LOCUS       NM_005647               5818 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens transducin beta like 1 X-linked (TBL1X), transcript
            variant 1, mRNA.
ACCESSION   NM_005647
VERSION     NM_005647.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5818)
  AUTHORS   Gong,Z., Zhang,H., Ge,Y. and Wang,P.
  TITLE     Long noncoding RNA MIAT regulates TP53 ubiquitination and expedites
            prostate adenocarcinoma progression by recruiting TBL1X
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1870 (7), 119527 (2023)
   PUBMED   37356458
  REMARK    GeneRIF: Long noncoding RNA MIAT regulates TP53 ubiquitination and
            expedites prostate adenocarcinoma progression by recruiting TBL1X.
REFERENCE   2  (bases 1 to 5818)
  AUTHORS   Lauffer,P., Naafs,J.C., Bikker,H., Garrelfs,M.R., Mooij,C.F.,
            Boelen,A., Zwaveling-Soonawala,N. and van Trotsenburg,A.S.P.
  TITLE     Further Delineation of Central Congenital Hypothyroidism due to
            Variants in TBL1X and IRS4
  JOURNAL   Thyroid 33 (7), 880-884 (2023)
   PUBMED   36860195
  REMARK    GeneRIF: Further Delineation of Central Congenital Hypothyroidism
            due to Variants in TBL1X and IRS4.
REFERENCE   3  (bases 1 to 5818)
  AUTHORS   Pray,B.A., Youssef,Y. and Alinari,L.
  TITLE     TBL1X: At the crossroads of transcriptional and posttranscriptional
            regulation
  JOURNAL   Exp Hematol 116, 18-25 (2022)
   PUBMED   36206873
  REMARK    GeneRIF: TBL1X: At the crossroads of transcriptional and
            posttranscriptional regulation.
            Review article
REFERENCE   4  (bases 1 to 5818)
  AUTHORS   Youssef,Y., Karkhanis,V., Chan,W.K., Jeney,F., Canella,A.,
            Zhang,X., Sloan,S., Prouty,A., Helmig-Mason,J., Tsyba,L., Hanel,W.,
            Zheng,X., Zhang,P., Chung,J.H., Lucas,D.M., Kauffman,Z., Larkin,K.,
            Strohecker,A.M., Ozer,H.G., Lapalombella,R., Zhou,H.,
            Xu-Monette,Z.Y., Young,K.H., Han,R., Nurmemmedov,E., Nuovo,G.,
            Maddocks,K., Byrd,J.C., Baiocchi,R.A. and Alinari,L.
  TITLE     Transducin beta-like protein 1 controls multiple oncogenic networks
            in diffuse large B-cell lymphoma
  JOURNAL   Haematologica 106 (11), 2927-2939 (2021)
   PUBMED   33054136
  REMARK    GeneRIF: Transducin beta-like protein 1 controls multiple oncogenic
            networks in diffuse large B-cell lymphoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5818)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 5818)
  AUTHORS   Zhang,J., Kalkum,M., Chait,B.T. and Roeder,R.G.
  TITLE     The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the
            JNK pathway through the integral subunit GPS2
  JOURNAL   Mol Cell 9 (3), 611-623 (2002)
   PUBMED   11931768
REFERENCE   7  (bases 1 to 5818)
  AUTHORS   Matsuzawa,S.I. and Reed,J.C.
  TITLE     Siah-1, SIP, and Ebi collaborate in a novel pathway for
            beta-catenin degradation linked to p53 responses
  JOURNAL   Mol Cell 7 (5), 915-926 (2001)
   PUBMED   11389839
REFERENCE   8  (bases 1 to 5818)
  AUTHORS   Li,J., Wang,J., Wang,J., Nawaz,Z., Liu,J.M., Qin,J. and Wong,J.
  TITLE     Both corepressor proteins SMRT and N-CoR exist in large protein
            complexes containing HDAC3
  JOURNAL   EMBO J 19 (16), 4342-4350 (2000)
   PUBMED   10944117
REFERENCE   9  (bases 1 to 5818)
  AUTHORS   Guenther,M.G., Lane,W.S., Fischle,W., Verdin,E., Lazar,M.A. and
            Shiekhattar,R.
