LOCUS       NM_001253676            4554 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens TATA-box binding protein like 1 (TBPL1), transcript
            variant 1, mRNA.
ACCESSION   NM_001253676
VERSION     NM_001253676.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4554)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4554)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 4554)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4554)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 4554)
  AUTHORS   Kuzmin,A., Jarvi,K., Lo,K., Spencer,L., Chow,G.Y., Macleod,G.,
            Wang,Q. and Varmuza,S.
  TITLE     Identification of potentially damaging amino acid substitutions
            leading to human male infertility
  JOURNAL   Biol Reprod 81 (2), 319-326 (2009)
   PUBMED   19369647
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 4554)
  AUTHORS   Martianov,I., Brancorsini,S., Gansmuller,A., Parvinen,M.,
            Davidson,I. and Sassone-Corsi,P.
  TITLE     Distinct functions of TBP and TLF/TRF2 during spermatogenesis:
            requirement of TLF for heterochromatic chromocenter formation in
            haploid round spermatids
  JOURNAL   Development 129 (4), 945-955 (2002)
   PUBMED   11861477
REFERENCE   7  (bases 1 to 4554)
  AUTHORS   Teichmann,M., Wang,Z., Martinez,E., Tjernberg,A., Zhang,D.,
            Vollmer,F., Chait,B.T. and Roeder,R.G.
  TITLE     Human TATA-binding protein-related factor-2 (hTRF2) stably
            associates with hTFIIA in HeLa cells
  JOURNAL   Proc Natl Acad Sci U S A 96 (24), 13720-13725 (1999)
   PUBMED   10570139
REFERENCE   8  (bases 1 to 4554)
  AUTHORS   Rabenstein,M.D., Zhou,S., Lis,J.T. and Tjian,R.
  TITLE     TATA box-binding protein (TBP)-related factor 2 (TRF2), a third
            member of the TBP family
  JOURNAL   Proc Natl Acad Sci U S A 96 (9), 4791-4796 (1999)
   PUBMED   10220372
REFERENCE   9  (bases 1 to 4554)
  AUTHORS   Ohbayashi,T., Kishimoto,T., Makino,Y., Shimada,M., Nakadai,T.,
            Aoki,T., Kawata,T., Niwa,S. and Tamura,T.
  TITLE     Isolation of cDNA, chromosome mapping, and expression of the human
            TBP-like protein
  JOURNAL   Biochem Biophys Res Commun 255 (1), 137-142 (1999)
   PUBMED   10082669
REFERENCE   10 (bases 1 to 4554)
  AUTHORS   Ohbayashi,T., Makino,Y. and Tamura,T.A.
  TITLE     Identification of a mouse TBP-like protein (TLP) distantly related
            to the drosophila TBP-related factor
  JOURNAL   Nucleic Acids Res 27 (3), 750-755 (1999)
   PUBMED   9889269
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI828497.1, AK292320.1,
            AI187713.1, R42082.1 and AL035699.4.
            
            On Aug 13, 2020 this sequence version replaced NM_001253676.1.
