LOCUS       NM_015130               5554 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens TBC1 domain family member 9 (TBC1D9), mRNA.
ACCESSION   NM_015130 XM_093895
VERSION     NM_015130.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5554)
  AUTHORS   Nozawa,T., Sano,S., Minowa-Nozawa,A., Toh,H., Nakajima,S.,
            Murase,K., Aikawa,C. and Nakagawa,I.
  TITLE     TBC1D9 regulates TBK1 activation through Ca2+ signaling in
            selective autophagy
  JOURNAL   Nat Commun 11 (1), 770 (2020)
   PUBMED   32034138
  REMARK    GeneRIF: TBC1D9 controls TBK1 activation during xenophagy and
            mitophagy through Ca(2+)-dependent ubiquitin-recognition.TBC1D9 is
            involved in TBK1 phosphorylation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5554)
  AUTHORS   Pondugula,S.R., Flannery,P.C., Abbott,K.L., Coleman,E.S., Mani,S.,
            Samuel,T. and Xie,W.
  TITLE     Diindolylmethane, a naturally occurring compound, induces CYP3A4
            and MDR1 gene expression by activating human PXR
  JOURNAL   Toxicol Lett 232 (3), 580-589 (2015)
   PUBMED   25542144
  REMARK    GeneRIF: This study concluded that diindolylmethane induces
            pregnane X receptor -regulated CYP3A4 and MDR1 gene expression.
REFERENCE   3  (bases 1 to 5554)
  AUTHORS   Popovic,D., Akutsu,M., Novak,I., Harper,J.W., Behrends,C. and
            Dikic,I.
  TITLE     Rab GTPase-activating proteins in autophagy: regulation of
            endocytic and autophagy pathways by direct binding to human ATG8
            modifiers
  JOURNAL   Mol Cell Biol 32 (9), 1733-1744 (2012)
   PUBMED   22354992
REFERENCE   4  (bases 1 to 5554)
  AUTHORS   Li,Y., Yan,P.W., Huang,X.E. and Li,C.G.
  TITLE     MDR1 gene C3435T polymorphism is associated with clinical outcomes
            in gastric cancer patients treated with postoperative adjuvant
            chemotherapy
  JOURNAL   Asian Pac J Cancer Prev 12 (9), 2405-2409 (2011)
   PUBMED   22296392
  REMARK    GeneRIF: The MDR1 gene CT/TT genotype of C3435T was significantly
            associated with a shorter progression-free survival (PFS) and
            overall survival (OS).
REFERENCE   5  (bases 1 to 5554)
  AUTHORS   Ishibashi,K., Kanno,E., Itoh,T. and Fukuda,M.
  TITLE     Identification and characterization of a novel Tre-2/Bub2/Cdc16
            (TBC) protein that possesses Rab3A-GAP activity
  JOURNAL   Genes Cells 14 (1), 41-52 (2009)
   PUBMED   19077034
REFERENCE   6  (bases 1 to 5554)
  AUTHORS   Shman,T.V., Fedasenka,U.U., Savitski,V.P. and Aleinikova,O.V.
  TITLE     CD34+ leukemic subpopulation predominantly displays lower
            spontaneous apoptosis and has higher expression levels of Bcl-2 and
            MDR1 genes than CD34- cells in childhood AML
  JOURNAL   Ann Hematol 87 (5), 353-360 (2008)
   PUBMED   18228020
  REMARK    GeneRIF: CD34+ leukemic subpopulation predominantly displays lower
            spontaneous apoptosis and has higher expression levels of MDR19TBC1
            domain family member 9 (with GRAM domain) ) genes than CD34- cells
            in childhood AML
REFERENCE   7  (bases 1 to 5554)
  AUTHORS   Rodriguez Novoa,S., Barreiro,P., Rendon,A., Barrios,A., Corral,A.,
            Jimenez-Nacher,I., Gonzalez-Lahoz,J. and Soriano,V.
  TITLE     Plasma levels of atazanavir and the risk of hyperbilirubinemia are
            predicted by the 3435C-->T polymorphism at the multidrug resistance
            gene 1
  JOURNAL   Clin Infect Dis 42 (2), 291-295 (2006)
   PUBMED   16355344
  REMARK    GeneRIF: Plasma levels of atazanavir were significantly higher in
            patients with MDR1 genotype CC than in those with CT or TT, and
            bilirubin levels correlated with atazanavir concentrations.
REFERENCE   8  (bases 1 to 5554)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   9  (bases 1 to 5554)
  AUTHORS   Islam,T.C., Asplund,A.C., Lindvall,J.M., Nygren,L., Liden,J.,
            Kimby,E., Christensson,B., Smith,C.I. and Sander,B.
