LOCUS       NM_015043               5155 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens TBC1 domain family member 9B (TBC1D9B), transcript
            variant 2, mRNA.
ACCESSION   NM_015043
VERSION     NM_015043.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5155)
  AUTHORS   Liao,Y., Li,M., Chen,X., Jiang,Y. and Yin,X.M.
  TITLE     Interaction of TBC1D9B with Mammalian ATG8 Homologues Regulates
            Autophagic Flux
  JOURNAL   Sci Rep 8 (1), 13496 (2018)
   PUBMED   30202024
  REMARK    GeneRIF: Study found that TBC1D9B, a GTPase activating protein for
            RAB11A, interacted with LC3B. TBC1D9B could also interact with
            other mammalian ATG8 homologues and revealed that TBC1D9B can
            positively regulate autophagic flux, possibly through its GTPase
            activity to inactivate RAB11A, facilitating the proper destination
            of the autophagosomes to the degradation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5155)
  AUTHORS   Popovic,D., Akutsu,M., Novak,I., Harper,J.W., Behrends,C. and
            Dikic,I.
  TITLE     Rab GTPase-activating proteins in autophagy: regulation of
            endocytic and autophagy pathways by direct binding to human ATG8
            modifiers
  JOURNAL   Mol Cell Biol 32 (9), 1733-1744 (2012)
   PUBMED   22354992
REFERENCE   3  (bases 1 to 5155)
  AUTHORS   Ishibashi,K., Kanno,E., Itoh,T. and Fukuda,M.
  TITLE     Identification and characterization of a novel Tre-2/Bub2/Cdc16
            (TBC) protein that possesses Rab3A-GAP activity
  JOURNAL   Genes Cells 14 (1), 41-52 (2009)
   PUBMED   19077034
REFERENCE   4  (bases 1 to 5155)
  AUTHORS   Yoshimura,S., Egerer,J., Fuchs,E., Haas,A.K. and Barr,F.A.
  TITLE     Functional dissection of Rab GTPases involved in primary cilium
            formation
  JOURNAL   J Cell Biol 178 (3), 363-369 (2007)
   PUBMED   17646400
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010285.4 and AC008393.7.
            
            On Aug 18, 2018 this sequence version replaced NM_015043.3.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            coding exon compared to variant 1. The resulting isoform (b) has
            the same N- and C-termini but is shorter compared to isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.227644.1,
                                           SRR1803615.71267.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355235.8/ ENSP00000347375.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               AC010285.4         24431-24624         c
            195-305             AC008393.7         164050-164160       c
            306-424             AC008393.7         158537-158655       c
            425-653             AC008393.7         153734-153962       c
            654-912             AC008393.7         152557-152815       c
            913-1120            AC008393.7         150727-150934       c
            1121-1330           AC008393.7         147451-147660       c
            1331-1492           AC008393.7         138976-139137       c
            1493-1643           AC008393.7         138395-138545       c
            1644-1858           AC008393.7         137657-137871       c
            1859-1976           AC008393.7         135268-135385       c
            1977-2262           AC008393.7         134250-134535       c
            2263-2392           AC008393.7         132467-132596       c
