LOCUS       NM_014719               5754 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens TRPM8 channel associated factor 1 (TCAF1), transcript
            variant 1, mRNA.
ACCESSION   NM_014719 XM_376710 XM_379957
VERSION     NM_014719.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5754)
  AUTHORS   Kong,L., Cheng,C., Cheruiyot,A., Yuan,J., Yang,Y., Hwang,S.,
            Foust,D., Tsao,N., Wilkerson,E., Mosammaparast,N., Major,M.B.,
            Piston,D.W., Li,S. and You,Z.
  TITLE     TCAF1 promotes TRPV2-mediated Ca2+ release in response to cytosolic
            DNA to protect stressed replication forks
  JOURNAL   Nat Commun 15 (1), 4609 (2024)
   PUBMED   38816425
  REMARK    GeneRIF: TCAF1 promotes TRPV2-mediated Ca[2+] release in response
            to cytosolic DNA to protect stressed replication forks.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5754)
  AUTHORS   Hsieh,P., Dang,V., Vollger,M.R., Mao,Y., Huang,T.H., Dishuck,P.C.,
            Baker,C., Cantsilieris,S., Lewis,A.P., Munson,K.M., Sorensen,M.,
            Welch,A.E., Underwood,J.G. and Eichler,E.E.
  TITLE     Evidence for opposing selective forces operating on human-specific
            duplicated TCAF genes in Neanderthals and humans
  JOURNAL   Nat Commun 12 (1), 5118 (2021)
   PUBMED   34433829
  REMARK    GeneRIF: Evidence for opposing selective forces operating on
            human-specific duplicated TCAF genes in Neanderthals and humans.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5754)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5754)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5754)
  AUTHORS   Gkika,D., Lemonnier,L., Shapovalov,G., Gordienko,D., Poux,C.,
            Bernardini,M., Bokhobza,A., Bidaux,G., Degerny,C., Verreman,K.,
            Guarmit,B., Benahmed,M., de Launoit,Y., Bindels,R.J., Fiorio Pla,A.
            and Prevarskaya,N.
  TITLE     TRP channel-associated factors are a novel protein family that
            regulates TRPM8 trafficking and activity
  JOURNAL   J Cell Biol 208 (1), 89-107 (2015)
   PUBMED   25559186
  REMARK    GeneRIF: Report novel TRP channel-associated factors that modulate
            TRPM8 activity.
            GeneRIF: TCAF1 binds to and promotes trafficking of the TRPM8 cold
            sensor channel to the cell surface, it contains a PI3K homology
            domain in its C-terminal tail that modifies TRPM8 gating properties
            and seems to facilitate channel opening, as assessed by
            menthol-induced response. Overexpression leads to a reduction in
            both the speed and directionality of migration of prostate cancer
            cells.
REFERENCE   6  (bases 1 to 5754)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   7  (bases 1 to 5754)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   8  (bases 1 to 5754)
  AUTHORS   Fortna,A., Kim,Y., MacLaren,E., Marshall,K., Hahn,G., Meltesen,L.,
            Brenton,M., Hink,R., Burgers,S., Hernandez-Boussard,T.,
            Karimpour-Fard,A., Glueck,D., McGavran,L., Berry,R., Pollack,J. and
            Sikela,J.M.
  TITLE     Lineage-specific gene duplication and loss in human and great ape
            evolution
  JOURNAL   PLoS Biol 2 (7), E207 (2004)
   PUBMED   15252450
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004742.1 and AC099548.6.
            
            On Nov 23, 2018 this sequence version replaced NM_014719.2.
