LOCUS       NM_001080508            6430 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens T-box transcription factor 18 (TBX18), mRNA.
ACCESSION   NM_001080508 XM_496819
VERSION     NM_001080508.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6430)
  AUTHORS   Zhou,J., Wu,J., Wu,G., Huang,J., Zhang,Y., Che,J., Zhu,K., Geng,J.
            and Fan,Q.
  TITLE     TBX18 knockdown sensitizes esophageal squamous cell carcinoma to
            radiotherapy by blocking the CHN1/RhoA axis
  JOURNAL   Radiother Oncol 186, 109788 (2023)
   PUBMED   37399907
  REMARK    GeneRIF: TBX18 knockdown sensitizes esophageal squamous cell
            carcinoma to radiotherapy by blocking the CHN1/RhoA axis.
REFERENCE   2  (bases 1 to 6430)
  AUTHORS   Engwerda,A., Abbott,K.M., Hitzert,M.M., van Ravenswaaij-Arts,C.M.A.
            and Kerstjens-Frederikse,W.S.
  TITLE     The role of TBX18 in congenital heart defects in humans not
            confirmed
  JOURNAL   Eur J Hum Genet 31 (2), 138-141 (2023)
   PUBMED   36418409
  REMARK    GeneRIF: The role of TBX18 in congenital heart defects in humans
            not confirmed.
REFERENCE   3  (bases 1 to 6430)
  AUTHORS   Sanchez,L., Mesquita,T., Zhang,R., Liao,K., Rogers,R., Lin,Y.N.,
            Miguel-Dos-Santos,R., Akhmerov,A., Li,L., Nawaz,A., Holm,K.,
            Marban,E. and Cingolani,E.
  TITLE     MicroRNA-dependent suppression of biological pacemaker activity
            induced by TBX18
  JOURNAL   Cell Rep Med 3 (12), 100871 (2022)
   PUBMED   36543116
  REMARK    GeneRIF: MicroRNA-dependent suppression of biological pacemaker
            activity induced by TBX18.
REFERENCE   4  (bases 1 to 6430)
  AUTHORS   Zhang,W., Zhao,H., Quan,D., Tang,Y., Wang,X. and Huang,C.
  TITLE     Tbx18 promoted the conversion of human-induced pluripotent stem
            cell-derived cardiomyocytes into sinoatrial node-like pacemaker
            cells
  JOURNAL   Cell Biol Int 46 (3), 403-414 (2022)
   PUBMED   34882885
  REMARK    GeneRIF: Tbx18 promoted the conversion of human-induced pluripotent
            stem cell-derived cardiomyocytes into sinoatrial node-like
            pacemaker cells.
REFERENCE   5  (bases 1 to 6430)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 6430)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 6430)
  AUTHORS   McNally,E.M. and Svensson,E.C.
  TITLE     Setting the pace: Tbx3 and Tbx18 in cardiac conduction system
            development
  JOURNAL   Circ Res 104 (3), 285-287 (2009)
   PUBMED   19213963
REFERENCE   8  (bases 1 to 6430)
  AUTHORS   Farin,H.F., Bussen,M., Schmidt,M.K., Singh,M.K.,
            Schuster-Gossler,K. and Kispert,A.
  TITLE     Transcriptional repression by the T-box proteins Tbx18 and Tbx15
            depends on Groucho corepressors
  JOURNAL   J Biol Chem 282 (35), 25748-25759 (2007)
   PUBMED   17584735
  REMARK    GeneRIF: Tbx18 interacts with Gata4 and Nkx2-5 and competes
            Tbx5-mediated activation of the cardiac Natriuretic peptide
            precursor type a-promoter. Tbx18 down-regulates Tbx6-activated
            Delta-like 1 expression in the somitic mesoderm in vivo
REFERENCE   9  (bases 1 to 6430)
  AUTHORS   King,M., Arnold,J.S., Shanske,A. and Morrow,B.E.
  TITLE     T-genes and limb bud development
  JOURNAL   Am J Med Genet A 140 (13), 1407-1413 (2006)
   PUBMED   16688725
  REMARK    Review article
REFERENCE   10 (bases 1 to 6430)
  AUTHORS   Yi,C.H., Terrett,J.A., Li,Q.Y., Ellington,K., Packham,E.A.,
            Armstrong-Buisseret,L., McClure,P., Slingsby,T. and Brook,J.D.