            2393-2491           AC008393.7         132240-132338       c
            2492-2560           AC008393.7         130810-130878       c
            2561-2801           AC008393.7         129603-129843       c
            2802-2867           AC008393.7         129117-129182       c
            2868-2939           AC008393.7         127126-127197       c
            2940-2990           AC008393.7         125186-125236       c
            2991-3097           AC008393.7         124602-124708       c
            3098-5155           AC008393.7         121419-123476       c
FEATURES             Location/Qualifiers
     source          1..5155
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..5155
                     /gene="TBC1D9B"
                     /gene_synonym="GRAMD9B"
                     /note="TBC1 domain family member 9B"
                     /db_xref="GeneID:23061"
                     /db_xref="HGNC:HGNC:29097"
                     /db_xref="MIM:618039"
     exon            1..194
                     /gene="TBC1D9B"
                     /gene_synonym="GRAMD9B"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..3778
                     /gene="TBC1D9B"
                     /gene_synonym="GRAMD9B"
                     /note="isoform b is encoded by transcript variant 2; TBC1
                     domain family, member 9B (with GRAM domain)"
                     /codon_start=1
                     /product="TBC1 domain family member 9B isoform b"
                     /protein_id="NP_055858.2"
                     /db_xref="CCDS:CCDS4450.1"
                     /db_xref="GeneID:23061"
                     /db_xref="HGNC:HGNC:29097"
                     /db_xref="MIM:618039"
                     /translation="MWLSPEEVLVANALWVTERANPFFVLQRRRGHGRGGGLTGLLVG
                     TLDVVLDSSARVAPYRILHQTQDSQVYWTVACGSSRKEITKHWEWLENNLLQTLSIFD
                     SEEDITTFVKGKIHGIIAEENKNLQPQGDEDPGKFKEAELKMRKQFGMPEGEKLVNYY
                     SCSYWKGRVPRQGWLYLTVNHLCFYSFLLGKEVSLVVQWVDITRLEKNATLLFPESIR
                     VDTRDQELFFSMFLNIGETFKLMEQLANLAMRQLLDSEGFLEDKALPRPIRPHRNISA
                     LKRDLDARAKNECYRATFRLPRDERLDGHTSCTLWTPFNKLHIPGQMFISNNYICFAS
                     KEEDACHLIIPLREVTIVEKADSSSVLPSPLSISTKSKMTFLFANLKDRDFLVQRISD
                     FLQKTPSKQPGSIGSRKASVVDPSTESSPAPQEGSEQPASPASPLSSRQSFCAQEAPT
                     ASQGLLKLFQKNSPMEDLGAKGAKEKMKEESWHIHFFEYGRGVCMYRTAKTRALVLKG
                     IPESLRGELWLLFSGAWNEMVTHPGYYAELVEKSTGKYSLATEEIERDLHRSMPEHPA
                     FQNELGIAALRRVLTAYAFRNPTIGYCQAMNIVTSVLLLYGSEEEAFWLLVALCERML
                     PDYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGVISSISLSWFLTLFLSVMPFE
                     SAVVIVDCFFYEGIKVILQVALAVLDANMEQLLGCSDEGEAMTMLGRYLDNVVNKQSV
                     SPPIPHLRALLSSSDDPPAEVDIFELLKVSYEKFSSLRAEDIEQMRFKQRLKVIQSLE
                     DTAKRSVVRAIPVDIGFSIEELEDLYMVFKAKHLASQYWGCSRTMAGRRDPSLPYLEQ
                     YRIDASQFRELFASLTPWACGSHTPLLAGRMFRLLDENKDSLINFKEFVTGMSGMYHG
                     DLTEKLKVLYKLHLPPALSPEEAESALEAAHYFTEDSSSEEALPQEEQEGSGSEERGE
                     EKGTSSPDYRHYLRMWAKEKEAQKETIKDLPKMNQEQFIELCKTLYNMFSEDPMEQDL
                     YHAIATVASLLLRIGEVGKKFSARTGRKPRDCATEEDEPPAPELHQDAARELQPPAAG
                     DPQAKAGGDTHLGKAPQESQVVVEGGSGEGQGSPSQLLSDDETKDDMSMSSYSVVSTG
                     SLQCEDLADDTVLVGGEACSPTARIGGTVDTDWCISFEQILASILTESVLVNFFEKRV