            
            Transcript Variant: This variant (1) encodes the longest protein
            (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly except for one retained mismatch in the
            coding region. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.102828.1,
                                           SRR1660809.119335.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000479870.6/ ENSP00000419235.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-216               AC004742.1         20650-20865         c
            217-850             AC099548.6         101751-102384       c
            851-1845            AC099548.6         88564-89558         c
            1846-1943           AC099548.6         88178-88275         c
            1944-2157           AC099548.6         86857-87070         c
            2158-2397           AC099548.6         85970-86209         c
            2398-2735           AC099548.6         84586-84923         c
            2736-2986           AC099548.6         82862-83112         c
            2987-5754           AC099548.6         77137-79904         c
FEATURES             Location/Qualifiers
     source          1..5754
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q35"
     gene            1..5754
                     /gene="TCAF1"
                     /gene_synonym="FAM115A; GATD9A"
                     /note="TRPM8 channel associated factor 1"
                     /db_xref="GeneID:9747"
                     /db_xref="HGNC:HGNC:22201"
                     /db_xref="MIM:616251"
     exon            1..216
                     /gene="TCAF1"
                     /gene_synonym="FAM115A; GATD9A"
                     /inference="alignment:Splign:2.1.0"
     exon            217..850
                     /gene="TCAF1"
                     /gene_synonym="FAM115A; GATD9A"
                     /inference="alignment:Splign:2.1.0"
     CDS             231..2996
                     /gene="TCAF1"
                     /gene_synonym="FAM115A; GATD9A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM115A; family with sequence similarity 115,
                     member A; TRP channel-associated factor 1"
                     /codon_start=1
                     /product="TRPM8 channel-associated factor 1 isoform 1"
                     /protein_id="NP_055534.2"
                     /db_xref="CCDS:CCDS5886.1"
                     /db_xref="GeneID:9747"
                     /db_xref="HGNC:HGNC:22201"
                     /db_xref="MIM:616251"
                     /translation="MATPSAAFEALMNGVTSWDVPEDAVPCELLLIGEASFPVMVNDM
                     GQVLIAASSYGRGRLVVVSHEDYLVEAQLTPFLLNAVGWLCSSPGAPIGVHPSLAPLA
                     KILEGSGVDAKVEPEVKDSLGVYCIDAYNETMTEKLVKFMKCGGGLLIGGQAWDWANQ
                     GEDERVLFTFPGNLVTSVAGIYFTDNKGDTSFFKVSKKMPKIPVLVSCEDDLSDDREE
                     LLHGISELDISNSDCFPSQLLVHGALAFPLGLDSYHGCVIAAARYGRGRVVVTGHKVL
                     FTVGKLGPFLLNAVRWLDGGRRGKVVVQTELRTLSGLLAVGGIDTSIEPNLTSDASVY
                     CFEPVSEVGVKELQEFVAEGGGLFVGAQAWWWAFKNPGVSPLARFPGNLLLNPFGISI
                     TSQSLNPGPFRTPKAGIRTYHFRSTLAEFQVIMGRKRGNVEKGWLAKLGPDGAAFLQI
