LOCUS       NM_024665               8182 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens TBL1X/Y related 1 (TBL1XR1), transcript variant 1,
            mRNA.
ACCESSION   NM_024665 NM_030921
VERSION     NM_024665.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8182)
  AUTHORS   Nagy,A., Molay,F., Hargadon,S., Brito Pires,C., Grant,N., De La
            Rosa Abreu,L., Chen,J.Y., D'Souza,P., Macnamara,E., Tifft,C.,
            Becker,C., Melo De Gusmao,C., Khurana,V., Neumeyer,A.M. and
            Eichler,F.S.
  TITLE     The spectrum of neurological presentation in individuals affected
            by TBL1XR1 gene defects
  JOURNAL   Orphanet J Rare Dis 19 (1), 79 (2024)
   PUBMED   38378692
  REMARK    GeneRIF: The spectrum of neurological presentation in individuals
            affected by TBL1XR1 gene defects.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8182)
  AUTHORS   Liao,L., Huang,P., Zhao,J., Wang,Z., Chen,H., Zhang,C. and Huang,L.
  TITLE     lncRNA799/TBL1XR1/ZEB1 Axis Forms a Feedback Loop to Promote the
            Epithelial-Mesenchymal Transition of Cervical Cancer Cells
  JOURNAL   Crit Rev Eukaryot Gene Expr 34 (2), 33-43 (2024)
   PUBMED   38073440
  REMARK    GeneRIF: lncRNA799/TBL1XR1/ZEB1 Axis Forms a Feedback Loop to
            Promote the Epithelial-Mesenchymal Transition of Cervical Cancer
            Cells.
REFERENCE   3  (bases 1 to 8182)
  AUTHORS   Mansoor,A., Akhter,A., Hamidi,M., Roshan,T.M., Shabani-Rad,M.T. and
            Stewart,D.
  TITLE     Exploring TBL1XR1 and NCOR1 Expression in B-cell Lymphoma Subtypes:
            Interaction With DNA Damage Repair Genes
  JOURNAL   Anticancer Res 43 (11), 4801-4807 (2023)
   PUBMED   37909960
  REMARK    GeneRIF: Exploring TBL1XR1 and NCOR1 Expression in B-cell Lymphoma
            Subtypes: Interaction With DNA Damage Repair Genes.
REFERENCE   4  (bases 1 to 8182)
  AUTHORS   Pons,L., Cordier,M.P., Labalme,A., Till,M., Louvrier,C.,
            Schluth-Bolard,C., Lesca,G., Edery,P. and Sanlaville,D.
  TITLE     A new syndrome of intellectual disability with dysmorphism due to
            TBL1XR1 deletion
  JOURNAL   Am J Med Genet A 167A (1), 164-168 (2015)
   PUBMED   25425123
  REMARK    GeneRIF: that TBL1XR1 haploinsufficiency can cause intellectual
            disability with a recognizable dysmorphism, without necessarily
            causing autistic behavior.
REFERENCE   5  (bases 1 to 8182)
  AUTHORS   Gonzalez-Aguilar,A., Idbaih,A., Boisselier,B., Habbita,N.,
            Rossetto,M., Laurenge,A., Bruno,A., Jouvet,A., Polivka,M., Adam,C.,
            Figarella-Branger,D., Miquel,C., Vital,A., Ghesquieres,H.,
            Gressin,R., Delwail,V., Taillandier,L., Chinot,O., Soubeyran,P.,
            Gyan,E., Choquet,S., Houillier,C., Soussain,C., Tanguy,M.L.,
            Marie,Y., Mokhtari,K. and Hoang-Xuan,K.
  TITLE     Recurrent mutations of MYD88 and TBL1XR1 in primary central nervous
            system lymphomas
  JOURNAL   Clin Cancer Res 18 (19), 5203-5211 (2012)
   PUBMED   22837180
  REMARK    GeneRIF: Our study provides new insights into the molecular
            tumorigenesis of PCNSL and identifies novel genetic alterations in
            this disease, especially MYD88 and TBL1XR1 mutations activating the
            NF-kappaB signaling pathway.
