LOCUS       NM_001060               2642 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens thromboxane A2 receptor (TBXA2R), transcript variant
            a, mRNA.
ACCESSION   NM_001060
VERSION     NM_001060.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2642)
  AUTHORS   Ganai,I., Saha,I., Banerjee,P., Laha,A., Sultana,S., Sultana,N.,
            Biswas,H., Moitra,S. and Podder,S.
  TITLE     In silico analysis of single nucleotide polymorphism (rs34377097)
            of TBXA2R gene and pollen induced bronchial asthma susceptibility
            in West Bengal population, India
  JOURNAL   Front Immunol 14, 1089514 (2023)
   PUBMED   36936944
  REMARK    GeneRIF: In silico analysis of single nucleotide polymorphism
            (rs34377097) of TBXA2R gene and pollen induced bronchial asthma
            susceptibility in West Bengal population, India.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2642)
  AUTHORS   Eckenstaler,R., Ripperger,A., Hauke,M., Braun,H., Ergun,S.,
            Schwedhelm,E. and Benndorf,R.A.
  TITLE     Thromboxane A2 receptor activation via
            Galpha13-RhoA/C-ROCK-LIMK2-dependent signal transduction inhibits
            angiogenic sprouting of human endothelial cells
  JOURNAL   Biochem Pharmacol 201, 115069 (2022)
   PUBMED   35525325
  REMARK    GeneRIF: Thromboxane A2 receptor activation via
            Galpha13-RhoA/C-ROCK-LIMK2-dependent signal transduction inhibits
            angiogenic sprouting of human endothelial cells.
REFERENCE   3  (bases 1 to 2642)
  AUTHORS   Liang,X., Zhou,Y. and Li,S.
  TITLE     Association of TBXA2R, P2Y12 and ADD1 genes polymorphisms with
            ischemic stroke susceptibility: A metaanalysis
  JOURNAL   Clin Invest Med 43 (3), E33-E43 (2020)
   PUBMED   32971583
  REMARK    GeneRIF: Association of TBXA2R, P2Y12 and ADD1 genes polymorphisms
            with ischemic stroke susceptibility: A metaanalysis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2642)
  AUTHORS   Coyle,A.T., Miggin,S.M. and Kinsella,B.T.
  TITLE     Characterization of the 5' untranslated region of alpha and beta
            isoforms of the human thromboxane A2 receptor (TP). Differential
            promoter utilization by the TP isoforms
  JOURNAL   Eur J Biochem 269 (16), 4058-4073 (2002)
   PUBMED   12180983
  REMARK    GeneRIF: The role of TXA2R 5' UTR in differential isoform
            expression was studied. Exons E1 & E1b associated with TXA2R
            transcript(s), but their expression was mutually exclusive. Major
            transcription initiation sites were between -115 & -92 in E1 & at
            -99 in E1b.
REFERENCE   5  (bases 1 to 2642)
  AUTHORS   Saffak,T. and Nusing,R.M.
  TITLE     The 5' region of the human thromboxane A(2) receptor gene
  JOURNAL   Prostaglandins Leukot Essent Fatty Acids 67 (1), 25-31 (2002)
   PUBMED   12213432
  REMARK    GeneRIF: Transcriptional activity of the 5'flanking region
REFERENCE   6  (bases 1 to 2642)
  AUTHORS   Hirata,T., Ushikubi,F., Kakizuka,A., Okuma,M. and Narumiya,S.
  TITLE     Two thromboxane A2 receptor isoforms in human platelets. Opposite
            coupling to adenylyl cyclase with different sensitivity to Arg60 to
            Leu mutation
  JOURNAL   J Clin Invest 97 (4), 949-956 (1996)
   PUBMED   8613548
REFERENCE   7  (bases 1 to 2642)
  AUTHORS   Raychowdhury,M.K., Yukawa,M., Collins,L.J., McGrail,S.H., Kent,K.C.
            and Ware,J.A.
  TITLE     Alternative splicing produces a divergent cytoplasmic tail in the
            human endothelial thromboxane A2 receptor
  JOURNAL   J Biol Chem 270 (12), 7011 (1995)
   PUBMED   7896853
  REMARK    Correction to:[J Biol Chem. 1994 Jul 29;269(30):19256-61.. PMID:
            8034687]
REFERENCE   8  (bases 1 to 2642)
  AUTHORS   Hirata,T., Kakizuka,A., Ushikubi,F., Fuse,I., Okuma,M. and
            Narumiya,S.