                     PAEEIPAYMSVHRLLRKLLSRYRLPVATRENPVINDCCRGAMLSLATGLAHSGSDLSL
                     LVPEIEDMYSSPYLRPSESPITVEVNCTNPGTRYCWMSTGLYIPGRQIIEVSLPEAAA
                     SADLKIQIGCHTDDLTRASKLFRGPLVINRCCLDKPTKSITCLWGGLLYIIVPQNSKL
                     GSVPVTVKGAVHAPYYKLGETTLEEWKRRIQENPGPWGELATDNIILTVPTANLRTLE
                     NPEPLLRLWDEVMQAVARLGAEPFPLRLPQRIVADVQISVGWMHAGYPIMCHLESVQE
                     LINEKLIRTKGLWGPVHELGRNQQRQEWEFPPHTTEATCNLWCVYVHETVLGIPRSRA
                     NIALWPPVREKRVRIYLSKGPNVKNWNAWTALETYLQLQEAFGWEPFIRLFTEYRNQT
                     NLPTENVDKMNLWVKMFSHQVQKNLAPFFEAWAWPIQKEVATSLAYLPEWKENIMKLY
                     LLTQMPH"
     exon            851..1845
                     /gene="TCAF1"
                     /gene_synonym="FAM115A; GATD9A"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1943
                     /gene="TCAF1"
                     /gene_synonym="FAM115A; GATD9A"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2157
                     /gene="TCAF1"
                     /gene_synonym="FAM115A; GATD9A"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2397
                     /gene="TCAF1"
                     /gene_synonym="FAM115A; GATD9A"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..2735
                     /gene="TCAF1"
                     /gene_synonym="FAM115A; GATD9A"
                     /inference="alignment:Splign:2.1.0"
     exon            2736..2986
                     /gene="TCAF1"
                     /gene_synonym="FAM115A; GATD9A"
                     /inference="alignment:Splign:2.1.0"
     exon            2987..5754
                     /gene="TCAF1"
                     /gene_synonym="FAM115A; GATD9A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5733..5738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCAF1"
                     /gene_synonym="FAM115A; GATD9A"
                     /note="hexamer: AATAAA"
     polyA_site      5754
                     /gene="TCAF1"
                     /gene_synonym="FAM115A; GATD9A"
                     /note="major polyA site"
ORIGIN      
        1 gcctaagact ttccaagtcc tgtagtttcg agcccgctgc cctttgcctc ctgggcggag
       61 aagctgcttc ctcctgggaa caaccgcctc ccgctcctag caggttgcta ctgccccgaa
      121 cccgcgctgc agggaacagc ggggcaaaca gtgagtgggg ttcagcgtag actctggacc
      181 aggagaggcc cgcggtgacc gaggcctggg ccccggaaac caatagagcc atggcgactc
      241 cctctgctgc cttcgaggcc cttatgaatg gtgtgacaag ctgggatgta cccgaagatg
      301 ctgttccatg tgaactgctt cttattggag aggcttcatt tcctgtgatg gtgaatgaca
      361 tgggccaggt cctcattgct gcctcctcct atggccgtgg ccgcctggtg gtcgtgtccc
      421 atgaggacta cttggtggaa gcccagctca cgccctttct cctgaacgca gtggggtggc
      481 tttgctcttc ccctggggct cccattggtg tacacccatc cctggcacct ttggccaaaa
      541 tcctcgaggg ctctggagtg gatgcaaagg ttgagccaga agtgaaagac tccctggggg
      601 tttactgtat tgatgcctac aatgaaacca tgacagaaaa gctggtcaag ttcatgaaat
      661 gtggtggcgg cttgctcata ggaggacaag cctgggattg ggccaaccag ggggaggatg
      721 aaagggttct gttcacgttc cctgggaacc tcgtgaccag tgtggctggc atttacttta
