LOCUS       NM_032811               5144 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens transforming growth factor beta regulator 1 (TBRG1),
            transcript variant 1, mRNA.
ACCESSION   NM_032811
VERSION     NM_032811.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5144)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5144)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 5144)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5144)
  AUTHORS   Slezak-Prochazka,I., Kluiver,J., de Jong,D., Smigielska-Czepiel,K.,
            Kortman,G., Winkle,M., Rutgers,B., Koerts,J., Visser,L.,
            Diepstra,A., Kroesen,B.J. and van den Berg,A.
  TITLE     Inhibition of the miR-155 target NIAM phenocopies the growth
            promoting effect of miR-155 in B-cell lymphoma
  JOURNAL   Oncotarget 7 (3), 2391-2400 (2016)
   PUBMED   26497687
  REMARK    GeneRIF: In primary B-cell lymphoma NIAM-positive cases have
            significant lower levels of miR-155 as compared to NIAM-negative
            cases, suggesting that NIAM is regulated by miR-155 in primary
            B-cell lymphoma.
REFERENCE   5  (bases 1 to 5144)
  AUTHORS   Reed,S.M., Hagen,J., Tompkins,V.S., Thies,K., Quelle,F.W. and
            Quelle,D.E.
  TITLE     Nuclear interactor of ARF and Mdm2 regulates multiple pathways to
            activate p53
  JOURNAL   Cell Cycle 13 (8), 1288-1298 (2014)
   PUBMED   24621507
  REMARK    GeneRIF: NIAM regulates 2 critical pathways that control p53
            function and are altered in human cancers, implying an important
            role for NIAM in tumorigenesis.
REFERENCE   6  (bases 1 to 5144)
  AUTHORS   Hagen,J., Tompkins,V., Dudakovic,A., Weydert,J.A. and Quelle,D.E.
  TITLE     Generation and characterization of monoclonal antibodies to NIAM: a
            nuclear interactor of ARF and Mdm2
  JOURNAL   Hybridoma (Larchmt) 27 (3), 159-166 (2008)
   PUBMED   18582208
  REMARK    GeneRIF: NIAM is a nuclear interactor of ARF and Mdm2
REFERENCE   7  (bases 1 to 5144)
  AUTHORS   Tompkins,V.S., Hagen,J., Frazier,A.A., Lushnikova,T.,
            Fitzgerald,M.P., di Tommaso,A., Ladeveze,V., Domann,F.E.,
            Eischen,C.M. and Quelle,D.E.
  TITLE     A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains
            chromosomal stability
  JOURNAL   J Biol Chem 282 (2), 1322-1333 (2007)
   PUBMED   17110379
  REMARK    GeneRIF: novel protein with tumor suppressor-like behaviors and
            functional links to ARF-MDM2-p53 signaling
REFERENCE   8  (bases 1 to 5144)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   9  (bases 1 to 5144)
  AUTHORS   Tompkins,V., Hagen,J., Zediak,V.P. and Quelle,D.E.
  TITLE     Identification of novel ARF binding proteins by two-hybrid
            screening
  JOURNAL   Cell Cycle 5 (6), 641-646 (2006)
   PUBMED   16582619
REFERENCE   10 (bases 1 to 5144)
  AUTHORS   Babalola,G.O. and Schultz,R.M.
  TITLE     Modulation of gene expression in the preimplantation mouse embryo
            by TGF-alpha and TGF-beta
  JOURNAL   Mol Reprod Dev 41 (2), 133-139 (1995)
   PUBMED   7654366
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA292015.1, DQ144542.1 and AP001524.4.
            
            On Nov 23, 2018 this sequence version replaced NM_032811.2.
