LOCUS       NM_001394755            3342 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens TBK1 binding protein 1 (TBKBP1), transcript variant 1,
            mRNA.
ACCESSION   NM_001394755 XM_005257859
VERSION     NM_001394755.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3342)
  AUTHORS   Sorosina,M., Barizzone,N., Clarelli,F., Anand,S., Lupoli,S.,
            Salvi,E., Mangano,E., Bordoni,R., Roostaei,T., Mascia,E.,
            Zuccala,M., Vecchio,D., Cavalla,P., Santoro,S., Ferre,L., Zollo,A.,
            Barlassina,C., Cusi,D., Martinelli,V., Comi,G., Leone,M.,
            Filippi,M., Patsopoulos,N.A., De Jager,P.L., De Bellis,G.,
            Esposito,F., D'Alfonso,S. and Martinelli Boneschi,F.
  CONSRTM   PROGEMUS
  TITLE     A multi-step genomic approach prioritized TBKBP1 gene as relevant
            for multiple sclerosis susceptibility
  JOURNAL   J Neurol 269 (8), 4510-4522 (2022)
   PUBMED   35545683
  REMARK    GeneRIF: A multi-step genomic approach prioritized TBKBP1 gene as
            relevant for multiple sclerosis susceptibility.
            Erratum:[J Neurol. 2022 Aug;269(8):4523-4524. doi:
            10.1007/s00415-022-11216-6.. PMID: 35751689]
REFERENCE   2  (bases 1 to 3342)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   3  (bases 1 to 3342)
  AUTHORS   Zheng,X., Li,Q., Li,X., Zhang,Y., Wu,X., Wei,Q., Cao,S., Yang,M.,
            Lin,Z., Liao,Z., Qi,J., Lv,Q., Wang,L., Li,Y., Irwanto,A.,
            Cheng,C.Y., Chai,X., Khor,C.C., Heng,C.K., Koh,W.P., Yuan,J.M.,
            Bei,J., Zhang,F., Zhang,X., Zeng,Y., Shen,Y., Liu,J. and Gu,J.
  TITLE     Analysis of 47 Non-MHC Ankylosing Spondylitis Susceptibility Loci
            Regarding Associated Variants across Whites and Han Chinese
  JOURNAL   J Rheumatol 47 (5), 674-681 (2020)
   PUBMED   31523044
  REMARK    GeneRIF: Analysis of 47 Non-MHC Ankylosing Spondylitis
            Susceptibility Loci Regarding Associated Variants across Whites and
            Han Chinese.
REFERENCE   4  (bases 1 to 3342)
  AUTHORS   Zhu,L., Li,Y., Xie,X., Zhou,X., Gu,M., Jie,Z., Ko,C.J., Gao,T.,
            Hernandez,B.E., Cheng,X. and Sun,S.C.
  TITLE     TBKBP1 and TBK1 form a growth factor signalling axis mediating
            immunosuppression and tumourigenesis
  JOURNAL   Nat Cell Biol 21 (12), 1604-1614 (2019)
   PUBMED   31792381
  REMARK    GeneRIF: The TBK1-TBKBP1 axis facilitates tumour-mediated
            immunosuppression.
REFERENCE   5  (bases 1 to 3342)
  AUTHORS   Li,S., Wang,L., Berman,M., Kong,Y.Y. and Dorf,M.E.