                     DIGLKIKDQKKVERQFSTASDHEQPGVSG"
     exon            195..305
                     /gene="TBC1D9B"
                     /gene_synonym="GRAMD9B"
                     /inference="alignment:Splign:2.1.0"
     exon            306..424
                     /gene="TBC1D9B"
                     /gene_synonym="GRAMD9B"
                     /inference="alignment:Splign:2.1.0"
     exon            425..653
                     /gene="TBC1D9B"
                     /gene_synonym="GRAMD9B"
                     /inference="alignment:Splign:2.1.0"
     exon            654..912
                     /gene="TBC1D9B"
                     /gene_synonym="GRAMD9B"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1120
                     /gene="TBC1D9B"
                     /gene_synonym="GRAMD9B"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1330
                     /gene="TBC1D9B"
                     /gene_synonym="GRAMD9B"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1492
                     /gene="TBC1D9B"
                     /gene_synonym="GRAMD9B"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1643
                     /gene="TBC1D9B"
                     /gene_synonym="GRAMD9B"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1858
                     /gene="TBC1D9B"
                     /gene_synonym="GRAMD9B"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..1976
                     /gene="TBC1D9B"
                     /gene_synonym="GRAMD9B"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2262
                     /gene="TBC1D9B"
                     /gene_synonym="GRAMD9B"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2392
                     /gene="TBC1D9B"
                     /gene_synonym="GRAMD9B"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2491
                     /gene="TBC1D9B"
                     /gene_synonym="GRAMD9B"
                     /inference="alignment:Splign:2.1.0"
     exon            2492..2560
                     /gene="TBC1D9B"
                     /gene_synonym="GRAMD9B"
                     /inference="alignment:Splign:2.1.0"
     exon            2561..2801
                     /gene="TBC1D9B"
                     /gene_synonym="GRAMD9B"
                     /inference="alignment:Splign:2.1.0"
     exon            2802..2867
                     /gene="TBC1D9B"
                     /gene_synonym="GRAMD9B"
                     /inference="alignment:Splign:2.1.0"
     exon            2868..2939
                     /gene="TBC1D9B"
                     /gene_synonym="GRAMD9B"
                     /inference="alignment:Splign:2.1.0"
     exon            2940..2990
                     /gene="TBC1D9B"
                     /gene_synonym="GRAMD9B"
                     /inference="alignment:Splign:2.1.0"
     exon            2991..3097
                     /gene="TBC1D9B"
                     /gene_synonym="GRAMD9B"
                     /inference="alignment:Splign:2.1.0"
     exon            3098..5155
                     /gene="TBC1D9B"
                     /gene_synonym="GRAMD9B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4464..4469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBC1D9B"
                     /gene_synonym="GRAMD9B"
                     /note="hexamer: AATAAA"
     polyA_site      4488
                     /gene="TBC1D9B"
                     /gene_synonym="GRAMD9B"
                     /note="major polyA site"