      781 ctgacaacaa aggggacacg agtttcttta aagtctccaa gaagatgccc aagatcccag
      841 tgttggttag ttgtgaagat gacctctccg acgacagaga agagcttctg catgggattt
      901 cagagctgga catcagcaac tcggattgtt tcccatccca gctgctagtg catggggctt
      961 tagcctttcc tctagggtta gattcctacc atggctgtgt tatagcggct gcccgctatg
     1021 gccggggccg ggtggttgtg actggccata aggtattatt cactgttggt aaactgggcc
     1081 cctttctgct caatgctgtc cgctggctgg atgggggccg cagaggcaag gttgtggtgc
     1141 agacagagct gagaaccctg agtggcctcc tcgcagtggg gggcatagac accagcatcg
     1201 agcccaatct gaccagtgat gcaagtgtct actgctttga acccgtgagt gaagtggggg
     1261 tcaaggaact gcaggagttt gtagcagagg gtggcgggct atttgttgga gcccaagcct
     1321 ggtggtgggc cttcaagaac cccggagtgt cccctttggc tcgattccca ggaaacctcc
     1381 tcctcaaccc ctttggcatc agcattacaa gccaaagcct caatccaggg ccctttcgta
     1441 ctcctaaagc agggataagg acctatcact tccgctccac cttggccgag ttccaggtta
     1501 taatgggcag gaagagagga aatgtggaaa agggctggtt ggcaaagctg ggaccagatg
     1561 gtgcagcttt cctgcagatt cccgcagaag agatccctgc ctacatgtct gtgcatcgac
     1621 tcctgaggaa gctgctaagt cgatatcggc ttccagtagc aacccgagag aaccctgtta
     1681 tcaatgactg ctgcagaggt gctatgcttt ccctggccac agggctggcc cactctggaa
     1741 gcgacctctc tctgttagtc ccagaaattg aagatatgta cagcagcccc tatctgcgcc
     1801 cctcagaatc tcctatcacc gtcgaggtca actgcaccaa tccaggcacc agatattgct
     1861 ggatgagtac tgggctctac atacctggaa ggcaaattat agaagtctca ctgcctgaag
     1921 ctgctgcctc tgccgacctg aagatacaga ttggctgcca cacagatgac ctgaccaggg
     1981 ccagcaagct tttccgaggc ccactcgtaa ttaaccggtg ctgcttggac aaacccacaa
     2041 aatcgatcac gtgcctctgg ggtggactcc tctatataat tgtgcctcag aacagcaaac
     2101 tgggttctgt gcctgtcacc gtgaaggggg ctgtgcatgc tccatactac aagctggggg
     2161 agaccaccct ggaggagtgg aagaggcgta tccaggagaa tccagggccc tggggagagc
     2221 tggccacgga caacatcatt ctgaccgtgc cgaccgcaaa tcttcgtact ctggagaacc
     2281 ctgagccgct gctccgcctc tgggatgagg tgatgcaggc tgtggcgcga ctgggagctg
     2341 agcccttccc tttgcgcctg cctcagagga ttgttgccga cgtgcagatc tcagtgggct
     2401 ggatgcatgc agggtacccc atcatgtgcc atctggagtc agtgcaggag ctcatcaacg
     2461 agaagctcat cagaaccaag gggctgtggg gccccgtcca tgagctgggc cgcaaccagc
     2521 agcggcagga gtgggagttc ccaccacaca ccaccgaggc cacctgcaac ctgtggtgtg
     2581 tgtatgtgca tgagacggtc ttgggcattc ctcgaagccg tgccaatatt gctctgtggc
     2641 ccccagttcg ggagaagaga gtcagaatct acctgagcaa gggtcccaat gtgaaaaact
     2701 ggaatgcatg gaccgcactg gaaacgtatt tacagctcca ggaagccttt ggttgggagc
     2761 cattcatccg tctcttcacc gagtacagga accagaccaa cttgcccaca gaaaatgttg
     2821 acaaaatgaa tctgtgggtc aagatgttct cccaccaagt gcagaagaac ctggctccgt
     2881 tctttgaggc ctgggcctgg cccatccaga aggaagtggc taccagcctg gcctatctgc
     2941 ctgaatggaa ggaaaatatt atgaaattgt acctcctcac acagatgccc cactgaaatt
     3001 gaagtcaaga aatgcaaaaa ggaactgaca catctcagca aagaaaactg aagggatttg
     3061 gttataagtg gagaggatct cagcatattt ctggaagata gaaagtggat gaagcatgat
     3121 aatgaaagag tgaagaacct ttcagataaa atgtaagctg atctgaacaa cataacccca
     3181 aagagacttg cgcacctgaa aagcttgtct actgaagaat tactccagtt gtaagattga
     3241 gccctctcct actctccccc aactcttatg cacagaacac aggcagtctc cactattgat