  TITLE     Mapping a dynamic innate immunity protein interaction network
            regulating type I interferon production
  JOURNAL   Immunity 35 (3), 426-440 (2011)
   PUBMED   21903422
  REMARK    Erratum:[Immunity. 2011 Oct 28;35(4):647-8]
REFERENCE   6  (bases 1 to 3342)
  AUTHORS   Evans,D.M., Spencer,C.C., Pointon,J.J., Su,Z., Harvey,D.,
            Kochan,G., Oppermann,U., Dilthey,A., Pirinen,M., Stone,M.A.,
            Appleton,L., Moutsianas,L., Leslie,S., Wordsworth,T., Kenna,T.J.,
            Karaderi,T., Thomas,G.P., Ward,M.M., Weisman,M.H., Farrar,C.,
            Bradbury,L.A., Danoy,P., Inman,R.D., Maksymowych,W., Gladman,D.,
            Rahman,P., Morgan,A., Marzo-Ortega,H., Bowness,P., Gaffney,K.,
            Gaston,J.S., Smith,M., Bruges-Armas,J., Couto,A.R., Sorrentino,R.,
            Paladini,F., Ferreira,M.A., Xu,H., Liu,Y., Jiang,L.,
            Lopez-Larrea,C., Diaz-Pena,R., Lopez-Vazquez,A., Zayats,T.,
            Band,G., Bellenguez,C., Blackburn,H., Blackwell,J.M., Bramon,E.,
            Bumpstead,S.J., Casas,J.P., Corvin,A., Craddock,N., Deloukas,P.,
            Dronov,S., Duncanson,A., Edkins,S., Freeman,C., Gillman,M.,
            Gray,E., Gwilliam,R., Hammond,N., Hunt,S.E., Jankowski,J.,
            Jayakumar,A., Langford,C., Liddle,J., Markus,H.S., Mathew,C.G.,
            McCann,O.T., McCarthy,M.I., Palmer,C.N., Peltonen,L., Plomin,R.,
            Potter,S.C., Rautanen,A., Ravindrarajah,R., Ricketts,M., Samani,N.,
            Sawcer,S.J., Strange,A., Trembath,R.C., Viswanathan,A.C.,
            Waller,M., Weston,P., Whittaker,P., Widaa,S., Wood,N.W., McVean,G.,
            Reveille,J.D., Wordsworth,B.P., Brown,M.A. and Donnelly,P.
  CONSRTM   Spondyloarthritis Research Consortium of Canada (SPARCC);
            Australo-Anglo-American Spondyloarthritis Consortium (TASC);
            Wellcome Trust Case Control Consortium 2 (WTCCC2)
  TITLE     Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis
            implicates peptide handling in the mechanism for HLA-B27 in disease
            susceptibility
  JOURNAL   Nat Genet 43 (8), 761-767 (2011)
   PUBMED   21743469
  REMARK    Erratum:[Nat Genet. 2011 Sep;43(9):919. Opperman, Udo [corrected to
            Oppermann, Udo]; Moutsianis, Loukas [corrected to Moutsianas,
            Loukas]]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3342)
  AUTHORS   Liebau,S., Proepper,C., Schmidt,T., Schoen,M., Bockmann,J. and
            Boeckers,T.M.
  TITLE     ProSAPiP2, a novel postsynaptic density protein that interacts with
            ProSAP2/Shank3
  JOURNAL   Biochem Biophys Res Commun 385 (3), 460-465 (2009)
   PUBMED   19481056
REFERENCE   8  (bases 1 to 3342)
  AUTHORS   Ryzhakov,G. and Randow,F.
  TITLE     SINTBAD, a novel component of innate antiviral immunity, shares a
            TBK1-binding domain with NAP1 and TANK
  JOURNAL   EMBO J 26 (13), 3180-3190 (2007)
   PUBMED   17568778
  REMARK    GeneRIF: results suggest that efficient signal transduction upon
            viral infection requires SINTBAD, TANK and NAP1 because they link
            TBK1 and IKKi to virus-activated signalling cascades
REFERENCE   9  (bases 1 to 3342)
  AUTHORS   Kim,J.M., Lee,K.H., Jeon,Y.J., Oh,J.H., Jeong,S.Y., Song,I.S.,
            Kim,J.M., Lee,D.S. and Kim,N.S.
  TITLE     Identification of genes related to Parkinson's disease using
            expressed sequence tags
  JOURNAL   DNA Res 13 (6), 275-286 (2006)
   PUBMED   17213182
REFERENCE   10 (bases 1 to 3342)
  AUTHORS   Bouwmeester,T., Bauch,A., Ruffner,H., Angrand,P.O., Bergamini,G.,
            Croughton,K., Cruciat,C., Eberhard,D., Gagneur,J., Ghidelli,S.,
            Hopf,C., Huhse,B., Mangano,R., Michon,A.M., Schirle,M., Schlegl,J.,
            Schwab,M., Stein,M.A., Bauer,A., Casari,G., Drewes,G., Gavin,A.C.,
            Jackson,D.B., Joberty,G., Neubauer,G., Rick,J., Kuster,B. and
            Superti-Furga,G.