  TITLE     A core SMRT corepressor complex containing HDAC3 and TBL1, a
            WD40-repeat protein linked to deafness
  JOURNAL   Genes Dev 14 (9), 1048-1057 (2000)
   PUBMED   10809664
REFERENCE   10 (bases 1 to 5818)
  AUTHORS   Bassi,M.T., Ramesar,R.S., Caciotti,B., Winship,I.M., De Grandi,A.,
            Riboni,M., Townes,P.L., Beighton,P., Ballabio,A. and Borsani,G.
  TITLE     X-linked late-onset sensorineural deafness caused by a deletion
            involving OA1 and a novel gene containing WD-40 repeats
  JOURNAL   Am J Hum Genet 64 (6), 1604-1616 (1999)
   PUBMED   10330347
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC073488.23, BC052304.1 and
            AC003036.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_005647.3.
            
            Summary: The protein encoded by this gene has sequence similarity
            with members of the WD40 repeat-containing protein family. The WD40
            group is a large family of proteins, which appear to have a
            regulatory function. It is believed that the WD40 repeats mediate
            protein-protein interactions and members of the family are involved
            in signal transduction, RNA processing, gene regulation, vesicular
            trafficking, cytoskeletal assembly and may play a role in the
            control of cytotypic differentiation. This encoded protein is found
            as a subunit in corepressor SMRT (silencing mediator for retinoid
            and thyroid receptors) complex along with histone deacetylase 3
            protein. This gene is located adjacent to the ocular albinism gene
            and it is thought to be involved in the pathogenesis of the ocular
            albinism with late-onset sensorineural deafness phenotype. Four
            transcript variants encoding two different isoforms have been found
            for this gene. This gene is highly similar to the Y chromosome
            TBL1Y gene. [provided by RefSeq, Nov 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1 and 2
            both encode isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y12781.1, BC052304.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000645353.2/ ENSP00000496215.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               AC073488.23        63354-63456
            104-2682            BC052304.1         1-2579
            2683-5818           AC003036.1         36399-39534         c
FEATURES             Location/Qualifiers
     source          1..5818
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.31-p22.2"
     gene            1..5818
                     /gene="TBL1X"
                     /gene_synonym="CHNG8; EBI; SMAP55; TBL1"
                     /note="transducin beta like 1 X-linked"
                     /db_xref="GeneID:6907"
                     /db_xref="HGNC:HGNC:11585"
                     /db_xref="MIM:300196"
     exon            1..390
                     /gene="TBL1X"
                     /gene_synonym="CHNG8; EBI; SMAP55; TBL1"
                     /inference="alignment:Splign:2.1.0"
     exon            391..460
                     /gene="TBL1X"
                     /gene_synonym="CHNG8; EBI; SMAP55; TBL1"
                     /inference="alignment:Splign:2.1.0"
     exon            461..548
                     /gene="TBL1X"
                     /gene_synonym="CHNG8; EBI; SMAP55; TBL1"
                     /inference="alignment:Splign:2.1.0"
     exon            549..693
                     /gene="TBL1X"
                     /gene_synonym="CHNG8; EBI; SMAP55; TBL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             591..2324
                     /gene="TBL1X"
                     /gene_synonym="CHNG8; EBI; SMAP55; TBL1"
                     /note="isoform a is encoded by transcript variant 1;
