LOCUS       NM_001128596            5158 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens tandem C2 domains, nuclear (TC2N), transcript variant
            3, mRNA.
ACCESSION   NM_001128596
VERSION     NM_001128596.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5158)
  AUTHORS   Hao,X.L., Lv,Y.F., Li,D.F., Bai,F.H., Gong,J., Pan,G.Q., Su,L.X.,
            Wang,Y.L., Fu,W.L., Liu,B., Huang,L., Yan,D., Tan,Q.L., Liu,J.Y.
            and Guo,Q.N.
  TITLE     TC2N inhibits distant metastasis and stemness of breast cancer via
            blocking fatty acid synthesis
  JOURNAL   J Transl Med 22 (1), 6 (2024)
   PUBMED   38167440
  REMARK    GeneRIF: TC2N inhibits distant metastasis and stemness of breast
            cancer via blocking fatty acid synthesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5158)
  AUTHORS   Lou,Y.X., Gu,J., Zhu,L., Sun,S.Q., Hao,X.L., Chen,J.P., Han,F.,
            Wang,D.D., Jiang,X. and Liu,J.Y.
  TITLE     TC2N Promotes Cell Proliferation and Metastasis in Hepatocellular
            Carcinoma by Targeting the Wnt/beta-Catenin Signaling Pathway
  JOURNAL   Lab Invest 103 (12), 100260 (2023)
   PUBMED   37839635
  REMARK    GeneRIF: TC2N Promotes Cell Proliferation and Metastasis in
            Hepatocellular Carcinoma by Targeting the Wnt/beta-Catenin
            Signaling Pathway.
REFERENCE   3  (bases 1 to 5158)
  AUTHORS   Li,H., Fang,H., Chang,L., Qiu,S., Ren,X., Cao,L., Bian,J., Wang,Z.,
            Guo,Y., Lv,J., Sun,Z., Wang,T. and Li,B.
  TITLE     TC2N: A Novel Vital Oncogene or Tumor Suppressor Gene In Cancers
  JOURNAL   Front Immunol 12, 764749 (2021)
   PUBMED   34925334
  REMARK    GeneRIF: TC2N: A Novel Vital Oncogene or Tumor Suppressor Gene In
            Cancers.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5158)
  AUTHORS   Hao,X., Gao,L.Y., Zhang,N., Chen,H., Jiang,X., Liu,W., Ao,L.,
            Cao,J., Han,F. and Liu,J.
  TITLE     Tac2-N acts as a novel oncogene and promotes tumor metastasis via
            activation of NF-kappaB signaling in lung cancer
  JOURNAL   J Exp Clin Cancer Res 38 (1), 319 (2019)
   PUBMED   31466523
  REMARK    GeneRIF: Study provided proof of principle to show that Tac2-N
            serves as a novel oncogene gene and plays an important role in the
            progression and metastasis of lung cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5158)
  AUTHORS   Hao,X.L., Han,F., Zhang,N., Chen,H.Q., Jiang,X., Yin,L., Liu,W.B.,
            Wang,D.D., Chen,J.P., Cui,Z.H., Ao,L., Cao,J. and Liu,J.Y.
  TITLE     TC2N, a novel oncogene, accelerates tumor progression by
            suppressing p53 signaling pathway in lung cancer
  JOURNAL   Cell Death Differ 26 (7), 1235-1250 (2019)
   PUBMED   30254375
  REMARK    GeneRIF: The TC2N attenuates p53 signaling pathway through
            inhibiting Cdk5-induced phosphorylation of p53 via inducing Cdk5
            degradation or disrupting the interaction between Cdk5 and p53.
REFERENCE   6  (bases 1 to 5158)
  AUTHORS   Antoni,G., Oudot-Mellakh,T., Dimitromanolakis,A., Germain,M.,
            Cohen,W., Wells,P., Lathrop,M., Gagnon,F., Morange,P.E. and
            Tregouet,D.A.
  TITLE     Combined analysis of three genome-wide association studies on vWF
            and FVIII plasma levels
  JOURNAL   BMC Med Genet 12, 102 (2011)
   PUBMED   21810271
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5158)
  AUTHORS   Morange,P.E., Saut,N., Antoni,G., Emmerich,J. and Tregouet,D.A.