     regulatory      5130..5135
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBC1D9B"
                     /gene_synonym="GRAMD9B"
                     /note="hexamer: AATAAA"
     polyA_site      5155
                     /gene="TBC1D9B"
                     /gene_synonym="GRAMD9B"
                     /note="major polyA site"
ORIGIN      
        1 acgctccgct ccgggacgcc gacggcggcg ggcgcttccg tctcgcgggc ctcggcccgg
       61 tgcgagcggc tccgcgatgt ggctgagccc ggaggaggtg ctggtggcca atgcgctgtg
      121 ggtgacggag cgggccaacc ccttcttcgt gctgcagcga cgccggggcc acggcagggg
      181 cggcggcctt acgggtcttc tcgtgggcac cctggacgtg gtgctggact ccagtgcccg
      241 cgtggcccct taccgcatcc tgcaccagac ccaggactcc caggtctact ggacagtggc
      301 gtgtggttct tcccgcaaag agatcacaaa acactgggaa tggctggaaa ataacttgct
      361 ccagacactg tccatcttcg acagtgagga agatatcacc accttcgtca agggcaagat
      421 acacggaatc atcgcagaag agaacaagaa cctgcagccc cagggagacg aggaccccgg
      481 gaagttcaag gaggctgagc tgaagatgcg gaagcagttt gggatgcctg agggcgagaa
      541 gctggtgaat tactactcct gcagctactg gaagggccgc gtgccccggc agggctggct
      601 gtacctgacg gtcaaccacc tgtgcttcta ctccttcctg ctggggaagg aagtgagcct
      661 cgtggtgcag tgggtggaca taacgcgtct ggagaagaac gccaccctgc tcttccccga
      721 gagcatccgt gtggacaccc gcgaccagga gctcttcttc tccatgttcc tcaacatcgg
      781 cgagaccttc aagctcatgg agcagttggc caacctggcc atgcggcagc tgctggacag
      841 cgagggcttc ctggaggaca aggccctgcc taggcccatc cggccacaca ggaacatctc
      901 agccctgaag cgagacctgg acgcccgagc caagaatgag tgctaccgag ccacgttccg
      961 gctgcccagg gatgagcggc tagacggcca cacaagctgc accctgtgga cgccgttcaa
     1021 caagctgcac atccctggcc agatgttcat ctccaacaac tacatctgct tcgccagcaa
     1081 ggaggaggac gcttgccacc tcatcatacc cctgagggag gtgaccattg tcgaaaaagc
     1141 tgacagctcc agcgtgctgc ccagccccct gtccatcagc accaaaagca aaatgacatt
     1201 cctgtttgcc aacctgaaag accgtgattt cttggtgcag aggatctctg acttcctcca
     1261 gaaaacacca tccaagcagc caggcagtat cgggagcagg aaagccagtg ttgtggaccc
     1321 tagcacagag tcttccccag ctcctcagga ggggtcggag cagcccgcca gcccagcctc
     1381 tcccctcagc agccgccaga gcttctgtgc gcaggaggcg ccaaccgcat cccagggcct
     1441 gctgaagctc ttccagaaaa actcgcccat ggaggacctt ggagccaagg gggccaagga
     1501 gaagatgaaa gaggagtcat ggcacatcca cttcttcgag tacgggcgtg gcgtgtgcat
     1561 gtaccgcaca gccaagacgc gggcactggt cctgaagggt atccctgaga gcctccgggg
     1621 agagctgtgg ctcctcttct ccggggcctg gaatgagatg gtgactcacc ccgggtacta
     1681 tgctgagctg gtggagaagt ccaccgggaa gtacagcctg gccacagagg agatcgagcg
     1741 agacctgcac cgctccatgc ccgagcaccc tgccttccag aacgagctgg ggattgctgc
     1801 cctccggcgg gtgctgactg cctatgcctt ccgaaacccc accatcggct actgccaggc
     1861 aatgaacatc gtgacctcgg tgctcctgct ctatggcagt gaggaggagg ccttctggct
     1921 cctggtggcc ctgtgcgagc gcatgctgcc cgactactac aacaccaggg tggtgggagc
     1981 cctggtggac caaggcatct tcgaagagct cacgagagac ttcctgccgc agctctcgga
     2041 gaagatgcag gacctggggg tgatctccag catctcgctg tcctggttcc tgaccctctt
     2101 cctcagcgtc atgcccttcg agagcgccgt ggtcatcgtc gactgctttt tctatgaggg
     2161 catcaaggtg atcctgcagg tggccctggc cgtcctggac gccaacatgg agcagctgct
     2221 gggctgcagc gacgagggcg aggccatgac catgctgggc agatacctgg ataatgtggt
     2281 caacaagcag agtgtctctc ctcctatccc gcacctccgt gccttgctga gcagcagcga
     2341 tgacccccct gcagaggtgg acatctttga gctcctgaaa gtgtcctatg agaaattcag
     2401 cagcctgagg gccgaagaca ttgagcagat gcggtttaaa cagaggctga aagtgatcca