  TITLE     Identification, mapping, and phylogenomic analysis of four new
            human members of the T-box gene family: EOMES, TBX6, TBX18, and
            TBX19
  JOURNAL   Genomics 55 (1), 10-20 (1999)
   PUBMED   9888994
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL035694.8, BC132715.1 and
            BC157841.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001080508.2.
            
            Summary: This genes codes for a member of an evolutionarily
            conserved family of transcription factors that plays a crucial role
            in embryonic development. The family is characterized by the
            presence of the DNA-binding T-box domain and is divided into five
            sub-families based on sequence conservation in this domain. The
            encoded protein belongs to the vertebrate specific Tbx1 sub-family.
            The protein acts as a transcriptional repressor by antagonizing
            transcriptional activators in the T-box family. The protein forms
            homo- or heterodimers with other transcription factors of the T-box
            family or other transcription factors. [provided by RefSeq, Nov
            2012].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC157841.1, SRR7346977.2169646.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369663.10/ ENSP00000358677.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-362               AL035694.8         41817-42178         c
            363-558             BC132715.1         1-196
            559-559             AL035694.8         41620-41620         c
            560-4554            BC157841.1         191-4185
            4555-4555           AL035694.8         11951-11951         c
            4556-4764           BC157841.1         4187-4395
            4765-6430           AL035694.8         10076-11741         c
FEATURES             Location/Qualifiers
     source          1..6430
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q14.3"
     gene            1..6430
                     /gene="TBX18"
                     /gene_synonym="CAKUT2; PUJO"
                     /note="T-box transcription factor 18"
                     /db_xref="GeneID:9096"
                     /db_xref="HGNC:HGNC:11595"
                     /db_xref="MIM:604613"
     exon            1..709
                     /gene="TBX18"
                     /gene_synonym="CAKUT2; PUJO"
                     /inference="alignment:Splign:2.1.0"
     CDS             418..2241
                     /gene="TBX18"
                     /gene_synonym="CAKUT2; PUJO"
                     /note="T-box protein 18; T-box 18"
                     /codon_start=1
                     /product="T-box transcription factor TBX18"
                     /protein_id="NP_001073977.1"
                     /db_xref="CCDS:CCDS34495.1"
                     /db_xref="GeneID:9096"
                     /db_xref="HGNC:HGNC:11595"
                     /db_xref="MIM:604613"
                     /translation="MAEKRRGSPCSMLSLKAHAFSVEALIGAEKQQQLQKKRRKLGAE
                     EAAGAVDDGGCSRGGGAGEKGSSEGDEGAALPPPAGATSGPARSGADLERGAAGGCED
                     GFQQGASPLASPGGSPKGSPARSLARPGTPLPSPQAPRVDLQGAELWKRFHEIGTEMI
                     ITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADSPV
                     PPRVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKD
                     CGDDLSPIKPVPSGEGVKAFSFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRDSGRN
                     RMGLEALVESYAFWRPSLRTLTFEDIPGIPKQGNASSSTLLQGTGNGVPATHPHLLSG
