LOCUS       NM_003192               1606 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens tubulin folding cofactor C (TBCC), mRNA.
ACCESSION   NM_003192
VERSION     NM_003192.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1606)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1606)
  AUTHORS   Garcia-Mayoral,M.F., Castano,R., Fanarraga,M.L., Zabala,J.C.,
            Rico,M. and Bruix,M.
  TITLE     The solution structure of the N-terminal domain of human tubulin
            binding cofactor C reveals a platform for tubulin interaction
  JOURNAL   PLoS One 6 (10), e25912 (2011)
   PUBMED   22028797
  REMARK    GeneRIF: a testable model for TBCC N-terminal domain/tubulin
            recognition in which the highly charged N-terminus as well as
            residues from the three helices and the loops interact with the
            acidic hypervariable regions of tubulin monomers
REFERENCE   3  (bases 1 to 1606)
  AUTHORS   Hage-Sleiman,R., Herveau,S., Matera,E.L., Laurier,J.F. and
            Dumontet,C.
  TITLE     Tubulin binding cofactor C (TBCC) suppresses tumor growth and
            enhances chemosensitivity in human breast cancer cells
  JOURNAL   BMC Cancer 10, 135 (2010)
   PUBMED   20384997
  REMARK    GeneRIF: Microtubule dynamicity was reduced in breast cancer cells
            overexpressing TBCC. Cell cycle distribution was altered in cells
            containing larger amounts of TBCC. TBCC had little effect on cell
            proliferation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1606)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   5  (bases 1 to 1606)
  AUTHORS   Grayson,C., Bartolini,F., Chapple,J.P., Willison,K.R.,
            Bhamidipati,A., Lewis,S.A., Luthert,P.J., Hardcastle,A.J.,
            Cowan,N.J. and Cheetham,M.E.
  TITLE     Localization in the human retina of the X-linked retinitis
            pigmentosa protein RP2, its homologue cofactor C and the RP2
            interacting protein Arl3
  JOURNAL   Hum Mol Genet 11 (24), 3065-3074 (2002)
   PUBMED   12417528
REFERENCE   6  (bases 1 to 1606)
  AUTHORS   Bartolini,F., Bhamidipati,A., Thomas,S., Schwahn,U., Lewis,S.A. and
            Cowan,N.J.
  TITLE     Functional overlap between retinitis pigmentosa 2 protein and the
            tubulin-specific chaperone cofactor C
  JOURNAL   J Biol Chem 277 (17), 14629-14634 (2002)
   PUBMED   11847227
  REMARK    GeneRIF: functional overlap with retinitis pigmenosa 2 protein
REFERENCE   7  (bases 1 to 1606)
  AUTHORS   Tian,G., Huang,Y., Rommelaere,H., Vandekerckhove,J., Ampe,C. and
            Cowan,N.J.
  TITLE     Pathway leading to correctly folded beta-tubulin
  JOURNAL   Cell 86 (2), 287-296 (1996)
   PUBMED   8706133
REFERENCE   8  (bases 1 to 1606)
  AUTHORS   Lewis,S.A., Tian,G., Vainberg,I.E. and Cowan,N.J.
  TITLE     Chaperonin-mediated folding of actin and tubulin
  JOURNAL   J Cell Biol 132 (1-2), 1-4 (1996)
   PUBMED   8567715
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL353716.18.
            
            On May 17, 2019 this sequence version replaced NM_003192.2.
