LOCUS       NM_001330677            4042 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens T-box transcription factor 15 (TBX15), transcript
            variant 1, mRNA.
ACCESSION   NM_001330677 XM_005271162
VERSION     NM_001330677.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4042)
  AUTHORS   Yan,D., Yu,Y., Ni,Q., Meng,Q., Wu,H., Ding,S., Liu,X., Tang,C.,
            Liu,Q. and Yang,K.
  TITLE     The overexpression and clinical significance of TBX15 in human
            gliomas
  JOURNAL   Sci Rep 13 (1), 9771 (2023)
   PUBMED   37328486
  REMARK    GeneRIF: The overexpression and clinical significance of TBX15 in
            human gliomas.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4042)
  AUTHORS   Li,P., Li,Y., Bai,S., Zhang,Y. and Zhao,L.
  TITLE     miR-4732-3p prevents lung cancer progression via inhibition of the
            TBX15/TNFSF11 axis
  JOURNAL   Epigenomics 15 (4), 195-207 (2023)
   PUBMED   37125501
  REMARK    GeneRIF: miR-4732-3p prevents lung cancer progression via
            inhibition of the TBX15/TNFSF11 axis.
REFERENCE   3  (bases 1 to 4042)
  AUTHORS   Zhang,Y., Li,J., Ji,Y., Cheng,Y. and Fu,X.
  TITLE     Mutations in the TBX15-ADAMTS2 pathway associate with a novel soft
            palate dysplasia
  JOURNAL   Hum Mutat 43 (12), 2102-2115 (2022)
   PUBMED   36124393
  REMARK    GeneRIF: Mutations in the TBX15-ADAMTS2 pathway associate with a
            novel soft palate dysplasia.
REFERENCE   4  (bases 1 to 4042)
  AUTHORS   Leyden,G.M., Shapland,C.Y., Davey Smith,G., Sanderson,E.,
            Greenwood,M.P., Murphy,D. and Richardson,T.G.
  TITLE     Harnessing tissue-specific genetic variation to dissect putative
            causal pathways between body mass index and cardiometabolic
            phenotypes
  JOURNAL   Am J Hum Genet 109 (2), 240-252 (2022)
   PUBMED   35090585
  REMARK    GeneRIF: Harnessing tissue-specific genetic variation to dissect
            putative causal pathways between body mass index and
            cardiometabolic phenotypes.
REFERENCE   5  (bases 1 to 4042)
  AUTHORS   Pan,D.Z., Miao,Z., Comenho,C., Rajkumar,S., Koka,A., Lee,S.H.T.,
            Alvarez,M., Kaminska,D., Ko,A., Sinsheimer,J.S., Mohlke,K.L.,
            Mancuso,N., Munoz-Hernandez,L.L., Herrera-Hernandez,M.,
            Tusie-Luna,M.T., Aguilar-Salinas,C., Pietilainen,K.H.,
            Pihlajamaki,J., Laakso,M., Garske,K.M. and Pajukanta,P.
  TITLE     Identification of TBX15 as an adipose master trans regulator of
            abdominal obesity genes
  JOURNAL   Genome Med 13 (1), 123 (2021)
   PUBMED   34340684
  REMARK    GeneRIF: Identification of TBX15 as an adipose master trans
            regulator of abdominal obesity genes.