  TITLE     High level of cannabinoid receptor 1, absence of regulator of G
            protein signalling 13 and differential expression of Cyclin D1 in
            mantle cell lymphoma
  JOURNAL   Leukemia 17 (9), 1880-1890 (2003)
   PUBMED   12970790
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC096733.3, AI439646.1, CN332502.1, AC108019.3, BQ308276.1,
            CN332501.1, BC038804.1 and AF131785.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015130.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.20738.1,
                                           SRR1660805.171223.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000442267.3/ ENSP00000411197.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AC096733.3         65180-65247         c
            69-425              AI439646.1         1-357
            426-966             CN332502.1         6-546
            967-1150            AC108019.3         123725-123908       c
            1151-1335           BQ308276.1         116-300             c
            1336-1948           CN332501.1         15-627
            1949-1965           AC108019.3         106813-106829       c
            1966-3492           BC038804.1         12-1538
            3493-3894           AC108019.3         67184-67585         c
            3895-5554           AF131785.1         1-1660
FEATURES             Location/Qualifiers
     source          1..5554
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.21"
     gene            1..5554
                     /gene="TBC1D9"
                     /gene_synonym="GRAMD9; MDR1"
                     /note="TBC1 domain family member 9"
                     /db_xref="GeneID:23158"
                     /db_xref="HGNC:HGNC:21710"
                     /db_xref="MIM:618035"
     exon            1..470
                     /gene="TBC1D9"
                     /gene_synonym="GRAMD9; MDR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             341..4141
                     /gene="TBC1D9"
                     /gene_synonym="GRAMD9; MDR1"
                     /note="TBC1 domain family member 9A; TBC1 domain family,
                     member 9 (with GRAM domain)"
                     /codon_start=1
                     /product="TBC1 domain family member 9"
                     /protein_id="NP_055945.2"
                     /db_xref="CCDS:CCDS47136.1"
                     /db_xref="GeneID:23158"
                     /db_xref="HGNC:HGNC:21710"
                     /db_xref="MIM:618035"
                     /translation="MWVNPEEVLLANALWITERANPYFILQRRKGHAGDGGGGGGLAG
                     LLVGTLDVVLDSSARVAPYRILYQTPDSLVYWTIACGGSRKEITEHWEWLEQNLLQTL
                     SIFENENDITTFVRGKIQGIIAEYNKINDVKEDDDTEKFKEAIVKFHRLFGMPEEEKL
                     VNYYSCSYWKGKVPRQGWMYLSINHLCFYSFLMGREAKLVIRWVDITQLEKNATLLLP
                     DVIKVSTRSSEHFFSVFLNINETFKLMEQLANIAMRQLLDNEGFEQDRSLPKLKRKSP
                     KKVSALKRDLDARAKSERYRALFRLPKDEKLDGHTDCTLWTPFNKMHILGQMFVSTNY
                     ICFTSKEENLCSLIIPLREVTIVEKADSSSVLPSPLSISTRNRMTFLFANLKDRDFLV
                     QRISDFLQQTTSKIYSDKEFAGSYNSSDDEVYSRPSSLVSSSPQRSTSSDADGERQFN
                     LNGNSVPTATQTLMTMYRRRSPEEFNPKLAKEFLKEQAWKIHFAEYGQGICMYRTEKT
                     RELVLKGIPESMRGELWLLLSGAINEKATHPGYYEDLVEKSMGKYNLATEEIERDLHR
                     SLPEHPAFQNEMGIAALRRVLTAYAFRNPNIGYCQAMNIVTSVLLLYAKEEEAFWLLV
                     ALCERMLPDYYNTRVVGALVDQGVFEELARDYVPQLYDCMQDLGVISTISLSWFLTLF
                     LSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDANVDKLLNCKDDGEAMTVLGRYLDS
                     VTNKDSTLPPIPHLHSLLSDDVEPYPEVDIFRLIRTSYEKFGTIRADLIEQMRFKQRL
                     KVIQTLEDTTKRNVVRTIVTETSFTIDELEELYALFKAEHLTSCYWGGSSNALDRHDP
