LOCUS       NM_001363538            5561 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens TRPM8 channel associated factor 2 (TCAF2), transcript
            variant 4, mRNA.
ACCESSION   NM_001363538 XM_006715927
VERSION     NM_001363538.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5561)
  AUTHORS   Yun,D., Liang,J., Wang,X., Fan,J., Wang,X., Li,J., Ren,X., Liu,J.,
            Ren,X., Zhang,H., Shang,G., Jin,W., Chen,L., Li,T., Zhang,C., Yu,S.
            and Yang,X.
  TITLE     TCAF2 drives glioma cellular migratory/invasion properties through
            STAT3 signaling
  JOURNAL   Mol Cell Biochem 479 (7), 1801-1815 (2024)
   PUBMED   38019450
  REMARK    GeneRIF: TCAF2 drives glioma cellular migratory/invasion properties
            through STAT3 signaling.
REFERENCE   2  (bases 1 to 5561)
  AUTHORS   Li,Y., Li,J., Chen,H., Lu,B., Lu,F., Chen,H., Liu,H. and Qian,C.
  TITLE     TCAF2 is associated with the immune microenvironment, promotes
            pathogenesis, and impairs prognosis in glioma
  JOURNAL   Gene 883, 147667 (2023)
   PUBMED   37506986
  REMARK    GeneRIF: TCAF2 is associated with the immune microenvironment,
            promotes pathogenesis, and impairs prognosis in glioma.
REFERENCE   3  (bases 1 to 5561)
  AUTHORS   Li,X., Qi,Q., Li,Y., Miao,Q., Yin,W., Pan,J., Zhao,Z., Chen,X.,
            Yang,F., Zhou,X., Huang,M., Wang,C., Deng,L., Huang,D., Qi,M.,
            Fan,S., Zhang,Y., Qiu,S., Deng,W., Liu,T., Chen,M., Ye,W. and
            Zhang,D.
  TITLE     TCAF2 in Pericytes Promotes Colorectal Cancer Liver Metastasis via
            Inhibiting Cold-Sensing TRPM8 Channel
  JOURNAL   Adv Sci (Weinh) 10 (30), e2302717 (2023)
   PUBMED   37635201
  REMARK    GeneRIF: TCAF2 in Pericytes Promotes Colorectal Cancer Liver
            Metastasis via Inhibiting Cold-Sensing TRPM8 Channel.
REFERENCE   4  (bases 1 to 5561)
  AUTHORS   Hsieh,P., Dang,V., Vollger,M.R., Mao,Y., Huang,T.H., Dishuck,P.C.,
            Baker,C., Cantsilieris,S., Lewis,A.P., Munson,K.M., Sorensen,M.,
            Welch,A.E., Underwood,J.G. and Eichler,E.E.
  TITLE     Evidence for opposing selective forces operating on human-specific
            duplicated TCAF genes in Neanderthals and humans
  JOURNAL   Nat Commun 12 (1), 5118 (2021)
   PUBMED   34433829
  REMARK    GeneRIF: Evidence for opposing selective forces operating on
            human-specific duplicated TCAF genes in Neanderthals and humans.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5561)
  AUTHORS   Gkika,D., Lemonnier,L., Shapovalov,G., Gordienko,D., Poux,C.,
            Bernardini,M., Bokhobza,A., Bidaux,G., Degerny,C., Verreman,K.,
            Guarmit,B., Benahmed,M., de Launoit,Y., Bindels,R.J., Fiorio Pla,A.
            and Prevarskaya,N.
  TITLE     TRP channel-associated factors are a novel protein family that
            regulates TRPM8 trafficking and activity
  JOURNAL   J Cell Biol 208 (1), 89-107 (2015)
   PUBMED   25559186
  REMARK    GeneRIF: Report novel TRP channel-associated factors that modulate
            TRPM8 activity.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073264.5 and AC106862.3.