                     F-box-like/WD repeat-containing protein TBL1X; transducin
                     beta-like protein 1X; transducin-beta-like protein 1,
                     X-linked; transducin beta like 1X-linked"
                     /codon_start=1
                     /product="F-box-like/WD repeat-containing protein TBL1X
                     isoform a"
                     /protein_id="NP_005638.1"
                     /db_xref="CCDS:CCDS14133.1"
                     /db_xref="GeneID:6907"
                     /db_xref="HGNC:HGNC:11585"
                     /db_xref="MIM:300196"
                     /translation="MTELAGASSSCCHRPAGRGAMQSVLHHFQRLRGREGGSHFINTS
                     SPRGEAKMSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALIS
                     ILQKGLQYVEAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQAS
                     AAAAAAAATAAATAATTTSAGVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEV
                     EIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRH
                     CIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFA
                     LKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDM
                     CIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDL
                     QAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPV
                     YSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASAS
                     DGSVCVLDLRK"
     exon            694..801
                     /gene="TBL1X"
                     /gene_synonym="CHNG8; EBI; SMAP55; TBL1"
                     /inference="alignment:Splign:2.1.0"
     exon            802..947
                     /gene="TBL1X"
                     /gene_synonym="CHNG8; EBI; SMAP55; TBL1"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1206
                     /gene="TBL1X"
                     /gene_synonym="CHNG8; EBI; SMAP55; TBL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1339
                     /gene="TBL1X"
                     /gene_synonym="CHNG8; EBI; SMAP55; TBL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1481
                     /gene="TBL1X"
                     /gene_synonym="CHNG8; EBI; SMAP55; TBL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1545
                     /gene="TBL1X"
                     /gene_synonym="CHNG8; EBI; SMAP55; TBL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1643
                     /gene="TBL1X"
                     /gene_synonym="CHNG8; EBI; SMAP55; TBL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1704
                     /gene="TBL1X"
                     /gene_synonym="CHNG8; EBI; SMAP55; TBL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1826
                     /gene="TBL1X"
                     /gene_synonym="CHNG8; EBI; SMAP55; TBL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1901
                     /gene="TBL1X"
                     /gene_synonym="CHNG8; EBI; SMAP55; TBL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2029
                     /gene="TBL1X"
                     /gene_synonym="CHNG8; EBI; SMAP55; TBL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2195
                     /gene="TBL1X"
                     /gene_synonym="CHNG8; EBI; SMAP55; TBL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..2297
                     /gene="TBL1X"
                     /gene_synonym="CHNG8; EBI; SMAP55; TBL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..5818
                     /gene="TBL1X"
                     /gene_synonym="CHNG8; EBI; SMAP55; TBL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5792..5797
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBL1X"
                     /gene_synonym="CHNG8; EBI; SMAP55; TBL1"