            Erratum:[Genome Med. 2021 Aug 30;13(1):139. doi:
            10.1186/s13073-021-00954-3.. PMID: 34461981]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4042)
  AUTHORS   Heid,I.M., Jackson,A.U., Randall,J.C., Winkler,T.W., Qi,L.,
            Steinthorsdottir,V., Thorleifsson,G., Zillikens,M.C.,
            Speliotes,E.K., Magi,R., Workalemahu,T., White,C.C.,
            Bouatia-Naji,N., Harris,T.B., Berndt,S.I., Ingelsson,E.,
            Willer,C.J., Weedon,M.N., Luan,J., Vedantam,S., Esko,T.,
            Kilpelainen,T.O., Kutalik,Z., Li,S., Monda,K.L., Dixon,A.L.,
            Holmes,C.C., Kaplan,L.M., Liang,L., Min,J.L., Moffatt,M.F.,
            Molony,C., Nicholson,G., Schadt,E.E., Zondervan,K.T., Feitosa,M.F.,
            Ferreira,T., Lango Allen,H., Weyant,R.J., Wheeler,E., Wood,A.R.,
            Estrada,K., Goddard,M.E., Lettre,G., Mangino,M., Nyholt,D.R.,
            Purcell,S., Smith,A.V., Visscher,P.M., Yang,J., McCarroll,S.A.,
            Nemesh,J., Voight,B.F., Absher,D., Amin,N., Aspelund,T., Coin,L.,
            Glazer,N.L., Hayward,C., Heard-Costa,N.L., Hottenga,J.J.,
            Johansson,A., Johnson,T., Kaakinen,M., Kapur,K., Ketkar,S.,
            Knowles,J.W., Kraft,P., Kraja,A.T., Lamina,C., Leitzmann,M.F.,
            McKnight,B., Morris,A.P., Ong,K.K., Perry,J.R., Peters,M.J.,
            Polasek,O., Prokopenko,I., Rayner,N.W., Ripatti,S., Rivadeneira,F.,
            Robertson,N.R., Sanna,S., Sovio,U., Surakka,I., Teumer,A., van
            Wingerden,S., Vitart,V., Zhao,J.H., Cavalcanti-Proenca,C.,
            Chines,P.S., Fisher,E., Kulzer,J.R., Lecoeur,C., Narisu,N.,
            Sandholt,C., Scott,L.J., Silander,K., Stark,K., Tammesoo,M.L.,
            Teslovich,T.M., Timpson,N.J., Watanabe,R.M., Welch,R.,
            Chasman,D.I., Cooper,M.N., Jansson,J.O., Kettunen,J.,
            Lawrence,R.W., Pellikka,N., Perola,M., Vandenput,L., Alavere,H.,
            Almgren,P., Atwood,L.D., Bennett,A.J., Biffar,R., Bonnycastle,L.L.,
            Bornstein,S.R., Buchanan,T.A., Campbell,H., Day,I.N., Dei,M.,
            Dorr,M., Elliott,P., Erdos,M.R., Eriksson,J.G., Freimer,N.B.,
            Fu,M., Gaget,S., Geus,E.J., Gjesing,A.P., Grallert,H., Grassler,J.,
            Groves,C.J., Guiducci,C., Hartikainen,A.L., Hassanali,N.,
            Havulinna,A.S., Herzig,K.H., Hicks,A.A., Hui,J., Igl,W.,
            Jousilahti,P., Jula,A., Kajantie,E., Kinnunen,L., Kolcic,I.,
            Koskinen,S., Kovacs,P., Kroemer,H.K., Krzelj,V., Kuusisto,J.,
            Kvaloy,K., Laitinen,J., Lantieri,O., Lathrop,G.M., Lokki,M.L.,
            Luben,R.N., Ludwig,B., McArdle,W.L., McCarthy,A., Morken,M.A.,
            Nelis,M., Neville,M.J., Pare,G., Parker,A.N., Peden,J.F.,
            Pichler,I., Pietilainen,K.H., Platou,C.G., Pouta,A.,
            Ridderstrale,M., Samani,N.J., Saramies,J., Sinisalo,J., Smit,J.H.,
            Strawbridge,R.J., Stringham,H.M., Swift,A.J., Teder-Laving,M.,
            Thomson,B., Usala,G., van Meurs,J.B., van Ommen,G.J., Vatin,V.,
            Volpato,C.B., Wallaschofski,H., Walters,G.B., Widen,E., Wild,S.H.,
            Willemsen,G., Witte,D.R., Zgaga,L., Zitting,P., Beilby,J.P.,
            James,A.L., Kahonen,M., Lehtimaki,T., Nieminen,M.S., Ohlsson,C.,