            
            On Jun 2, 2019 this sequence version replaced NM_001363538.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.179878.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000684770.1/ ENSP00000506869.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                AC073264.5         170293-170339
            48-681              AC106862.3         2180-2813
            682-1673            AC106862.3         18879-19870
            1674-1771           AC106862.3         20477-20574
            1772-1985           AC106862.3         21854-22067
            1986-2225           AC106862.3         22407-22646
            2226-2563           AC106862.3         23556-23893
            2564-5561           AC106862.3         26609-29606
FEATURES             Location/Qualifiers
     source          1..5561
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q35"
     gene            1..5561
                     /gene="TCAF2"
                     /gene_synonym="FAM115C; FAM139A; GATD9; GATD9B"
                     /note="TRPM8 channel associated factor 2"
                     /db_xref="GeneID:285966"
                     /db_xref="HGNC:HGNC:26878"
                     /db_xref="MIM:616252"
     exon            1..47
                     /gene="TCAF2"
                     /gene_synonym="FAM115C; FAM139A; GATD9; GATD9B"
                     /inference="alignment:Splign:2.1.0"
     exon            48..681
                     /gene="TCAF2"
                     /gene_synonym="FAM115C; FAM139A; GATD9; GATD9B"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..2818
                     /gene="TCAF2"
                     /gene_synonym="FAM115C; FAM139A; GATD9; GATD9B"
                     /note="isoform C is encoded by transcript variant 4;
                     family with sequence similarity 139, member A; protein
                     FAM115C; family with sequence similarity 115, member C;
                     TRP channel-associated factor 2"
                     /codon_start=1
                     /product="TRPM8 channel-associated factor 2 isoform C"
                     /protein_id="NP_001350467.1"
                     /db_xref="CCDS:CCDS87559.1"
                     /db_xref="GeneID:285966"
                     /db_xref="HGNC:HGNC:26878"
                     /db_xref="MIM:616252"
                     /translation="MATIAAAAFEALMDGVTCWDVPRGPIPSELLLIGEAAFPVMVND
                     KGQVLIAASSYGRGRLVVVSHEGYLSHTGLAPFLLNAVSWLCPCPGAPVGVHPSLAPL
                     VNILQDAGLEAQVKPEPGEPLGVYCINAYNDTLTATLIQFVKHGGGLLIGGQAWYWAS
                     QHGPDKVLSRFPGNKVTSVAGVYFTDTYGDRDRFKVSKKVPKIPLHVRYGEDVRQDQQ
                     QLLEGISELDIRTGGVPSQLLVHGALAFPLGLDASLNCFLAAAHYGRGRVVLAAHECL
                     LCAPKMGPFLLNAVRWLARGQTGKVGVNTNLKDLCPLLSEHGLQCSLEPHLNSDLCVY
                     CCKAYSDKEAKQLQEFVAEGGGLLIGGQAWWWASQNPGHCPLAGFPGNIILNCFGLSI
                     LPQTLKAGCFPVPTPEMRSYHFRKALSQFQAILNHENGNLEKSCLAKLRVDGAAFLQI
                     PAEGVPAYISLHRLLRKMLRGSGLPAVSRENPVASDSYEAAVLSLATGLAHSGTDCSQ