                     /note="hexamer: AATAAA"
     polyA_site      5818
                     /gene="TBL1X"
                     /gene_synonym="CHNG8; EBI; SMAP55; TBL1"
                     /note="major polyA site"
ORIGIN      
        1 gcgctcgcgg cagctccccg tggaggtcac tgtccgtgcc agtccctccc gctgtcccgc
       61 cctctcccgc tgccgccgcc gccgccgccg cgcccgcctc agcgccccca ctccgcgctt
      121 gggagcgagg agccgccagc gcccccgccc cgccgccgcc gcagcgccct caggccgcca
      181 ttcgccaccg aaactttcca gcgcccgcgc tctctccggg actcggcggc ggcggggcgg
      241 gggcggcccg ggggcggcgc gcggctgctc cggggcgccg ggccctcttc ggccgccgca
      301 cggccgggac tcggaggctg ccggctggag ggaggttcgg agcgcggccg ggcgcgcggc
      361 gccgccacaa gttgcgctgc tcgcgacgag atttccgtga gggtggaaga aaatcatacc
      421 atatcagatg cctcgcagag caccaggccc accgtgaaag gctggtccct gcagacggct
      481 tcccattttt atgaccggat gctgggaagc ctgctggtcc acaggtccat acatgaagtc
      541 accataagga gccctggcct ccttgcagaa acatcgaggt gacatgtagc atgaccgagc
      601 tcgctggcgc ctcttcatcg tgctgccacc gccctgcagg aagaggggcc atgcagtcag
      661 tcttgcacca ctttcaacgt ttgcgaggga gagagggtgg ttcccacttc atcaacacct
      721 catcgccgcg aggtgaggct aagatgagca taaccagtga cgaggtgaac tttctggtgt
      781 atcggtatct ccaggagtca ggtttttccc actcggcttt cacgtttggg attgagagcc
      841 acatcagcca gtccaacatc aatgggacgc tagtgccacc ggccgccctc atctccattc
      901 tccagaaggg cctgcagtat gtagaggccg agatcagtat caacgaggat ggcacagtgt
      961 tcgacggccg ccccatagag tccctgtcac tgatagacgc cgtgatgccc gacgtggtgc
     1021 agacgcggca gcaggcattc cgagagaagc tcgctcagca gcaagccagt gcggcggcgg
     1081 cggcggctgc ggccacggca gcagcgacag cagccaccac gacctcagcc ggcgtttccc
     1141 accaaaatcc atcgaagaac agagaggcca cggtgaatgg ggaagagaac agagcacatt
     1201 cagtcaataa tcacgcgaag ccaatggaaa tagatggaga ggttgagatt ccatccagca
     1261 aagccacagt ccttcggggc catgagtctg aggtgttcat ttgtgcctgg aatcctgtca
     1321 gtgatttgct agcctccgga tctggagact caactgcaag gatatggaac ctgaatgaga
     1381 atagcaacgg gggctccacc cagctcgtgt tgaggcactg tatacgagag gggggccatg
     1441 acgtcccgag taacaaagac gtcacctcac tggactggaa taccaatgga acactcttgg
     1501 ctacgggttc atatgacggt tttgcaagaa tatggacgga agatggtaac ctggccagca
     1561 ccttaggcca acataaaggc cccatctttg ccttgaaatg gaaccgaaag gggaattaca
     1621 ttttgagtgc tggtgtagac aaaacaacaa taatttggga tgcccacaca ggagaagcca
     1681 aacagcagtt tccttttcat tcagcccctg cccttgatgt ggactggcag aacaacacga
     1741 cctttgcctc ctgtagcaca gacatgtgta tccatgtgtg caggctcggc tgtgaccgcc
     1801 cagtcaaaac cttccaggga cacacaaacg aggtcaacgc catcaaatgg gatccgtctg
     1861 gaatgttgct ggcatcctgc tcggatgaca tgacattgaa gatctggagc atgaaacagg
     1921 aggtgtgcat ccatgatctt caggctcaca ataaagagat ctacaccatc aagtggagcc
     1981 ccactgggcc cgccaccagc aacccaaact ccaacatcat gttggcaagt gcttcgtttg
     2041 attctacggt gcgactgtgg gacatagaac gaggcgtctg cacccacacg ctcacgaagc
     2101 atcaggagcc tgtctatagc gtagctttca gccctgatgg gaagtacttg gccagtggat
     2161 ccttcgacaa gtgcgtccat atctggaata ctcagagtgg aaatcttgtc cacagctacc
     2221 gaggcactgg cggcatcttc gaggtgtgct ggaacgcccg aggagacaaa gtgggtgcca
     2281 gcgcgtccga cggctctgtg tgtgttttgg atctgcggaa gtaaccacaa aatattatcg
     2341 aaaaaagaaa agaattctaa tgaccagccg tgaatgtgta gggttgcagc tctattctcc
     2401 aaaactgtag gaacttgact tgcgttagag tgtactctga aaccaactcg tctctggccg
     2461 caggagtcta tatgttttcg taatcttcat caagaagttt ttaaaaggca agcaaaaaca
     2521 gaagcaaatc atatcaaacg gggatagaat ggtttccact gaggacattc agcctgggaa
     2581 ggaggaagtc accagctcga ggcgtgtgga ttggtttcca cccggaacag gctctgtgat
     2641 ggctgaatgg aaagaaacgt aaaaagctgt gccaaaaaaa aagcaaaatg ctgtgataaa
     2701 ccaaacaggg aagggggaaa aaccctcctc cttgggattt tttttttttg ttttccctaa
     2761 caatttggac actacaattg ctctcacaaa ggaggttcaa agaccagttt gtaccgatga