REFERENCE   6  (bases 1 to 8182)
  AUTHORS   Yoon,H.G., Choi,Y., Cole,P.A. and Wong,J.
  TITLE     Reading and function of a histone code involved in targeting
            corepressor complexes for repression
  JOURNAL   Mol Cell Biol 25 (1), 324-335 (2005)
   PUBMED   15601853
  REMARK    GeneRIF: TBL1 and TBLR1 are functionally redundant and essential
            for transcriptional repression by unliganded thyroid hormone
            receptors (TR) but not essential for transcriptional activation by
            liganded TR
REFERENCE   7  (bases 1 to 8182)
  AUTHORS   Perissi,V., Aggarwal,A., Glass,C.K., Rose,D.W. and Rosenfeld,M.G.
  TITLE     A corepressor/coactivator exchange complex required for
            transcriptional activation by nuclear receptors and other regulated
            transcription factors
  JOURNAL   Cell 116 (4), 511-526 (2004)
   PUBMED   14980219
REFERENCE   8  (bases 1 to 8182)
  AUTHORS   Yoon,H.G., Chan,D.W., Huang,Z.Q., Li,J., Fondell,J.D., Qin,J. and
            Wong,J.
  TITLE     Purification and functional characterization of the human N-CoR
            complex: the roles of HDAC3, TBL1 and TBLR1
  JOURNAL   EMBO J 22 (6), 1336-1346 (2003)
   PUBMED   12628926
REFERENCE   9  (bases 1 to 8182)
  AUTHORS   Zhang,J., Kalkum,M., Chait,B.T. and Roeder,R.G.
  TITLE     The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the
            JNK pathway through the integral subunit GPS2
  JOURNAL   Mol Cell 9 (3), 611-623 (2002)
   PUBMED   11931768
REFERENCE   10 (bases 1 to 8182)
  AUTHORS   Zhang,X., Dormady,S.P. and Basch,R.S.
  TITLE     Identification of four human cDNAs that are differentially
            expressed by early hematopoietic progenitors
  JOURNAL   Exp Hematol 28 (11), 1286-1296 (2000)
   PUBMED   11063877
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC078799.28, AC023235.24 and
            KF457713.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 21, 2019 this sequence version replaced NM_024665.6.
            
            Summary: This gene is a member of the WD40 repeat-containing gene
            family and shares sequence similarity with transducin (beta)-like
            1X-linked (TBL1X). The protein encoded by this gene is thought to
            be a component of both nuclear receptor corepressor (N-CoR) and
            histone deacetylase 3 (HDAC 3) complexes, and is required for
            transcriptional activation by a variety of transcription factors.
            Mutations in these gene have been associated with some autism
            spectrum disorders, and one finding suggests that
            haploinsufficiency of this gene may be a cause of intellectual
            disability with dysmorphism. Mutations in this gene as well as
            recurrent translocations involving this gene have also been
            observed in some tumors. [provided by RefSeq, Mar 2016].
