LOCUS       NM_001318809            2311 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens TBC1D7-LOC100130357 readthrough (TBC1D7-LOC100130357),
            transcript variant 1, mRNA.
ACCESSION   NM_001318809
VERSION     NM_001318809.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2311)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2311)
  AUTHORS   Yang,H., Yu,Z., Chen,X., Li,J., Li,N., Cheng,J., Gao,N., Yuan,H.X.,
            Ye,D., Guan,K.L. and Xu,Y.
  TITLE     Structural insights into TSC complex assembly and GAP activity on
            Rheb
  JOURNAL   Nat Commun 12 (1), 339 (2021)
   PUBMED   33436626
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2311)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2311)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2311)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 2311)
  AUTHORS   Dibble,C.C., Elis,W., Menon,S., Qin,W., Klekota,J., Asara,J.M.,
            Finan,P.M., Kwiatkowski,D.J., Murphy,L.O. and Manning,B.D.
  TITLE     TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of
            mTORC1
  JOURNAL   Mol Cell 47 (4), 535-546 (2012)
   PUBMED   22795129
REFERENCE   7  (bases 1 to 2311)
  AUTHORS   Popovic,D., Akutsu,M., Novak,I., Harper,J.W., Behrends,C. and
            Dikic,I.
  TITLE     Rab GTPase-activating proteins in autophagy: regulation of
            endocytic and autophagy pathways by direct binding to human ATG8
            modifiers
  JOURNAL   Mol Cell Biol 32 (9), 1733-1744 (2012)
   PUBMED   22354992
REFERENCE   8  (bases 1 to 2311)
  AUTHORS   Ishibashi,K., Kanno,E., Itoh,T. and Fukuda,M.
  TITLE     Identification and characterization of a novel Tre-2/Bub2/Cdc16
            (TBC) protein that possesses Rab3A-GAP activity
  JOURNAL   Genes Cells 14 (1), 41-52 (2009)
   PUBMED   19077034
REFERENCE   9  (bases 1 to 2311)
  AUTHORS   Nakashima,A., Yoshino,K., Miyamoto,T., Eguchi,S., Oshiro,N.,
            Kikkawa,U. and Yonezawa,K.
  TITLE     Identification of TBC7 having TBC domain as a novel binding protein
            to TSC1-TSC2 complex
  JOURNAL   Biochem Biophys Res Commun 361 (1), 218-223 (2007)
   PUBMED   17658474
REFERENCE   10 (bases 1 to 2311)
  AUTHORS   Yoshimura,S., Egerer,J., Fuchs,E., Haas,A.K. and Barr,F.A.
  TITLE     Functional dissection of Rab GTPases involved in primary cilium
            formation
  JOURNAL   J Cell Biol 178 (3), 363-369 (2007)
   PUBMED   17646400
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK057228.1, AL589984.7 and AL008729.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001318809.1.
            
            Summary: This locus represents naturally occurring readthrough
            transcription between the neighboring TBC1D7 (TBC1 domain family
            member 7) gene and downstream uncharacterized LOC100130357 on
            chromosome 6. Readthrough transcripts may encode the same protein
            as TBC1 domain family member 7 or may be candidates for
            nonsense-mediated mRNA decay (NMD). [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1) represents the longer
            readthrough transcript and encodes a protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK057228.1, SRR18074967.3722331.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 51256,
                                      100130357
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-307               AK057228.1         8-314
            308-308             AL589984.7         18034-18034         c
            309-1140            AK057228.1         315-1146
            1141-2029           AL008729.1         89698-90586         c
            2030-2305           AK057228.1         2037-2312
            2306-2311           AL008729.1         89416-89421         c
FEATURES             Location/Qualifiers
     source          1..2311
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p24.1"
     gene            1..2311
                     /gene="TBC1D7-LOC100130357"
                     /note="TBC1D7-LOC100130357 readthrough"
                     /db_xref="GeneID:107080638"
     exon            1..82
                     /gene="TBC1D7-LOC100130357"
                     /inference="alignment:Splign:2.1.0"
     exon            83..202
                     /gene="TBC1D7-LOC100130357"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..972
                     /gene="TBC1D7-LOC100130357"
                     /codon_start=1
                     /product="TBC1 domain family member 7"
                     /protein_id="NP_001305738.1"