            
            Summary: This gene encodes a member of the TATA box-binding protein
            family. TATA box-binding proteins play a critical role in
            transcription by RNA polymerase II as components of the
            transcription factor IID (TFIID) complex. The encoded protein does
            not bind to the TATA box and initiates transcription from TATA-less
            promoters. This gene plays a critical role in spermatogenesis, and
            single nucleotide polymorphisms in this gene may be associated with
            male infertility. Alternatively spliced transcript variants have
            been observed for this gene, and a pseudogene of this gene is
            located on the long arm of chromosome 3. [provided by RefSeq, Nov
            2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.911033.1, AK292320.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                BI828497.1         5-45
            42-1437             AK292320.1         1-1396
            1438-1614           AI187713.1         5-181               c
            1615-1622           R42082.1           10-17               c
            1623-4554           AL035699.4         15695-18626         c
FEATURES             Location/Qualifiers
     source          1..4554
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q23.2"
     gene            1..4554
                     /gene="TBPL1"
                     /gene_synonym="MGC:8389; MGC:9620; STUD; TLF; TLP; TRF2"
                     /note="TATA-box binding protein like 1"
                     /db_xref="GeneID:9519"
                     /db_xref="HGNC:HGNC:11589"
                     /db_xref="MIM:605521"
     exon            1..557
                     /gene="TBPL1"
                     /gene_synonym="MGC:8389; MGC:9620; STUD; TLF; TLP; TRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            558..736
                     /gene="TBPL1"
                     /gene_synonym="MGC:8389; MGC:9620; STUD; TLF; TLP; TRF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             602..1162
                     /gene="TBPL1"
                     /gene_synonym="MGC:8389; MGC:9620; STUD; TLF; TLP; TRF2"
                     /note="TBP-related factor 2; 21-kDA TBP-like protein; TATA
                     box-binding protein-like protein 1; TBP-like 1;
                     TBP-related protein; second TBP of unique DNA protein;
                     TATA box-binding protein-related factor 2"
                     /codon_start=1
                     /product="TATA box-binding protein-like 1"
                     /protein_id="NP_001240605.1"
                     /db_xref="CCDS:CCDS5168.1"
                     /db_xref="GeneID:9519"
                     /db_xref="HGNC:HGNC:11589"
                     /db_xref="MIM:605521"
                     /translation="MDADSDVALDILITNVVCVFRTRCHLNLRKIALEGANVIYKRDV
                     GKVLMKLRKPRITATIWSSGKIICTGATSEEEAKFGARRLARSLQKLGFQVIFTDFKV
                     VNVLAVCNMPFEIRLPEFTKNNRPHASYEPELHPAVCYRIKSLRATLQIFSTGSITVT
                     GPNVKAVATAVEQIYPFVFESRKEIL"
     exon            737..819
                     /gene="TBPL1"
                     /gene_synonym="MGC:8389; MGC:9620; STUD; TLF; TLP; TRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            820..883
                     /gene="TBPL1"
                     /gene_synonym="MGC:8389; MGC:9620; STUD; TLF; TLP; TRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            884..987
                     /gene="TBPL1"
                     /gene_synonym="MGC:8389; MGC:9620; STUD; TLF; TLP; TRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1082
                     /gene="TBPL1"
