LOCUS       NM_001349074            6500 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens TBC1 domain family member 5 (TBC1D5), transcript
            variant 4, mRNA.
ACCESSION   NM_001349074 XM_005265611
VERSION     NM_001349074.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6500)
  AUTHORS   Healy,M.D., McNally,K.E., Butkovic,R., Chilton,M., Kato,K.,
            Sacharz,J., McConville,C., Moody,E.R.R., Shaw,S.,
            Planelles-Herrero,V.J., Yadav,S.K.N., Ross,J., Borucu,U.,
            Palmer,C.S., Chen,K.E., Croll,T.I., Hall,R.J., Caruana,N.J.,
            Ghai,R., Nguyen,T.H.D., Heesom,K.J., Saitoh,S., Berger,I.,
            Schaffitzel,C., Williams,T.A., Stroud,D.A., Derivery,E.,
            Collins,B.M. and Cullen,P.J.
  TITLE     Structure of the endosomal Commander complex linked to
            Ritscher-Schinzel syndrome
  JOURNAL   Cell 186 (10), 2219-2237 (2023)
   PUBMED   37172566
REFERENCE   2  (bases 1 to 6500)
  AUTHORS   Tu,Y.X.I., Sydor,A.M., Coyaud,E., Laurent,E.M.N., Dyer,D.,
            Mellouk,N., St-Germain,J., Vernon,R.M., Forman-Kay,J.D., Li,T.,
            Hua,R., Zhao,K., Ridgway,N.D., Kim,P.K., Raught,B. and Brumell,J.H.
  TITLE     Global Proximity Interactome of the Human Macroautophagy Pathway
  JOURNAL   Autophagy 18 (5), 1174-1186 (2022)
   PUBMED   34524948
REFERENCE   3  (bases 1 to 6500)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 6500)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   5  (bases 1 to 6500)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 6500)
  AUTHORS   Seaman,M.N., Harbour,M.E., Tattersall,D., Read,E. and Bright,N.
  TITLE     Membrane recruitment of the cargo-selective retromer subcomplex is
            catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP
            TBC1D5
  JOURNAL   J Cell Sci 122 (Pt 14), 2371-2382 (2009)
   PUBMED   19531583
  REMARK    GeneRIF: Membrane recruitment of the cargo-selective retromer
            subcomplex VPS35/29/26 is catalysed by the small GTPase Rab7 and
            inhibited by the Rab-GAP TBC1D5.
REFERENCE   7  (bases 1 to 6500)
  AUTHORS   Ishibashi,K., Kanno,E., Itoh,T. and Fukuda,M.
  TITLE     Identification and characterization of a novel Tre-2/Bub2/Cdc16
            (TBC) protein that possesses Rab3A-GAP activity
  JOURNAL   Genes Cells 14 (1), 41-52 (2009)
   PUBMED   19077034
REFERENCE   8  (bases 1 to 6500)
  AUTHORS   Yoshimura,S., Egerer,J., Fuchs,E., Haas,A.K. and Barr,F.A.
  TITLE     Functional dissection of Rab GTPases involved in primary cilium
            formation
  JOURNAL   J Cell Biol 178 (3), 363-369 (2007)
   PUBMED   17646400
REFERENCE   9  (bases 1 to 6500)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   10 (bases 1 to 6500)
  AUTHORS   Brill,L.M., Salomon,A.R., Ficarro,S.B., Mukherji,M.,
            Stettler-Gill,M. and Peters,E.C.
  TITLE     Robust phosphoproteomic profiling of tyrosine phosphorylation sites
            from human T cells using immobilized metal affinity chromatography
            and tandem mass spectrometry
  JOURNAL   Anal Chem 76 (10), 2763-2772 (2004)
   PUBMED   15144186
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104451.2, AC144531.2, AC090960.3 and AC090644.2.
            
            On Aug 14, 2020 this sequence version replaced NM_001349074.1.
