LOCUS       NM_013351               2583 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens T-box transcription factor 21 (TBX21), mRNA.
ACCESSION   NM_013351
VERSION     NM_013351.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2583)
  AUTHORS   Li,L., Shan,J., Fang,H., An,G., Zhang,M., Zhou,P., Xie,K., Jin,B.,
            Zhu,H., Jin,X., Yang,P. and Du,L.
  TITLE     Correlation of TBX21 gene polymorphisms with ankylosing spondylitis
            in a Chinese population
  JOURNAL   Int J Immunogenet 51 (3), 143-148 (2024)
   PUBMED   38468428
  REMARK    GeneRIF: Correlation of TBX21 gene polymorphisms with ankylosing
            spondylitis in a Chinese population.
REFERENCE   2  (bases 1 to 2583)
  AUTHORS   Rodrigues,R.R., Freitas,V.S., Alves,P.M., Almeida Freitas,R.,
            Souza,L.B. and Andrade Santos,P.P.
  TITLE     Evaluation of the presence of Th1 response through T-bet and
            IFN-gamma immunohistochemical expression in lower lip and oral
            tongue squamous cell carcinomas
  JOURNAL   Pathol Res Pract 253, 155010 (2024)
   PUBMED   38101155
  REMARK    GeneRIF: Evaluation of the presence of Th1 response through T-bet
            and IFN-gamma immunohistochemical expression in lower lip and oral
            tongue squamous cell carcinomas.
REFERENCE   3  (bases 1 to 2583)
  AUTHORS   Jiang,X., Du,W., Yang,C., Wang,S., Li,Y., Shen,X., Yang,X., Yao,J.,
            Du,R., Zhang,X., Huang,Y. and Shen,W.
  TITLE     TBX21 attenuates colorectal cancer progression via an
            ARHGAP29/RSK/GSK3beta dependent manner
  JOURNAL   Cell Oncol (Dordr) 46 (5), 1269-1283 (2023)
   PUBMED   37067748
  REMARK    GeneRIF: TBX21 attenuates colorectal cancer progression via an
            ARHGAP29/RSK/GSK3beta dependent manner.
REFERENCE   4  (bases 1 to 2583)
  AUTHORS   Wong,P., Foltz,J.A., Chang,L., Neal,C.C., Yao,T., Cubitt,C.C.,
            Tran,J., Kersting-Schadek,S., Palakurty,S., Jaeger,N.,
            Russler-Germain,D.A., Marin,N.D., Gang,M., Wagner,J.A., Zhou,A.Y.,
            Jacobs,M.T., Foster,M., Schappe,T., Marsala,L., McClain,E.,
            Pence,P., Becker-Hapak,M., Fisk,B., Petti,A.A., Griffith,O.L.,
            Griffith,M., Berrien-Elliott,M.M. and Fehniger,T.A.
  TITLE     T-BET and EOMES sustain mature human NK cell identity and antitumor
            function
  JOURNAL   J Clin Invest 133 (13), e162530 (2023)
   PUBMED   37279078
  REMARK    GeneRIF: T-BET and EOMES sustain mature human NK cell identity and
            antitumor function.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2583)
  AUTHORS   Ganjali,F., Asri,N., Rostami-Nejad,M., Hashemi,M., Ainy,E.,
            Masotti,A. and Asadzadeh Aghdaei,H.
  TITLE     Expression analysis of IL-2, TBX21 and SOCS1 in peripheral blood
            cells of celiac disease patients reveals the diagnostic potential
            of IL-2
  JOURNAL   Mol Biol Rep 50 (6), 4841-4849 (2023)
   PUBMED   37039998
  REMARK    GeneRIF: Expression analysis of IL-2, TBX21 and SOCS1 in peripheral
            blood cells of celiac disease patients reveals the diagnostic
            potential of IL-2.
REFERENCE   6  (bases 1 to 2583)
  AUTHORS   Yu,H.R., Chang,J.C., Chen,R.F., Chuang,H., Hong,K.C., Wang,L. and
            Yang,K.D.