                     SLPYLEQYRIDFEQFKGMFALLFPWACGTHSDVLASRLFQLLDENGDSLINFREFVSG
                     LSAACHGDLTEKLKLLYKMHVLPEPSSDQDEPDSAFEATQYFFEDITPECTHVVGLDS
                     RSKQGADDGFVTVSLKPDKGKRANSQENRNYLRLWTPENKSKSKNAKDLPKLNQGQFI
                     ELCKTMYNMFSEDPNEQELYHATAAVTSLLLEIGEVGKLFVAQPAKEGGSGGSGPSCH
                     QGIPGVLFPKKGPGQPYVVESVEPLPASLAPDSEEHSLGGQMEDIKLEDSSPRDNGAC
                     SSMLISDDDTKDDSSMSSYSVLSAGSHEEDKLHCEDIGEDTVLVRSGQGTAALPRSTS
                     LDRDWAITFEQFLASLLTEPALVKYFDKPVCMMARITSAKNIRMMGKPLTSASDYEIS
                     AMSG"
     exon            471..581
                     /gene="TBC1D9"
                     /gene_synonym="GRAMD9; MDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            582..700
                     /gene="TBC1D9"
                     /gene_synonym="GRAMD9; MDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            701..929
                     /gene="TBC1D9"
                     /gene_synonym="GRAMD9; MDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1191
                     /gene="TBC1D9"
                     /gene_synonym="GRAMD9; MDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1399
                     /gene="TBC1D9"
                     /gene_synonym="GRAMD9; MDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1606
                     /gene="TBC1D9"
                     /gene_synonym="GRAMD9; MDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1777
                     /gene="TBC1D9"
                     /gene_synonym="GRAMD9; MDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1928
                     /gene="TBC1D9"
                     /gene_synonym="GRAMD9; MDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2143
                     /gene="TBC1D9"
                     /gene_synonym="GRAMD9; MDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2261
                     /gene="TBC1D9"
                     /gene_synonym="GRAMD9; MDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2547
                     /gene="TBC1D9"
                     /gene_synonym="GRAMD9; MDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2548..2677
                     /gene="TBC1D9"
                     /gene_synonym="GRAMD9; MDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2678..2776
                     /gene="TBC1D9"
                     /gene_synonym="GRAMD9; MDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2777..2845
                     /gene="TBC1D9"
                     /gene_synonym="GRAMD9; MDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2846..3086
                     /gene="TBC1D9"
                     /gene_synonym="GRAMD9; MDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3087..3152
                     /gene="TBC1D9"
                     /gene_synonym="GRAMD9; MDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3153..3239
                     /gene="TBC1D9"
                     /gene_synonym="GRAMD9; MDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3240..3314
                     /gene="TBC1D9"
                     /gene_synonym="GRAMD9; MDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3315..3418
                     /gene="TBC1D9"
                     /gene_synonym="GRAMD9; MDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3419..5554
                     /gene="TBC1D9"
                     /gene_synonym="GRAMD9; MDR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4232..4237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBC1D9"
                     /gene_synonym="GRAMD9; MDR1"
                     /note="hexamer: ATTAAA"
     polyA_site      4254
                     /gene="TBC1D9"