                     /gene_synonym="MGC:8389; MGC:9620; STUD; TLF; TLP; TRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..4554
                     /gene="TBPL1"
                     /gene_synonym="MGC:8389; MGC:9620; STUD; TLF; TLP; TRF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1594..1599
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBPL1"
                     /gene_synonym="MGC:8389; MGC:9620; STUD; TLF; TLP; TRF2"
                     /note="hexamer: AATAAA"
     polyA_site      1612
                     /gene="TBPL1"
                     /gene_synonym="MGC:8389; MGC:9620; STUD; TLF; TLP; TRF2"
                     /note="major polyA site"
     regulatory      2367..2372
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBPL1"
                     /gene_synonym="MGC:8389; MGC:9620; STUD; TLF; TLP; TRF2"
                     /note="hexamer: AATAAA"
     polyA_site      2387
                     /gene="TBPL1"
                     /gene_synonym="MGC:8389; MGC:9620; STUD; TLF; TLP; TRF2"
     regulatory      3324..3329
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBPL1"
                     /gene_synonym="MGC:8389; MGC:9620; STUD; TLF; TLP; TRF2"
                     /note="hexamer: AATAAA"
     polyA_site      3348
                     /gene="TBPL1"
                     /gene_synonym="MGC:8389; MGC:9620; STUD; TLF; TLP; TRF2"
     regulatory      4528..4533
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBPL1"
                     /gene_synonym="MGC:8389; MGC:9620; STUD; TLF; TLP; TRF2"
                     /note="hexamer: AATAAA"
     polyA_site      4554
                     /gene="TBPL1"
                     /gene_synonym="MGC:8389; MGC:9620; STUD; TLF; TLP; TRF2"
ORIGIN      
        1 gttacgcgat tttcgctccc gcgggcagcg cctctcaggc cactcccgag ggaccccgag
       61 gacgcactcg ggccccaggg cgacggttca aacgggccat tgtgcgcccc cggggtcccc
      121 cggcccctgc agggctactt gggcgcagag ccgcggaggg tctccgttcc tagaggtcct
      181 cctatcccgg gctgcctgag tcctcgccag catccgccct ctcccactcc catccttcct
      241 ggatccgcct ctcggttccc gagggacagt cccgaccgca aacccacgta gagtaaggaa
      301 tgtgggacag gcgacagaag tggcatacgg tcctgcgtta tccctccgtc tcgccacacc
      361 ttgtgtctcc atctctcccc acttccttcc ctccgtctgt catctgtcat ccccggtcgc
      421 tctaagacca ggattccaat tcgcctagtg aggaatctca ctaggggaat ttatcgcgac
      481 atcataaatt aacgggttca ttttgactga aaaagcgaag gacttttttc aggcagaaaa
      541 caagtctcgt ctggacggat gtgatcttcg tggtggaaag ctaaatttta aaaccacccc
      601 aatggatgca gacagtgatg ttgcattgga cattctaatt acaaatgtag tctgtgtttt
      661 tagaacaaga tgtcatttaa acttaaggaa gattgctttg gaaggagcaa atgtaattta
      721 taaacgtgat gttggaaaag tattaatgaa gcttagaaaa cctagaatta cagctacaat
      781 ttggtcctca ggaaaaatta tttgcactgg agcaacaagt gaagaagaag ctaaatttgg
      841 tgccagacgc ttagcccgta gtctgcagaa actaggtttt caggtaatat ttacagattt
      901 taaggttgtt aacgttctgg cagtgtgtaa catgccattt gaaatccgtt tgccagaatt
      961 cacaaagaac aatagacctc atgccagtta cgaacctgaa cttcatcctg ctgtgtgcta
     1021 tcggataaaa tctctaagag ctacattaca gattttttca acaggaagta tcacagtaac
     1081 agggcccaat gtaaaggctg ttgctactgc tgtggaacag atttacccat ttgtgtttga
     1141 aagcaggaaa gaaattttat aattcaccac ttaattggtt agaatctcta actgagcacc
     1201 ttttaaacct gctgcacatt ggactcaaaa ggaaaactgg accaacaata attgaggaaa
     1261 tagactcttt tattcattca cggctacagt gtaagctcca gtccctttgg attttattcc
     1321 aaaccttgct gtaatataaa aggaagttta caagacatga tattgctgct tttacaaaag
     1381 gacattctat ttattttcgc agtaattctc atgtccccat aagcagagct gtcacagtgt
     1441 gcactacctt agattgtttt attgtcgtca ttgttatttt tttccatttt gagctaatgt
     1501 gttttatttg tgaatagtct tttacatttt tgtatgctga atatgggcac caaagaacct
     1561 gtaaaagtta tctttttcaa ttgaatgtgc acaaataaaa gtttggaaaa gatctctctt
