA; TF2S; TFIIS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1869..1874
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCEA1"
                     /gene_synonym="GTF2S; SII; TCEA; TF2S; TFIIS"
                     /note="hexamer: AATAGA"
     polyA_site      1889
                     /gene="TCEA1"
                     /gene_synonym="GTF2S; SII; TCEA; TF2S; TFIIS"
                     /note="major polyA site"
     regulatory      2174..2179
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCEA1"
                     /gene_synonym="GTF2S; SII; TCEA; TF2S; TFIIS"
                     /note="hexamer: ATTAAA"
     polyA_site      2213
                     /gene="TCEA1"
                     /gene_synonym="GTF2S; SII; TCEA; TF2S; TFIIS"
                     /note="major polyA site"
     regulatory      2750..2755
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCEA1"
                     /gene_synonym="GTF2S; SII; TCEA; TF2S; TFIIS"
                     /note="hexamer: AATAAA"
     polyA_site      2777
                     /gene="TCEA1"
                     /gene_synonym="GTF2S; SII; TCEA; TF2S; TFIIS"
                     /note="major polyA site"
ORIGIN      
        1 agccggaagc cacgcctgcc cactagcccg acgcccgcct ggcgggaaca tgggctcgcc
       61 cctcaccagc gatctgcagt cagttggtag cgcctgcacg tcgcgcgcgg tgttcgattg
      121 tcgctgcctg gggaggagga gccggagccg ccgccgccgc cgccgccgcc gcgggcttcg
      181 ttcgtaagga agggggccta ggcccgggcc tgcggtggtg ggggttgctg cgcgccgggg
      241 gtcgctcctg ctgtgtcttc cgctccagct tcgcccactt ccccttgcca gcggggtggg
      301 cgcggagaag acctgccgga gccatggagg acgaagtggt ccgctttgcc aagaagatgg
      361 acaagatggt gcagaagaag aacgcggctg gagcattgga tttgctaaag gagcttaaga
      421 atattcctat gaccctggaa ttactgcagt ccacaagaat cggaatgtca gttaatgcta
      481 ttcgcaagca gagtacagat gaggaagtta catctttggc aaagtctctc atcaaatcct
      541 ggaaaaaatt attagatggg ccatcaactg agaaagacct tgacgaaaag aagaaagaac
      601 ctgcaattac atcgcagaac agccctgagg caagagaaga aagtacttcc agcggcaatg
      661 taagcaacag aaaggatgag acaaatgctc gagatactta tgtttcatcc tttcctcggg
      721 caccaagcac ttctgattct gtgcggttga agtgtaggga gatgcttgct gcagctcttc
      781 gaacagggga tgactacatt gcaattggag ctgatgagga agaattagga tctcaaattg
      841 aagaagctat atatcaagaa ataaggaata cagacatgaa atacaaaaat agagtacgaa
      901 gtaggatatc aaatcttaaa gatgcaaaaa atccaaattt aaggaaaaat gtcctctgtg
      961 ggaatattcc tcctgactta tttgctagaa tgacagcaga ggaaatggct agtgatgagc
     1021 tgaaagagat gcggaaaaac ttgaccaaag aagccatcag agagcatcag atggccaaga
     1081 ctggtgggac ccagactgac ttgttcacat gtggcaaatg taaaaagaag aattgcactt
     1141 acacacaggt acaaacccgt agtgctgatg aaccaatgac aacatttgtt gtctgtaatg
     1201 aatgtggaaa tcgatggaag ttctgttgag ttggaagaat tggcaaaata tctggaccat
     1261 taagaaaacg gattttgtaa ctagctttaa actaggccaa gcaactagtt ttcctgcaaa
     1321 tcaaattttt aaagcaactt gggttagact ttgtttttga cctaacatcc cttccttaaa
     1381 tgccttctgt agtttcagat cagtagggag accatataat aattttatgg tacctgtttc
     1441 aaaacatatt ttttctgttt ttataagtaa gttgatatta attaaactct tggcaatatt
     1501 tcttctttct taaaggaaaa tataccttaa ctttttttct tttacactgt gaaacataca
     1561 cagtagaaat tctgttactc tctgttatta atacataaat gaaaatacat ttttttccat
     1621 attggcatgt agctacaaat attaaaggag gagaaaaggt aatataattt taggtttacc
     1681 aaatatggtg tgtattcaaa taatacttga ccagcttatc taaaatgtac ataattttga
     1741 ggtagcttat gaatttgatt ttaattatta tgttcacaag cttggaatat tagatattat
     1801 tttgcatctg taactaaccg tgatcatcat ttcttgtaat ttcttgtaca tgtatattac
     1861 ttgttcttaa tagatttttg gaaacaagac tttattgaga tcagtttggt tttcctgtta
     1921 atttacctgt ttgactttat aatgtgtttt agttttgcag aagaacactg ttgtagttta
     1981 gaaggctttt cataaatccc ctcataggca aagatgaaaa cttcccacta tttttttccc
     2041 ctcttaggaa gacatactgg aaagaaaatg tttagcatct tagtgtagta tagctattgt
     2101 aaacagttca tgactagatt ttgattcgga aatctatact gaccaaggat taatcttaag
     2161 gattgtataa ttcattaaag ctgtggtctt tccatgtgga gactgataga aaataatttt
     2221 gtcccaagtc ttatttgctg actttttctg tcatgagtga gattgttgaa caaactgaat
     2281 atatgggcta tagcaagtag ctttacagta cagatcttac aattaagttt tgcttttgtt
     2341 aaagtgtgta ccattttttc tgtttggagt aagacaaaaa ttgttttgac ataggttccc
     2401 tagggtacac ttgctctagc atactttaaa ggccactgtt gcaaagtcta cattttatgc
     2461 tgaatctgca ttctgtcagg cacccgtaga aagacctcag tacatgcttt gcactctcct
     2521 ttgctccctt tttccaattt cttattgcat atcattttgt tgtaatacag aaagcagcat
     2581 ttttaaatgt ccgtgttaag aattggccca ctggtaccaa ctcacctcta ttttgtcagt
     2641 tcatagttga agattttgtt ttatttcaaa aacaaagtac atttttgaaa taatgtttca
     2701 gaataaaata atctcacttt taagtgatcc attttaaaat ttgtaattca ataaagtttt
     2761 ttttgttgtt aaacata
//