                     LAQGLGTWTCSSSLYPSKHPITVEINGINPGNNDCWVSTGLYLLEGQNAEVSLSEAAA
                     SAGLRVQIGCHTDDLTKARKLSRAPVVTHQCWMDRTERSVSCLWGGLLYVIVPKGSQL
                     GPVPVTIRGAVPAPYYKLGKTSLEEWKRQMQENLAPWGELATDNIILTVPTTNLQALK
                     DPEPVLRLWDEMMQAVARLAAEPFPFRRPERIVADVQISAGWMHSGYPIMCHLESVKE
                     IINEMDMRSRGVWGPIHELGHNQQRHGWEFPPHTTEATCNLWSVYVHETVLGIPRAQA
                     HEALSPPERERRIKAHLGKGAPLCDWNVWTALETYLQLQEAFGWEPFTQLFAEYQTLS
                     HLPKDNTGRMNLWVKKFSEKVKKNLVPFFEAWGWPIQKEVADSLASLPEWQENPMQVY
                     LRARK"
     exon            682..1673
                     /gene="TCAF2"
                     /gene_synonym="FAM115C; FAM139A; GATD9; GATD9B"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1771
                     /gene="TCAF2"
                     /gene_synonym="FAM115C; FAM139A; GATD9; GATD9B"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1985
                     /gene="TCAF2"
                     /gene_synonym="FAM115C; FAM139A; GATD9; GATD9B"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2225
                     /gene="TCAF2"
                     /gene_synonym="FAM115C; FAM139A; GATD9; GATD9B"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2563
                     /gene="TCAF2"
                     /gene_synonym="FAM115C; FAM139A; GATD9; GATD9B"
                     /inference="alignment:Splign:2.1.0"
     exon            2564..5561
                     /gene="TCAF2"
                     /gene_synonym="FAM115C; FAM139A; GATD9; GATD9B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5210..5215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCAF2"
                     /gene_synonym="FAM115C; FAM139A; GATD9; GATD9B"
                     /note="hexamer: AATAAA"
     polyA_site      5242
                     /gene="TCAF2"
                     /gene_synonym="FAM115C; FAM139A; GATD9; GATD9B"
                     /note="major polyA site"
ORIGIN      
        1 actgcagagc ctgtccgtca gtccctaggt atccgcactg ctcagggctg atagaaccat
       61 ggcgaccatt gctgctgctg cgtttgaggc cctcatggat ggagtgacat gctgggatgt
      121 ccccagaggc cccatcccca gtgaactcct tcttattgga gaagccgcct tccccgtgat
      181 ggtgaatgac aagggccagg tgctcattgc tgcctcctcc tacggccgag gccgcctcgt
      241 ggttgtgtcc catgagggct acctgtcgca tactggcttg gctccatttc tcctcaatgc
      301 agtgagctgg ctctgtccct gtcctggggc tcccgtggga gtgcatccat ccctggcacc
      361 tctagtaaac atcctacagg atgctgggct tgaggcacag gtcaagccag aaccaggaga
      421 gcccctaggg gtttactgta tcaatgccta caatgacacc ttgactgcaa cgctgatcca
      481 gtttgtgaaa catggagggg gcttgttaat cgggggccag gcctggtact gggccagcca
      541 gcacggccct gacaaggtgc tctccaggtt ccctgggaac aaggtgacaa gtgtagctgg
      601 agtgtacttc actgacacct atggggacag agaccggttc aaggtctcta agaaggtgcc
      661 caagatccca ctccatgtca ggtatgggga ggatgtcagg caggaccagc agcagctcct
      721 ggaggggatc tcagagctgg acatcaggac agggggagtc ccctcacagc tgcttgtaca