  TITLE     Arg60 to Leu mutation of the human thromboxane A2 receptor in a
            dominantly inherited bleeding disorder
  JOURNAL   J Clin Invest 94 (4), 1662-1667 (1994)
   PUBMED   7929844
REFERENCE   9  (bases 1 to 2642)
  AUTHORS   Nusing,R.M., Hirata,M., Kakizuka,A., Eki,T., Ozawa,K. and
            Narumiya,S.
  TITLE     Characterization and chromosomal mapping of the human thromboxane
            A2 receptor gene
  JOURNAL   J Biol Chem 268 (33), 25253-25259 (1993)
   PUBMED   8227091
REFERENCE   10 (bases 1 to 2642)
  AUTHORS   Hirata,M., Hayashi,Y., Ushikubi,F., Yokota,Y., Kageyama,R.,
            Nakanishi,S. and Narumiya,S.
  TITLE     Cloning and expression of cDNA for a human thromboxane A2 receptor
  JOURNAL   Nature 349 (6310), 617-620 (1991)
   PUBMED   1825698
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005175.1, BC028027.1,
            AY429110.1, BC121148.1 and BM990145.1.
            
            On Aug 31, 2019 this sequence version replaced NM_001060.5.
            
            Summary: This gene encodes a member of the G protein-coupled
            receptor family. The protein interacts with thromboxane A2 to
            induce platelet aggregation and regulate hemostasis. A mutation in
            this gene results in a bleeding disorder. Multiple transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (a) represents the longer
            transcript but encodes the shorter isoform (alpha).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.29402.1,
                                           SRR18074969.791827.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375190.10/ ENSP00000364336.4
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AC005175.1         23180-23221         c
            43-429              BC028027.1         1-387
            430-1461            AY429110.1         1-1032
            1462-2070           BC121148.1         678-1286
            2071-2597           BC121148.1         1288-1814
            2598-2642           BM990145.1         20-64               c
FEATURES             Location/Qualifiers
     source          1..2642
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2642
                     /gene="TBXA2R"
                     /gene_synonym="BDPLT13; TXA2-R"
                     /note="thromboxane A2 receptor"
                     /db_xref="GeneID:6915"
                     /db_xref="HGNC:HGNC:11608"
                     /db_xref="MIM:188070"
     exon            1..346
                     /gene="TBXA2R"
                     /gene_synonym="BDPLT13; TXA2-R"
                     /inference="alignment:Splign:2.1.0"
     exon            347..1215
                     /gene="TBXA2R"
                     /gene_synonym="BDPLT13; TXA2-R"
                     /inference="alignment:Splign:2.1.0"
     CDS             430..1461
                     /gene="TBXA2R"
                     /gene_synonym="BDPLT13; TXA2-R"
                     /note="isoform alpha is encoded by transcript variant a;
                     prostanoid TP receptor"
                     /codon_start=1
                     /product="thromboxane A2 receptor isoform alpha"
                     /protein_id="NP_001051.1"
                     /db_xref="CCDS:CCDS42467.1"
                     /db_xref="GeneID:6915"
                     /db_xref="HGNC:HGNC:11608"
                     /db_xref="MIM:188070"
                     /translation="MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLL
                     ALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGC
                     RLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAA
                     LALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVS
                     VATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAM
                     SPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQP
                     QLTQRSGLQ"
     exon            1216..2642
                     /gene="TBXA2R"
                     /gene_synonym="BDPLT13; TXA2-R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2346..2351
