LOCUS       NM_013254               3022 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens TANK binding kinase 1 (TBK1), mRNA.
ACCESSION   NM_013254
VERSION     NM_013254.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3022)
  AUTHORS   Lv,B., Dion,W.A., Yang,H., Xun,J., Kim,D.H., Zhu,B. and Tan,J.X.
  TITLE     A TBK1-independent primordial function of STING in lysosomal
            biogenesis
  JOURNAL   Mol Cell 84 (20), 3979-3996 (2024)
   PUBMED   39423796
  REMARK    GeneRIF: A TBK1-independent primordial function of STING in
            lysosomal biogenesis.
REFERENCE   2  (bases 1 to 3022)
  AUTHORS   Endo,R., Kinefuchi,H., Sawada,M., Kikuchi,R., Kojima,W., Matsuda,N.
            and Yamano,K.
  TITLE     TBK1 adaptor AZI2/NAP1 regulates NDP52-driven mitochondrial
            autophagy
  JOURNAL   J Biol Chem 300 (10), 107775 (2024)
   PUBMED   39276928
  REMARK    GeneRIF: TBK1 adaptor AZI2/NAP1 regulates NDP52-driven
            mitochondrial autophagy.
REFERENCE   3  (bases 1 to 3022)
  AUTHORS   Clement,J.F., Meloche,S. and Servant,M.J.
  TITLE     The IKK-related kinases: from innate immunity to oncogenesis
  JOURNAL   Cell Res 18 (9), 889-899 (2008)
   PUBMED   19160540
  REMARK    Review article
REFERENCE   4  (bases 1 to 3022)
  AUTHORS   Fitzgerald,K.A., McWhirter,S.M., Faia,K.L., Rowe,D.C., Latz,E.,
            Golenbock,D.T., Coyle,A.J., Liao,S.M. and Maniatis,T.
  TITLE     IKKepsilon and TBK1 are essential components of the IRF3 signaling
            pathway
  JOURNAL   Nat Immunol 4 (5), 491-496 (2003)
   PUBMED   12692549
  REMARK    GeneRIF: IKKepsilon and TBK1 have a pivotal role in coordinating
            the activation of IRF3 and NF-kappaB in the innate immune response.
REFERENCE   5  (bases 1 to 3022)
  AUTHORS   Li,S.F., Fujita,F., Hirai,M., Lu,R., Niida,H. and Nakanishi,M.
  TITLE     Genomic structure and characterization of the promoter region of
            the human NAK gene
  JOURNAL   Gene 304, 57-64 (2003)
   PUBMED   12568715
REFERENCE   6  (bases 1 to 3022)
  AUTHORS   Kishore,N., Huynh,Q.K., Mathialagan,S., Hall,T., Rouw,S.,
            Creely,D., Lange,G., Caroll,J., Reitz,B., Donnelly,A.,
            Boddupalli,H., Combs,R.G., Kretzmer,K. and Tripp,C.S.
  TITLE     IKK-i and TBK-1 are enzymatically distinct from the homologous
            enzyme IKK-2: comparative analysis of recombinant human IKK-i,
            TBK-1, and IKK-2
  JOURNAL   J Biol Chem 277 (16), 13840-13847 (2002)
   PUBMED   11839743
  REMARK    GeneRIF: IKK-i and TBK-1 are enzymatically distinct from the
            homologous enzyme IKK-2: comparative analysis of recombinant human
            IKK-i, TBK-1, and IKK-2.
REFERENCE   7  (bases 1 to 3022)
  AUTHORS   Tojima,Y., Fujimoto,A., Delhase,M., Chen,Y., Hatakeyama,S.,
            Nakayama,K., Kaneko,Y., Nimura,Y., Motoyama,N., Ikeda,K., Karin,M.
            and Nakanishi,M.
  TITLE     NAK is an IkappaB kinase-activating kinase
  JOURNAL   Nature 404 (6779), 778-782 (2000)
   PUBMED   10783893
REFERENCE   8  (bases 1 to 3022)
  AUTHORS   Pomerantz,J.L. and Baltimore,D.
  TITLE     NF-kappaB activation by a signaling complex containing TRAF2, TANK
            and TBK1, a novel IKK-related kinase
  JOURNAL   EMBO J 18 (23), 6694-6704 (1999)
   PUBMED   10581243
REFERENCE   9  (bases 1 to 3022)
  AUTHORS   Chou,M.M. and Hanafusa,H.