  TITLE     Impact on venous thrombosis risk of newly discovered gene variants
            associated with FVIII and VWF plasma levels
  JOURNAL   J Thromb Haemost 9 (1), 229-231 (2011)
   PUBMED   21029358
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 5158)
  AUTHORS   Fukuda,M. and Mikoshiba,K.
  TITLE     Tac2-N, an atypical C-type tandem C2 protein localized in the
            nucleus
  JOURNAL   FEBS Lett 503 (2-3), 217-218 (2001)
   PUBMED   11526914
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590328.2 and AL121839.3.
            
            On Nov 22, 2018 this sequence version replaced NM_001128596.2.
            
            Transcript Variant: This variant (3) represents use of an alternate
            promoter and differs in the 5' UTR, compared to variant 1. Variants
            1, 2, and 3 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.9007.1, AK093876.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000435962.7/ ENSP00000387882.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-275               AL590328.2         92415-92689
            276-398             AL121839.3         42107-42229
            399-632             AL121839.3         43387-43620
            633-800             AL121839.3         53511-53678
            801-892             AL121839.3         55560-55651
            893-968             AL121839.3         56868-56943
            969-1069            AL121839.3         57533-57633
            1070-1186           AL121839.3         58031-58147
            1187-1378           AL121839.3         63374-63565
            1379-1493           AL121839.3         68305-68419
            1494-1693           AL121839.3         70571-70770
            1694-5158           AL121839.3         72722-76186
FEATURES             Location/Qualifiers
     source          1..5158
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.12"
     gene            1..5158
                     /gene="TC2N"
                     /gene_synonym="C14orf47; C2CD1; MTAC2D1; Tac2-N; TAC2N"
                     /note="tandem C2 domains, nuclear"
                     /db_xref="GeneID:123036"
                     /db_xref="HGNC:HGNC:19859"
                     /db_xref="MIM:619305"
     exon            1..275
                     /gene="TC2N"
                     /gene_synonym="C14orf47; C2CD1; MTAC2D1; Tac2-N; TAC2N"
                     /inference="alignment:Splign:2.1.0"
     exon            276..398
                     /gene="TC2N"
                     /gene_synonym="C14orf47; C2CD1; MTAC2D1; Tac2-N; TAC2N"
                     /inference="alignment:Splign:2.1.0"
     CDS             332..1804
                     /gene="TC2N"
                     /gene_synonym="C14orf47; C2CD1; MTAC2D1; Tac2-N; TAC2N"
                     /note="isoform 1 is encoded by transcript variant 3;
                     membrane targeting (tandem) C2 domain containing 1; C2
                     calcium-dependent domain containing 1; tandem C2 domains
                     nuclear protein; tandem C2 protein in nucleus"
                     /codon_start=1
                     /product="tandem C2 domains nuclear protein isoform 1"
                     /protein_id="NP_001122068.2"
                     /db_xref="CCDS:CCDS9897.1"
                     /db_xref="GeneID:123036"
                     /db_xref="HGNC:HGNC:19859"
                     /db_xref="MIM:619305"
                     /translation="MATEFIKSCCGGCFYGETEKHNFSVERDFKAAVPNSQNATISVP
                     PLTSVSVKPQLGCTEDYLLSKLPSDGKEVPFVVPKFKLSYIQPRTQETPSHLEELEGS
