LOCUS       NM_004749               2226 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens transforming growth factor beta regulator 4 (TBRG4),
            transcript variant 1, mRNA.
ACCESSION   NM_004749
VERSION     NM_004749.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2226)
  AUTHORS   Tao,S., Cui,D., Cheng,H., Liu,X., Jiang,Z., Chen,H. and Gao,Y.
  TITLE     High expression of TBRG4 in relation to unfavorable outcome and
            cell ferroptosis in hepatocellular carcinoma
  JOURNAL   BMC Cancer 24 (1), 194 (2024)
   PUBMED   38347489
  REMARK    GeneRIF: High expression of TBRG4 in relation to unfavorable
            outcome and cell ferroptosis in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2226)
  AUTHORS   Zhang,H., Wong,J.P., Ni,G., Cano,P., Dittmer,D.P. and Damania,B.
  TITLE     Mitochondrial protein, TBRG4, modulates KSHV and EBV reactivation
            from latency
  JOURNAL   PLoS Pathog 18 (11), e1010990 (2022)
   PUBMED   36417478
  REMARK    GeneRIF: Mitochondrial protein, TBRG4, modulates KSHV and EBV
            reactivation from latency.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2226)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 2226)
  AUTHORS   Ohkubo,A., Van Haute,L., Rudler,D.L., Stentenbach,M., Steiner,F.A.,
            Rackham,O., Minczuk,M., Filipovska,A. and Martinou,J.C.
  TITLE     The FASTK family proteins fine-tune mitochondrial RNA processing
  JOURNAL   PLoS Genet 17 (11), e1009873 (2021)
   PUBMED   34748562
  REMARK    GeneRIF: The FASTK family proteins fine-tune mitochondrial RNA
            processing.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2226)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 2226)
  AUTHORS   Simarro,M., Gimenez-Cassina,A., Kedersha,N., Lazaro,J.B.,
            Adelmant,G.O., Marto,J.A., Rhee,K., Tisdale,S., Danial,N.,
            Benarafa,C., Orduna,A. and Anderson,P.
  TITLE     Fast kinase domain-containing protein 3 is a mitochondrial protein
            essential for cellular respiration
  JOURNAL   Biochem Biophys Res Commun 401 (3), 440-446 (2010)
   PUBMED   20869947
REFERENCE   7  (bases 1 to 2226)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   8  (bases 1 to 2226)
  AUTHORS   Rival-Gervier,S., Thepot,D., Jolivet,G. and Houdebine,L.M.
  TITLE     Pig whey acidic protein gene is surrounded by two ubiquitously
            expressed genes
  JOURNAL   Biochim Biophys Acta 1627 (1), 7-14 (2003)
   PUBMED   12759187
REFERENCE   9  (bases 1 to 2226)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   10 (bases 1 to 2226)
  AUTHORS   Edwards,M.C., Liegeois,N., Horecka,J., DePinho,R.A., Sprague,G.F.
            Jr., Tyers,M. and Elledge,S.J.