            
            Transcript Variant: This variant (1), as well as variants 2, 3, 5,
            6, and 7, encodes isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.2525688.1, AF268193.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000457928.7/ ENSP00000413251.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-362               AC078799.28        81445-81806         c
            363-438             AC023235.24        150367-150442       c
            439-541             AC023235.24        116821-116923       c
            542-687             AC023235.24        105674-105819       c
            688-910             AC023235.24        103405-103627       c
            911-1043            AC023235.24        102379-102511       c
            1044-1185           AC023235.24        101898-102039       c
            1186-1249           KF457713.1         113-176
            1250-1347           KF457713.1         265-362
            1348-1408           AC023235.24        98030-98090         c
            1409-1530           AC023235.24        90214-90335         c
            1531-1605           AC023235.24        89999-90073         c
            1606-1733           AC023235.24        86099-86226         c
            1734-1899           AC023235.24        84872-85037         c
            1900-2001           AC023235.24        78274-78375         c
            2002-8182           AC023235.24        71245-77425         c
FEATURES             Location/Qualifiers
     source          1..8182
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26.32"
     gene            1..8182
                     /gene="TBL1XR1"
                     /gene_synonym="C21; DC42; IRA1; MRD41; TBLR1"
                     /note="TBL1X/Y related 1"
                     /db_xref="GeneID:79718"
                     /db_xref="HGNC:HGNC:29529"
                     /db_xref="MIM:608628"
     exon            1..362
                     /gene="TBL1XR1"
                     /gene_synonym="C21; DC42; IRA1; MRD41; TBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            363..438
                     /gene="TBL1XR1"
                     /gene_synonym="C21; DC42; IRA1; MRD41; TBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            439..541
                     /gene="TBL1XR1"
                     /gene_synonym="C21; DC42; IRA1; MRD41; TBLR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             484..2028
                     /gene="TBL1XR1"
                     /gene_synonym="C21; DC42; IRA1; MRD41; TBLR1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     TBL1-related protein 1; nuclear receptor
                     co-repressor/HDAC3 complex subunit; transducin beta like 1
                     X-linked receptor 1; F-box-like/WD repeat-containing
                     protein TBL1XR1; nuclear receptor corepressor/HDAC3
                     complex subunit TBLR1; TBL1X receptor 1"
                     /codon_start=1
                     /product="F-box-like/WD repeat-containing protein TBL1XR1
                     isoform 1"
                     /protein_id="NP_078941.2"
                     /db_xref="CCDS:CCDS46961.1"
                     /db_xref="GeneID:79718"
                     /db_xref="HGNC:HGNC:29529"
                     /db_xref="MIM:608628"
                     /translation="MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALV
                     PPAALISIIQKGLQYVEAEVSINEDGTLFDGRPIESLSLIDAVMPDVVQTRQQAYRDK
                     LAQQQAAAAAAAAAAASQQGSAKNGENTANGEENGAHTIANNHTDMMEVDGDVEIPPN
                     KAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREG