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBXA2R"
                     /gene_synonym="BDPLT13; TXA2-R"
                     /note="hexamer: AATATA"
     polyA_site      2369
                     /gene="TBXA2R"
                     /gene_synonym="BDPLT13; TXA2-R"
                     /note="major polyA site"
     regulatory      2621..2626
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBXA2R"
                     /gene_synonym="BDPLT13; TXA2-R"
                     /note="hexamer: ATTAAA"
     polyA_site      2642
                     /gene="TBXA2R"
                     /gene_synonym="BDPLT13; TXA2-R"
ORIGIN      
        1 agagactgga cggagagagc gagccgcggg ctgccagcgg cccccacccg tcccagctcg
       61 gcttagcccc cgcggacccc tccaggccgc gaccccaggg cgtcctgtgc cgccacgccc
      121 tccatctgtg tgggtcctct gctgggcccg cccctggtca cagccagact gactcagttt
      181 ccctgggagg tcccgctcga gcccgtcctt cccctccctc tgcccgcccc cagccctcgc
      241 cccaccctcg gcgcccgcac atctgcctgc tcagctccag acggcgcccg gacccccggg
      301 cgcgggatcc agccaggtgg gagccccgca gatgaggtct ctgaaggtgt gcctgaacca
      361 gtgccagcct gccctgtctg cagcatcggc ctgatggggt ggtgactgat ccctcagggc
      421 tccggagcca tgtggcccaa cggcagttcc ctggggccct gtttccggcc cacaaacatt
      481 accctggagg agagacggct gatcgcctcg ccctggttcg ccgcctcctt ctgcgtggtg
      541 ggcctggcct ccaacctgct ggccctgagc gtgctggcgg gcgcgcggca ggggggttcg
      601 cacacgcgct cctccttcct caccttcctc tgcggcctcg tcctcaccga cttcctgggg
      661 ctgctggtga ccggtaccat cgtggtgtcc cagcacgccg cgctcttcga gtggcacgcc
      721 gtggaccctg gctgccgtct ctgtcgcttc atgggcgtcg tcatgatctt cttcggcctg
      781 tccccgctgc tgctgggggc cgccatggcc tcagagcgct acctgggtat cacccggccc
      841 ttctcgcgcc cggcggtcgc ctcgcagcgc cgcgcctggg ccaccgtggg gctggtgtgg
      901 gcggccgcgc tggcgctggg cctgctgccc ctgctgggcg tgggtcgcta caccgtgcaa
      961 tacccggggt cctggtgctt cctgacgctg ggcgccgagt ccggggacgt ggccttcggg
     1021 ctgctcttct ccatgctggg cggcctctcg gtcgggctgt ccttcctgct gaacacggtc
     1081 agcgtggcca ccctgtgcca cgtctaccac gggcaggagg cggcccagca gcgtccccgg
     1141 gactccgagg tggagatgat ggctcagctc ctggggatca tggtggtggc cagcgtgtgt
     1201 tggctgcccc ttctggtctt catcgcccag acagtgctgc gaaacccgcc tgccatgagc
     1261 cccgccgggc agctgtcccg caccacggag aaggagctgc tcatctactt gcgcgtggcc
     1321 acctggaacc agatcctgga cccctgggtg tatatcctgt tccgccgcgc cgtgctccgg
     1381 cgtctccagc ctcgcctcag cacccggccc aggtcgctgt ccctccagcc ccagctcacg
     1441 cagcgctccg ggctgcagta ggaagtggac agagcgcccc tcccgcgcct ttccgcggag
     1501 cccttggccc ctcggacagc ccatctgcct gttctgagga ttcaggggct gggggtgctg
     1561 gatggacagt gggcatcagc agcagggttt tgggttgacc ccaatccaac ccggggaccc
     1621 ccaactcctc cctgatcctt ttaccaagca ctctcccttc ctcggcccct ttttcccatc
     1681 cagagctccc accccttctc tgcgtccctc ccaaccccag gaagggcatg cagacattgg
     1741 aagagggtct tgcattgcta tttttttttt tagacggagt cttgctctgt cccccaggct
     1801 ggagtgcagt ggcgcaatct cagctcactg caacctccac ctcccgggtt caagcgattc
     1861 tcctgcctca gcctcctgag tagctgggac tataggcgcg cgccaccacg cccggctaat
     1921 ttttgtattt ttagtagaga cggggtttca ccgtgttggc caggctggtc ttgaactcct
     1981 gacctcaggt gattcaccag cctcagcctc ccaaagtgct gggatcacag gcatgaacca
     2041 ccacacctgg ccattttttt tttttttttt agacggagtc tcactctgtg gcccagcctg
     2101 gagtacagtg gcacgatctc ggctcactgc aacctccgcc tcccgggttc aagcgattct
     2161 cgtgcctcag cctcccgagc agctgggatt acaggcgtaa gccactgcgc ccggccttgc
     2221 atgctctttg accctgaatt tgacctactt gctggggtac agttgcttcc ttttgaacct
     2281 ccaacaggga aggctctgtc cagaaaggat tgaatgtgaa cgggggcacc cccttttctt
     2341 gccaaaatat atctctgcct ttggttttat tttcctttgg gtccagaagt tttcaatctc
     2401 tggagtttgt gcattgggcc tcacccggag cagacgaggg cagggctggg aaggatgggg
     2461 agggacatag aggattcggt tcctccccca ccttgtttct tgagtgtttc ctaatcactt
     2521 gatgggtggt accacctaga attcttccag cagcctgtaa tgggagggct acaggttagc
     2581 cctggaacct gcaatcaaac cacctttgaa tctgtgtgtc attaaaagta gatataaatg
     2641 gg
//