  TITLE     Human CPR (cell cycle progression restoration) genes impart a Far-
            phenotype on yeast cells
  JOURNAL   Genetics 147 (3), 1063-1076 (1997)
   PUBMED   9383053
  REMARK    GeneRIF: 13 human CPR (cell cycle progression restoration) genes
            and 11 yeast OPY (overproduction-induced pheromone-resistant yeast)
            genes that specifically block the G1 arrest by mating pheromone.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA980367.1, BC017235.2 and BM150942.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004749.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL833840.1, SRR1803613.212836.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000258770.8/ ENSP00000258770.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                DA980367.1         51-73
            24-2214             BC017235.2         1-2191
            2215-2226           BM150942.1         16-27               c
FEATURES             Location/Qualifiers
     source          1..2226
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p13"
     gene            1..2226
                     /gene="TBRG4"
                     /gene_synonym="CPR2; FASTKD4"
                     /note="transforming growth factor beta regulator 4"
                     /db_xref="GeneID:9238"
                     /db_xref="HGNC:HGNC:17443"
                     /db_xref="MIM:611325"
     exon            1..55
                     /gene="TBRG4"
                     /gene_synonym="CPR2; FASTKD4"
                     /inference="alignment:Splign:2.1.0"
     exon            56..516
                     /gene="TBRG4"
                     /gene_synonym="CPR2; FASTKD4"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..2001
                     /gene="TBRG4"
                     /gene_synonym="CPR2; FASTKD4"
                     /note="isoform 1 is encoded by transcript variant 1; FAST
                     kinase domains 4; H_TD2522F11.8; protein TBRG4; cell cycle
                     progression protein 2; FAST kinase domain-containing
                     protein 4; cell cycle progression restoration protein 2"
                     /codon_start=1
                     /product="FAST kinase domain-containing protein 4 isoform
                     1"
                     /protein_id="NP_004740.2"
                     /db_xref="CCDS:CCDS5501.1"
                     /db_xref="GeneID:9238"
                     /db_xref="HGNC:HGNC:17443"
                     /db_xref="MIM:611325"
                     /translation="MAAHLVKRCTCLLREAARQAPAMAPVGRLRLAWVAHKTLTSSAT
                     SPISHLPGSLMEPVEKERASTPYIEKQVDHLIKKATRPEELLELLGGSHDLDSNQAAM
                     VLIRLSHLLSEKPEDKGLLIQDAHFHQLLCLLNSQIASVWHGTLSKLLGSLYALGIPK
                     ASKELQSVEQEVRWRMRKLKYKHLAFLAESCATLSQEQHSQELLAELLTHLERRWTEI
                     EDSHTLVTVMMKVGHLSEPLMNRLEDKCLELVEHFGPNELRKVLVMLAAQSRRSVPLL
                     RAISYHLVQKPFSLTKDVLLDVAYAYGKLSFHQTQVSQRLATDLLSLMPSLTSGEVAH
                     CAKSFALLKWLSLPLFEAFAQHVLNRAQDITLPHLCSVLLAFARLNFHPDQEDQFFSL
                     VHEKLGSELPGLEPALQVDLVWALCVLQQAREAELQAVLHPEFHIQFLGGKSQKDQNT
                     FQKLLHINATALLEYPEYSGPLLPASAVAPGPSALDRKVTPLQKELQETLKGLLGSAD
                     KGSLEVATQYGWVLDAEVLLDSDGEFLPVRDFVAPHLAQPTGSQSPPPGSKRLAFLRW
                     EFPNFNSRSKDLLGRFVLARRHIVAAGFLIVDVPFYEWLELKSEWQKGAYLKDKMRKA
                     VAEELAK"
     exon            517..840
                     /gene="TBRG4"
                     /gene_synonym="CPR2; FASTKD4"
                     /inference="alignment:Splign:2.1.0"
     exon            841..1012
                     /gene="TBRG4"
                     /gene_synonym="CPR2; FASTKD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1170
                     /gene="TBRG4"
                     /gene_synonym="CPR2; FASTKD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1281