  TITLE     A physical and functional map of the human TNF-alpha/NF-kappa B
            signal transduction pathway
  JOURNAL   Nat Cell Biol 6 (2), 97-105 (2004)
   PUBMED   14743216
  REMARK    Erratum:[Nat Cell Biol. 2004 May;6(5):465]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC015674.12.
            
            On May 4, 2021 this sequence version replaced XM_005257859.4.
            
            Summary: TBKBP1 is an adaptor protein that binds to TBK1 (MIM
            604834) and is part of the interaction network in the TNF (MIM
            191160)/NFKB (see MIM 164011) pathway (Bouwmeester et al., 2004
            [PubMed 14743216]).[supplied by OMIM, Mar 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.2449741.1,
                                           SRR14038192.1576727.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000578982.6/ ENSP00000462339.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AC015674.12        102794-102827       c
            35-293              AC015674.12        100651-100909       c
            294-416             AC015674.12        100155-100277       c
            417-521             AC015674.12        99795-99899         c
            522-702             AC015674.12        98213-98393         c
            703-878             AC015674.12        97493-97668         c
            879-940             AC015674.12        97291-97352         c
            941-1059            AC015674.12        88476-88594         c
            1060-1787           AC015674.12        87536-88263         c
            1788-3342           AC015674.12        84936-86490         c
FEATURES             Location/Qualifiers
     source          1..3342
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.32"
     gene            1..3342
                     /gene="TBKBP1"
                     /gene_synonym="ProSAPiP2; SINTBAD"
                     /note="TBK1 binding protein 1"
                     /db_xref="GeneID:9755"
                     /db_xref="HGNC:HGNC:30140"
                     /db_xref="MIM:608476"
     exon            1..34
                     /gene="TBKBP1"
                     /gene_synonym="ProSAPiP2; SINTBAD"
                     /inference="alignment:Splign:2.1.0"
     exon            35..293
                     /gene="TBKBP1"
                     /gene_synonym="ProSAPiP2; SINTBAD"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1916
                     /gene="TBKBP1"
                     /gene_synonym="ProSAPiP2; SINTBAD"
                     /codon_start=1
                     /product="TANK-binding kinase 1-binding protein 1"
                     /protein_id="NP_001381684.1"
                     /db_xref="CCDS:CCDS45722.1"
                     /db_xref="GeneID:9755"
                     /db_xref="HGNC:HGNC:30140"
                     /db_xref="MIM:608476"
                     /translation="MESMFEDDISILTQEALGPSEVWLDSPGDPSLGGDMCSASHFAL
                     ITAYGDIKERLGGLERENATLRRRLKVYEIKYPLISDFGEEHGFSLYEIKDGSLLEVE
                     KVSLQQRLNQFQHELQKNKEQEEQLGEMIQAYEKLCVEKSDLETELREMRALVETHLR
                     QICGLEQQLRQQQGLQDAAFSNLSPPPAPAPPCTDLDLHYLALRGGSGLSHAGWPGST
