LOCUS       NM_005994               3433 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens T-box transcription factor 2 (TBX2), mRNA.
ACCESSION   NM_005994
VERSION     NM_005994.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3433)
  AUTHORS   Wang,X., Li,Z. and Sun,Y.
  TITLE     T-box transcription factor 2 mediates antitumor immune response in
            cutaneous squamous cell carcinoma by regulating the expression of
            programmed death ligand 1
  JOURNAL   Skin Res Technol 29 (1), e13254 (2023)
   PUBMED   36478592
  REMARK    GeneRIF: T-box transcription factor 2 mediates antitumor immune
            response in cutaneous squamous cell carcinoma by regulating the
            expression of programmed death ligand 1.
REFERENCE   2  (bases 1 to 3433)
  AUTHORS   Zhou,R., Liang,J., Chen,Q., Tian,H., Yang,C. and Liu,C.
  TITLE     A 3-Gene Random Forest Model to Diagnose Non-obstructive
            Azoospermia Based on Transcription Factor-Related Henes
  JOURNAL   Reprod Sci 30 (1), 233-246 (2023)
   PUBMED   35715550
  REMARK    GeneRIF: A 3-Gene Random Forest Model to Diagnose Non-obstructive
            Azoospermia Based on Transcription Factor-Related Henes.
REFERENCE   3  (bases 1 to 3433)
  AUTHORS   Golovchenko,O.V., Abramova,M.Y., Orlova,V.S., Batlutskaya,I.V. and
            Sorokina,I.N.
  TITLE     Clinical and Genetic Characteristics of Preeclampsia
  JOURNAL   Arch Razi Inst 77 (1), 293-299 (2022)
   PUBMED   35891763
  REMARK    GeneRIF: Clinical and Genetic Characteristics of Preeclampsia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3433)
  AUTHORS   Ding,N., Zhang,T., Yu,X. and Zhuang,S.
  TITLE     T-Box Transcription Factor 2 Enhances Chemoresistance of
            Endometrial Cancer by Mediating NRF2 Expression
  JOURNAL   Curr Protein Pept Sci 23 (8), 563-570 (2022)
   PUBMED   36017860
  REMARK    GeneRIF: T-Box Transcription Factor 2 Enhances Chemoresistance of
            Endometrial Cancer by Mediating NRF2 Expression.
REFERENCE   5  (bases 1 to 3433)
  AUTHORS   Fernando,F., Veenboer,G.J.M., Oudijk,M.A., Kampman,M.A.M.,
            Heida,K.Y., Lagendijk,L.J.M., van der Post,J.A.M., Jongejan,A.,
            Afink,G.B. and Ris-Stalpers,C.
  TITLE     TBX2, a Novel Regulator of Labour
  JOURNAL   Medicina (Kaunas) 57 (6), 515 (2021)
   PUBMED   34064060
  REMARK    GeneRIF: TBX2, a Novel Regulator of Labour.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3433)
  AUTHORS   He,Ml., Wen,L., Campbell,C.E., Wu,J.Y. and Rao,Y.
  TITLE     Transcription repression by Xenopus ET and its human ortholog TBX3,
            a gene involved in ulnar-mammary syndrome
  JOURNAL   Proc Natl Acad Sci U S A 96 (18), 10212-10217 (1999)
   PUBMED   10468588
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1999 Nov 9;96(23):13589]
REFERENCE   7  (bases 1 to 3433)
  AUTHORS   Carreira,S., Dexter,T.J., Yavuzer,U., Easty,D.J. and Goding,C.R.
  TITLE     Brachyury-related transcription factor Tbx2 and repression of the
            melanocyte-specific TRP-1 promoter
  JOURNAL   Mol Cell Biol 18 (9), 5099-5108 (1998)
   PUBMED   9710594
REFERENCE   8  (bases 1 to 3433)
  AUTHORS   Campbell,C.E., Casey,G. and Goodrich,K.