                     /gene_synonym="GRAMD9; MDR1"
     regulatory      5531..5536
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBC1D9"
                     /gene_synonym="GRAMD9; MDR1"
                     /note="hexamer: AATAAA"
     polyA_site      5554
                     /gene="TBC1D9"
                     /gene_synonym="GRAMD9; MDR1"
                     /note="major polyA site"
ORIGIN      
        1 ctcctcctcc cgctcctccc gccgccgtgg gccgggagcc gggctgcaga gtgccaggcc
       61 gggcgtctgc ggccgcgggc tctcgcgggg cggcgacgcc gcggggagga tgctgcttgc
      121 cgcgcccgcg tcctcaccgt cctcccgggc cgcctgctgg ggctttgttg tggcccggac
      181 gccgcgggcc accccctgaa gtcgcctgcc gccgccgccg ccgcacctag cggacgggcg
      241 ggcgggcgcg cgtgtgccca ggagtgcgcg cctgtcgcgg tggtgggtgc aggactggac
      301 ccacgggccc attgtgcgcc cgcccgcggc agccaggacc atgtgggtga acccggagga
      361 ggtgttgctg gccaacgcgc tgtggatcac cgagagggcc aacccatact tcatcctgca
      421 gcggaggaag ggccacgccg gcgatggagg cggcggcggc ggactggcgg gcctgctggt
      481 gggtaccctt gatgttgtgt tggactccag cgcccgggtc gctccttacc gaatcttgta
      541 ccagactcca gactccctgg tctactggac catcgcctgt ggtggttcca ggaaagaaat
      601 cactgaacac tgggaatggc ttgagcaaaa tctcttgcag acactctcca tctttgaaaa
      661 tgagaatgat atcaccacat ttgtgagagg aaaaatacag ggcatcattg cagaatacaa
      721 caaaatcaat gatgtaaagg aagatgatga cacggagaag tttaaagaag ccattgtgaa
      781 atttcatagg ctgtttggga tgccagagga agagaaactc gtcaactatt actcttgcag
      841 ctattggaag gggaaggtcc cccgtcaggg ttggatgtac ctcagcatta accacctttg
      901 cttttattct tttcttatgg gaagggaagc gaaactggtc atccggtggg tagacatcac
      961 tcagcttgag aagaatgcca ccctgcttct gcctgatgtg atcaaagtga gcacacggtc
     1021 cagtgagcat ttcttctctg tattcctcaa catcaacgag accttcaagt taatggagca
     1081 gcttgccaac atagccatga ggcaactctt agacaatgag ggatttgaac aagatcgatc
     1141 cctgcccaaa ctcaaaagga aatctcctaa aaaagtgtct gctctaaaac gtgatcttga
     1201 tgccagggca aagagtgaga gataccgtgc acttttccgg ctgcccaaag atgaaaaatt
     1261 agatggccac acagactgca ctctctggac tccatttaac aaaatgcaca ttttggggca
     1321 gatgtttgtg tccacaaatt acatctgttt taccagcaag gaggagaact tatgtagcct
     1381 cattatcccg ctccgtgagg tgacaattgt ggaaaaggca gacagctcca gtgtgctccc
     1441 cagtccctta tccatcagca cccgaaacag gatgaccttc ctatttgcca acttgaaaga
     1501 tagagacttt ctagtgcaga ggatctcaga tttcctgcaa cagactactt ccaaaatata
     1561 ttctgacaag gagtttgcag gaagttacaa cagttcagat gatgaggtgt actctcgacc
     1621 cagcagcctc gtctcctcca gcccccagag aagcacgagc tctgatgctg atggagagcg
     1681 ccagtttaac ctaaatggca acagcgtccc cacagccaca cagaccctga tgaccatgta
     1741 tcggcggcgg tctcccgagg agttcaaccc gaaattggcc aaagagtttc tgaaagagca
     1801 agcctggaag attcactttg ctgagtatgg gcaagggatc tgcatgtacc gcacagagaa
     1861 aacgcgggag ctggtgttga agggcatccc ggagagcatg cgtggggagc tctggctgct
     1921 gctgtcaggt gccatcaatg agaaggccac acatcctggg tactatgaag acctagtgga
     1981 gaagtccatg gggaagtata atctcgccac ggaggagatt gagagggatt tacaccgctc
     2041 ccttccagaa cacccagctt ttcagaatga aatgggcatt gctgcactaa ggagagtctt
     2101 aacagcttat gcttttcgaa atcccaacat agggtattgc caggccatga atattgtcac
     2161 ttcagtgctg ctgctttatg ccaaagagga ggaagctttc tggctgcttg tggctttgtg
     2221 tgagcgcatg ctcccagatt actacaacac cagagttgtg ggtgcactgg tggaccaagg
     2281 tgtctttgag gagctagcac gagactacgt cccacagctg tacgactgca tgcaagacct
     2341 gggcgtgatt tccaccatct ccctgtcttg gttcctcaca ctatttctca gtgtgatgcc
     2401 ttttgagagt gcagttgtgg ttgttgactg tttcttctat gaaggaatta aagtgatatt
     2461 ccagttggcc ctagctgtgc tggatgcaaa tgtggacaaa ctgttgaact gcaaggatga
     2521 tggggaggcc atgaccgttt tgggaaggta tttagacagt gtgaccaata aagacagcac
     2581 actgcctccc attcctcacc tccactcctt gctcagcgat gatgtggaac cttaccctga