                     SSCSSPAFHLGPNTSQLCSLAPADYSACARSGLTLNRYSTSLAETYNRLTNQAGETFA
                     PPRTPSYVGVSSSTSVNMSMGGTDGDTFSCPQTSLSMQISGMSPQLQYIMPSPSSNAF
                     ATNQTHQGSYNTFRLHSPCALYGYNFSTSPKLAASPEKIVSSQGSFLGSSPSGTMTDR
                     QMLPPVEGVHLLSSGGQQSFFDSRTLGSLTLSSSQVSAHMV"
     exon            710..914
                     /gene="TBX18"
                     /gene_synonym="CAKUT2; PUJO"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1016
                     /gene="TBX18"
                     /gene_synonym="CAKUT2; PUJO"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1188
                     /gene="TBX18"
                     /gene_synonym="CAKUT2; PUJO"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1356
                     /gene="TBX18"
                     /gene_synonym="CAKUT2; PUJO"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1421
                     /gene="TBX18"
                     /gene_synonym="CAKUT2; PUJO"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1516
                     /gene="TBX18"
                     /gene_synonym="CAKUT2; PUJO"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..6430
                     /gene="TBX18"
                     /gene_synonym="CAKUT2; PUJO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2333..2338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBX18"
                     /gene_synonym="CAKUT2; PUJO"
                     /note="hexamer: TATAAA"
     polyA_site      2357
                     /gene="TBX18"
                     /gene_synonym="CAKUT2; PUJO"
                     /note="major polyA site"
     regulatory      4463..4468
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBX18"
                     /gene_synonym="CAKUT2; PUJO"
                     /note="hexamer: ATTAAA"
     polyA_site      4487
                     /gene="TBX18"
                     /gene_synonym="CAKUT2; PUJO"
     regulatory      6295..6300
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBX18"
                     /gene_synonym="CAKUT2; PUJO"
                     /note="hexamer: AATAAA"
     polyA_site      6324
                     /gene="TBX18"
                     /gene_synonym="CAKUT2; PUJO"
                     /note="major polyA site"
     regulatory      6407..6412
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBX18"
                     /gene_synonym="CAKUT2; PUJO"
                     /note="hexamer: AATACA"
     polyA_site      6430
                     /gene="TBX18"
                     /gene_synonym="CAKUT2; PUJO"
ORIGIN      
        1 accgctctcc tgcctggaag tgctgacaga tcaaggcaac aaatttcaat tacaatccct
       61 aatttgtgtc cacagagtgt tttttaccca tgttagtcct ctctggcgca tcagttgagg
      121 cagacctcgg agcagcagga ggaggtggaa ggggtgggag caaaggagtg catcagtgag
      181 agagcgcgcg agagagaccc aggaaaggag acttggccgg cgcgtcgccg gttcctggat
      241 cccaacacaa gcgagaaagc ggaaacgcca aatctgtttt ttgcccgcgg tggggaaggg
      301 ggcagatctc gggaggcccc gagagccttt tagtttttgg tgggggaaga gcgagagcgc
      361 gcgtgtgccc gcgtgagtgt atatgagaga ggggcgggcg ggcgcggggc gggggggatg
      421 gccgagaagc gaaggggctc gccgtgcagc atgctaagcc tcaaggcgca cgctttctcg
      481 gtggaggcgc tgatcggcgc cgagaagcag caacagcttc agaagaagcg gcgaaaactg
      541 ggcgccgaag aggcggcggg ggccgtggac gacggaggct gcagccgcgg cggcggcgcg
      601 ggcgaaaagg gttcttctga gggagacgaa ggcgctgcgc tcccgccgcc ggctggggcg
      661 acgtctgggc cggctcggag tggcgcagac ctggagcgcg gagccgcggg cggctgtgag
      721 gacggcttcc agcagggagc ttcccctctg gcgtcaccgg gaggctcccc caaggggtct