                     GQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNK
                     KGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVC
                     KLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNK
                     EIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAF
                     SPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGSVC
                     VLDLRK"
     exon            542..687
                     /gene="TBL1XR1"
                     /gene_synonym="C21; DC42; IRA1; MRD41; TBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            688..910
                     /gene="TBL1XR1"
                     /gene_synonym="C21; DC42; IRA1; MRD41; TBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1043
                     /gene="TBL1XR1"
                     /gene_synonym="C21; DC42; IRA1; MRD41; TBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1185
                     /gene="TBL1XR1"
                     /gene_synonym="C21; DC42; IRA1; MRD41; TBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1249
                     /gene="TBL1XR1"
                     /gene_synonym="C21; DC42; IRA1; MRD41; TBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1347
                     /gene="TBL1XR1"
                     /gene_synonym="C21; DC42; IRA1; MRD41; TBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1408
                     /gene="TBL1XR1"
                     /gene_synonym="C21; DC42; IRA1; MRD41; TBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1530
                     /gene="TBL1XR1"
                     /gene_synonym="C21; DC42; IRA1; MRD41; TBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1605
                     /gene="TBL1XR1"
                     /gene_synonym="C21; DC42; IRA1; MRD41; TBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1733
                     /gene="TBL1XR1"
                     /gene_synonym="C21; DC42; IRA1; MRD41; TBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1899
                     /gene="TBL1XR1"
                     /gene_synonym="C21; DC42; IRA1; MRD41; TBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..2001
                     /gene="TBL1XR1"
                     /gene_synonym="C21; DC42; IRA1; MRD41; TBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..8182
                     /gene="TBL1XR1"
                     /gene_synonym="C21; DC42; IRA1; MRD41; TBLR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3058..3063
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBL1XR1"
                     /gene_synonym="C21; DC42; IRA1; MRD41; TBLR1"
                     /note="hexamer: ATTAAA"
     polyA_site      3080
                     /gene="TBL1XR1"
                     /gene_synonym="C21; DC42; IRA1; MRD41; TBLR1"
                     /note="major polyA site"
     regulatory      6751..6756
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBL1XR1"
                     /gene_synonym="C21; DC42; IRA1; MRD41; TBLR1"
                     /note="hexamer: AATAAA"
     polyA_site      6772
                     /gene="TBL1XR1"
                     /gene_synonym="C21; DC42; IRA1; MRD41; TBLR1"
                     /note="major polyA site"
     regulatory      8094..8099
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBL1XR1"
                     /gene_synonym="C21; DC42; IRA1; MRD41; TBLR1"
                     /note="hexamer: ATTAAA"
     polyA_site      8110
                     /gene="TBL1XR1"
                     /gene_synonym="C21; DC42; IRA1; MRD41; TBLR1"
     regulatory      8143..8148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBL1XR1"
