LOCUS       NM_173826               3370 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens T cell activation inhibitor, mitochondrial (TCAIM),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_173826
VERSION     NM_173826.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3370)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 3370)
  AUTHORS   Schumann,J., Stanko,K., Woertge,S., Appelt,C., Schumann,M.,
            Kuhl,A.A., Panov,I., Schliesser,U., Vogel,S., Ahrlich,S., Vaeth,M.,
            Berberich-Siebelt,F., Waisman,A. and Sawitzki,B.
  TITLE     The mitochondrial protein TCAIM regulates activation of T cells and
            thereby promotes tolerance induction of allogeneic transplants
  JOURNAL   Am J Transplant 14 (12), 2723-2735 (2014)
   PUBMED   25363083
REFERENCE   3  (bases 1 to 3370)
  AUTHORS   Donckier,V., Craciun,L., Miqueu,P., Troisi,R.I., Lucidi,V.,
            Rogiers,X., Boon,N., Degre,D., Buggenhout,A., Moreno,C., Gustot,T.,
            Sainz-Barriga,M., Bourgeois,N., Colle,I., Van Vlierberghe,H.,
            Amrani,M., Remmelink,M., Lemmers,A., Roelen,D.L., Claas,F.H.,
            Reinke,P., Sawitzki,B., Volk,H.D., Le Moine,A., de Hemptinne,B. and
            Goldman,M.
  TITLE     Expansion of memory-type CD8+ T cells correlates with the failure
            of early immunosuppression withdrawal after cadaver liver
            transplantation using high-dose ATG induction and rapamycin
  JOURNAL   Transplantation 96 (3), 306-315 (2013)
   PUBMED   23799424
REFERENCE   4  (bases 1 to 3370)
  AUTHORS   Viklicky,O., Krystufkova,E., Brabcova,I., Sekerkova,A.,
            Wohlfahrt,P., Hribova,P., Wohlfahrtova,M., Sawitzki,B.,
            Slatinska,J., Striz,I., Volk,H.D. and Reinke,P.
  TITLE     B-cell-related biomarkers of tolerance are up-regulated in
            rejection-free kidney transplant recipients
  JOURNAL   Transplantation 95 (1), 148-154 (2013)
   PUBMED   23222918
REFERENCE   5  (bases 1 to 3370)
  AUTHORS   Hutchinson,J.A., Riquelme,P., Sawitzki,B., Tomiuk,S., Miqueu,P.,
            Zuhayra,M., Oberg,H.H., Pascher,A., Lutzen,U., Janssen,U.,
            Broichhausen,C., Renders,L., Thaiss,F., Scheuermann,E., Henze,E.,
            Volk,H.D., Chatenoud,L., Lechler,R.I., Wood,K.J., Kabelitz,D.,
            Schlitt,H.J., Geissler,E.K. and Fandrich,F.
  TITLE     Cutting Edge: Immunological consequences and trafficking of human
            regulatory macrophages administered to renal transplant recipients
  JOURNAL   J Immunol 187 (5), 2072-2078 (2011)
   PUBMED   21804023
REFERENCE   6  (bases 1 to 3370)
  AUTHORS   Keeren,K., Friedrich,M., Gebuhr,I., Philipp,S., Sabat,R.,
            Sterry,W., Brandt,C., Meisel,C., Grutz,G., Volk,H.D. and
            Sawitzki,B.
  TITLE     Expression of tolerance associated gene-1, a mitochondrial protein
            inhibiting T cell activation, can be used to predict response to
            immune modulating therapies
  JOURNAL   J Immunol 183 (6), 4077-4087 (2009)
   PUBMED   19684086
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC038420.1, BC101060.2, BC047231.1 and AL833118.1.