            
            Summary: Cofactor C is one of four proteins (cofactors A, D, E, and
            C) involved in the pathway leading to correctly folded beta-tubulin
            from folding intermediates. Cofactors A and D are believed to play
            a role in capturing and stabilizing beta-tubulin intermediates in a
            quasi-native confirmation. Cofactor E binds to the cofactor
            D/beta-tubulin complex; interaction with cofactor C then causes the
            release of beta-tubulin polypeptides that are committed to the
            native state. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR3476690.452306.1,
                                        SRR3476690.353594.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372876.2/ ENSP00000361967.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1606              AL353716.18        4444-6049           c
FEATURES             Location/Qualifiers
     source          1..1606
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..1606
                     /gene="TBCC"
                     /gene_synonym="CFC"
                     /note="tubulin folding cofactor C"
                     /db_xref="GeneID:6903"
                     /db_xref="HGNC:HGNC:11580"
                     /db_xref="MIM:602971"
     exon            1..1606
                     /gene="TBCC"
                     /gene_synonym="CFC"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1071
                     /gene="TBCC"
                     /gene_synonym="CFC"
                     /codon_start=1
                     /product="tubulin-specific chaperone C"
                     /protein_id="NP_003183.2"
                     /db_xref="CCDS:CCDS4872.1"
                     /db_xref="GeneID:6903"
                     /db_xref="HGNC:HGNC:11580"
                     /db_xref="MIM:602971"
                     /translation="MESVSCSAAAVRTGDMESQRDLSLVPERLQRREQERQLEVERRK
                     QKRQNQEVEKENSHFFVATFVRERAAVEELLERAESVERLEEAASRLQGLQKLINDSV
                     FFLAAYDLRQGQEALARLQAALAERRRGLQPKKRFAFKTRGKDAASSTKVDAAPGIPP
                     AVESIQDSPLPKKAEGDLGPSWVCGFSNLESQVLEKRASELHQRDVLLTELSNCTVRL
                     YGNPNTLRLTKAHSCKLLCGPVSTSVFLEDCSDCVLAVACQQLRIHSTKDTRIFLQVT
                     SRAIVEDCSGIQFAPYTWSYPEIDKDFESSGLDRSKNNWNDVDDFNWLARDMASPNWS
                     ILPEEERNIQWD"
     regulatory      1585..1590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBCC"
                     /gene_synonym="CFC"
                     /note="hexamer: AATAAA"
     polyA_site      1606
                     /gene="TBCC"
                     /gene_synonym="CFC"
                     /note="major polyA site"
ORIGIN      
        1 aagacaagag agaggaagct tgaagccaat atggagtccg tcagttgctc cgctgctgct
       61 gtcaggaccg gagacatgga gtcccagcgg gacctgagcc tggtgcctga gcggcttcag
      121 agacgcgaac aagaacggca gctggaagtt gaaaggcgga aacaaaagcg gcagaaccag
      181 gaggtagaga aggagaacag ccactttttc gtcgccacct ttgttcggga gcgagcggcc
      241 gtggaagagc ttctggagcg cgcggagtcg gtcgagcggc tggaggaggc ggcctctcgg
      301 ctccaggggc tgcagaaact aatcaacgac tcagtttttt tcctagccgc ttacgacctg
      361 cggcagggac aagaggcgct ggcgcggctg caggcggcct tggccgagcg gcgccggggg
      421 ctgcagccca agaagcgttt cgctttcaag acccggggaa aggatgctgc ttcgtctacc
      481 aaagtagacg cggctcctgg catccccccg gcagttgaaa gcatacagga ctccccgctg
      541 cccaagaagg cggaaggaga cctcggcccc agctgggtct gcggtttctc caacctggag
      601 tcccaagtct tggagaagag agccagcgag ttgcaccagc gcgacgttct tttgaccgaa
      661 ctgagcaact gcacggtcag actgtatgga aatcccaaca ccctgcggct aaccaaggcc
      721 cacagctgca agctgctctg cggtccggtg tctacctctg ttttcctgga ggactgcagt
      781 gactgcgtgc tggcagtggc ctgccaacag ctccgcatac acagtacgaa agacacccgc
      841 atcttcctgc aggtgaccag cagggccatc gtggaggact gcagtgggat ccagttcgcc
      901 ccttacacct ggagctaccc ggagatcgac aaggacttcg agagctctgg tttagatagg
      961 agcaaaaata actggaacga tgttgacgat tttaactggc tggcccggga tatggcctcc
     1021 ccaaactgga gtattcttcc tgaagaggag cgaaatatcc agtgggacta agcagttgtc
     1081 actctgttct tcactcctac caaatacttt ccacgttgga ctttccccct tattgggtct
     1141 cgaagtttac ttattgtcac actgtgtatg ttttcagcat tttaaggcta gagattgtaa
     1201 tgggctccta cttgtaattt ccattaaatt cgtaacaggt ataacactaa agcatttttg
     1261 ctattttcgt catgcctttg agactgagtc ttactccgtc ccccagcgtg gtggcgcgct
     1321 gggattacag gcgcgcgcca ccacgcgaac ttgtattttt agtagagacg gggtttcgcc
     1381 atgttgtccg ggctgctctc gaactcctga cctcaggtga tccacccgct tcagcttccc
     1441 aaagtgctgg cattacaggc gtgagccacc acgccagggc tttatttatt tatttttacc
     1501 acaatagttt gaagcagtaa gggggaagga gggtgattat attgctttgt aatggtttgt
     1561 gatacttgaa acatcacggt gcataataaa gtaggtctgc agtaaa
//