     3301 accagttaaa aatttcttgt tattgttgct gttgttgttt gtataaagga attgaacagg
     3361 ctgcttgcag agagataaga gttggtgctc cagaaaaaaa tttctcttct agtggaaata
     3421 agtgccccta cccccagccg gtcagctaat tctctactga cagctgagac ctcctactca
     3481 agtgcctgtt gccttcaggt atagaagagg tttcctgaag aaacagacct aactgtacaa
     3541 cagcagagga aacccatgcc aactgttata caagttaaca gttatgttga tttttaaatg
     3601 ggaatggtga gttagaaatt cccagacatg ggcgatgggg agggaagagg aataagaaaa
     3661 gtcacgaggt agaattaggg gccttgaaaa tatgacaaac tctgagggaa acaaagacaa
     3721 tgtggaaaga ataacttaat tttaattcca tctccagaga gatttgaggt gtatttaaga
     3781 tgaaaaacag gatactacaa agaaacggaa aactcaggag ttcgagacca gcctaggcaa
     3841 gatggcaaca tcccgtctct acaaaataat ttttaaaaat tagccaagca tggtggcatg
     3901 tgcctgtggt cctagctact tgggaggctg aagtgggaag atcacttgag cccaggagtt
     3961 caaggcttca gtgagccatg atggtgccac tgcactccag cctgggggac agagtgagac
     4021 cctgtctctt aaaaagcaag aaaagaaaga gaagactgag aataagaaga tctctttgaa
     4081 aataaaataa gactgctaaa agtatttggt atacagtctg gaaaataaag ttgagggaat
     4141 ctctccagat aaagagcaaa aagaaataga tagaaaaata taaagaaaga aaaaagacat
     4201 agacaatcaa tatgtaatgt taggagttcc tggaagagag aacagagaca gtgtaggtga
     4261 agaaataaaa agaaaaagaa ttgaagaaca gagcaagcta agtctccaga ttgagagggc
     4321 ccaatacaat ctacatctag acacaatatt gtaaaatttt ggaatattaa ggatagaagg
     4381 aagatattaa agtggccagg gagaaaacaa atgaggtcat cacgattagc tcaacacaaa
     4441 aatggatgag aaatagactg ctaacagatt tgtcatcagc aacactgaat gccagaagtc
     4501 aatggatcaa catcttcaga gcttaaggaa aatttttgta cctagaattt catagtaagg
     4561 cagactgtca agaagaacat caaagtgaag acattttctg tcaggcaaat tttcagaaag
     4621 tctcctttgc acccttactg aggaagtatc ttgaggaaat tctccagcaa aatgaggatg
     4681 aaaaccagga aagaagaaga aatgggatcc ataaaacagt ggaccttact taggatgtct
     4741 cattctagag tgacagccaa aagggtatct caccctagag tgacagctat ccagcagact
     4801 aatttcagat gagagcatac tgtctcgggc tttctgggaa gaatgtgcat tcagtgccat
     4861 agatagtatc attgaagagc tgggatgctt gagaagatta tttagtcaag aaaaaagaaa
     4921 gacaaatcaa caatatgtca aaaaattcag gtccaattat agagcaaaat aaaatgaggc
     4981 atgattttga gttattcatg aagaataaga agaggcttga taggtacatt tccttttcta
     5041 tggcacaggc atgatgatat tgggtgtgta gggaagaaaa tatcctagct tatactaggc
     5101 tcccagtaag aagtatttaa atagccaaaa taatgtggat atcatttatt agtattcaat
     5161 gttcagatca gcctattaac aaagtgtgaa aggtttcatt ttttattcag aactgaagtt
     5221 gaaagtaatt aatgctgaca aagggaaaga aagcagaaag agattgagaa ttagaggaag
     5281 agaagtggaa tcaaaggtag agatacttat atattcaaag tggggatgaa aagatcttca
     5341 gttaatggaa caagaactag aggattagtg tattgttcaa agctataaaa tcaaaccaat
     5401 agatgtatta aaaagtgatg taactatcag acatttggag agagatggac aaaggaaagt
     5461 ggcgatagtg taagttaaat ccttatcttt tgtaatgggg aattattaaa gatgttgtaa
     5521 agtcagtaag tcaagaaatt attgctcaaa catattattt aaagttagaa agttaccaga
     5581 cgatctaaaa taaatattgt taaaagcatt acctctaggg aatgggattt agatttaaaa
     5641 agggtgggat gggaaactgt gtttttcatt ttaagtcctt ctgtactatt taatttttta
     5701 ccttgtgcat gtattacttt gaaaaaattt ttaataaacc caaataaaaa tctt
//