     1621 cattctataa cttttattcc ccattttcta ttttaacaaa aattgtattc atacttcttt
     1681 tttttaaaat ctatgcaagc ttaagacttt ggctaaagtg tgttggcttc tttttgaagt
     1741 gtattttgtg tgtgtgtgtg tgtgtgtgtg tatatatata tatatatatg caccacatgt
     1801 gtatagtatc ttttaatgct ctgttaccaa ataacaaata ggaatttttt ttcttgcaga
     1861 ttagaaataa aaacgtgtat ataaactcta gggaaccaga ctagaagttt atagataaag
     1921 gataatgttt tatgttgcta atttaatatg atagaaaatg ttaaataact tgtaaaggtt
     1981 aagaaattgt agttttaaga agagaaacct cttacccact agatggaaat gagaaagaag
     2041 ctgtgatgaa tggtgcctca tttggacctt tgtttttctg gaaagactca acacctgtag
     2101 ttgtagagaa gtgattgagg ttcttgactt taatcttggg ttgatgccca agcctatact
     2161 aagagtcttg tcagaagttg gtaacatgga gatgttttaa caagaagtgc ccataagctg
     2221 cctctgtgcc acagtgtaat tatcaaatag ccccacttga atttgaaagc cattttgtgt
     2281 gatactgtcc ttccccttgc tgtatcttat ttaatggagt taaagagtga ctattcagta
     2341 tatgagattg ctactcttaa agttataata aatatgcatt tatgaaacag tgtctctggc
     2401 tcacccagga gccctgatgt ggtaatacag gatcaagctg tagttgtgcc ctgtcattta
     2461 ggtttaggag tttagtgtaa ccaacagtga ttatacctag aaataaagct gagtggagag
     2521 tccaattagc ttctcaggag aaacttaatg gggacaatat tccaacacaa tgttccacaa
     2581 aaacttgtat ttccaaaatg tttttaaacc tttgtggaaa aattgcaaca tcctaatctc
     2641 catatatagt acattttcct tactgtatta taaaatcttg aaaacctagc ttaggcactg
     2701 cactgaacaa cacatattat ttttatcttt tttcttctca atgccttccc taacctcctg
     2761 cttattccaa agtggaaagc aaaggctaac ttacattttt ccttcttgtg aaatatttca
     2821 ttgagatttt tagacttgta tttttccttt tttttaaaaa aaaagtgttt atttccttta
     2881 ttttaagatt cagtaggata gccaaattca tagagaataa aattacatga aagagttaca
     2941 agctcactgt tttaaagact tgacattttt catttagttt taattaacag taataagtca
     3001 cctcctgttt ttcaatgttc accaaaaaaa gaaacataga atagggggaa aacatgctta
     3061 tatagccaag gtacagatcc agatgatgta acctttttag tattcgcatg acttgaaaac
     3121 tgggcagatc aatagataat cgaagtgctt tatctgaagg gagagggtaa agacagtgtg
     3181 accaggtttg ttttcagggc tgccgaatga gcctcaccta acagtgtcca tgggtaattc
     3241 gctaacctta acaaagatgg gaagaagtga gtgctctgat gtcttctgct ggctctccat
     3301 aagtactgta aatttttttt ataaataaaa actgtgaata tatatgtaca agttgtaagt
     3361 atttccccct ttttattttt gaaaatcaag aagcttgatt tggtgtggtg caatggatat
     3421 tggataaaaa tttgaagaca aaattgttta gttacagact caggataata aaagaaaaat
     3481 ataaaagaat gctcaagata ctgaagtcaa ggtcactagt aataaactgg ctaggttgat
     3541 aaacaatttc ctgcccattt ataatgaagg gctaaacaaa aaatacctga agtatatata
     3601 gagtttgaac tataaacacg gaaggaaaca tggggcagaa cacacttccc ttctctttcc
     3661 aaaaacaaaa aacaatgcat gctctgattt gcgtatgaaa tacaccatga tagaattgag
     3721 atctccaatc tcctttcctt ttagcttccc cctgccaatt tttatacaga taatacactg
     3781 cagatccagg ccttttagtc agtctcctga gtctctgata tagttttact acttacatag
     3841 gtttatagtc tctccacatt gttataaagg aatgtaatag atcatgtttc cttatatgac
     3901 attgggacag tttgttagga accaatagga aaattccaag ctaaataaaa aggagctttg
     3961 gctcttagga ttctcttttc ttcaggttaa tcatatttta aaattctttt tcaagttagg
     4021 ttgttcgtgc ttttaagttt tttgtgtgtc ttccatcact taaatattag taatttaata
     4081 tgttatttgg ttcaagattt gattgtggat tttctatcat acccaaattt tattagtaag
     4141 acctcttaac aagtctttaa aatcaactgg agaagtaaga gaacagttca tcgttgtgtg
     4201 ggtgaaaccc acgttgctgg tacaggtggc catcatagaa aagaacatga gggaattgtc
     4261 ctgatgtctg aatgtcattt attgtgtctt cagttatctg aacatcatca tcaattatag
     4321 cctgtgtacc gtaacctgag gtagtgatat tcctgaggag tgtgaagaat tggacactgt
     4381 ggattactat acattgtcat gaaagcctta caaggaggca gcttttctag gcttgactta
     4441 ataacttcaa cctaattgct tagagatttg gataaataac ctaatggcct gactcctttt
     4501 ctaatgtttt actaacagct acttctaaat aaatatggtc ccaggatttt aaaa
//