  TITLE     Different antigens trigger different Th1/Th2 reactions in neonatal
            mononuclear cells (MNCs) relating to T-bet/GATA-3 expression
  JOURNAL   J Leukoc Biol 74 (5), 952-958 (2003)
   PUBMED   12960249
  REMARK    GeneRIF: VZV virus and mite antigens induce expression of this
            transcriptionn factor in cord blood mononuclear cells,
            differenetially affecting Th1 and Th2 cells.
REFERENCE   7  (bases 1 to 2583)
  AUTHORS   Chung,H.T., Kim,L.H., Park,B.L., Lee,J.H., Park,H.S., Choi,B.W.,
            Hong,S.J., Chae,S.C., Kim,J.J., Park,C.S. and Shin,H.D.
  TITLE     Association analysis of novel TBX21 variants with asthma phenotypes
  JOURNAL   Hum Mutat 22 (3), 257 (2003)
   PUBMED   12938094
  REMARK    GeneRIF: Among twenty-three novel polymorphisms identified in the
            human TBX21 gene of Korean asthma patients, no significant
            associations of TBX21 variants with risk of asthma were observed.
            GeneRIF: Observational study of genotype prevalence and
            gene-disease association. (HuGE Navigator)
REFERENCE   8  (bases 1 to 2583)
  AUTHORS   Faedo,A., Ficara,F., Ghiani,M., Aiuti,A., Rubenstein,J.L. and
            Bulfone,A.
  TITLE     Developmental expression of the T-box transcription factor
            T-bet/Tbx21 during mouse embryogenesis
  JOURNAL   Mech Dev 116 (1-2), 157-160 (2002)
   PUBMED   12128215
  REMARK    GeneRIF: distribution of T-BET/TBX21 expression in the
            haematopoietic compartment
REFERENCE   9  (bases 1 to 2583)
  AUTHORS   Zhang,W.X. and Yang,S.Y.
  TITLE     Cloning and characterization of a new member of the T-box gene
            family
  JOURNAL   Genomics 70 (1), 41-48 (2000)
   PUBMED   11087660
REFERENCE   10 (bases 1 to 2583)
  AUTHORS   Szabo,S.J., Kim,S.T., Costa,G.L., Zhang,X., Fathman,C.G. and
            Glimcher,L.H.
  TITLE     A novel transcription factor, T-bet, directs Th1 lineage commitment
  JOURNAL   Cell 100 (6), 655-669 (2000)
   PUBMED   10761931
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC015674.12 and AF093098.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_013351.1.
            
            Summary: This gene is a member of a phylogenetically conserved
            family of genes that share a common DNA-binding domain, the T-box.
            T-box genes encode transcription factors involved in the regulation
            of developmental processes. This gene is the human ortholog of
            mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is
            a Th1 cell-specific transcription factor that controls the
            expression of the hallmark Th1 cytokine, interferon-gamma (IFNG).