  TITLE     Genomic structure of TBX2 indicates conservation with distantly
            related T-box genes
  JOURNAL   Mamm Genome 9 (1), 70-73 (1998)
   PUBMED   9434949
REFERENCE   9  (bases 1 to 3433)
  AUTHORS   Law,D.J., Gebuhr,T., Garvey,N., Agulnik,S.I. and Silver,L.M.
  TITLE     Identification, characterization, and localization to chromosome
            17q21-22 of the human TBX2 homolog, member of a conserved
            developmental gene family
  JOURNAL   Mamm Genome 6 (11), 793-797 (1995)
   PUBMED   8597636
REFERENCE   10 (bases 1 to 3433)
  AUTHORS   Campbell,C., Goodrich,K., Casey,G. and Beatty,B.
  TITLE     Cloning and mapping of a human gene (TBX2) sharing a highly
            conserved protein motif with the Drosophila omb gene
  JOURNAL   Genomics 28 (2), 255-260 (1995)
   PUBMED   8530034
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005746.1, BC052566.1, AW006595.1 and BM985069.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005994.3.
            
            Summary: This gene is a member of a phylogenetically conserved
            family of genes that share a common DNA-binding domain, the T-box.
            T-box genes encode transcription factors involved in the regulation
            of developmental processes. This gene product is the human homolog
            of mouse Tbx2, and shares strong sequence similarity with
            Drosophila omb protein. Expression studies indicate that this gene
            may have a potential role in tumorigenesis as an immortalizing
            agent. Transcript heterogeneity due to alternative polyadenylation
            has been noted for this gene. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052566.1, AL832900.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000240328.4/ ENSP00000240328.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AC005746.1         15037-15089         c
            54-2158             BC052566.1         1-2105
            2159-2166           AW006595.1         401-408             c
            2167-3039           BC052566.1         2114-2986
            3040-3433           BM985069.1         17-410              c
FEATURES             Location/Qualifiers
     source          1..3433
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q23.2"
     gene            1..3433
                     /gene="TBX2"
                     /gene_synonym="VETD"
                     /note="T-box transcription factor 2"
                     /db_xref="GeneID:6909"
                     /db_xref="HGNC:HGNC:11597"
                     /db_xref="MIM:600747"
     exon            1..729
                     /gene="TBX2"
                     /gene_synonym="VETD"
                     /inference="alignment:Splign:2.1.0"
     CDS             335..2473
                     /gene="TBX2"
                     /gene_synonym="VETD"
                     /note="T-box protein 2; T-box 2"
                     /codon_start=1
                     /product="T-box transcription factor TBX2"
                     /protein_id="NP_005985.3"
                     /db_xref="CCDS:CCDS11627.2"
                     /db_xref="GeneID:6909"
                     /db_xref="HGNC:HGNC:11597"
                     /db_xref="MIM:600747"
                     /translation="MREPALAASAMAYHPFHAPRPADFPMSAFLAAAQPSFFPALALP