                     PSVSDLERRRLEEALEAAQGEARGAQLREEQLQAECERLQGELKQLQETRAQDLASNQ
                     SERDMAWVKRVGDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARSGGQRH
                     SPLSQRHSPAPQCPSPSPPARAAPPCPPCQSPVPQRRSPVPPCPSPQQRRSPASPSCP
                     SPVPQRRSPVPPSCQSPSPQRRSPVPPSCPAPQPRPPPPPPPGERTLAERAYAKPPSH
                     HVKAGFQGRRSYSELAEGAAYAGASPPWLQAEAATLPKPRAYGSELYGPGRPLSPRRA
                     FEGIRLRFEKQPSEEDEWAVPTSPPSPEVGTIRCASFCAGFPIPESPAATAYAHAEHA
                     QSWPSINLLMETVGSDIRSCPLCQLGFPVGYPDDALIKHIDSHLENSKI"
     exon            294..416
                     /gene="TBKBP1"
                     /gene_synonym="ProSAPiP2; SINTBAD"
                     /inference="alignment:Splign:2.1.0"
     exon            417..521
                     /gene="TBKBP1"
                     /gene_synonym="ProSAPiP2; SINTBAD"
                     /inference="alignment:Splign:2.1.0"
     exon            522..702
                     /gene="TBKBP1"
                     /gene_synonym="ProSAPiP2; SINTBAD"
                     /inference="alignment:Splign:2.1.0"
     exon            703..878
                     /gene="TBKBP1"
                     /gene_synonym="ProSAPiP2; SINTBAD"
                     /inference="alignment:Splign:2.1.0"
     exon            879..940
                     /gene="TBKBP1"
                     /gene_synonym="ProSAPiP2; SINTBAD"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1059
                     /gene="TBKBP1"
                     /gene_synonym="ProSAPiP2; SINTBAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1787
                     /gene="TBKBP1"
                     /gene_synonym="ProSAPiP2; SINTBAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..3342
                     /gene="TBKBP1"
                     /gene_synonym="ProSAPiP2; SINTBAD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3323..3328
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBKBP1"
                     /gene_synonym="ProSAPiP2; SINTBAD"
                     /note="hexamer: AATAAA"
     polyA_site      3342
                     /gene="TBKBP1"
                     /gene_synonym="ProSAPiP2; SINTBAD"
                     /note="major polyA site"
ORIGIN      
        1 aagctgcgat tacaagcagg aaccggcagc agctgaggcc ccgtgtgggc cgcggcccgg
       61 ccctcaccat ggagtccatg ttcgaggacg acatcagcat cctgacgcag gaggccctgg
      121 ggcctagtga ggtgtggctg gacagtcccg gagacccctc gcttgggggc gacatgtgct
      181 ccgcctccca ctttgccctc atcactgctt acggagacat caaggaacgg ctggggggcc
      241 tggagaggga gaacgccacc ctccgacgcc gcctcaaagt ctacgagatc aagtacccac
      301 tgatcagtga ctttggagag gagcatggct tttctctgta tgaaatcaag gatggctccc
      361 tgctggaggt ggagaaggtc agcctgcagc aacggctcaa ccagttccag catgagttac
      421 agaagaacaa ggagcaggaa gaacagcttg gagagatgat ccaggcctac gagaaactct
      481 gcgtggagaa gagtgacttg gagacagagc tgagggagat gagggccctg gtggagacgc
      541 acctgcgtca gatctgtggt ttggagcagc agctgcggca acagcaaggc ctccaggatg
      601 cagccttctc caacctgagc ccaccgccag cccccgcccc tccctgcact gatttagacc
      661 tgcactacct ggcactgaga gggggatctg gcttgagtca tgcaggctgg ccgggctcca
      721 cacccagtgt gagtgacctg gagcggcggc ggctagaaga ggctttggag gccgcgcagg