  TITLE     A novel ligand for SH3 domains. The Nck adaptor protein binds to a
            serine/threonine kinase via an SH3 domain
  JOURNAL   J Biol Chem 270 (13), 7359-7364 (1995)
   PUBMED   7706279
REFERENCE   10 (bases 1 to 3022)
  AUTHORS   Siddique,N. and Siddique,T.
  TITLE     Amyotrophic Lateral Sclerosis Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301623
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC034950.2, AC135279.3,
            AC136977.4 and AA970899.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 6, 2018 this sequence version replaced NM_013254.3.
            
            Summary: The NF-kappa-B (NFKB) complex of proteins is inhibited by
            I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in
            the cytoplasm. Phosphorylation of serine residues on the IKB
            proteins by IKB kinases marks them for destruction via the
            ubiquitination pathway, thereby allowing activation and nuclear
            translocation of the NFKB complex. The protein encoded by this gene
            is similar to IKB kinases and can mediate NFKB activation in
            response to certain growth factors. The protein is also an
            important kinase for antiviral innate immunity response. [provided
            by RefSeq, Sep 2021].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.267405.1,
                                           SRR1803615.195354.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in immune response or antiviral
                                      activity
            MANE Ensembl match     :: ENST00000331710.10/ ENSP00000329967.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1076              BC034950.2         1-1076
            1077-1077           AC135279.3         3693-3693           c
            1078-1260           BC034950.2         1078-1260
            1261-1261           AC135279.3         1228-1228           c
            1262-1806           BC034950.2         1262-1806
            1807-1807           AC136977.4         12064-12064
            1808-2961           BC034950.2         1808-2961
            2962-3022           AA970899.1         17-77               c
FEATURES             Location/Qualifiers
     source          1..3022
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q14.2"
     gene            1..3022
                     /gene="TBK1"
                     /gene_synonym="AIARV; FTDALS4; IIAE8; NAK; T2K"
                     /note="TANK binding kinase 1"
                     /db_xref="GeneID:29110"
                     /db_xref="HGNC:HGNC:11584"
                     /db_xref="MIM:604834"
     exon            1..68
                     /gene="TBK1"
                     /gene_synonym="AIARV; FTDALS4; IIAE8; NAK; T2K"
                     /inference="alignment:Splign:2.1.0"
     exon            69..186
                     /gene="TBK1"
                     /gene_synonym="AIARV; FTDALS4; IIAE8; NAK; T2K"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..2289
                     /gene="TBK1"
                     /gene_synonym="AIARV; FTDALS4; IIAE8; NAK; T2K"
                     /EC_number="2.7.11.1"
                     /note="NF-kB-activating kinase; NF-kappa-B-activating
                     kinase"
                     /codon_start=1
                     /product="serine/threonine-protein kinase TBK1"
                     /protein_id="NP_037386.1"
                     /db_xref="CCDS:CCDS8968.1"
                     /db_xref="GeneID:29110"
                     /db_xref="HGNC:HGNC:11584"
                     /db_xref="MIM:604834"
                     /translation="MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNIS
                     FLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPS
                     NAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGA
                     ARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGS
                     LPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVL
                     LTPVLANILEADQEKCWGFDQFFAETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATI
                     FHELVYKQTKIISSNQELIYEGRRLVLEPGRLAQHFPKTTEENPIFVVSREPLNTIGL
                     IYEKISLPKVHPRYDLDGDASMAKAITGVVCYACRIASTLLLYQELMRKGIRWLIELI
                     KDDYNETVHKKTEVVITLDFCIRNIEKTVKVYEKLMKINLEAAELGEISDIHTKLLRL
                     SSSQGTIETSLQDIDSRLSPGGSLADAWAHQEGTHPKDRNVEKLQVLLNCMTEIYYQF
                     KKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTHFTDECVKKYEAFLNKSEEWIRKML
                     HLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETLPQKMFTASSGIKHTMTPIYPSSNT
                     LVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMDGGLRNVDCL"
     exon            187..327
                     /gene="TBK1"
                     /gene_synonym="AIARV; FTDALS4; IIAE8; NAK; T2K"
                     /inference="alignment:Splign:2.1.0"
     exon            328..457
                     /gene="TBK1"
                     /gene_synonym="AIARV; FTDALS4; IIAE8; NAK; T2K"
                     /inference="alignment:Splign:2.1.0"
     exon            458..639
                     /gene="TBK1"
                     /gene_synonym="AIARV; FTDALS4; IIAE8; NAK; T2K"
                     /inference="alignment:Splign:2.1.0"
     exon            640..800
                     /gene="TBK1"
                     /gene_synonym="AIARV; FTDALS4; IIAE8; NAK; T2K"
                     /inference="alignment:Splign:2.1.0"
     exon            801..911
                     /gene="TBK1"
                     /gene_synonym="AIARV; FTDALS4; IIAE8; NAK; T2K"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1091
                     /gene="TBK1"
                     /gene_synonym="AIARV; FTDALS4; IIAE8; NAK; T2K"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1288
                     /gene="TBK1"
                     /gene_synonym="AIARV; FTDALS4; IIAE8; NAK; T2K"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1347
                     /gene="TBK1"
                     /gene_synonym="AIARV; FTDALS4; IIAE8; NAK; T2K"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1439
                     /gene="TBK1"
                     /gene_synonym="AIARV; FTDALS4; IIAE8; NAK; T2K"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1541
                     /gene="TBK1"
                     /gene_synonym="AIARV; FTDALS4; IIAE8; NAK; T2K"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1620
                     /gene="TBK1"
                     /gene_synonym="AIARV; FTDALS4; IIAE8; NAK; T2K"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1742
                     /gene="TBK1"
                     /gene_synonym="AIARV; FTDALS4; IIAE8; NAK; T2K"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1819
                     /gene="TBK1"
                     /gene_synonym="AIARV; FTDALS4; IIAE8; NAK; T2K"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1859
                     /gene="TBK1"
                     /gene_synonym="AIARV; FTDALS4; IIAE8; NAK; T2K"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..1961
                     /gene="TBK1"
                     /gene_synonym="AIARV; FTDALS4; IIAE8; NAK; T2K"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2058
                     /gene="TBK1"
                     /gene_synonym="AIARV; FTDALS4; IIAE8; NAK; T2K"
                     /inference="alignment:Splign:2.1.0"
     exon            2059..2165
                     /gene="TBK1"
                     /gene_synonym="AIARV; FTDALS4; IIAE8; NAK; T2K"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2237
                     /gene="TBK1"
                     /gene_synonym="AIARV; FTDALS4; IIAE8; NAK; T2K"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..3022
                     /gene="TBK1"
                     /gene_synonym="AIARV; FTDALS4; IIAE8; NAK; T2K"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2997..3002
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBK1"
                     /gene_synonym="AIARV; FTDALS4; IIAE8; NAK; T2K"