      781 ccggcgcgct ccctggcccg gcccgggacc cctctgccct cgccgcaggc cccgcgggtg
      841 gatctgcagg gagccgagct ctggaagcgc tttcatgaga taggcactga gatgatcatc
      901 accaaggccg gcaggcgcat gtttccagca atgagagtga agatctctgg attagatcct
      961 caccagcaat attacattgc catggatatt gtaccagtgg acaacaaaag atacaggtat
     1021 gtttaccaca gttcgaaatg gatggtggca ggtaatgctg actcgcctgt gccaccccgt
     1081 gtgtacattc atccagactc gcctgcctcg ggggagactt ggatgagaca agttatcagc
     1141 ttcgacaagc tgaagctcac caacaatgaa ctggatgacc aaggccatat tattcttcat
     1201 tctatgcaca aataccaacc gcgagtgcac gtcatccgta aagactgtgg agacgatctt
     1261 tctcccatca agcctgttcc atccggggag ggagtaaagg cattctcctt tccagaaact
     1321 gtcttcacaa ccgtcactgc ctatcagaat cagcagatta ctcgcctgaa gatagatagg
     1381 aatccatttg ctaaaggctt ccgagactcc gggcgcaaca gaatgggttt ggaagccttg
     1441 gtggaatcat atgcattctg gcgaccatca ctacggactc tgacctttga agatatccct
     1501 ggaattccca agcaaggcaa tgcaagttcc tccaccttgc tccaaggtac tgggaatggc
     1561 gttcctgcca ctcaccctca ccttttgtct ggctcctctt gctcctctcc tgccttccat
     1621 ctggggccca acaccagcca gctgtgtagt ctggcccctg ctgactattc tgcctgtgcc
     1681 cgctcaggcc tcaccctcaa ccgatacagc acatctttgg cagagaccta caacaggctc
     1741 accaaccagg ctggtgagac ctttgccccg cccaggactc cctcctatgt gggcgtgagc
     1801 agcagcacct ccgtgaacat gtccatgggt ggcactgatg gggacacctt cagctgccca
     1861 cagaccagct tatccatgca gatttcggga atgtcccccc agctccagta tatcatgcca
     1921 tcaccctcca gcaatgcctt cgccactaac cagacccatc agggttccta taatactttt
     1981 agattacaca gcccctgtgc actatatgga tataacttct ccacatcccc caaactggct
     2041 gccagtcctg agaaaattgt ttcttcccaa ggaagtttct tggggtcctc accgagtggg
     2101 accatgacgg atcggcagat gttgccccct gtggaaggag tgcacctgct tagcagtggg
     2161 ggtcagcaga gtttctttga ctctaggacc ctaggaagct taactctgtc atcatctcaa
     2221 gtatctgcac atatggtctg atgaagcctt taagttaaat gacatttgga tctgtctaac
     2281 atattttctt tttctttttt aaaagctatg tggaaagaaa ctctctgtgg tttataaaat
     2341 gtacatataa tagaaaatga aggctcactg ggttttttga ctttatcatg gtgagattgt
     2401 aattatctat ggtatatatg tatgctgtat atacatagca catggagtat cacggcccct
     2461 attgttcccc tgtttcatcc agttgcacgg agtattggca tgcgtgtagt atgtttaagc
     2521 aaagttctca gactctttta aaaacaagat ggtaaactta aaacttggca attatactat
     2581 ccagaagaac acttataact taatttatca gaaaaatgct ctaaacggtt tcatacttga
     2641 tgtattgata accagcagta accagcatgt agagtcttgt gatttctgtt attcttggac
     2701 acagtgtgag aatctaaaat acaaaagcca gttgaagtct tagtgttagt cctgaggtat
     2761 ttgtaatcat gaaggatcag ctttttcatt cctgcttatt atttaccaca catactatat
     2821 gaccttgggt ctataaaaaa atcataaccc ataataattg ttattttctt aaggaaggta
     2881 aaggagaggc ttgtgatttt tttttttaca ctttccattg ggcacataag aggttcttat
     2941 tcatctgtag agaacaaatt tccagtattt tcgatttttt gcttatttta tatatcaaat
     3001 agaccattaa agaatgttct ataaacattt ttaaattcca attttcacca ggggaggaat
     3061 atgtgatatg agtggaatgg caaaaggaaa ataaatccac ctcaaattca ttgattccaa
     3121 tgagaaatgt ctatctttta aatcaagagt aatactattg ttaactatac cttatgtttt
     3181 tgtatagttt gtttttaaat ttagaatatt ttttccatct tgctctgagc ttcctgaccg
     3241 atagtatata agtaaaaaaa atgcatttat gctacttatt tatatcttgt aattcctaca
     3301 cattgaaccc ttttcccctt cttaaccttg tccgtctgcc tgagtctttc ccaaaacaga
     3361 tagttcctag gcctgtatgg tgttaaataa cacggtgagg aatttcagta ggttatctcc
     3421 agcaatctgt cttttgggag ctatagtgca aaggccaaag cccattacta taaagaccct
     3481 cttggaggac taagaaggaa gatactaatt atgataaagg aactataaaa cttttaacct
     3541 caacagaatt tgtaatgtca gaactggaga aattaaaatc agtattaaat tttttaattc