      781 gagaggcccg gggggctcag ctccgggagg agcagctcca ggccgagtgc gagcggctgc
      841 agggggagct gaagcagctg caggagaccc gggcccagga tctggcctcc aaccagtcgg
      901 agcgagacat ggcgtgggtg aaaagagttg gggatgatca ggtgaatttg gcgctggcct
      961 acaccgagct gacggaggag ctgggccggc ttcgggagtt gagttcccta caggggagaa
     1021 tcttgaggac tctgttgcag gaacaggccc ggagtggcgg ccagaggcac tcgccgctgt
     1081 cacaacgcca ctccccggcc ccccagtgcc cctccccctc cccgcctgcc cgagcggctc
     1141 ccccgtgccc cccgtgccag tcccccgtcc cccagcgccg ctctcccgtg cccccgtgcc
     1201 cctcgccgca gcagcgccgc tctccggcct caccctcctg cccgtcgccc gtcccgcagc
     1261 gccgctcgcc ggtgccgccg tcgtgccagt cccccagccc gcagcgccgt tccccggtgc
     1321 cccccagctg cccggccccg cagccccggc caccgccgcc gcccccgccg ggcgagagga
     1381 cgctggccga gcgcgcctac gccaagccgc ccagccacca cgtgaaggcc ggcttccagg
     1441 gccgccgcag ctactctgag ctggcggagg gcgcggccta cgcgggcgcc tccccgccct
     1501 ggctgcaggc cgaagcggcc actctcccca agccccgggc ctacggcagc gagctctacg
     1561 gccctggcag gcccctcagc ccgcggcgcg ccttcgaggg catccggctg cgcttcgaga
     1621 agcagccgtc ggaggaggac gagtgggctg tgcccaccag cccgcccagc ccggaggtgg
     1681 gcaccatccg ctgcgcctcc ttctgcgcgg gcttccccat ccccgagtcg cccgccgcca
     1741 ccgcctacgc ccacgccgag cacgcgcagt cctggccgtc catcaacttg ctgatggaga
     1801 cggtgggctc cgacatccgc agctgccccc tctgccagct gggtttccct gtcgggtacc
     1861 cggatgatgc cctcatcaaa cacattgact cccacctgga gaacagcaag atctagggca
     1921 ccagccccac ccactggctg tttctccgtc ctctcctatc acccccaaac actcactttg
     1981 aatgctgcat gaatctcgtg gggggtccct gcccttgcga cccccagata cctccacttg
     2041 ctaccgagtc aacgtgtgtg ccatcttccc tggtccaggc accactcagc tctggctctt
     2101 cctgggaggt cagccgaggc tccccccatg ctcctggttt ctgcttagga ggtggggact
     2161 tgggctggga tggggacggc atacccctcc caggcctctc cctctgcctt tctgttctta
     2221 atcagggttg gatccaagaa ggtgtccagt gcttgggcct ggggtggggg gaaggtgtta
     2281 gaggactcca ggagctcctg cacccctccc caaatgtcca tctttctcag acggggctct
     2341 gtctggggag cacccacagg ctgcctttgg ggtcccagag cctgctctgt gcactgaccc
     2401 cagttcctcc atcctgtggc cagcctaggg ctcatggcat gggcccccac tgggggaggg
     2461 aggcatcttg tttcttgtgg ttccctgcag gccagtcctg tcctcctttc cctgttctgc
     2521 ccactctggg gaatagggag gggaggagag gagaggagag ggaggatcct ggaggactgg
     2581 gaagatctag cctaaagagg cttctctgag ggccagggcc ctacagcatg cccctacggc
     2641 caggggactg tctgccagcc tcccaggccc atgccctcct ggtgcccctg gcactgaggc
     2701 acagatcgtc aaggcaggta ccccctcaac ccttcttcca ctggagcccc tgacaccaca
     2761 ggtgccctgg agcccttgtg tgactcagcc tctgttagct gggtgggtgt catcagcccc
     2821 tgcctcccag gccagaacct gagaacgggc ccagggtgct gtggagatca acttcaaaag
     2881 agctaacccc ttcccacact ccacccaccc acctacattt cctctgtgaa atctacctca
     2941 gagttgtacc ctcagaagga cgggtaagca ggaggccagg gggtccccag ggctgaggtg
     3001 gggagccttc tacggcgaaa gcctgccacc ccacaatgaa tccaccctgc tccactgcgc
     3061 gcctctccca ggtctcagct ctgggtgggg agcagtggcc gctaccgaca gcgcatgtcc
     3121 cgctcttatc caactcttcc aggccccacc tccctgcacc cctcccctct atagagcagg
     3181 ggagtgaagg ggtatgtcag gcggggaagg ggccaaggac acgtcattgt accctgagcg
     3241 tccccaggga gtggaaatgg ggaagggggc ctggagaggg gaggcagggg cccctgtgct
     3301 ctctgaacaa gttgaaagtc caaataaaac ttacctgttc ca
//