            Palmer,L.J., Raitakari,O., Ridker,P.M., Stumvoll,M., Tonjes,A.,
            Viikari,J., Balkau,B., Ben-Shlomo,Y., Bergman,R.N., Boeing,H.,
            Smith,G.D., Ebrahim,S., Froguel,P., Hansen,T., Hengstenberg,C.,
            Hveem,K., Isomaa,B., Jorgensen,T., Karpe,F., Khaw,K.T., Laakso,M.,
            Lawlor,D.A., Marre,M., Meitinger,T., Metspalu,A., Midthjell,K.,
            Pedersen,O., Salomaa,V., Schwarz,P.E., Tuomi,T., Tuomilehto,J.,
            Valle,T.T., Wareham,N.J., Arnold,A.M., Beckmann,J.S., Bergmann,S.,
            Boerwinkle,E., Boomsma,D.I., Caulfield,M.J., Collins,F.S.,
            Eiriksdottir,G., Gudnason,V., Gyllensten,U., Hamsten,A.,
            Hattersley,A.T., Hofman,A., Hu,F.B., Illig,T., Iribarren,C.,
            Jarvelin,M.R., Kao,W.H., Kaprio,J., Launer,L.J., Munroe,P.B.,
            Oostra,B., Penninx,B.W., Pramstaller,P.P., Psaty,B.M.,
            Quertermous,T., Rissanen,A., Rudan,I., Shuldiner,A.R., Soranzo,N.,
            Spector,T.D., Syvanen,A.C., Uda,M., Uitterlinden,A., Volzke,H.,
            Vollenweider,P., Wilson,J.F., Witteman,J.C., Wright,A.F.,
            Abecasis,G.R., Boehnke,M., Borecki,I.B., Deloukas,P.,
            Frayling,T.M., Groop,L.C., Haritunians,T., Hunter,D.J.,
            Kaplan,R.C., North,K.E., O'Connell,J.R., Peltonen,L.,
            Schlessinger,D., Strachan,D.P., Hirschhorn,J.N., Assimes,T.L.,
            Wichmann,H.E., Thorsteinsdottir,U., van Duijn,C.M., Stefansson,K.,
            Cupples,L.A., Loos,R.J., Barroso,I., McCarthy,M.I., Fox,C.S.,
            Mohlke,K.L. and Lindgren,C.M.
  CONSRTM   MAGIC
  TITLE     Meta-analysis identifies 13 new loci associated with waist-hip
            ratio and reveals sexual dimorphism in the genetic basis of fat
            distribution
  JOURNAL   Nat Genet 42 (11), 949-960 (2010)
   PUBMED   20935629
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
            Erratum:[Nat Genet. 2011 Nov;43(11):1164]
REFERENCE   7  (bases 1 to 4042)
  AUTHORS   Jugessur,A., Shi,M., Gjessing,H.K., Lie,R.T., Wilcox,A.J.,
            Weinberg,C.R., Christensen,K., Boyles,A.L., Daack-Hirsch,S.,
            Nguyen,T.T., Christiansen,L., Lidral,A.C. and Murray,J.C.
  TITLE     Maternal genes and facial clefts in offspring: a comprehensive
            search for genetic associations in two population-based cleft
            studies from Scandinavia
  JOURNAL   PLoS One 5 (7), e11493 (2010)
   PUBMED   20634891
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4042)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   9  (bases 1 to 4042)
  AUTHORS   Lausch,E., Hermanns,P., Farin,H.F., Alanay,Y., Unger,S., Nikkel,S.,
            Steinwender,C., Scherer,G., Spranger,J., Zabel,B., Kispert,A. and
            Superti-Furga,A.
  TITLE     TBX15 mutations cause craniofacial dysmorphism, hypoplasia of
            scapula and pelvis, and short stature in Cousin syndrome
  JOURNAL   Am J Hum Genet 83 (5), 649-655 (2008)
   PUBMED   19068278
  REMARK    GeneRIF: TBX15 mutations cause craniofacial dysmorphism, hypoplasia
            of scapula and pelvis, and short stature in Cousin syndrome.
REFERENCE   10 (bases 1 to 4042)
  AUTHORS   Agulnik,S.I., Papaioannou,V.E. and Silver,L.M.