                     /note="hexamer: AATAAA"
     polyA_site      3022
                     /gene="TBK1"
                     /gene_synonym="AIARV; FTDALS4; IIAE8; NAK; T2K"
                     /note="major polyA site"
ORIGIN      
        1 ggaagtgtcc tgagtctcga ggaggccgcg ggagcccgcc ggcggtggcg cggcggagac
       61 ccggctggta taacaagagg attgcctgat ccagccaaga tgcagagcac ttctaatcat
      121 ctgtggcttt tatctgatat tttaggccaa ggagctactg caaatgtctt tcgtggaaga
      181 cataagaaaa ctggtgattt atttgctatc aaagtattta ataacataag cttccttcgt
      241 ccagtggatg ttcaaatgag agaatttgaa gtgttgaaaa aactcaatca caaaaatatt
      301 gtcaaattat ttgctattga agaggagaca acaacaagac ataaagtact tattatggaa
      361 ttttgtccat gtgggagttt atacactgtt ttagaagaac cttctaatgc ctatggacta
      421 ccagaatctg aattcttaat tgttttgcga gatgtggtgg gtggaatgaa tcatctacga
      481 gagaatggta tagtgcaccg tgatatcaag ccaggaaata tcatgcgtgt tataggggaa
      541 gatggacagt ctgtgtacaa actcacagat tttggtgcag ctagagaatt agaagatgat
      601 gagcagtttg tttctctgta tggcacagaa gaatatttgc accctgatat gtatgagaga
      661 gcagtgctaa gaaaagatca tcagaagaaa tatggagcaa cagttgatct ttggagcatt
      721 ggggtaacat tttaccatgc agctactgga tcactgccat ttagaccctt tgaagggcct
      781 cgtaggaata aagaagtgat gtataaaata attacaggaa agccttctgg tgcaatatct
      841 ggagtacaga aagcagaaaa tggaccaatt gactggagtg gagacatgcc tgtttcttgc
      901 agtctttctc ggggtcttca ggttctactt acccctgttc ttgcaaacat ccttgaagca
      961 gatcaggaaa agtgttgggg ttttgaccag ttttttgcag aaactagtga tatacttcac
     1021 cgaatggtaa ttcatgtttt ttcgctacaa caaatgacag ctcataagat ttatattcat
     1081 agctataata ctgctactat atttcatgaa ctggtatata aacaaaccaa aattatttct
     1141 tcaaatcaag aacttatcta cgaagggcga cgcttagtct tagaacctgg aaggctggca
     1201 caacatttcc ctaaaactac tgaggaaaac cctatatttg tagtaagccg ggaacctctg
     1261 aataccatag gattaatata tgaaaaaatt tccctcccta aagtacatcc acgttatgat
     1321 ttagacgggg atgctagcat ggctaaggca ataacagggg ttgtgtgtta tgcctgcaga
     1381 attgccagta ccttactgct ttatcaggaa ttaatgcgaa aggggatacg atggctgatt
     1441 gaattaatta aagatgatta caatgaaact gttcacaaaa agacagaagt tgtgatcaca
     1501 ttggatttct gtatcagaaa cattgaaaaa actgtgaaag tatatgaaaa gttgatgaag
     1561 atcaacctgg aagcggcaga gttaggtgaa atttcagaca tacacaccaa attgttgaga
     1621 ctttccagtt ctcagggaac aatagaaacc agtcttcagg atatcgacag cagattatct
     1681 ccaggtggat cactggcaga cgcatgggca catcaagaag gcactcatcc gaaagacaga
     1741 aatgtagaaa aactacaagt cctgttaaat tgcatgacag agatttacta tcagttcaaa
     1801 aaagacaaag cagaacgtag attagcttat aatgaagaac aaatccacaa atttgataag
     1861 caaaaactgt attaccatgc cacaaaagct atgacgcact ttacagatga atgtgttaaa
     1921 aagtatgagg catttttgaa taagtcagaa gaatggataa gaaagatgct tcatcttagg
     1981 aaacagttat tatcgctgac taatcagtgt tttgatattg aagaagaagt atcaaaatat
     2041 caagaatata ctaatgagtt acaagaaact ctgcctcaga aaatgtttac agcttccagt
     2101 ggaatcaaac ataccatgac cccaatttat ccaagttcta acacattagt agaaatgact
     2161 cttggtatga agaaattaaa ggaagagatg gaaggggtgg ttaaagaact tgctgaaaat
     2221 aaccacattt tagaaaggtt tggctcttta accatggatg gtggccttcg caacgttgac
     2281 tgtctttagc tttctaatag aagtttaaga aaagtttccg tttgcacaag aaaataacgc
     2341 ttgggcatta aatgaatgcc tttatagata gtcacttgtt tctacaattc agtatttgat
     2401 gtggtcgtgt aaatatgtac aatattgtaa atacataaaa aatatacaaa tttttggctg
     2461 ctgtgaagat gtaattttat cttttaacat ttataattat atgaggaaat ttgacctcag
     2521 tgatcacgag aagaaagcca tgaccgacca atatgttgac atactgatcc tctactctga
     2581 gtggggctaa ataagttatt ttctctgacc gcctactgga aatattttta agtggaacca
     2641 aaataggcat ccttacaaat caggaagact gacttgacac gtttgtaaat ggtagaacgg
     2701 tggctactgt gagtggggag cagaaccgca ccactgttat actgggataa caattttttt
     2761 gagaaggata aagtggcatt attttatttt acaaggtgcc cagatcccag ttatccttgt
     2821 atccatgtaa tttcagatga attattaagc aaacatttta aagtgaattc attattaaaa
     2881 actattcatt tttttccttt ggccataaat gtgtaattgt cattaaaatt ctaaggtcat
     2941 ttcaactgtt ttaagctgta tatttcttta attctgctta ctatttcatg gaaaaaaata
     3001 aatttctcaa ttttaatgta aa
//