                     ARASFGDRKVELSSSSQHGPSYDVYNPFYMYQHISPDLSRRFPPRSEVKRLYGSVCDL
                     RTNKLPGSPGLSKSMFDLTNSSQRFIQRHDSLSSVPSSSSSRKNSQGSNRSLDTITLS
                     GDERDFGRLNVKLFYNSSVEQIWITVLQCRDLSWPSSYGDTPTVSIKGILTLPKPVHF
                     KSSAKEGSNAIEFMETFVFAIKLQNLQTVRLVFKIQTQTPRKKTIGECSMSLRTLSTQ
                     EMDYSLDITPPSKISVCHAELELGTCFQAVNSRIQLQILEARYLPSSSTPLTLSFFVK
                     VGMFSSGELIYKKKTRLLKASNGRVKWGETMIFPLIQSEKEIVFLIKLYSRSSVRRKH
                     FVGQIWISEDSNNIEAVNQWKETVINPEKVVIRWHKLNPS"
     exon            399..632
                     /gene="TC2N"
                     /gene_synonym="C14orf47; C2CD1; MTAC2D1; Tac2-N; TAC2N"
                     /inference="alignment:Splign:2.1.0"
     exon            633..800
                     /gene="TC2N"
                     /gene_synonym="C14orf47; C2CD1; MTAC2D1; Tac2-N; TAC2N"
                     /inference="alignment:Splign:2.1.0"
     exon            801..892
                     /gene="TC2N"
                     /gene_synonym="C14orf47; C2CD1; MTAC2D1; Tac2-N; TAC2N"
                     /inference="alignment:Splign:2.1.0"
     exon            893..968
                     /gene="TC2N"
                     /gene_synonym="C14orf47; C2CD1; MTAC2D1; Tac2-N; TAC2N"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1069
                     /gene="TC2N"
                     /gene_synonym="C14orf47; C2CD1; MTAC2D1; Tac2-N; TAC2N"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1186
                     /gene="TC2N"
                     /gene_synonym="C14orf47; C2CD1; MTAC2D1; Tac2-N; TAC2N"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1378
                     /gene="TC2N"
                     /gene_synonym="C14orf47; C2CD1; MTAC2D1; Tac2-N; TAC2N"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1493
                     /gene="TC2N"
                     /gene_synonym="C14orf47; C2CD1; MTAC2D1; Tac2-N; TAC2N"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1693
                     /gene="TC2N"
                     /gene_synonym="C14orf47; C2CD1; MTAC2D1; Tac2-N; TAC2N"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..5158
                     /gene="TC2N"
                     /gene_synonym="C14orf47; C2CD1; MTAC2D1; Tac2-N; TAC2N"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2069..2074
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TC2N"
                     /gene_synonym="C14orf47; C2CD1; MTAC2D1; Tac2-N; TAC2N"
                     /note="hexamer: TATAAA"
     polyA_site      2091
                     /gene="TC2N"
                     /gene_synonym="C14orf47; C2CD1; MTAC2D1; Tac2-N; TAC2N"
                     /note="major polyA site"
     regulatory      3690..3695
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TC2N"
                     /gene_synonym="C14orf47; C2CD1; MTAC2D1; Tac2-N; TAC2N"
                     /note="hexamer: AATAAA"
     polyA_site      3726
                     /gene="TC2N"
                     /gene_synonym="C14orf47; C2CD1; MTAC2D1; Tac2-N; TAC2N"
     regulatory      4837..4842
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TC2N"
                     /gene_synonym="C14orf47; C2CD1; MTAC2D1; Tac2-N; TAC2N"
                     /note="hexamer: ATTAAA"
     polyA_site      4857
                     /gene="TC2N"
                     /gene_synonym="C14orf47; C2CD1; MTAC2D1; Tac2-N; TAC2N"
                     /note="major polyA site"
     regulatory      4955..4960
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TC2N"