                     PGALAKPLPDPGLAGAAAAAAAAAAAAEAGLHVSALGPHPPAAHLRSLKSLEPEDEVE
                     DDPKVTLEAKELWDQFHKLGTEMVITKSGRRMFPPFKVRVSGLDKKAKYILLMDIVAA
                     DDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNISDK
                     HGFTILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETDFIAVTAYQNDKITQLKI
                     DNNPFAKGFRDTGNGRREKRKQLTLPSLRLYEEHCKPERDGAESDASSCDPPPAREPP
                     TSPGAAPSPLRLHRARAEEKSCAADSDPEPERLSEERAGAPLGRSPAPDSASPTRLTE
                     PERARERRSPERGKEPAESGGDGPFGLRSLEKERAEARRKDEGRKEAAEGKEQGLAPL
                     VVQTDSASPLGAGHLPGLAFSSHLHGQQFFGPLGAGQPLFLHPGQFTMGPGAFSAMGM
                     GHLLASVAGGGNGGGGGPGTAAGLDAGGLGPAASAASTAAPFPFHLSQHMLASQGIPM
                     PTFGGLFPYPYTYMAAAAAAASALPATSAAAAAAAAAGSLSRSPFLGSARPRLRFSPY
                     QIPVTIPPSTSLLTTGLASEGSKAAGGNSREPSPLPELALRKVGAPSRGALSPSGSAK
                     EAANELQSIQRLVSGLESQRALSPGRESPK"
     exon            730..997
                     /gene="TBX2"
                     /gene_synonym="VETD"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1144
                     /gene="TBX2"
                     /gene_synonym="VETD"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1221
                     /gene="TBX2"
                     /gene_synonym="VETD"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1385
                     /gene="TBX2"
                     /gene_synonym="VETD"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..2020
                     /gene="TBX2"
                     /gene_synonym="VETD"
                     /inference="alignment:Splign:2.1.0"
     exon            2021..3433
                     /gene="TBX2"
                     /gene_synonym="VETD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3067..3072
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBX2"
                     /gene_synonym="VETD"
                     /note="hexamer: AATAAA"
     polyA_site      3091
                     /gene="TBX2"
                     /gene_synonym="VETD"
     regulatory      3413..3418
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBX2"
                     /gene_synonym="VETD"
                     /note="hexamer: AATAAA"
     polyA_site      3433
                     /gene="TBX2"
                     /gene_synonym="VETD"
                     /note="major polyA site"
ORIGIN      
        1 gttagcgcag gggatccgag ctgggcagga catgtgagat agtcacagtt ttccagagat
       61 cacgacaaga tctaaccagt cgcgcgtggt ccccggcgcc ggagcgggcc agctcagccc
      121 ggcccagccc ggccccgcgc agagcccccg ccgcccccgc gcacagagcc gggtgcccct
      181 tgcggtgcgc cggacgggaa gccccgagga gcagctgctg cgcccgccac ccgggtcgtc
      241 cgtccaccgc gcgcgccgcc gcccgggccg ggggtccgag ccgcgcgccc ccggccccgg
      301 ccccggcccc cgggcgcctg ggccggatgt cccgatgaga gagccggcgc tggcggccag
      361 cgccatggct taccacccgt tccacgcgcc acggcccgcc gacttcccca tgtccgcctt
      421 tctggcggcg gcgcagccct ccttcttccc ggcactcgcg ctgccgcccg gcgcgctggc
      481 caagccgctg cccgacccgg gcctggcggg ggcggcggcc gcggcggcgg cggcggcagc
      541 agcggccgag gcggggctgc acgtctcggc actgggcccg cacccgcccg ccgcgcatct
      601 gcgctccctc aagagcctgg agcccgagga cgaggtggag gacgacccca aggtgacgct
      661 ggaggccaag gagctgtggg accagttcca caagctaggc acggagatgg tcatcaccaa
      721 gtccgggagg cggatgttcc cccccttcaa ggtgcgagtc agcggcctgg acaagaaggc