            
            On Nov 22, 2018 this sequence version replaced NM_173826.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1). Both variants 1 and
            4 encode the same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL832473.1, SRR1803612.193881.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000342649.9/
                                                  ENSP00000341539.4
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BC038420.1         235-244
            11-2655             BC101060.2         2-2646
            2656-3368           BC047231.1         2589-3301
            3369-3370           AL833118.1         3101-3102
FEATURES             Location/Qualifiers
     source          1..3370
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..3370
                     /gene="TCAIM"
                     /gene_synonym="C3orf23; TOAG-1; TOAG1"
                     /note="T cell activation inhibitor, mitochondrial"
                     /db_xref="GeneID:285343"
                     /db_xref="HGNC:HGNC:25241"
                     /db_xref="MIM:620787"
     exon            1..69
                     /gene="TCAIM"
                     /gene_synonym="C3orf23; TOAG-1; TOAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            70..142
                     /gene="TCAIM"
                     /gene_synonym="C3orf23; TOAG-1; TOAG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..1604
                     /gene="TCAIM"
                     /gene_synonym="C3orf23; TOAG-1; TOAG1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tolerance associated gene-1 protein"
                     /codon_start=1
                     /product="T-cell activation inhibitor, mitochondrial
                     isoform 1"
                     /protein_id="NP_776187.2"
                     /db_xref="CCDS:CCDS2712.1"
                     /db_xref="GeneID:285343"
                     /db_xref="HGNC:HGNC:25241"
                     /db_xref="MIM:620787"
                     /translation="MFCHLRPMRRLCLEKIFPHWFPFSRALSGAEAVNALRPFYFAVH
                     PDFFGQHPVEREINENSLKRLSVYLENLQKPGFKSLKPTQLTFYVRETDQSSSDGQEP
                     FSTSGFRAVKFTLHTRDLLSTVLYILNSCSLSVEHIQSLNTNMHTQPLKEAKRMPDRP
                     IKWDKSYYSFTGFKDPDEDLEQVSRVETTLTSWLDNNGKSAVKKLKNSLPLRKELDRL
                     KDELSHQLQLSDIRWQRSWGIAHRCSQLHSLSRLAQQNLETLKKAKGCTIIFTDRSGM
                     SAVGHVMLGTMDVHHHWTKLFERLPSYFDLQRRLMILEDQISYLLGGIQVVYIEELQP
                     VLTLEEYYSLLDVFYNRLLKSRILFHPRSLRGLQMILNSDRYAPSLHELGHFNIPTLC
                     DPANLQWFILTKAQQARENMKRKEELKVIENELIQASTKKFSLEKLYKEPSISSIQMV
                     DCCKRLLEQSLPYLHGMHLCISHFYSVMQDGDLCIPWNWKNGEAIK"
     exon            143..278
                     /gene="TCAIM"
                     /gene_synonym="C3orf23; TOAG-1; TOAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            279..432
                     /gene="TCAIM"
                     /gene_synonym="C3orf23; TOAG-1; TOAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            433..685
                     /gene="TCAIM"
                     /gene_synonym="C3orf23; TOAG-1; TOAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            686..808
                     /gene="TCAIM"
                     /gene_synonym="C3orf23; TOAG-1; TOAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            809..906
                     /gene="TCAIM"
                     /gene_synonym="C3orf23; TOAG-1; TOAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            907..998
                     /gene="TCAIM"
                     /gene_synonym="C3orf23; TOAG-1; TOAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1231
                     /gene="TCAIM"
                     /gene_synonym="C3orf23; TOAG-1; TOAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1363
                     /gene="TCAIM"
                     /gene_synonym="C3orf23; TOAG-1; TOAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..3370
                     /gene="TCAIM"
                     /gene_synonym="C3orf23; TOAG-1; TOAG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3349..3354
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCAIM"
                     /gene_synonym="C3orf23; TOAG-1; TOAG1"
                     /note="hexamer: AATAAA"
     polyA_site      3370
                     /gene="TCAIM"