  TITLE     Cloning, mapping, and expression analysis of TBX15, a new member of
            the T-Box gene family
  JOURNAL   Genomics 51 (1), 68-75 (1998)
   PUBMED   9693034
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL139420.13 and AL357045.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001330677.1.
            
            Summary: This gene belongs to the T-box family of genes, which
            encode a phylogenetically conserved family of transcription factors
            that regulate a variety of developmental processes. All these genes
            contain a common T-box DNA-binding domain. Mutations in this gene
            are associated with Cousin syndrome.[provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.52695.1,
                                           SRR1660805.298151.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369429.5/ ENSP00000358437.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-753               AL139420.13        47893-48645         c
            754-967             AL357045.10        133098-133311       c
            968-1069            AL357045.10        127989-128090       c
            1070-1241           AL357045.10        126125-126296       c
            1242-1409           AL357045.10        124915-125082       c
            1410-1474           AL357045.10        115594-115658       c
            1475-1572           AL357045.10        100507-100604       c
            1573-4042           AL357045.10        84526-86995         c
FEATURES             Location/Qualifiers
     source          1..4042
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p12"
     gene            1..4042
                     /gene="TBX15"
                     /gene_synonym="TBX14"
                     /note="T-box transcription factor 15"
                     /db_xref="GeneID:6913"
                     /db_xref="HGNC:HGNC:11594"
                     /db_xref="MIM:604127"
     exon            1..753
                     /gene="TBX15"
                     /gene_synonym="TBX14"
                     /inference="alignment:Splign:2.1.0"
     CDS             549..2357
                     /gene="TBX15"
                     /gene_synonym="TBX14"
                     /note="isoform 1 is encoded by transcript variant 1; T-box
                     14; T-box transcription factor TBX15; T-box protein 14;
                     T-box protein 15; T-box transcription factor TBX14; T-box
                     15"
                     /codon_start=1
                     /product="T-box transcription factor TBX15 isoform 1"
                     /protein_id="NP_001317606.1"
                     /db_xref="CCDS:CCDS81360.1"
                     /db_xref="GeneID:6913"
                     /db_xref="HGNC:HGNC:11594"
                     /db_xref="MIM:604127"
                     /translation="MSERRRSAVALSSRAHAFSVEALIGSNKKRKLRDWEEKGLDLSM
                     EALSPAGPLGDTEDAAAHGLEPHPDSEQSTGSDSEVLTERTSCSFSTHTDLASGAAGP
                     VPAAMSSMEEIQVELQCADLWKRFHDIGTEMIITKAGRRMFPAMRVKITGLDPHQQYY
                     IAMDIVPVDNKRYRYVYHSSKWMVAGNADSPVPPRVYIHPDSLASGDTWMRQVVSFDK
                     LKLTNNELDDQGHIILHSMHKYQPRVHVIRKDFSSDLSPTKPVPVGDGVKTFNFPETV
                     FTTVTAYQNQQITRLKIDRNPFAKGFRDSGRNRTGLEAIMETYAFWRPPVRTLTFEDF
                     TTMQKQQGGSTGTSPTTSSTGTPSPSASSHLLSPSCSPPTFHLAPNTFNVGCRESQLC