            
            Transcript Variant: This variant (1) represents the longer,
            protein-coding transcript.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.223413.1,
                                           SRR1660805.219109.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000441174.8/ ENSP00000409016.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               DA292015.1         19-238
            221-1456            DQ144542.1         1-1236
            1457-5144           AP001524.4         107211-110898
FEATURES             Location/Qualifiers
     source          1..5144
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.2"
     gene            1..5144
                     /gene="TBRG1"
                     /gene_synonym="NIAM; TB-5"
                     /note="transforming growth factor beta regulator 1"
                     /db_xref="GeneID:84897"
                     /db_xref="HGNC:HGNC:29551"
                     /db_xref="MIM:610614"
     exon            1..370
                     /gene="TBRG1"
                     /gene_synonym="NIAM; TB-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..1456
                     /gene="TBRG1"
                     /gene_synonym="NIAM; TB-5"
                     /note="nuclear interactor of ARF and MDM2"
                     /codon_start=1
                     /product="transforming growth factor beta regulator 1"
                     /protein_id="NP_116200.2"
                     /db_xref="CCDS:CCDS8448.2"
                     /db_xref="GeneID:84897"
                     /db_xref="HGNC:HGNC:29551"
                     /db_xref="MIM:610614"
                     /translation="MSLLDGLASSPRAPLQSSKARMKKLPKKSQNEKYRLKYLRLRKA
                     AKATVFENAAICDEIARLEEKFLKAKEERRYLLKKLLQLQALTEGEVQAAAPSHSSSL
                     PLTYGVASSVGTIQGAGPISGPSTGAEEPFGKKTKKEKKEKGKENNKLEVLKKTCKKK
                     KMAGGARKLVQPIALDPSGRPVFPIGLGGLTVYSLGEIITDRPGFHDESAIYPVGYCS
                     TRIYASMKCPDQKCLYTCQIKDGGVQPQFEIVPEDDPQNAIVSSSADACHAELLRTIS
                     TTMGKLMPNLLPAGADFFGFSHPAIHNLIQSCPGARKCINYQWVKFDVCKPGDGQLPE
                     GLPENDAAMSFEAFQRQIFDEDQNDPLLPGSLDLPELQPAAFVSSYQPMYLTHEPLVD
                     THLQHLKSPSQGSPIQSSD"
     exon            371..441
                     /gene="TBRG1"
                     /gene_synonym="NIAM; TB-5"
                     /inference="alignment:Splign:2.1.0"
     exon            442..674
                     /gene="TBRG1"
                     /gene_synonym="NIAM; TB-5"
                     /inference="alignment:Splign:2.1.0"
     exon            675..811
                     /gene="TBRG1"
                     /gene_synonym="NIAM; TB-5"
                     /inference="alignment:Splign:2.1.0"
     exon            812..958
                     /gene="TBRG1"
                     /gene_synonym="NIAM; TB-5"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1056
                     /gene="TBRG1"
                     /gene_synonym="NIAM; TB-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1167
                     /gene="TBRG1"
                     /gene_synonym="NIAM; TB-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1310
                     /gene="TBRG1"
                     /gene_synonym="NIAM; TB-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..5144
                     /gene="TBRG1"
                     /gene_synonym="NIAM; TB-5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1637..1642
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBRG1"
                     /gene_synonym="NIAM; TB-5"
                     /note="hexamer: AATAAA"
     polyA_site      1655
                     /gene="TBRG1"
                     /gene_synonym="NIAM; TB-5"