                     /gene="TBRG4"
                     /gene_synonym="CPR2; FASTKD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1426
                     /gene="TBRG4"
                     /gene_synonym="CPR2; FASTKD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1672
                     /gene="TBRG4"
                     /gene_synonym="CPR2; FASTKD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1784
                     /gene="TBRG4"
                     /gene_synonym="CPR2; FASTKD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1899
                     /gene="TBRG4"
                     /gene_synonym="CPR2; FASTKD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..2226
                     /gene="TBRG4"
                     /gene_synonym="CPR2; FASTKD4"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2226
                     /gene="TBRG4"
                     /gene_synonym="CPR2; FASTKD4"
                     /note="major polyA site"
ORIGIN      
        1 atggttccgg ggacagttag ggcggcggat ggaggtcagc ggtggtgctc gctgcggttt
       61 ggaatcactt gctaggagtc ttgtctctct gccacccagg acatcatggc agctcacctg
      121 gtaaagcgat gcacgtgcct cctgagagaa gctgctcgtc aggcccctgc catggctcca
      181 gttggccgac tgagacttgc ctgggtagcc cataagactc tgacttcctc agccacctca
      241 cccatttccc acctcccagg ttccttgatg gagccggtgg agaaggaacg agcatctact
      301 ccctacatag agaagcaggt ggaccacctc atcaagaagg ccacaaggcc agaggagctc
      361 ctggagctac ttggtggcag tcacgacttg gacagcaatc aagcagcaat ggtacttatc
      421 cggctctctc acttgctgtc tgagaagcca gaagataaag gcttgctcat acaggatgcc
      481 cactttcatc aacttctctg tctgctcaac agtcagattg cctcggtctg gcatggtacc
      541 ctctcgaagc tgctgggaag cctgtatgct ctgggcatcc ccaaggcctc caaggagctg
      601 cagtcggtgg agcaggaggt ccgctggcgc atgcggaagc tcaagtacaa gcacctggcc
      661 ttcctggcag agtcctgtgc caccctctca caggagcagc actcgcagga gctgctggct
      721 gagctgctca cacacctgga aaggcgttgg acagaaattg aagattccca cacattagtg
      781 accgtcatga tgaaggtggg acacctctcg gagccactaa tgaaccgcct ggaagacaag
      841 tgcctggagt tggtggagca ctttggcccc aatgagctgc ggaaggtgct ggtgatgctg
      901 gcagctcaga gccggcggtc cgtgcccttg ctgcgggcca tctcctacca cctggtgcag
      961 aagcccttct ctctgacgaa agatgtgctc ttggacgtgg cctatgccta tggcaaactc
     1021 agctttcacc agacccaggt gtcccagcgc ctggccaccg acctgctatc cctcatgccc
     1081 agcctgactt ctggtgaggt ggcccactgt gccaagtcct tcgccttact caagtggctc
     1141 agcctgcccc tgtttgaggc ctttgcccag cacgtcctga acagagcgca ggacatcacc
     1201 ctgccccacc tgtgcagcgt acttctggct tttgcgcgtc tgaacttcca tccagaccaa
     1261 gaggatcagt tcttcagcct ggtacatgag aagctggggt cagagctgcc aggcctggag
     1321 ccagccctgc aggtggacct ggtgtgggcc ctgtgtgtgc tgcagcaggc acgggaagca
     1381 gagctgcaag ccgtcctcca ccctgaattt cacatccaat ttctaggggg caagtctcag
     1441 aaggatcaga acaccttcca gaagctgctc cacatcaacg ccactgccct gctggagtac
     1501 cccgagtact cgggtcccct tctgcctgcc tcggctgtgg cccctgggcc ctcagccctt
     1561 gacaggaagg tgacccccct gcaaaaggag ctgcaggaga cgctgaaggg gctgctgggg
     1621 agcgccgaca agggcagcct cgaggtggcc acgcagtatg gctgggtgct ggatgctgag
     1681 gtgctgctgg acagtgacgg cgagtttctg cccgtaaggg actttgtggc acctcacctt
     1741 gcccagccaa ctgggagcca gtcaccacct ccagggtcta agaggctagc gttcttgcgg
     1801 tgggagttcc ccaacttcaa cagccgaagc aaggacttgc tgggtcgctt tgttctggcc
     1861 cggcgacaca tagtggctgc aggcttcctg atagtggacg tcccattcta tgagtggctg
     1921 gaactcaagt ctgaatggca gaaaggcgcc tacctcaagg acaagatgcg caaagcggtg
     1981 gctgaggagc tggccaagtg acttgtgcca gcagcatgga ctgcgtgcct ctccgccgga
     2041 ggtctagctg tgggcggcca agaagggtca cccttgagga caaacctctg tgcaggacct
     2101 tggccagagt ggggagggtg gccagccact ctgagggaca gaacgtcctc ttgtgtataa
     2161 taaaccttta attttggtgt tggacccctg gggccttccc aggcttggtc accctctgca
     2221 ctgtca
//