     2821 aacgcgcaac tttgtaatcc caacactttc tattttctag aatcttcttt gttcattggg
     2881 tggtttttca gtcggctgga attctatctt ctgggggcct tccgtctgag atggaagctg
     2941 tcttgggctt gttgtctctt ccttctgttg ctccctgccc ctccccctgc ctttccactc
     3001 tgtctggtga gctctgcttt ttcagtgcac catcaagaga tgcagccccg tggacatgaa
     3061 gacacaatct cccacggaca gctttccccc ttccgccctc tcccaccctc tcctcccctt
     3121 gcgctcgcgc tcgcgctcgc tttctcactg gcgtgctctc tttctctctc tctctccctc
     3181 tgtacctttc tcatagttgc ttcagatctt aggtctcaag ggcactttgg cgcgtagtaa
     3241 gtgctttatg taagaaggca gggcaggggg gctttttaca ggagaaaaaa aaatgactta
     3301 taagagaaag agcctggagt atttttggaa aaaaaaataa tatttttatg ttaaaacaat
     3361 tttaaaatct taaaatggcc atcagacata gagagctttg tgtgattcat gttttaaaaa
     3421 gaaccgaaga agccacaggc agggcctgag ggagcccctg gctttcccct cagcctcagg
     3481 aaaggtggtc aggaaaactc tggctggaca agggtcagtc ttcggggtca gcagcgagat
     3541 tgctctgcag ccagtgaggg aggtccccgc catgccggct ggaagaagaa cctcgcatct
     3601 tttggtgtgt atgcaccttg gcagccagca ggaaagcagc gaagagccgc gcgccctctg
     3661 gcctcaaggg agcattggca gaaccataag gtactgcaga agccgtcgaa accgactgct
     3721 cggctggatt aggcgtgttg gctacatctt tcccacaacc gtataacgac cgatggtcat
     3781 ttctccaaga gcaggcttgg cgagtccttg cagagctgac atagaggcgc ccgcatgtca
     3841 cttagtctaa cgctgacaga aatgaatgca gaaggaagat tttcagtcct gaacgtgaat
     3901 tatagaggta gaacgtcgct aataatttct gccatcttta taatttcttt gtctcacaga
     3961 agactaggag aaagatcttt tttaaataat ctttttgctg tttttaaaaa attaaacaag
     4021 gctttgtgtt cctagaagag cttcatttca gtgaatctgg tgacctccat ctgcttgctg
     4081 tcataacccg acacggactt atttttgtca ttagcaaggg ggaaaaggcc aaaggacaag
     4141 ggcctcttct cccattggtt ttcctgtggg cagaagggct gaggaagatg gcccagcccg
     4201 tgggggctgc tgggtcacca gcagtgggta gggtgcaatc tggtgtgtgt tccagcagtg
     4261 agacggtgtt attgtgaagg tggcattcat ctgcggagcc aaaacccagc catcggggaa
     4321 gggtcagggc ttctgtggaa cttggaacgt gccaggacca cctgcaaaag ccagggtgcg
     4381 ttgatcattc tcagatcatt gattggcctc cacttgggta tgtgaattat tcatgtccca
     4441 gaagaccaaa aagtgctctg gttctgagat gagtatttta ttcgtgttct gtttccgaaa
     4501 cacttagcaa agaaggtcac agtgatgtgg agtcgccgca cccatctttg aagatagcca
     4561 gtgtccctgg atgaggtgat gatttcccgt cccaaggact ctgtgaagtt tagagtacag
     4621 tttgttgggg tccaaaagac accatctcta ccccacccaa ataaaaatgc actcatctct
     4681 gtagaacatc tgctgtcaaa ggccagcctg tcgttagggc atggcttatg cttgacaaac
     4741 cagtaacaac tgtgggatgg cgatggtggg atgtgtcgca agcaattcac tagacaatct
     4801 tcacatgaat gtcggtagcc agggtctctc ccgagggatg gctttagtct tgatgaatgt
     4861 gaaccatgtc ggaattgtta ggtagaaacc tgggctggga ggcctcggac cccaggctcc
     4921 atccctggct tccccagcct gcggccgcaa gcaaaaccaa gcgcgagatg cagctagcac
     4981 ccttcatatc catccccgtt ctcagcggga caacaccatg gacagccgtt ttcagagcct
     5041 ccagcatttg cacaccacta ctcaccctct ctgctgctgg catgttggta gagtcatccc
     5101 tgtaatcaag aaatggcctg tggaatgtta ttgttcaacg ttgtttacag ctcttaaaac
     5161 atggtgagga atgcctaagt cttagtgacc aaacgtgacc ttgaaagcag acatagcatg
     5221 acagaccttc ctagagtgtt tggtcgggtt cacagtgacc gagagtcagg tccagcacac
     5281 acctgggaaa gggatgctgc cccaaggggg accaaaaggg ccggacgtta cagggtgaaa
     5341 ccctctgacc cctcgcgaca ccgtaggact tgacttttgt ttagtctttc taagaaatag
     5401 atcatggagc caagtgaagt gcactttgtc aaatgtaagg gtctgctttg ttcttgttgc
     5461 ttttctgttt tttaaccttt tgttccgcca tttaaaaaaa gaaaaaaaaa aagcttatgt
     5521 ttcttgtcaa atgcagaaat gttccttccg ccactcactg aagttttgca ttctggcttg
     5581 tgcagttttt attgtctgtg tcagacgtac agccagacat gttctctatt ggcatttttc
     5641 cgattctgtt cagatgacag cgaccgcctt ttcattcccc ccgccacctg tactcaccct
     5701 cacgctcttt gaagaaaaaa aaaaaaatca ccttgtgtgt tgtagctcat ttgtttcaag
     5761 agagaatcaa cagatcatat tcagtgtctt gaataaattg ctctattttg atattaga
//