            Expression of the human ortholog also correlates with IFNG
            expression in Th1 and natural killer cells, suggesting a role for
            this gene in initiating Th1 lineage development from naive Th
            precursor cells. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF093098.1, BC039739.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000177694.2/ ENSP00000177694.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AC015674.12        63745-63752         c
            9-2580              AF093098.1         1-2572
            2581-2583           AC015674.12        50866-50868         c
FEATURES             Location/Qualifiers
     source          1..2583
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.32"
     gene            1..2583
                     /gene="TBX21"
                     /gene_synonym="IMD88; T-bet; T-PET; TBET; TBLYM"
                     /note="T-box transcription factor 21"
                     /db_xref="GeneID:30009"
                     /db_xref="HGNC:HGNC:11599"
                     /db_xref="MIM:604895"
     exon            1..710
                     /gene="TBX21"
                     /gene_synonym="IMD88; T-bet; T-PET; TBET; TBLYM"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..1827
                     /gene="TBX21"
                     /gene_synonym="IMD88; T-bet; T-PET; TBET; TBLYM"
                     /note="T-box expressed in T cells; T-box protein 21;
                     transcription factor TBLYM; T-cell-specific T-box
                     transcription factor T-bet; T-box 21; T-box transcription
                     factor expressed in T cells"
                     /codon_start=1
                     /product="T-box transcription factor TBX21"
                     /protein_id="NP_037483.1"
                     /db_xref="CCDS:CCDS11514.1"
                     /db_xref="GeneID:30009"
                     /db_xref="HGNC:HGNC:11599"
                     /db_xref="MIM:604895"
                     /translation="MGIVEPGCGDMLTGTEPMPGSDEGRAPGADPQHRYFYPEPGAQD
                     ADERRGGGSLGSPYPGGALVPAPPSRFLGAYAYPPRPQAAGFPGAGESFPPPADAEGY
                     QPGEGYAAPDPRAGLYPGPREDYALPAGLEVSGKLRVALNNHLLWSKFNQHQTEMIIT
                     KQGRRMFPFLSFTVAGLEPTSHYRMFVDVVLVDQHHWRYQSGKWVQCGKAEGSMPGNR
                     LYVHPDSPNTGAHWMRQEVSFGKLKLTNNKGASNNVTQMIVLQSLHKYQPRLHIVEVN
                     DGEPEAACNASNTHIFTFQETQFIAVTAYQNAEITQLKIDNNPFAKGFRENFESMYTS
                     VDTSIPSPPGPNCQFLGGDHYSPLLPNQYPVPSRFYPDLPGQAKDVVPQAYWLGAPRD
                     HSYEAEFRAVSMKPAFLPSAPGPTMSYYRGQEVLAPGAGWPVAPQYPPKMGPASWFRP
                     MRTLPMEPGPGGSEGRGPEDQGPPLVWTEIAPIRPESSDSGLGEGDSKRRRVSPYPSS
                     GDSSSPAGAPSPFDKEAEGQFYNYFPN"
     exon            711..865
                     /gene="TBX21"
                     /gene_synonym="IMD88; T-bet; T-PET; TBET; TBLYM"
                     /inference="alignment:Splign:2.1.0"
     exon            866..987
                     /gene="TBX21"
                     /gene_synonym="IMD88; T-bet; T-PET; TBET; TBLYM"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1146
                     /gene="TBX21"
                     /gene_synonym="IMD88; T-bet; T-PET; TBET; TBLYM"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1208
                     /gene="TBX21"
                     /gene_synonym="IMD88; T-bet; T-PET; TBET; TBLYM"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..2583
                     /gene="TBX21"
                     /gene_synonym="IMD88; T-bet; T-PET; TBET; TBLYM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2563..2568