                     /gene_synonym="C21; DC42; IRA1; MRD41; TBLR1"
                     /note="hexamer: ATTAAA"
     regulatory      8161..8166
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBL1XR1"
                     /gene_synonym="C21; DC42; IRA1; MRD41; TBLR1"
                     /note="hexamer: AGTAAA"
     polyA_site      8169
                     /gene="TBL1XR1"
                     /gene_synonym="C21; DC42; IRA1; MRD41; TBLR1"
     polyA_site      8182
                     /gene="TBL1XR1"
                     /gene_synonym="C21; DC42; IRA1; MRD41; TBLR1"
ORIGIN      
        1 gaaccgtttg gctctttccc ttagtaacag cttttacctt ctgcctcaat tcctctcccc
       61 gctcgcgccc ttcccccgcg cgccgcctcc ccccgccgcc ggccgcgtgc gcccccgccc
      121 ctccccccgc ggcgggagca cctccgctcg ccacctgggg acccgcgccg cgctccccgc
      181 ccccgcccgc ccggcgccca tcccccgcgc cctccgctcg ctggggttat aattgcctct
      241 caccccccgg aggggttatt ttgggggtgg ttggaggcgg tggcggcggc ggcgaggagg
      301 ggaatttcct tgtgcctcca ttcccgggag gggggagcgg cgttggaggc caccgtttcc
      361 agcatcaaca acagcaactt gtgattggcg gtgaccggat attcagttgc acatccccac
      421 atcaatgcac tgccaatggg ttatatcctg tgttgtgacc tcatggttta agtgggaata
      481 aagatgagta taagcagtga tgaggtcaac ttcttggtat atagatactt gcaagagtca
      541 ggattttctc attcagcatt tacctttggt atagaaagcc atatcagtca gtccaatata
      601 aatggtgccc tcgtcccacc cgctgcattg atttctatca tccagaaagg tctacagtat
      661 gtagaagcag aagttagtat taatgaggat ggtaccttgt ttgatggtcg accaatagag
      721 tctctgtccc tgatagatgc cgtaatgcct gatgtagtac aaacaagaca acaagcttat
      781 agagataagc ttgcacagca acaggcagca gctgctgcag ctgccgcagc tgcagccagc
      841 caacaaggat ctgcaaaaaa tggagaaaac acagcaaatg gggaggagaa tggagcacat
      901 actatagcaa ataatcatac tgatatgatg gaagtggatg gggatgttga aatccctcct
      961 aataaagctg ttgtgttgcg gggccatgaa tctgaagttt ttatctgtgc ctggaaccct
     1021 gttagtgatc tcctagcatc agggtctgga gactcaacag caagaatatg gaatcttagt
     1081 gagaacagca ccagtggctc tacacagtta gtacttagac attgtatacg agaaggaggg
     1141 caagatgttc caagcaacaa ggatgtcaca tctctagatt ggaatagtga aggtacactt
     1201 ctagcaactg gttcctatga tgggtttgcc agaatatgga ctaaagatgg taaccttgct
     1261 agcaccttag ggcagcataa aggccctata tttgcattaa aatggaataa gaaaggaaat
     1321 ttcatcctaa gtgctggagt agacaagact acaattattt gggacgcaca tactggtgaa
     1381 gccaagcaac agtttccttt tcattcagca ccagcattgg atgttgattg gcagagcaac
     1441 aacacctttg cttcttgtag tacagatatg tgcattcatg tctgtaaatt aggacaagac
     1501 agacctatta aaacattcca aggacatacg aatgaagtaa atgctatcaa atgggaccca
     1561 actggcaatc tcttggcctc ctgttctgac gacatgactt taaagatatg gagtatgaaa
     1621 caagacaatt gtgtccatga tttgcaagca cataataaag aaatttatac tatcaaatgg
     1681 agtccaacag gaccagggac taataatcca aatgccaacc ttatgttagc aagtgcatcc
     1741 tttgattcta ctgttaggtt atgggatgta gaccgaggga tatgcatcca taccttgaca
     1801 aaacaccaag agcctgtgta cagtgtagct ttcagtcctg atggcaggta tctggcaagt
     1861 ggttcttttg acaaatgtgt acacatctgg aacacgcaga caggtgctct agttcacagc
     1921 tataggggaa caggtggaat atttgaagtt tgctggaatg cagcaggaga caaagttgga
     1981 gccagtgcat cagatggttc agtttgtgta ttagaccttc ggaaatagcg ctactagttg
     2041 gaagccatgg accgactatg aatgtgtaca tagccaaaat gactgtccct gacccatgta
     2101 ctgctatagt cccacttgaa ccatggccag tccactacag ccaaatctaa aagaaatata
     2161 tacatacagt gtatataaac aaaattgcac cctgaagatg acagagtttt gtcacagctt
     2221 gtgaattctg ttcaccaagt gctggaatct aatctgctgt gcccctaaaa tagcatttag
     2281 aagttttgga tatgaaaaac agaagagaga aaaatataca ttataaaagc agaacataca
     2341 tgtaccagtt tttggatact aaatgacagc cttgtttctc ccctttgaat cagcagacac