     2641 ggtagacatc tttagactca tcagaacttc ctacgagaaa ttcggaacta tccgggcaga
     2701 tttgattgaa cagatgagat tcaaacagag actgaaagtg atccagacgc tggaggatac
     2761 tacgaaacgc aacgtggtac gaaccattgt gacagaaact tcctttacca ttgatgagct
     2821 ggaagaactt tatgctcttt tcaaggcaga acatctcacc agctgctact ggggcgggag
     2881 cagcaacgcg ctggaccggc atgaccccag cctgccctac ctggaacagt atcgcattga
     2941 cttcgagcag ttcaagggaa tgtttgctct tctctttcct tgggcatgtg gaactcactc
     3001 tgacgttctg gcctcccgct tgttccagtt attagatgaa aatggagact ctttgattaa
     3061 cttccgggag tttgtctctg ggctaagtgc tgcatgccat ggggacctca cagagaagct
     3121 caaactcctg tacaaaatgc acgtcttgcc tgagccatcc tctgatcaag atgaaccaga
     3181 ttctgctttt gaagcaactc agtacttctt tgaagatatt accccagaat gtacacatgt
     3241 tgttggattg gatagcagaa gcaaacaggg tgcagatgat ggctttgtta cggtgagcct
     3301 aaagccagac aaagggaaga gagcaaattc ccaagaaaat cgtaattatt tgagactgtg
     3361 gactccagaa aataaatcta agtcaaagaa tgcaaaggat ttacccaaat taaatcaggg
     3421 gcagttcatt gaactgtgta agacaatgta taacatgttc agcgaagacc ccaatgagca
     3481 ggagctgtac cacgccacgg cagcagtgac cagcctcctg ctggagattg gggaggtcgg
     3541 caagttgttc gtggcccagc ctgcaaagga gggcgggagc ggaggcagtg ggccgtcctg
     3601 ccaccagggc atcccaggcg tgctcttccc caagaaaggg ccaggccagc cttacgtggt
     3661 ggagtctgtt gagcccctgc cggccagcct ggcccccgac agcgaggaac actcccttgg
     3721 aggacaaatg gaggacatca agctggagga ctcctcgccc cgggacaacg gggcctgctc
     3781 ctccatgctg atctctgacg acgacaccaa ggacgacagc tccatgtcct catactcggt
     3841 gctgagtgcc ggctcccacg aggaggacaa gctgcactgc gaggacatcg gagaggacac
     3901 ggtcctggtg cggagcggcc agggcacggc ggcactgccc cggagcacca gcctggaccg
     3961 ggactgggcc atcaccttcg agcagttcct ggcctccctc ttaactgagc ctgccctggt
     4021 caagtacttt gacaagcccg tgtgcatgat ggccaggatt accagtgcaa aaaacatccg
     4081 gatgatgggc aagcccctca cctcggccag tgactatgaa atctcggcca tgtccggctg
     4141 acacgggcgc cttcccgggg gagtgggagg agagggaggg gagggatttt ttatgttctt
     4201 ctgtgttgag ttttttcttt ctttctttta aattaaatat ttattagtac ctggcttgaa
     4261 gcctagtgtt ttcataatgt aattcaatga aaactgttgg agaaatattt aaacacctca
     4321 atgtaggtac attacactct tgttgcgggg aggggattta ccagaataca gtttatttcg
     4381 tgaattctaa aaaacaaaaa gatgaatctg tcagtgatat gtgtgtatta taacttatta
     4441 atcttgctgt tgagctgtat acatggttta aaaaatagta ctgtttaatg ctaagtaagg
     4501 cagcagtcat ttgtgtattc aggcttttta aataaaatta gagctgtaag gaaaatgaaa
     4561 agccacaaat gcaagactgt tcttaaatgg aaggcatagt cagcgagggt aaatcctata
     4621 ccactttagg aagtattaaa aatattttta agatttgaaa tatatttcat agaagtcctc
     4681 tattcaaaat catattccac agatgttccc cttcaaaggg aaaacatttg gggttctaaa
     4741 cagttatgaa agtaagtgat ttttacatga ttccagaata acacttgtat tgaccaattt
     4801 agacagatac cagaccaatt ttgcatttaa gaaattgttc tgattattta cgtcaactca
     4861 ttagaattca gtgaaaagta acagtctttt gtcacagaga atctgaaagt agcagcaaag
     4921 acagagggct catgacaggt ttttgctttt gctttgcttt tgtttttgaa agagtaaaag
     4981 tactgatgct tctgatactg gatgtttagc ttcttactgc aaaaacataa gtaaaacagt
     5041 caactttacc atttccgtat tctccataga ttgaagaaat ttataccaca tatcgcatat
     5101 gaccatcttt ccatcaaatc aatgtagaga taatgtaaac tgaaaaaaaa tctgcaagat
     5161 aatgtaactg aatgttttaa aaacagaact tgtcacttta tataaaagaa tagtatgctc
     5221 tatttcctga atggatgtgg aaatgaaagc tagcgcacct gcactttgaa ttcttgcttc
     5281 ttttttatta ctgttatgat tttgcttttt acagatgttg gacgattttt tcttctgatt
     5341 gttgaattca taatcatggt ctcatttcct ttgcttcttt ggaatatttc tttcaacaca
     5401 ttcctttatt ttattataca ttgtgtcctt tttttagcta ttgctgctgt tgttttttat
     5461 tctatttaca ggatgatttt taaactgtca aatgaagtag tgttaacctc aaataggcta
     5521 aatgtgaaca aataaaatac agcaaatact caga
//