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBX21"
                     /gene_synonym="IMD88; T-bet; T-PET; TBET; TBLYM"
                     /note="hexamer: AATAAA"
     polyA_site      2583
                     /gene="TBX21"
                     /gene_synonym="IMD88; T-bet; T-PET; TBET; TBLYM"
                     /note="major polyA site"
ORIGIN      
        1 agtgacagcg gcccgctgga gaggaagccc gagagctgcc gcgcgcctgc cggacgaggg
       61 cgtagaagcc aggcgtcaga gcccgggctc cggtggggtc ccccacccgg ccctcgggtc
      121 ccccgccccc tgctccctgc ccatcccagc ccacgcgacc ctctcgcgcg cggaggggcg
      181 ggtcctcgac ggctacggga aggtgccagc ccgccccgga tgggcatcgt ggagccgggt
      241 tgcggagaca tgctgacggg caccgagccg atgccgggga gcgacgaggg ccgggcgcct
      301 ggcgccgacc cgcagcaccg ctacttctac ccggagccgg gcgcgcagga cgcggacgag
      361 cgtcgcgggg gcggcagcct ggggtctccc tacccggggg gcgccttggt gcccgccccg
      421 ccgagccgct tccttggagc ctacgcctac ccgccgcgac cccaggcggc cggcttcccc
      481 ggcgcgggcg agtccttccc gccgcccgcg gacgccgagg gctaccagcc gggcgagggc
      541 tacgccgccc cggacccgcg cgccgggctc tacccggggc cgcgtgagga ctacgcgcta
      601 cccgcgggac tggaggtgtc ggggaaactg agggtcgcgc tcaacaacca cctgttgtgg
      661 tccaagttta atcagcacca gacagagatg atcatcacca agcagggacg gcggatgttc
      721 ccattcctgt catttactgt ggccgggctg gagcccacca gccactacag gatgtttgtg
      781 gacgtggtct tggtggacca gcaccactgg cggtaccaga gcggcaagtg ggtgcagtgt
      841 ggaaaggccg agggcagcat gccaggaaac cgcctgtacg tccacccgga ctcccccaac
      901 acaggagcgc actggatgcg ccaggaagtt tcatttggga aactaaagct cacaaacaac
      961 aagggggcgt ccaacaatgt gacccagatg attgtgctcc agtccctcca taagtaccag
     1021 ccccggctgc atatcgttga ggtgaacgac ggagagccag aggcagcctg caacgcttcc
     1081 aacacgcata tctttacttt ccaagaaacc cagttcattg ccgtgactgc ctaccagaat
     1141 gccgagatta ctcagctgaa aattgataat aacccctttg ccaaaggatt ccgggagaac
     1201 tttgagtcca tgtacacatc tgttgacacc agcatcccct ccccgcctgg acccaactgt
     1261 caattccttg ggggagatca ctactctcct ctcctaccca accagtatcc tgttcccagc
     1321 cgcttctacc ccgaccttcc tggccaggcg aaggatgtgg ttccccaggc ttactggctg
     1381 ggggcccccc gggaccacag ctatgaggct gagtttcgag cagtcagcat gaagcctgca
     1441 ttcttgccct ctgcccctgg gcccaccatg tcctactacc gaggccagga ggtcctggca
     1501 cctggagctg gctggcctgt ggcaccccag taccctccca agatgggccc ggccagctgg
     1561 ttccgcccta tgcggactct gcccatggaa cccggccctg gaggctcaga gggacgggga
     1621 ccagaggacc agggtccccc cttggtgtgg actgagattg cccccatccg gccggaatcc
     1681 agtgattcag gactgggcga aggagactct aagaggaggc gcgtgtcccc ctatccttcc
     1741 agtggtgaca gctcctcccc tgctggggcc ccttctcctt ttgataagga agctgaagga
     1801 cagttttata actattttcc caactgagca gatgacatga tgaaaggaac agaaacagtg
     1861 ttattaggtt ggaggacacc gactaatttg ggaaacggat gaaggactga gaaggccccc
     1921 gctccctctg gcccttctct gtttagtagt tggttgggga agtggggctc aagaaggatt
     1981 ttggggttca ccagatgctt cctggcccac gatgaaacct gagaggggtg tccccttgcc
     2041 ccatcctctg ccctaactac agtcgtttac ctggtgctgc gtcttgcttt tggtttccag
     2101 ctggagaaaa gaagacaaga aagtcttggg catgaaggag ctttttgcat ctagtgggtg
     2161 ggaggggtca ggtgtgggac atgggagcag gagactccac tttcttcctt tgtacagtaa
     2221 ctttcaacct tttcgttggc atgtgtgtta atccctgatc caaaaagaac aaatacacgt
     2281 atgttataac catcagcccg ccagggtcag ggaaaggact cacctgactt tggacagctg
     2341 gcctgggctc cccctgctca aacacagtgg ggatcagaga aaaggggctg gaaagggggg
     2401 aatggcccac atctcaagaa gcaagatatt gtttgtggtg gttgtgtgtg ggtgtgtgtt
     2461 ttttcttttt ctttcttttt attttttttg aatgggggag gctatttatt gtactgagag
     2521 tggtgtctgg atatattcct tttgtcttca tcactttctg aaaataaaca taaaactgtt
     2581 gaa
//