                     /gene_synonym="C14orf47; C2CD1; MTAC2D1; Tac2-N; TAC2N"
                     /note="hexamer: ATTAAA"
     polyA_site      4982
                     /gene="TC2N"
                     /gene_synonym="C14orf47; C2CD1; MTAC2D1; Tac2-N; TAC2N"
     regulatory      5139..5144
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TC2N"
                     /gene_synonym="C14orf47; C2CD1; MTAC2D1; Tac2-N; TAC2N"
                     /note="hexamer: AATAAT"
     polyA_site      5158
                     /gene="TC2N"
                     /gene_synonym="C14orf47; C2CD1; MTAC2D1; Tac2-N; TAC2N"
ORIGIN      
        1 agtcagggtc aagtggtgtt agcaatcaca tcagcaccaa atggctcagg atgctctggt
       61 ttcaaagctt ataaaacaga gggtgattcc cttgggactc actcagctcg gctccgaaaa
      121 gcaaaggcca gaaggcagca gtgagcctgg gtccctgctg tgtagggaga ctcaggggct
      181 gggaagaagg atggaatcag aaatgctgaa ggtttacgtg agctttgcac cgagcgcctc
      241 cgaaccactg cctctgggct caacagaaca cagggattaa tattaagatt ggaagtttgt
      301 gtcttttgct ggatattgga aattgaatgt aatggcaaca gaatttataa agagttgctg
      361 tggaggatgt ttctatggtg aaacagaaaa acacaacttt tctgtggaaa gagattttaa
      421 agcagcagtc ccaaatagtc aaaatgctac tatctctgta cctccattga cttctgtttc
      481 tgtaaagcct cagcttggct gtactgagga ttatttgctt tccaaattac catctgatgg
      541 caaagaagta ccatttgtgg tgcccaagtt taagttatct tacattcaac ccaggacaca
      601 agaaactcct tcacatctgg aagaacttga aggatctgcc agagcatctt ttggagatcg
      661 aaaggtagaa ctttccagtt catcccagca cggacctagc tatgatgtgt ataacccatt
      721 ctatatgtat cagcacattt cacctgattt gagtcgacgc tttcctcccc gttcagaagt
      781 gaagagactg tatggatcgg tttgtgattt aaggacgaac aaacttcccg gttcccctgg
      841 gctaagcaaa tctatgtttg atcttacaaa ctcatctcag cgattcatcc agagacatga
      901 ttcattgtcc agtgtaccca gtagttcttc ttcaaggaaa aattctcagg ggagtaacag
      961 aagcctggat acaattactc tatcaggaga tgaaagggac tttgggagac tgaatgtgaa
     1021 attgttttat aattcttcag tagaacagat ctggatcaca gttttacagt gcagagattt
     1081 aagttggccc tctagttatg gagacactcc tactgtttct ataaaaggaa tacttacatt
     1141 gcccaaacca gtgcatttca aatcttcagc caaggaaggt tccaacgcta ttgaatttat
     1201 ggaaacgttt gtatttgcta ttaaacttca aaatctacaa actgtaagac ttgtatttaa
     1261 gattcaaacc cagactccca ggaagaaaac cattggagaa tgctcaatgt cactcagaac
     1321 ccttagcaca caggaaatgg attactcttt ggatataaca ccaccttcaa aaatttctgt
     1381 ttgccatgca gaacttgaat tggggacttg ttttcaagca gtaaatagca gaattcagtt
     1441 acaaattctt gaggcacggt accttccaag ctcatcaaca cctctgactt tgagtttttt
     1501 cgtgaaggtg ggaatgttta gctcgggaga gttgatttat aagaaaaaga cacgcttact
     1561 gaaggcctcc aatggaagag tcaagtgggg agagactatg atttttccac ttatacagag
     1621 tgaaaaagaa attgtttttc tcattaagct ttacagtcga agctctgtaa gaagaaaaca
     1681 ctttgtgggc cagatttgga taagtgaaga cagtaataac attgaagcag tgaaccagtg
     1741 gaaagagaca gtaataaatc cagaaaaggt tgttatcagg tggcacaaat taaatccatc
     1801 ttgaagactt cacacattaa tttggtgaag aacttgacat tcttttagaa gacttatgat
     1861 ttcaatttgc taccaatgag aagaggcaaa tcaacaaatt tgtcaattta tgggggctat
     1921 aattatggta tataatgtat ctgatagaaa atttgataag aaaatgtaat gaattttatc
     1981 agatatccaa agtaaaggaa atgttttaaa actgcaacaa gagacacaga cagtaaaatc
     2041 aaagtattat taggatgact aaataaatta taaagtctgt gagaatatca accatagata
     2101 gttctttcta tattatgttt tcgcttttgt attttaagct ttacttagat attcaaaacc
     2161 tggtatatca agtctctgtt agtactattg gcatttagaa gactttacca ttatttcagt
     2221 gctaggcatt attgattagg tcttggctcc actgtttacc tcttgctatg tattttctcc
     2281 cggtaaaaat gaattgaacc atttcaacta ttttctatat ttggagaaag tttgtgccct