                     NLNLSDYPPCARSNMAALQSYPGLSDSGYNRLQSGTTSATQPSETFMPQRTPSLISGI
                     PTPPSLPGNSKMEAYGGQLGSFPTSQFQYVMQAGNAASSSSSPHMFGGSHMQQSSYNA
                     FSLHNPYNLYGYNFPTSPRLAASPEKLSASQSTLLCSSPSNGAFGERQYLPSGMEHSM
                     HMISPSPNNQQATNTCDGRQYGAVPGSSSQMSVHMV"
     exon            754..967
                     /gene="TBX15"
                     /gene_synonym="TBX14"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1069
                     /gene="TBX15"
                     /gene_synonym="TBX14"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1241
                     /gene="TBX15"
                     /gene_synonym="TBX14"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1409
                     /gene="TBX15"
                     /gene_synonym="TBX14"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1474
                     /gene="TBX15"
                     /gene_synonym="TBX14"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1572
                     /gene="TBX15"
                     /gene_synonym="TBX14"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..4042
                     /gene="TBX15"
                     /gene_synonym="TBX14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4023..4028
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBX15"
                     /gene_synonym="TBX14"
                     /note="hexamer: AATAAA"
     polyA_site      4042
                     /gene="TBX15"
                     /gene_synonym="TBX14"
                     /note="major polyA site"
ORIGIN      
        1 ccccctccct ctccctcacc cctcggacag gagcgcaccg cctgccccct gttcctcggg
       61 aagggaggaa tttagcggaa aaaaaagttt cccagaagtt tggatcacag ggaggacggg
      121 aaggcagaga ggaagagaga gagaggggga ggagagaaaa agagagggag gggagagaga
      181 gagagagaga gagaggagag agaataataa taataacaaa aacaagatga agttcagtgg
      241 acacagtctg tgagcgcctg ccccggtggg tgggaagcag gactcgggcg ctcatgcagc
      301 gagcgggcgg cgctcggggc gctagttcct agcagctggg ccagcgtagg ggcgcaggtc
      361 ggatccggca gaggagggcg gaggaggacg cagggggagg gtggagagac ccgcgagccg
      421 cagtctcagc ctcgtccgac gcgcctccgc ctctcccggg ccgggcccgg tgggcgctca
      481 gagcttgagg gcgccggctg ctccctcggt agcgggggca agcggaggca ggggtgtggg
      541 cggctaaaat gagtgaaagg agaagatctg cagtcgccct gagctcgcga gcacatgcct
      601 tctccgttga agccttgatc ggctcaaata aaaaacggaa actgcgagac tgggaggaga
      661 aggggctgga cctgtctatg gaggcgctga gccccgcggg cccactcgga gacacggagg
      721 acgcggcggc acacggcctg gagcctcacc cggattctga gcagagcact ggttcagatt
      781 ctgaggtcct cactgagcgg acttcctgct ccttcagtac tcacactgac ctggcctctg
      841 gtgctgcagg ccctgtgcct gctgccatgt cttccatgga ggagattcag gtggagctgc
      901 aatgtgctga cctctggaag cggttccatg atattggaac tgaaatgatc atcaccaaag
      961 caggcaggag gatgtttcct gccatgagag tgaaaatcac tggcctagat ccacatcagc
     1021 agtactacat agcaatggac attgtgcctg tggacaataa aagatacaga tatgtgtatc
     1081 atagctccaa gtggatggtg gctggcaatg ctgattcccc tgtgccccca agagtttata
     1141 tacaccctga ttctctagct tctggagaca cctggatgag acaggtggtc agttttgaca
     1201 aactcaagct taccaacaat gagttggatg atcaaggaca tatcattctg cactctatgc
     1261 acaaatacca gcctcgagtt catgtgattc gcaaagactt cagcagtgac ctttcaccca
     1321 ctaagcctgt tcctgttggg gatggggtga aaacgttcaa ctttcctgag actgtgttca