     2461 gtccttggag gacacggcca agaggagtgt ggtccgagct atacctgtgg acattggttt
     2521 ctccattgaa gagctggagg acctttacat ggtgtttaag gccaagcacc tggctagcca
     2581 gtactggggg tgcagccgca caatggccgg ccgtcgggac cccagcctgc cctacctgga
     2641 gcagtaccgg attgatgcca gccagttccg ggaactcttt gccagcctga caccctgggc
     2701 ctgtggctcc cacacacctc tgctggcagg gcgcatgttc aggctcctgg acgaaaacaa
     2761 ggactcgctg atcaacttca aggagttcgt gacagggatg agcgggatgt accacgggga
     2821 cctgacagag aagctcaagg tgctctacaa gctacacctt cccccagctc tgagcccaga
     2881 ggaagccgag tcagccctgg aggcggccca ttatttcaca gaggacagct cctcagaaga
     2941 agcactacca caggaagagc aagaaggaag tggaagtgag gagagaggag aggagaaggg
     3001 gaccagctct ccggactatc ggcactacct tcgaatgtgg gccaaggaga aagaggctca
     3061 gaaggagacg attaaggatc ttcccaagat gaaccaggag cagttcattg agctgtgcaa
     3121 gacgctttac aacatgttca gtgaagaccc catggagcag gacctgtacc acgccatcgc
     3181 caccgtggcc agcctcctgc tccgcatcgg agaggtgggg aagaagttct cagcccgcac
     3241 aggcaggaag cccagggact gtgccactga ggaggacgag ccaccagcac ccgaactgca
     3301 tcaggacgca gccagggagc ttcagccccc agctgcagga gacccccaag ccaaagcagg
     3361 cggagacaca cacctcggaa aagccccaca ggagagccag gtggtggtgg aggggggcag
     3421 cggcgaggga cagggctcac cctcccagct gctgtctgac gatgaaacca aagacgacat
     3481 gtccatgtcc tcctactcgg tggtcagcac gggctccctg caatgtgaag accttgcaga
     3541 cgacacggtg ctggtgggcg gggaggcctg cagccccaca gcgcgcatcg gcggcaccgt
     3601 cgacaccgac tggtgcatct cctttgagca gatcctggcc tccatcctga cggagtccgt
     3661 gctggtgaac ttctttgaga agagagtgga cattggactc aagatcaagg accaaaagaa
     3721 agtggagaga cagttcagca ccgccagtga ccatgagcag cctggagttt ccggctgatg
     3781 cctgcagctg tgaggcctgg cccaaggtgt catcagtggg gctggcctca tctcctcctg
     3841 cctttcctcc cttatcagtt tctctttaaa ggtgtgcccc tcctgctctc ccaggagcag
     3901 tgagttgtga gtggaaagaa ggctggtgca gacccagctg ccttagacag attccctggg
     3961 cctgcatctc ctggcgccgg ctgcttctgg gcccaggaag aggctgtggc tcccaccttc
     4021 cttacacctg gtgggagccc gcctcgcacc agctgcacct gcctagcatt acaggctctc
     4081 agatctgccc ttgcttgcct catacctctg tgctccacac tgcggccagg ccagctgagt
     4141 ccctccatcc gtggatgctt tcctgcagct atgtggtatg ggggtcattc ctgcctcttg
     4201 gcaccaggtt ggggggcatg tgcttgttgg gcaccaaagt gatggaaccc tcaggtgctc
     4261 tccgggagcc tgaacctcct gactgaggaa catgggcaga acatgtttat tgcacagagt
     4321 gggcgctgcg cacaggcgtg gctgtacacg tgctctcagc tcatcatcct ttccagtaac
     4381 tttaaaaaaa catccctcag gtcctgatat atttccttgg attcatttca cttggctaga
     4441 aattacactg tgctcaatgc cttaataaat ccctgaaaga aataaaaacc actgtgtgca
     4501 atgccttgct gtggccccca accactgctt aggcctccca acttctcccc aggccaagta
     4561 tggggccctg gctgtgttct ggaagttcaa gacacttagt cctccacagt gggtggaaga
     4621 gtgcaaggtc tgccaggtca gatggagacg cagaacctgc tggtgcaagc tgggcaggtc
     4681 ctgaccaacc tgcatcaggg gatgccctga gctccacagg tcttcatggg caggggttgt
     4741 gggtcctggt gaaggaagtg catcctcagg cctgggctgt agcaagctgt ctgcccttgg
     4801 gttcaagaac cagactgtgg agccaaaggt gaccgcaggg ggccccaggg ctggagccac
     4861 aaggataccc tcactttgca tgaggagctg aaactgacca gtgtccagtg ttagccccca
     4921 catggggctg ctcttgcttc tactaaaaga tacagcagtt acccccttat ccacagggga
     4981 tacagtggat atctaaaacc agacccccag tggatgtcta aaaccacaga taataacaaa
     5041 ccttatacat actgtttttt cctatgcata catacctgtg attaagttta tgaattaggc
     5101 accttaagag attgacaaca ataactaata ataaaatgta acggttatac tgtaa
//