     2401 catggattat attctttttt tcccttcagt agtgagcagt ttgtatgtac agagaaaatg
     2461 gacttacaaa aacttgcagc agtagtttgt tcttgcttta aaatttcgtt tttggtttag
     2521 attatggatg catgaagtaa gggagtgaat cagtttcttg tttatatttt tttcaccttt
     2581 taaacaaaaa attctttaaa atattttaat gcattctttt gaagaggtag atgtttggta
     2641 cattttatgg ctcccagagc atatattcag ttggtgcatg ttgtggaagg gggaattgga
     2701 aattaaatga aaacctatga ctttggtcat gtcaatctgt aagacacatc agtaaaaggg
     2761 tattatgctc tgttggtttt gtttttttgt tttgcttttt tttttttttt ttcttttttg
     2821 ttttttggtg atgtggctta aatgcaatag tttctttttt gggacatatt tctgccaatt
     2881 aaagactaga agggcacaac ttttttttta attaccatag agaagataca ttaaaaaaaa
     2941 tcttctgatg ttttgtagcc ataactaaat tatggtaaaa atgtgcacta ttgtgaaaag
     3001 gagcaacgta gttttgggtt ttttgttgtt tgtttgtttt gctttgtttt ttaagagatt
     3061 aaaatgtttc tggataagga ttagcttctc gaagtgtcca tcattctgtg tagaagctta
     3121 aatatgtaat gtaaccaaac tccagtatta aaaatctctc atgttgtttt ctttatacaa
     3181 agcaagataa cggcatataa cactgccatt acatggcaaa atgtttgcta ccttagttta
     3241 aaaaacaatc tcaaacaaaa gacttgcttc aaggtgtttt taaatagcag tgattcagaa
     3301 ttttttttaa tgaaagtata attgcactaa ccttcttcct gctgctctga ttctgcattt
     3361 gtggtacttg tgactacgtt ttttcaaata tagatagatt taagctgcta attttttttt
     3421 ttttagtaat cactactata tcatgtcttt tactctgttt ataatatcaa gtattttctt
     3481 aaagatatag atattaaacc ttgtgctcat gcaacttaga gtaacatata cagacaaatg
     3541 attgcatgag gccatgttta tatgtgtgac taataaggct tgtcatgatt aacataatcc
     3601 aggtatgtca tttctgaaga gaatagtcat caaatttata tctcgaagat tttaattaag
     3661 gaattgctta ttgttgagct tagcaaatta ataacactat ttctgtcact aattattttg
     3721 aggcctttta gtactaaaat tttaacctgt gttctaagta gaaactgatt taacccaagt
     3781 aatgcagctt tgattgattt cagcattcgt tgctttgcta tttttacaaa acagcattga
     3841 ttgaagcaag tcttggtttt actaaggtag ggtagcattt gctattggta aagagaataa
     3901 atacacttaa tttcacaata cattgttata tgtaccccag ttgttgttag tggggactat
     3961 gatactgtaa taatattttt aaaaatttac atcaagagag gcagtcattc acgatggttt
     4021 tgtgccagct ctttttaggg ttttggatca cattagagat atttagaaca tattaccctg
     4081 tgacttacgt aggaaaccta atatgctgag tatctggcac ttgaattcct gcttttattg
     4141 ctggaggtcc acatctgtgg ttgacctctg ttattgttta aaaaaaataa ataaaaatta
     4201 aaaaaatctg tgcaataatt ttaaaatgtg ctcccaggaa tagacacaaa tgttttgagt
     4261 atcttttaag ctgcattttc ctttagtgat gcatttgtca attgcactga atttaaatct
     4321 gaaagtcaga ggtgattatt gatagtactt ttgtattttg atatggacag tttattcatt
     4381 tgcatacagt tattgacttt ttcccagctg attaaaagat agtcaagaaa ttctgcaata
     4441 tagctgccaa aatagacagc tacattttta tgatattgtc atcttttctg tttttttttt
     4501 cttttttttc tttagctatt ttacttaagc ataatagcca caataggaca tataaaagat
     4561 tataaataca gagctttatt atcctgacgt cttgggtctt ttaagtatat acttttctga
     4621 aaggtatcca ttttgtaggc ttgggttctt catgagcata cgattgttta tttttgctgc
     4681 tgttctcaac atcatcattg cctgctgatg tgccacgatg ctgctccaat agacagcaat
     4741 aagattgtct ctaatttgag cagtaacatg attgcaagag accaagtttc acagcttgta
     4801 aagttctgta tttgggattc ttgcttattt ttccgcctgt gtttttctga gaacttattc
     4861 ctgatgatca attgaatcca gtagtttttc tatgctattt gttgttgtat aagctactgt
     4921 aagaaactta tcataaggaa aaatagaaag gaaaacttga atcaatactc attgattaaa
     4981 atggaataaa gaaagagcag ctgccacttt taaacaacat aaaggaatat ctttttttgt
     5041 ctccgtgtag gaaatcccat aagttcttat atttgttcca gttcccattt cctgccattg
     5101 accagataac atcattgact ttcaaatgac ttttagaagt gataactctt aatttcctaa
     5161 tagatactag attgtattga attctgtttt aattattctc taggtaagta tgttttagga
     5221 ttaaatacct tttacagata ctgaaagtgc ctccttttgt ggtgtaaaaa acaaattatg