      781 caagtatatc ctgctgatgg acattgtagc cgctgacgat tgccgctata agttccacaa
      841 ctcgcgctgg atggtggcgg gcaaggccga ccctgagatg cccaaacgca tgtacatcca
      901 cccagacagc ccagccacgg gggagcagtg gatggctaag cctgtggcct tccacaagct
      961 gaagctgacc aacaacatct ctgacaagca cggcttcacc atcctaaact ccatgcacaa
     1021 gtaccagccg cgcttccaca tagtgcgagc caacgacatc ctgaagctgc cttacagcac
     1081 cttccgcacc tacgtgttcc cggagaccga cttcatcgcc gtcactgcct accagaatga
     1141 caagatcaca cagctgaaga tcgacaacaa cccgtttgcc aagggcttcc gggacaccgg
     1201 gaacggccgg cgggagaaaa ggaagcagct gacgctgccg tctctacgct tgtacgagga
     1261 gcactgcaaa cccgagcgcg atggcgcgga gtcagacgcc tcgtcgtgcg accctccccc
     1321 cgcgcgggaa ccacccacct ccccgggcgc agcgcccagt ccgctgcgcc tgcaccgggc
     1381 ccgagctgag gagaagtcgt gcgccgcgga cagcgacccg gagcctgagc ggttgagcga
     1441 ggagcgtgcg ggggcgccgc taggccgcag cccggctcca gacagcgcca gccccactcg
     1501 cttgaccgaa cccgagcgcg cccgggagcg gcgtagtccc gagaggggca aggagccggc
     1561 cgagagcggc ggggacggcc cgttcggcct gaggagcctg gagaaggagc gcgccgaagc
     1621 tcggaggaag gacgaggggc gcaaggaggc ggccgagggc aaggagcagg gcctggcgcc
     1681 gctggtggtg cagacagaca gtgcgtcccc cctgggcgcc ggacacctgc ccggcctggc
     1741 cttttccagc cacttgcacg ggcagcagtt ctttgggccg ctgggagccg gccagccgct
     1801 cttcctgcac cctggacagt tcaccatggg ccctggcgcc ttctccgcca tgggcatggg
     1861 tcacctactg gcctcggtgg caggcggcgg caacggcgga ggtggcgggc ctgggaccgc
     1921 cgcggggctg gacgcaggcg ggctgggtcc cgcggccagc gcagcaagca ccgccgcgcc
     1981 cttcccgttc cacctctccc agcacatgct ggcatctcag ggaattccaa tgcccacttt
     2041 cggaggcctc ttcccctacc cctacaccta catggcagca gcagccgcag ccgcctcggc
     2101 tttgcccgcc actagtgctg cagctgccgc cgccgcagcc gccggctccc tctcccggag
     2161 ccccttcctg ggcagtgccc ggccccgact gcgtttcagc ccctatcaga tcccggtcac
     2221 catcccgcct agcactagcc tcctcaccac cgggctggcc tctgagggct ccaaggccgc
     2281 tggtggaaac agccgggagc ctagccccct gcccgagctg gctctccgca aagtaggggc
     2341 cccatcccgc ggtgccctgt cgcccagtgg ctcggccaag gaggcggcca atgaactgca
     2401 gagcatccag agactggtga gtgggctgga gagccagcga gccctctccc caggccggga
     2461 gtcgcccaag tgaggggctg cccagctgct cccctgccac gcaggccacc cgggctgcct
     2521 gcccctgctg cttgggacgt gtacagcaca gaatgagtat ttatttaaat aaaggagaaa
     2581 agtgggctgc agcagccgga atagagcctc gtctggcaag tcggggcctg ggacacttcc
     2641 ctgggcctca acaaggatca ggctgctgga aacacagtca cttgggagct gctgggctag
     2701 gtccagatcc gctccagcgt caaggtggca tccgaaggtg tctctggtct tccagcgagg
     2761 tgggagaggc ctcatccagg gcccagcggt ccctgcagaa gccagaaggt gcaggggcca
     2821 ggggtgggag catcggaggg agtcccagag ccctggacct tgggcctaga ccgcgtgata
     2881 aaactgggtt gagggatgct ggaaccagtt acgactgaag tcagtgtaga cctgagctgg
     2941 gagggaacct gttagtctcc ccacctcttc cctgaagaga caggcacccc tcccagccgt
     3001 ggtcaacgga gggagtggca cttctgcctt gagtccccag gggaaaaaaa aaaaagatat
     3061 ttatgaaata aatggtaatt tgtgtaaata agctttaagg ttcccagaat atgcaaattg
     3121 gtattaattt attcaaaggt gtacattgct gtgtacatat atttagagat taactcatac
     3181 atttaaagtt tttttcattt tacgtgagca tctatattgt acagggctgg gggggccctt
     3241 ggctgcggga gaaggcccag agccctggag gagccaccac cccgccggcc cctcgacccc
     3301 tcggcccctc ggcccctccg cccgggtttg gctcgcccgg cccgcgggct ccacctcagg
     3361 ttttcacttt tcgctccgga gcgagaacga aacgacaaaa acgcaagaaa acaataaaac
     3421 gctagaaagc gaa
//