     1381 ccacagttac ggcctatcag aatcagcaga ttaccagatt aaaaattgac cgaaaccctt
     1441 ttgctaaagg attcagagat tctgggagaa acagaactgg acttgaagcc atcatggaga
     1501 catatgcatt ctggagacct cctgtgcgca cactcacctt cgaagacttc accaccatgc
     1561 agaagcagca aggaggcagc acaggcactt ccccaaccac ctccagcact gggacaccat
     1621 ccccttcggc ttcttctcat cttttatctc catcctgttc tcctccaact tttcatctgg
     1681 cccccaacac tttcaatgtg ggctgccgag aaagccagct gtgtaatcta aacctctctg
     1741 attatccacc atgtgcccga agcaacatgg ctgccttgca gagctaccca gggctgagtg
     1801 acagtggcta caacaggctt cagagtggca ccacttcagc cactcagccc tctgaaacct
     1861 tcatgcctca gaggactcca tccctgatct caggaatacc aactcctccc tcgttgcctg
     1921 gcaacagcaa gatggaagcc tacggtggcc agctggggtc ctttcccact tcccagtttc
     1981 agtatgtcat gcaggcaggc aatgctgcct ccagctcctc atcaccacac atgttcgggg
     2041 gcagccacat gcagcagagc tcctacaatg ccttctccct tcacaaccct tacaacctgt
     2101 atggatacaa tttccccact tcccctaggc tagctgcaag cccggaaaaa ctgagcgcct
     2161 ctcaaagcac tttactctgt tcttctcctt ccaacggggc ctttggagag aggcagtacc
     2221 tgccgtcagg gatggagcac agcatgcaca tgattagccc ttcacccaat aaccaacagg
     2281 caaccaacac ttgtgatggc cggcagtatg gggcagttcc aggctcctcc tcccagatgt
     2341 ccgtgcacat ggtttaaagg ccagtccaaa caccacggag catttggcaa tcaaggcccc
     2401 agagtctccg tggtcagatc ctcctctttg ggagtccagt gtctttgaaa aacaggaacc
     2461 gtgttttttt tttttttttt tttctggccg aagacatata cccaagaaca agagatacct
     2521 ttaagccagt gaaggatact tgcgatagaa tcatccgcaa ctcagtggcc attcttctgc
     2581 cttcccagac cttagtttta taaagcattg tctgttccag agtggccttt gaagagactg
     2641 aataatcact tcgtcataat gttaagggag atgctagtgt gtggcagcca tgaaaagtta
     2701 cacatacaca cccacataca gacagaccta cctatacata cgtgcacaca cacatacata
     2761 ttcatacaca attcatacac atgcaatcat acatgcacac tgactctgaa ctgggtgaac
     2821 tctgtggagg gaggcccaga atgggtgctt tcaccaagaa tttgtctgtg tacaactcta
     2881 gatggagtgg gccagcagta gctgccagtc tttctcccct gcagcttcct ctgcttctgg
     2941 aatgaaccat gtatcctgga gaccctccca atggatgaga gtggaaagac atcagtacaa
     3001 ctggacttgg cttccggaaa aagattgctt ttgaactttg gctctcttca cttgtatgct
     3061 atcattgata ttcccagtgg tgcccgtgga aagagggaga aagagaagct gaacaggaga
     3121 aagacaaaca gaaagaatag agaacaggaa cgaggtggag agcaagactg acagagaaag
     3181 tgtgagcaat gatgagaatt ttaattcacc aaggagacgt gtttttggtt tgtcccccca
     3241 aaccccgccc gccccactac aggttatgga aagaatcatg gcattactga ggagtaaacc
     3301 tctctggcac actgagcatg gtcagggcat tggtcagagg gacagagcaa ggaatgcatc
     3361 ctgagcccac agctttgacc actgtgatcc agaagagagg tgcactacgt gggaagtgct
     3421 gattccacag catgcagcct ggtaggggaa ggaaaataaa agggtgtgaa gaaggaatag
     3481 ttttataatc tcggaagatg ataccaagag cagaggcaac aaatagaggc ctggcctcca
     3541 ggtgccggat ccagacacct gacctagaat gcctgcccgc tatccctgtg gcaggaaata
     3601 tcccctcatg tcccagggaa ttgcagatgg gtcttctata cccttctacc tgcccttaga
     3661 tctccatttt tatcaaatag tacattgcat tttgaagttt tgggttttgt ccttcatctt
     3721 tccctttccc ttcaaatctt ttaatggtaa gaaagcaagt gaagcttggt gcaagctaaa
     3781 atttttaaat ggtgtggaaa tgcaaataat accaagtaaa ataatacaga tattattaaa
     3841 gtttctggtt ttgaggtgtt gtagataaat gtatttatgt gcctagtggg gaatccaata
     3901 ttatgaatat gaaaaagggg gcaataaaag ggtatgtaaa atatgtatga agaaaaggtg
     3961 tacaaaaatt tgcccttatg cacggaactc tgtttctaag tgccaagcac agaaagccgc
     4021 taaataaaat ctttgcaatt gt
//