                     /note="major polyA site"
     regulatory      3904..3909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBRG1"
                     /gene_synonym="NIAM; TB-5"
                     /note="hexamer: AATAAA"
     polyA_site      3931
                     /gene="TBRG1"
                     /gene_synonym="NIAM; TB-5"
                     /note="major polyA site"
     regulatory      4590..4595
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBRG1"
                     /gene_synonym="NIAM; TB-5"
                     /note="hexamer: AATAAA"
     polyA_site      4612
                     /gene="TBRG1"
                     /gene_synonym="NIAM; TB-5"
     regulatory      5117..5122
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBRG1"
                     /gene_synonym="NIAM; TB-5"
                     /note="hexamer: AATAAA"
     polyA_site      5144
                     /gene="TBRG1"
                     /gene_synonym="NIAM; TB-5"
ORIGIN      
        1 acttccaaga cagacacgga agtgctggga ggcgccggga gcccgttcgg ttgcgggtgt
       61 ctctggccct gcggtcagcc ctgggaacgt cccggagagc tagattccta gaggcccgat
      121 tccgctagcc cggaacagac aaagccagcg ctcccgcccg ctccccgact taggatccga
      181 tgccggcagc gtcctggggc ccccgtagcg gggctggacc atgagcctgc tggacggcct
      241 cgcttcctcg ccgcgggctc cgctgcagtc cagcaaggcc aggatgaaaa agctcccgaa
      301 gaagagccag aatgagaagt accggctgaa gtacctgcgg ctgcgcaaag cggccaaggc
      361 cacggtgttt gaaaatgctg ctatttgtga tgaaattgct cgtcttgagg aaaaatttct
      421 taaagcaaaa gaagaaagaa ggtacttgct aaagaagctc ctccagcttc aggctctaac
      481 tgaaggggaa gtacaggctg cagctccttc ccacagttcc agtttgcccc tgacttatgg
      541 tgtggccagc tctgtgggaa ctatacaggg agctgggcct atttcagggc ccagcactgg
      601 ggctgaggaa ccatttggga agaaaactaa gaaggagaaa aaagaaaaag gcaaagagaa
      661 caacaaactg gaagttctga agaaaacatg caagaaaaag aaaatggcgg gaggtgctcg
      721 caagctggtt cagcccattg ccctggatcc ctcaggacgg cctgtgttcc ccatcggact
      781 agggggtcta acagtatata gcctggggga gatcatcacc gaccgacctg gctttcatga
      841 tgagagtgcc atctaccccg tgggctattg cagtactcga atatatgcca gcatgaagtg
      901 cccagaccag aagtgtctat atacctgtca gatcaaggat ggtggtgtgc agcctcagtt
      961 tgaaattgtt cctgaagatg acccccagaa tgccattgtc agctcttctg cagatgcttg
     1021 tcatgcagaa ctgctcagga ctataagcac tactatgggg aaactaatgc ctaacctgct
     1081 tccagctgga gctgactttt ttggattttc tcatccagcc atccacaacc tgatccagag
     1141 ctgtccagga gctcgaaaat gcatcaatta ccagtgggtg aaatttgatg tgtgcaaacc
     1201 tggagatggg cagctacctg aggggctgcc ggagaatgat gcagctatga gctttgaagc
     1261 ctttcagaga cagatctttg atgaagatca gaatgatccc cttctgccag gatccttgga
     1321 cctcccagag cttcagcctg cagcctttgt gtcttcttac cagcccatgt acctgacaca
     1381 tgaacccttg gtagatactc acctgcagca cttgaagtct ccatcacagg gtagcccaat
     1441 tcagtcttca gattgaacaa gaagggatca gatgccacat cgtttttgtc gtgattaatt
     1501 taacttaaac taaaattttg ggtatatgaa agaaggcagc aattcagaag taaagaagat
     1561 actaacgtat ttcatcatgg aaggtcctgt ggtgatggtt ttccctggga aaaccttcag
     1621 ctgctttatt tttagtaata aatttctctt gtcaattctg tttactttca tcttgtaatc
     1681 gggatgtaat cttttttgct tagctctgcc tgaggtaaag taaacttcag cctcttataa
     1741 acaagagtga tagagagctg caggctgcta caacaaatac catagacagg ttggtttata
     1801 aataacatga atttatttct cacagttctg gatgctggga agtccaagtt caaggagcgc
     1861 agattcaatg tctggtgagg gcccacttcc tagttcttag acagctgtct tcctgcagtg
     1921 tcctcacgtg gtagaagagg aaggcagctc tccggggtcc cttttataag atcactaagc
     1981 cggttcatga gaggtctgct ctcatgacct aatcacctcc caaaggcccc acctcccaat
     2041 accatcacat taggggttag gatttaacat gaattttggg gacatataaa cattaagtct
     2101 gtagtagcag cagctgacta acgagggaga tagggagatt ctgacaaact tctactcttg