      781 tggagccctg gccttccctc tggggctgga tgcctcactc aactgcttcc tggcggctgc
      841 tcactatggc cggggccggg tggtcctggc tgcccacgag tgcctgctct gtgctcccaa
      901 gatggggccc ttcttgctca atgcggtgcg ctggctggcc agaggccaga caggcaaagt
      961 tggggtgaac acaaatctaa aagatctgtg tcctctccta tcggagcatg gcctgcaatg
     1021 cagcctggag ccccatctga acagcgactt gtgtgtctac tgctgcaagg cgtacagtga
     1081 caaggaggct aagcagctgc aggagtttgt ggctgagggt ggggggctgc tgattggggg
     1141 ccaggcctgg tggtgggcct cccagaaccc tggccactgc cccttggctg gcttccctgg
     1201 taacatcatc ctcaactgct ttggcctcag catcctgcct cagactctca aagcaggctg
     1261 cttccccgtt cccacccctg agatgagaag ctaccacttc cgcaaggcgc tctctcaatt
     1321 ccaggctata ctgaaccacg agaatgggaa cttggaaaag agctgtctgg caaagttgag
     1381 agttgatggt gcagccttcc tacagattcc tgcggagggg gtccctgctt acatatccct
     1441 gcacaggctc ctgaggaaga tgctacgagg gtctggcctc ccagctgtga gccgggaaaa
     1501 tccagttgcc agtgactcct atgaggctgc ggtgctctcc ctggccactg ggctggctca
     1561 ctctggaact gactgctccc agctggccca ggggcttggc acctggacct gctcctccag
     1621 tttgtacccc tcaaaacacc ccatcaccgt ggagatcaat ggaatcaacc caggcaacaa
     1681 tgattgctgg gtgagtaccg ggctctacct cctggaagga caaaatgcag aagtctcact
     1741 gtctgaagct gctgcctctg ctggcctgag ggtacagata ggctgccaca ccgatgacct
     1801 taccaaggcc aggaagctat ctcgagcccc cgtggtgact caccaatgct ggatggacag
     1861 gactgagcgg tcagtctcct gcctctgggg cggcctcctc tacgtcatcg tgcccaaggg
     1921 cagccaacta ggccctgtgc ctgtcactat caggggagct gtgcctgccc catactacaa
     1981 gctgggtaag acatcgctgg aggagtggaa gaggcagatg caggagaacc tggctccctg
     2041 gggagagctg gccacggaca acatcatcct gacagtgcca accacaaacc ttcaggccct
     2101 gaaggacccc gagcctgtgc tccgcctctg ggatgagatg atgcaggctg tggccaggct
     2161 ggcggctgag cccttccctt tccgccgtcc tgagaggatt gtggctgatg tgcagatctc
     2221 agctggctgg atgcattcag gataccccat catgtgccac ctggagtctg tgaaggagat
     2281 catcaatgag atggacatga ggagcagggg tgtgtggggc cccatccatg agctgggcca
     2341 caaccaacag cggcatggat gggagttccc cccacacact actgaggcca cctgtaacct
     2401 ttggtcagtc tacgtgcatg aaacagtcct ggggatcccc agggctcagg cccacgaggc
     2461 tctgagccct ccagagcgag agaggagaat caaggcccac ctgggaaagg gagcccccct
     2521 gtgtgactgg aatgtatgga cagccctgga aacatatcta cagctccaag aggccttcgg
     2581 gtgggagcca ttcacccagc tctttgctga gtaccagacc ctctctcacc tccccaaaga
     2641 caacactggc aggatgaatc tatgggtgaa gaagttctct gaaaaagtga agaagaatct
     2701 ggttcccttc tttgaggcct ggggctggcc tatccagaag gaggtggctg acagcctggc
     2761 ctccctacca gagtggcagg aaaaccccat gcaagtgtac ctccgtgcca ggaagtaaag
     2821 gatgccccac aaggcgggag agaaaaggca gggtcacgcc atcaactcca ccatggggct
     2881 ttggccgtgt gctcagtatc tggagcctga atcccgcttc caagcctgac cactagatgg
     2941 tggccacggt cataagaaaa aatggaaccc ctttctgtaa aaggtgcctt gtgcttcttt
     3001 ttattgtttt tctgcctacg ctattgcttt ccccaagaga ctcacttcac ctcttagtct
     3061 tccagagagg atctttcatc ctgccatcct gaggcttcta tttttgacca atagctctaa
     3121 agaccacggg ttcccataac aacctgatat ccctttctca tccctgccat ccctgaataa