                     /db_xref="GeneID:107080638"
                     /translation="MTEDSQRNFRSVYYEKVGFRGVEEKKSLEILLKDDRLDTEKLCT
                     FSQRFPLPSMYRALVWKVLLGILPPHHESHAKVMMYRKEQYLDVLHALKVVRFVSDAT
                     PQAEVYLRMYQLESGKLPRSPSFPLEPDDEVFLAIAKAMEEMVEDSVDCYWITRRFVN
                     QLNTKYRDSLPQLPKAFEQYLNLEDGRLLTHLRMCSAAPKLPYDLWFKRCFAGCLPES
                     SLQRVWDKVVSGSCKILVFVAVEILLTFKIKVMALNSAEKITKFLENIPQDSSDAIVS
                     KAIDLWHKHCGTPVHSS"
     exon            203..283
                     /gene="TBC1D7-LOC100130357"
                     /inference="alignment:Splign:2.1.0"
     exon            284..471
                     /gene="TBC1D7-LOC100130357"
                     /inference="alignment:Splign:2.1.0"
     exon            472..609
                     /gene="TBC1D7-LOC100130357"
                     /inference="alignment:Splign:2.1.0"
     exon            610..755
                     /gene="TBC1D7-LOC100130357"
                     /inference="alignment:Splign:2.1.0"
     exon            756..885
                     /gene="TBC1D7-LOC100130357"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1011
                     /gene="TBC1D7-LOC100130357"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..2311
                     /gene="TBC1D7-LOC100130357"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2286..2291
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBC1D7-LOC100130357"
                     /note="hexamer: ATTAAA"
     polyA_site      2311
                     /gene="TBC1D7-LOC100130357"
                     /note="major polyA site"
ORIGIN      
        1 cgtccggcgg cggcggcagc ggcagcggca gcggcgctga gttttgtctc ccgggccgtc
       61 tgggcgcgcg cgggtgtccc agaatgaaat atgactgagg actctcagag aaactttcgt
      121 tcagtatatt atgagaaagt ggggtttcgt ggagttgaag aaaagaaatc attagaaatt
      181 ctcctaaaag atgaccgtct ggatactgag aaactttgta cttttagtca gaggttccct
      241 ctcccgtcca tgtaccgtgc attggtatgg aaggtgcttc taggaatctt gcctccacac
      301 cacgagtccc atgccaaggt gatgatgtat cgtaaggagc agtacttgga tgtccttcat
      361 gccctgaaag tcgttcgctt tgttagtgat gccacacctc aggctgaagt ctatctccgc
      421 atgtatcagc tggagtctgg gaagttacct cgaagtccct cttttccact ggagccagat
      481 gatgaagtgt ttcttgccat agctaaagcc atggaggaaa tggtggaaga tagtgtcgac
      541 tgttactgga tcacccgacg ctttgtgaac caattaaata ccaagtaccg ggattccttg
      601 ccccagttgc caaaagcgtt tgaacaatac ttgaatctgg aagatggcag actgctgact
      661 catctgagga tgtgttccgc ggcgcccaaa cttccttatg atctctggtt caagaggtgc
      721 tttgcgggat gtttgcctga atccagttta cagagggttt gggataaagt tgtgagtgga
      781 tcctgtaaga tcctagtttt tgtagctgtc gaaattttat taacctttaa aataaaagtt
      841 atggcactga acagtgcaga gaagataaca aagtttctgg aaaatattcc ccaggacagc
      901 tcagacgcga tcgtgagcaa ggccattgac ttgtggcaca aacactgtgg gaccccggtc
      961 cattcaagct gaacgcaccc gctggttgtg gaccgtctgc caggcaccac aatcattcct
     1021 ggacccccga gggcctctga gtttgagacg ctggctgaga tcaaatgata agaattccaa
     1081 tttttgtttt cctaagtctt tcatctgcta atctacccaa catgaaccac gggccacatg
     1141 aagggccaga cacattctta agcggctcac agcctagagg tgcacatctg tgattacaat
     1201 gtgcaaggta aaactggatc aacagtttcc aaggactggc atgtaataaa atatcctcaa
     1261 aacaacaagc aagttgggcg tgacttagac tttcactgcc catgtagaag gcactgtaca
     1321 ttcttgcagc atctcagttg gccagcaaga ggtgagtcag aaaaaaacca ttcagcagcc
     1381 acatggaagt ggggctcact gggcacaagg caaaactgtg aagaagataa agtgtctgtg
     1441 gttctgcatt gactctattc cctggagtcc tcccctctcg agttcctaga attatgttat
     1501 cactcttgct ctatctcatt cctatcaaga cctgttttag aaatgggtgc cacagactca
     1561 gttacattca aatgtaaacc cattcattca tttagcaagt tacttattag tgccagtgct
     1621 gtgtcaggtt ctacattagg taccagagta cagtgatgag caaaaccagt ccctgccctt
     1681 ctggaacaga gaagactgga agaggatggg ggtagccatt aatcaaacag tcacagaaat
     1741 gagtgcaaaa tgtagctgga gtaagggctt ccatggtgag gcacttggtg cagggatctc
     1801 tggatctgac caaatcagga ggtcaggaaa ggcttccagg aggaagtgac actgtgccca
     1861 gagctcaggg atggaagaag gatgctcctt ctgggcagag agtaaggaga gaagattggt
     1921 gggaaggagg gcaggggcca gatgccgtgg gtgtgatttg gatctgtgtc cctgccaatc
     1981 acatgttgaa ttgtagtccc cagtgttgga ggtggagcct ggtgggacat gattggatca
     2041 tgggggtagt ttttcatgaa cggtttagta ccaaccactt ggtgctgttc tagtgagttg
     2101 agtgcattct cgcgagatct ggttgtttaa aagtgtgtag cacccttccc tcttgctcct
     2161 gctcctccaa tgtgagactc cttgctttcc ctctgttttc caccatgatt ggaagcttcc
     2221 tgaggcctca ccagaggcag atgccagcat catgcttcct gtgcagcctg cagaactgtg
     2281 agccaattaa acctcttttc gttataaact a
//