     2161 attgtgatcc taattcaagg aatatcaagt cccagcccct gcaacccagg ctgctgctta
     2221 attttcatgt cagtatcatc aaaatccaat gttctgctta aactcaagat ggaaagtcca
     2281 gtccaaggta cactgttcat ctttttcttc acattttgca catccttcaa ggggatcttt
     2341 aacctcttta acctttgtat tgcacctcag ataatgtgct ttttagctca gtacactgaa
     2401 accatatgat aacacaaatt cacatataat tgggggttag tcccatactc tataacagac
     2461 ttagtcctgt cttttcatta gccatgtaat aatataactc catgttccat gcaactggat
     2521 ttttggaccc tgttaatagc attaaggtag aggtttactc tatcacctaa cacctcaaca
     2581 ctacctgtgg gatgccttag ttacccagca gcaggttacc aagggctgtc tggaaaggga
     2641 gggacaaaag gacccagaag tagaagaatg gggatggagt ggtgagaatt gaatggttaa
     2701 tgcactgcca ttcataattg ccaattgagg acaacacaaa tgggattggt actttatagt
     2761 aataaatctg accagcagag ggagggatca ggcagcagtg tttagagcac accacactgg
     2821 ccactgtaaa ctgagaagct aagttaactg gtattttatg attttgagta tagtcttttt
     2881 ataagttgta tacactttac aatgtaaaag aaacaaactt tgtataatag caaatcggga
     2941 aggggactgc ttaaaatgtt aatgcagtgt ttttcttttt ttctctgcat aaatggcttg
     3001 agcatactgg catttacaca gaaatgatat atgctgcttt tatcatataa caaatatttt
     3061 cccactatta cagcctgagt aatacccgta ttaaaagagc ctcattttag aaagacattt
     3121 aaaatttttg gaacatacca catgtagaaa ggttgaactg gtttttcagc tataatgcat
     3181 atacaactat agtgtgtacg tataccacat atacatatac ttgtatgaag atatgtgtaa
     3241 aatgttttta ctatggatca tggatttaag aaacttgaaa agctgggcac ggtggctcac
     3301 gcctgtaatc ccagcacttt gggaggctga ggcgggtgga tcaagaggtc aggagatcga
     3361 gaccatcctg gctaagtcgg tctctaataa aaatacaaaa aattagccag gcgtggtggc
     3421 acgcgcctgt agtcccagct actcgggagg ctgaggcagg aagaatcgct tgaacccggg
     3481 aggcagaggt tgcagtgagc cgagaccgcg ccactgcact ccagcctggg caacagagca
     3541 aaactccaac tcaaaaacaa aaacaaaaac accttgaaaa acactgcctt agtatactta
     3601 aactatcttt tcatctatca gattgttaag gatttttttt aaatttgaca acatccagtg
     3661 tcaatgaggg tgagggcaaa aaaaggacta ccttggtgag aatgtaagtt gtttaatcct
     3721 ttgggagggt taagctgtag atatctaaat tttaaatata tatttatcct cttccatgtt
     3781 aagaacccta agaaataact ggacgagtgt ggtatgatgt ttgcatgtga tattcattac
     3841 agtattattt taatagtaga aaattgttaa aaatctatat gtccattaat aggaaattgg
     3901 ttaaataaaa tgaggcttcc acaaactgaa acactctaaa tctatattct attatttaca
     3961 taagaaaatt attttggtaa agtaagtaag tcaaaaacac agattacaaa ataatatgta
     4021 ctgtataaaa ttatataact caagtcaagt gaatggttca gcaaaatagt gtttctctga
     4081 atgatgaatt tgggggtgat ttttacttgc ttatacttta gtgtccaaat tttctacagt
     4141 gactataaat ttcattttaa aactaaaaag ttcttacatt tggggaaatg cagtgaattc
     4201 ccacatcatg ttttaaatta ctcagccact aaaaatgaat gtgcatggcg tcattaacat
     4261 aatcattgcc tgaaccgtat ttttcacact atgtactcta ggttcctgga ggtgaaagga
     4321 atctggactt agagttcttg gctacctctg gctgcccccg aattagaaca gcccatgggg
     4381 gtatgtgtat tgggagtgga ggagtggacg ggtagattga ctttttctca ggcatcaatc
     4441 tgttacaagg ttcatggttt ctatggggcc agatgcatga gaggtcaaag catgggcaat
     4501 aggggttaac tgaacgagtt gaatgctagg aagtcctcag gggagccaac gttccttgta
     4561 aagtgtgtag attttttgtt ttttaactaa ataaaatctt ggcactgaca aagttattcc
     4621 tgctgtttgg agctacacca gaaccccttg gaactctaca gaggggtaga actaaagcaa
     4681 aaaccatcat tcaccctaca gagtattata aatttcattt tcacacagta aaaagttcct
     4741 aaattggggg aaacatagtg aattccacat aatgttttaa attattcagc cactaaaaat
     4801 aaatttacat atgatttcat taatatattc actatctaaa ccatattttt tacactacgt
     4861 aaaatacatt gtatatgtac agtgagtgat gctttttgct ttagttctca tttttcacat
     4921 taaggggagg aaagctaccc atagatagta ttcttactcc ttttcacatg cttcaaggac
     4981 agtttgcaag tggatataaa tacatacaca tcactagtga ttatgctttt atttatttcc
     5041 aacttcttat aggtaacata attttcagac aatgttagct gtttttaatc catcagtaaa
     5101 ctgcattaag attcttaata aacaaacact gaaggcctct ttca
//