                     /gene_synonym="C3orf23; TOAG-1; TOAG1"
                     /note="major polyA site"
ORIGIN      
        1 cttctggtgt actgggtggg aggtggaact agtcggacaa agccctcgcg tcggaccctt
       61 gccagaactc aattaatgga tgcctcgaag ttgacgtaca tatatattca gaaatgtttt
      121 gccacctgag acctatgagg aggttatgtc tagagaagat atttccacac tggtttccct
      181 tttcaagagc tttatcggga gctgaagcag tcaatgcctt gaggcctttc tattttgcag
      241 tacatccaga tttctttgga cagcaccccg tagaaaggga aatcaatgaa aattctctta
      301 aaaggttaag tgtctaccta gaaaacctcc agaaaccagg cttcaagtct ttgaaaccaa
      361 ctcagcttac attttatgta agagaaacag accagagttc ctccgatggc caggaacctt
      421 ttagtacttc cggatttcga gcagtcaaat ttactttgca caccagagat ctgctaagca
      481 cagtgttata tattctcaac tcctgcagtt tatctgttga acatatccaa agcttgaata
      541 ctaatatgca tacccagcct ctcaaagaag ctaaaaggat gcctgacagg cccatcaaat
      601 gggacaagtc ttattactcc tttactggat tcaaggaccc tgatgaagac cttgaacaag
      661 tctcgagagt ggaaacaact ctcacatcct ggttagataa caatgggaaa agtgctgtta
      721 aaaagctaaa gaacagtttg ccacttagaa aagaactaga tcgtttaaaa gatgaactgt
      781 ctcatcaatt gcaactctca gatatcaggt ggcagaggag ctggggcatc gcccaccgct
      841 gtagccagct gcatagttta agccgcttag cacagcagaa tttggaaaca cttaaaaaag
      901 caaaagggtg tacaatcata tttacagacc gttctggcat gagtgcagtg ggccatgtga
      961 tgctaggaac aatggatgtc catcaccact ggacaaaact ttttgaaaga ttgccaagtt
     1021 attttgacct tcagaggagg ctgatgattt tagaagacca aataagctat cttttaggtg
     1081 gcatacaagt tgtttatatt gaagaattac agccagtatt gacacttgaa gaatattact
     1141 ctcttcttga tgtgttttat aatagactgt tgaaaagtag aatactattt caccctcgaa
     1201 gtttgcgtgg tttacaaatg atccttaaca gtgacagata tgctccaagc ttgcatgaac
     1261 tcgggcattt taatattcca acactctgtg atccagcaaa tctccagtgg tttattctca
     1321 ccaaagctca gcaggcaaga gagaacatga aaagaaagga agagttaaag gttattgaaa
     1381 atgaattgat acaggcatca acaaagaaat tttctttgga gaagttatat aaagagccca
     1441 gcatttctag tatacaaatg gtggattgtt gtaagagact tctagaacaa tcactgcctt
     1501 acctacatgg gatgcacctc tgcatttcac atttttactc tgttatgcaa gatggagacc
     1561 tttgtattcc ttggaattgg aagaatggag aagccattaa gtaacacaga aatctgtttt
     1621 atttttttaa gagataagaa aggaacttaa attaaaaata tttaaatcca caatttgata
     1681 taacagtatt atttacataa gaacaaagtt tctaactgct gctttaaaag tagacttttt
     1741 taaaaaaatt aatttctgct aggagaggtt ttatatgcca ggcgtggtgg ctcatgcctg
     1801 cggtcccagc tacttaggga ggctaagata ggaggatcac ttgagcccag gaggccaagg
     1861 ttgcagtggg cccagattgc accattgccc tccagcctga gcaacagaac aagaccttgt
     1921 ctcaaaaaat aataatgata atttaaaata aataagtaac taataaaaag attttatatc
     1981 ccagtcttat gatgttggtt ggcaaggcta gataaaaaga tgttagaatg aaagaacata
     2041 tttttagtga tatgtaaatg aaggattcta caatagtcat atatttttat atgaatgaat
     2101 gttgggttgg gctggagagg tatgtgtgtg taaatataaa ggtctcacat tcagagtata
     2161 gctctgaaat aatggaactc atgtctacaa ttcaacatgc atctgtatag ttacatctca
     2221 tgtaaatata cacagacata ttttgcagcc agtaattgac agttaatgtc caaaacaggt
     2281 gattgatagg taacagaaat tagataacca ccaattttgc ccaagagaaa gactagaagg
     2341 actaaaagca gttgaatgta tggtactgac attgtcataa gcagtctgat aaccagttta
     2401 ttgaaacgtg tgcattaaca gagaatttaa ttttaaaccc ataatttctc ctatccatta
     2461 aaatattata attgttagta gtatgaaacc aacaggaaat gttttttaat catttagtga
     2521 ggtgattcat ttgtttcatg ggcaaacact atccaggaaa agccttgctt gcctgtttcc
     2581 caaagagctc taagaaatag aatcaagtgt aaaatggttc agaccattca ggatttcttg
     2641 tcactcttct caaccacgat cttcctgtta ttactgatgt ttgaaaccct gtcattagcc
     2701 ccggcctggt taaagcccct cagagtcacc tctcattcat agcaatagaa ttcaacccca
     2761 agtggttgat ggtgtcccca gcacagccga gagacctgat ctctggattc agtgctttta
     2821 gctcttcgag tttaccctaa gataccttcg ggcaatattt ttaaccaacc caaaagctct
     2881 tcaggtcatt tctgaagagg acaaggtgaa tcttggcttg gaacaccatt tttgggctct
     2941 tgctactgaa tgaatcagaa aggaattttt tctgaagagc attagaaagt aaaagagatg
     3001 ttaaaataag ttcttgaagt atgttttata tttatctaaa acactgattt taaaagttta
     3061 cattcaaatg tgtattcaaa agaagtactg atttgtaatt attatagttt gtgtgtatca
     3121 tcccttttaa ccgtgcctaa caactgtact taaattttgt tttctagtgt aacaaatgtt
     3181 tcccataaga ttttctagag ccaaataatg ggagtgaaaa attccttaag tgttatataa
     3241 gaaaatatat tagaaaatca gctttggatt atacgatttc taaaatatac taatacagaa
     3301 tcctcagtaa tatgttttga attggatttt ttctcagaac tgttacataa taaataatac
     3361 atcaaccaga
//