     2341 gtgttttata atttttttac ccataagaca tcacattatc cctttgtaag ctacttatct
     2401 ccaaaaaact tcagaaatag aaaactacat tttggcagga ataattgaaa acaccagaag
     2461 gttgaagttt aattggaaac ccagaatata catactttgc tgttttcttc cctcaaatat
     2521 tttactattt gttttatttg gagttaaaat aagagtatca tccatatggt ccatcctaat
     2581 tcacagaatt aaatgagctt aaatagaaaa ttcagtattt tatgataatc acttcgtttt
     2641 tagtttttaa aatttagatt attctataat ttaccgtgtt tgagtatttt ctcatttttt
     2701 tcataaccat acctgattat actgtgtaac aaatattttc tattgcagtt ttctttccag
     2761 tacttattag aactcagtat ttggaaataa tttcagctta attgaccata agaactgtgg
     2821 ccaaaaagaa cagttttttg gagaggcaga tgacattata cctgatttta gaaaatctca
     2881 ctttattttt gctaataagt agactaagtg ctctgtgttc tcagtcttcc ctttttttct
     2941 gcccccattc ttactttgtc ccaggcatgc agagaaagat ggtgatattt taggccagga
     3001 gtataccttg ctataaccta agcatgcctt ctttattcca gctcctatgt tctgtgtata
     3061 tcattaacat tttcccaaat aaacacttaa ttctcttttc cctaggtgcc atctcctcaa
     3121 gctacaaaat gtccacatct tatatcccct ttgcttctac tgctctgatt ttgtggtacc
     3181 agtactctct gccactgaac attttgaaat atttttgttt tagatttgca aaaaatgaca
     3241 tataggtcag tactcacatg gatttttaag ataaatcacc tgtgtgataa tattttgaat
     3301 ctgagacgaa tacaactttt aaaaattgtt tttaaaaata gacttttttt tttagagcag
     3361 ttgtaggtta acagaaaaat tgagaggaag atagagattt cctttctccc ctgacaaagc
     3421 cctcaacagc ctcccaggct atcagtatcc tgcaccacaa tggtacattt gttacaatca
     3481 atgaacctac tctgaaacat cattatcatc caaagttcat ggtttacatt agagtcccct
     3541 cttggtgtta tacatgctag aggacaaata tatgatgata tgtatgcatc attataatat
     3601 agtatagttt cgctgcccta aacatcctct gcaaatgcaa ctattttaat gggtaccaaa
     3661 gaagtaaatg tatttactgg cttttagata ataaataacg ggctttattg tttattttaa
     3721 aagctacaat ttgttttagc tggtttctct gttctattaa tgctttgaat ttccaaattt
     3781 aatatatgta gtcatgcatt taacttaata tttaattatt tgatttattt aattttctat
     3841 attcttacaa tgtatgtatg atgtataatt taagggaaag ctatgacttc tcagtttctt
     3901 agaatcctag gtaaataaaa caataaaaag aaaaccctta catttaaaag agctttcagg
     3961 tacagaagta ttgatacaac taagatccta aatgttttaa ttagtgttta cttaagcctt
     4021 tttcaggtga ggaggtacta atgctggtta tttccttgaa gctttatgtg gacctataaa
     4081 taaaaatcca atctcctgct aataggtatg catattgtga gaaaaacgtt aggagctggt
     4141 agtaaaaaat gagattctat gccaaaataa cttctcttca tatttgccta ggcatttctt
     4201 gacctttacc cacttacgca aggagaagga aatcataatg atgtcatgtg atcaaaggaa
     4261 accatggaag ggttcacgct gatagctgat agcttttaca gtgctcattc ctaacagtgg
     4321 atttacttgt aagctttcag atcaacacaa atagctgcag cctgggttaa aatataacat
     4381 cactatttgg cttttgtttt gcatgatttt taaaagcagt actcctaggg aaatggcctc
     4441 tgaagtatat cagtttcatc tcttaccaag actgttaaga agaaactagt gggattttga
     4501 acaagttata taattgtggt ctgaaaagac cctaaactga agttctgttt aaatatagtt
     4561 acatgaattt ctctgatact aatgtactca acagccaggt ataaactata tctcctagta
     4621 acattttcca tttttgttta atcaaatact tgcttatgaa ggatttcaga aatttgtaat
     4681 aaatgtcagc ttttgatagc atagcagtaa ttgacatttc aaaaatatat atttctttct
     4741 gtgtttggtt gggtgtaatg aggaaaatac ctgataaaat gtctgaagac actttctaat
     4801 gttatcttgg tgcataagct gtaattttta ttcaaaatta aatttcaaat gtttgcagtt
     4861 ttggctaaaa cattgagttg aaagaattat gaaaagtggg cccatatgaa gtaccatgtt
     4921 cattttgaaa tatagattta agatttagaa atatattaaa agagttaatg gagcctccta
     4981 aattggattt tattttgtgg gtgaagaatt gtaggaagat gaatgtggcc tacagtttta
     5041 gtaatctcct agtggagttt tttttaactt agtacttttt tagttttaag ttttttaatc
     5101 tataaaaaat gtgatttcta taaaccatga ttacaataaa taattatatt aaactgta
//