     3181 ggcttctaat ttattatgct ttaacaagtt ttcaaatagc aagcgagaca cgctggaata
     3241 gtggagagag ccccaaacca gctttggttc tatggaaaat cactccacct ctctgtgttt
     3301 ctgtcttcac atccatgaca tgaggataca aatcttttcc tcacaaagct gttgtttgat
     3361 ttctcctggt cccatagtgg actgttaacg gtgtccagtc tagcgtgcac atcctgggtg
     3421 ctgaatctca cttcagtgtt gacccccttg gggttagcat tcagtccttg tatatttaga
     3481 gaatgtcaat gttttcccag acatggtatc aataatggta gttgtcagca gtatcttagc
     3541 cctttctaca ttttttctcc cacttctgga aggattcttg ggtataacct aacccaaaga
     3601 aaagtggcat gtgctgaaac tgagtgtcac agagctgtga ggttgggtct ttgggattag
     3661 cttcattttc cagggtttgc cctttgccct tcaaccaaag gacaaagtca tgttaacagc
     3721 tgctactaag tctatatgcc cattcgttca taccacaaaa caggcatctg actcctctgg
     3781 tcaccatgga atcaaggcac tgtcaagtgg tggggggtcc acaggcacag tgggcttcac
     3841 tctggaacag gattactggg tgcagcggat gtaatcctca cttaatcaac ccacacccca
     3901 gcatcccctg agctttctct taatctcatt ctagcccatc ttgactcttc ggttagaggg
     3961 agttctcatt ggagatttgt ctctgggatt aatgagtgta tgcctagcta ctttctccag
     4021 tttactttta gaccatattg ttgtttgttt tgaatatcat tccttaggct atgttgagag
     4081 tagagtggct tcccattagg agaactaatt tagggcatgt cttttgctga atcccgtcag
     4141 catatttaac aaattcccaa ttctagataa tttcctttta tttctctagt accctttgcc
     4201 aggggctcta cacatcaaag gtgttcatga agtatttgtc aaaggaaaga acagtaatga
     4261 cacctaacac ataatgagtg attagtatgt tccaggcatt gcgtgagcta tttactgtga
     4321 gtgatttaat gttatcttcc cagcagacct ctgaggtagg tactagtatg atccccattt
     4381 cgtacatgag gaaactgaca ctaagggaca taaaataagt tttttgaagt cacaaagtga
     4441 ataaaaggaa gaaccagggt ttaattgaag cccatagcaa tgaaaacatt gtggaactta
     4501 ttcttcatga atggtttaca atttaaacaa aatgtcacct agaaaataga tgaaaatatg
     4561 ttcaaccagg tctggatttt tccaatgttt actactgaat tttcattcaa taacaagttt
     4621 aacttccaaa aaggtgttgg tatctgattt tctgcctgcc tcagaatgtg atttgtctgc
     4681 ctttgggtca tccagccttg ggtagagaag gaatttgaac tcaggaaatt caactccaga
     4741 actgatgttc tttttttttt ttcatttaag ttctgggata catgtgcaga acgtgcaggt
     4801 ttgttacata ggtatacatg tgccatggtg gtttgctgca cctatcaatc catcatctag
     4861 attttaagct ctgcatgcat tagatatttg tcctaatgct ctccctccca ttgcccccaa
     4921 cctcccgaca ggccccagtg tgatgtttcc ctccctgtgt ccatttgttc tcatttttca
     4981 tctcccactt atgagtgaga acatgtgttg tttggttttc tgttcctgtg ttagtttgct
     5041 gagaattatg gcttccagct tcatccatgt ccctgcaaag gacatgaact cattcttttt
     5101 catggctgca tggtattcaa tggtatatat gccatatttt ctttatccag tctatcattg
     5161 gtgggcattt gggttggttc caagtctttg ctattgtaaa taatgctgca ataaaagtat
     5221 gtgtgcatgt gtctttatag tagaatggtt tatagtcctt tgggtgtata tccagtaatg
     5281 ggattgctgg gtcaaatggt atttctggtt ctagatcttt gaggaatcat cacattgtct
     5341 tccacaatgg ttgaactaat ttacactccc aacaacagtg taaaagcatt cctgtttctc
     5401 cacagcctca ccaacatctg ttgtttcctg actttttaat gatcgccatt ctaactggca
     5461 tgagatggta ccccattgtg gttttgattt acatttccct aatgaccagt aatgatgagc
     5521 tttttttcat gtttattggc cacataaatg tcttcttttg a
//