     5281 gtgcaaaaag taatcactag attgaaatac atgaaggttt tttgcttttt gacatacgaa
     5341 aatgtcaaga gaaaggccaa agatttgtac tttttcactt acaaagcact cctttttccc
     5401 ttaaacttct ttctgtcaaa ttagatttaa tgagagagta ctatttttaa ggagctatct
     5461 gtttatgtag aatgattttg ttaagagtaa tgtaaactat tattgagtag aggcctaaag
     5521 aggactgtgc atttttgcta tttaaaggaa tcacaaatga tcatacttaa gtgagcaaaa
     5581 atgacaagtt ttactagcta agtagagaaa taaatctcaa atgcagcgct acaattttca
     5641 ttatcttaag tacattgtac atttctacag aacctgtgat tattctcgca tgataaggat
     5701 ggtacttgca tatggtgaat tactactgtt gacagtttcc gcagaaatcc tatttcagtg
     5761 gaccaacatt gtggcatggc agcaaatgcc aacattttgt ggaatagcag caaatctaca
     5821 agagaccctg gttggttttt cgttttgttt tctttgtttt ttcccccttc tcctgaatca
     5881 gcagggatgg aaggagggta gggaagttat gaattactcc ttccagtagt agctctgaag
     5941 tgtcacattt aatatcagtt ttttttaaac atgattctag ttaaatgtag aagagagaag
     6001 aaagaggaag tgttcacttt tttaatacac tgatttagaa atttgatgtc ttatatcagt
     6061 agttctgagg tattgatagc ttgctttatt tctgccttta cgttgacagt gttgaagcag
     6121 ggtgaataac tagggcatat attttttttt tttttgtaag ctgtttcatg atgttttctt
     6181 tggaatttcc ggataagttc aggaaaacat tctgcatgtt gtatctagtc tgatgtactt
     6241 atccatctca ttacaaacaa aaacacacag actgcatttg tagctctgta atccttgaat
     6301 acggaagtaa attttcttct ttcctgactt tgacattgta gctatactgt ttccattttt
     6361 gtttttacaa atcctttggg tctaattctg tgagcctacc tatagcactg gattaaaatg
     6421 tctgcatcat ttctttagtt atccagttaa ctttaaaact gttgtaaaag tgtaaaccag
     6481 cccatgacag gtttttgtac atgttaaaga acttcattgt tcagttttca tgattattgt
     6541 gtaaggaaga ctgatgtaga tgttctgtgc tgtcctggac catgttaatt acacttacga
     6601 cgtattttag ttccacatca caatgatttg tccccagtga cccttttatc ctttctaggc
     6661 acatttcttg ttgttgttgt tgttgcagtt cccctttgca ttgtattgct ttgacaactg
     6721 taatttgaat cagatctgaa agaggtccag aataaaatat attttgatat tatgttggct
     6781 gtgtacatat ataaaacctt tgatgtctat gtagtttata tagactattt actagtcagg
     6841 taaagagaga gggatggtat ttcttgttta cagtttgttt acattttaat tgcttttact
     6901 tctccagtgt tctattgtag aataaacctt tttttccaag ttagccttca taacctataa
     6961 cacattcatt ctctcccata ctggtgttac tgattaataa ctgccatcag aacccaaacc
     7021 actgtttttc ataaacgtat tgtttcccaa gatatatact ttaagcccat aataaaatta
     7081 caaattttac tatttttatt acttcttgca ggagataaga tttttttaaa tgaaggggtt
     7141 atttactatt tttattaaag tataatagag catctaatca gctaagggat tgtaattttt
     7201 aattcttttg aaaaataaat attgtattta aaagacgtta tttcacagaa gctgaaaaag
     7261 agaccttaga taacatttgt ttggttagcc acacggttga gcacaaaaca atgtgtagat
     7321 gtgttgaaga ttagggcagg aggctcaact tctcggtgac ctttttttgc ttcacaacaa
     7381 gccaattata gttgaatcat tttctctctt agctagttgt tactacaaac tttataagaa
     7441 aaacaactag acaccttcta gttttaatta ataccaactc ctttagagtt agagactttt
     7501 taaaaagaat cattgagcat attttctttt tttttttttt aagaatttac actctctagg
     7561 tcttctattt ttcctgttta tttccttaaa cagaaataaa ttcaagcata gttttatgtt
     7621 ttattagaaa taagccactg cagttgctag aactgacatg ctttcatttt caaggggtta
     7681 acttttattg catggcatag attattagta atatcctgca ttgtatactt ttccaaaaag
     7741 ggttggactc ctaaggatta gaatccttat aagcttgagg gaaagctgaa actaatttga
     7801 acagtaatag aagggattat ttttaatttc atagttaaca ctttacaatg gattagattt
     7861 attacctagt ataatccgta gcagatcaga tcaaagttta ctgttttacc aatatattca
     7921 tttgaaaaaa tacagtggag gaaaagacac tttagatggt agttttatgg tgcttttctc
     7981 tgctgtacca aagtgctttg tcatcaatga aatgttaacc ctatgctact ttttctgcat
     8041 gcttcttaaa tgtcatctta atgcttaatt gtcctaactt gtaatatttt tgtattaaat
     8101 ttttttagga gttccttgta atttctttac aatttaaaat atattaaaca caaagtgttt
     8161 agtaaagtac agaagacaat ta
//