     3601 ctaaaataat atatgcatgg ttgaagagtt aaaaacaagt aactttgaga gcacagtatg
     3661 agataaataa aaaaggctaa gaatacatga tgaggcacat tccccttctg aggagaaagc
     3721 gaaataacat gtctgtgcat tgacccattc attacatttc atgtatctta agcaaaagag
     3781 catgattttc tctcattgct aaaaagagtt gctttaactc atccctggat ttggtgggga
     3841 aagggtacaa ctcctgattt gctgtttcac tttgaaacaa cacaatttgt tagatactta
     3901 gggagatata ctgttgaatt tgcacaggat gtgactctgt ttatacatat taacaaattt
     3961 ccttttggat tccttagcag ttcatcaaat tagtattaaa tttttaaatt taaaactagc
     4021 atgaagggac atgaaatatt tgcagtaggt ggatctatgt aagatgtttg ggtatggcat
     4081 taatagcttg acaaagattt ggggaaaggt gttaagaatg agtccatctc agccaatagt
     4141 gcttggtgta taattcaaga acagagagtt ttccatcttg aaaaaacatg gaaagtaatg
     4201 ctctataccc atatgtatta ataagagcat tttccttctt gccgttgatc atttcagatg
     4261 ataccacaat atgagtataa ttttttatta atcttttttc tggtaaaatt ttagcaatat
     4321 tgtacaaatg ctttttttag gttttactgt aaatattaat caccacgtca cttcagagac
     4381 tagcctttta ttgctgaatt aaatgacatg catacattga taattatata tctgtatttt
     4441 attaaaaagt acttaaaatt atattaaaat atgttattaa acccttttat gattttggag
     4501 ggtaatcatt ttaatgtcta aaaatattga tccaagaata agcacacaca tgcacacccc
     4561 aaacgcaaat tctgtacctc tcaaatacat ggcagaaaga aatgggcctg ctgttcatgt
     4621 ttcatgtgtt aaatgtaatt tcttggtgtg ttgaccatgt cattgaaggt gaaggccctg
     4681 acaaatgttg aacacatgaa aatttgaatg tgagaggaaa gggatggggt ggtatgtttt
     4741 gttttgggtc caggggagaa aggcaaggtt acaagaatga gtggcttgca ccactgacta
     4801 gtgatgacag attacttcta tgccccttga ctagtaaaca ttccaaggga catcgcgatg
     4861 gggtgaggtt gctgctatca agaccagtca cattttgaaa attaacactt gcttccttac
     4921 aagctgcctt ccagaggtca acagcttttc acaagtgagg cacccagttg ctgacccttg
     4981 atttctggaa tgtaaggggt caggaatcct tggtggcccc cagagaaggt tggggcacag
     5041 tgtaacctat ataaggaagg atcatactca ctctttacat caattagcaa aattttgagg
     5101 aaaaagaatc tcacttttaa aatgtaaata gctcttcatt acccctccag acttaatcct
     5161 accagtaact cacaccttag tgtgaaatta ataaacagca gctttggaga tagctggagg
     5221 tttgacttag aggaaaaagt aatttttgta gcaggacaat tctgggaaga tttgtatggg
     5281 aaggagaagg tgcaagaaga gagatcccta actaaactct gcagtgtccc atgaagtcct
     5341 ggtgcagagc attaaaaata atcatttcat aaacttcttt caggaacctt ggtagaggtg
     5401 gtggatgcta cctaccctga tgctgtctct aattagagag gtttgtaaag attcctttgt
     5461 tgcaaagtgt aacacagtgt tatttcctca tgagaaattt attggctcat ctacatgaag
     5521 ttttttctaa gctttccctt aagaactaat tgtattaaat tattaccatg ttgtgtttta
     5581 atctcattgt tcatcctttc taaaaagaaa tgctcagata agttgagagt aaggttaaat
     5641 atatgagcag ttaagtactc atacatgatt acagcattct aagagttcaa accttaaaaa
     5701 ttatcagtgc tagaaatcga caaatatatt caagtataca aacattcaac agatatataa
     5761 acttagtatc cctctacatg ctgatatatt ttcaaataat gtgctttctt ttcattgaac
     5821 tgtggtatga tgagaataac atgtcctcgg gaattagaga acttagtttg agactatgga
     5881 tttctcaatc atgattttgg gtaaaaaaat tagctgcttt atgtctcagt tttgctatgt
     5941 gtgaaaggaa tggctgggat gataattgtt agtattcctt ttagtttcca attcatatgg
     6001 tcctattata taaatattta gcttaatatt gggaaactag ttttataaaa ctattatatc
     6061 ttttggaata tattctgttt atttttggat atatatatat atatactgta tctgtggctt
     6121 tacaaagaat ataacactat cagtattatt ttcaacttgt tgaattatgt gaaatttatc
     6181 ctttaaatgg aactgtgctt tagttttaca ggataaattt tagtatttta atatcagaag
     6241 gaagctatac ttagtaacgt atttgctact ttatagtgaa tagtaaaaga cattaataaa
     6301 atttcttttt catgatgctc ttaattgcat ggcattaaat tattttgttt tgaaataagt
     6361 atagcagtct attataatat atggagatca ttccaagtcc attcaaaata catttaaatc
     6421 ctcgagaaaa
//