            
            Transcript Variant: This variant (4), as well as variants 1, 3, and
            5, encodes isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.1615026.1,
                                           SRR14038197.369255.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000696125.1/ ENSP00000512418.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               AC104451.2         117130-117280       c
            152-216             AC144531.2         124073-124137       c
            217-348             AC144531.2         8698-8829           c
            349-418             AC090960.3         31726-31795
            419-527             AC090960.3         53719-53827
            528-617             AC090960.3         55284-55373
            618-692             AC090960.3         55477-55551
            693-760             AC090960.3         56997-57064
            761-863             AC090960.3         76230-76332
            864-952             AC090960.3         83632-83720
            953-1003            AC090960.3         85566-85616
            1004-1073           AC090960.3         85705-85774
            1074-1246           AC090960.3         87998-88170
            1247-1389           AC090960.3         152111-152253
            1390-1496           AC090960.3         168244-168350
            1497-1582           AC090644.2         169745-169830       c
            1583-1839           AC090644.2         149402-149658       c
            1840-1905           AC090644.2         144924-144989       c
            1906-2069           AC090644.2         125446-125609       c
            2070-2169           AC090644.2         96348-96447         c
            2170-2249           AC090644.2         78988-79067         c
            2250-2411           AC090644.2         78006-78167         c
            2412-6500           AC090644.2         68407-72495         c
FEATURES             Location/Qualifiers
     source          1..6500
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p24.3"
     gene            1..6500
                     /gene="TBC1D5"
                     /note="TBC1 domain family member 5"
                     /db_xref="GeneID:9779"
                     /db_xref="HGNC:HGNC:19166"
                     /db_xref="MIM:615740"
     exon            1..151
                     /gene="TBC1D5"
                     /inference="alignment:Splign:2.1.0"
     exon            152..216
                     /gene="TBC1D5"
                     /inference="alignment:Splign:2.1.0"
     exon            217..348
                     /gene="TBC1D5"
                     /inference="alignment:Splign:2.1.0"
     CDS             252..2705
                     /gene="TBC1D5"
                     /note="isoform a is encoded by transcript variant 4"
                     /codon_start=1
                     /product="TBC1 domain family member 5 isoform a"
                     /protein_id="NP_001336003.1"
                     /db_xref="CCDS:CCDS46770.1"
                     /db_xref="GeneID:9779"
                     /db_xref="HGNC:HGNC:19166"
                     /db_xref="MIM:615740"
                     /translation="MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSS
                     TLDSEGTFNSYRKEWEELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDK
                     SQWISRIEELRAWYSNIKEIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELR
                     SMIEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLH
                     CDHQAFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGK
                     ETLMTPIPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRW
                     VRLLFGREFPLQDLLVVWDALFADGLSLGLVDYIFVAMLLYIRDALISSNYQTCLGLL
                     MHYPFIGDVHSLILKALFLRDPKRNPRPVTYQFHPNLDYYKARGADLMNKSRTNAKGA
                     PLNINKVSNSLINFGRKLISPAMAPGSAGGPVPGGNSSSSSSVVIPTRTSAEAPSHHL
                     QQQQQQQRLMKSESMPVQLNKGDVVTGSDAQVSVPVQTLTDLQGLSSKNISSSPSVES
                     LPGGREFTGSPPSSATKKDSFFSNISRSRSHSKTMGRKESEEELEAQISFLQGQLNDL
                     DAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQL
                     EAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQASSETPGCTDRGNSDDFILI
                     SKDDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVFSDPLMGPASASSSNPSSS
                     PDDDSSKDSGFTIVSPLDI"
     exon            349..418
                     /gene="TBC1D5"
                     /inference="alignment:Splign:2.1.0"
     exon            419..527
                     /gene="TBC1D5"
                     /inference="alignment:Splign:2.1.0"
     exon            528..617
                     /gene="TBC1D5"
                     /inference="alignment:Splign:2.1.0"
     exon            618..692
                     /gene="TBC1D5"
                     /inference="alignment:Splign:2.1.0"
     exon            693..760
                     /gene="TBC1D5"
                     /inference="alignment:Splign:2.1.0"
     exon            761..863
                     /gene="TBC1D5"
                     /inference="alignment:Splign:2.1.0"
     exon            864..952
                     /gene="TBC1D5"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1003
                     /gene="TBC1D5"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1073
                     /gene="TBC1D5"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1246
                     /gene="TBC1D5"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1389
                     /gene="TBC1D5"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1496
                     /gene="TBC1D5"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1582
                     /gene="TBC1D5"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1839
                     /gene="TBC1D5"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1905
                     /gene="TBC1D5"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2069
                     /gene="TBC1D5"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2169
                     /gene="TBC1D5"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2249
                     /gene="TBC1D5"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2411
                     /gene="TBC1D5"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..6500
                     /gene="TBC1D5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6481..6486
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBC1D5"
                     /note="hexamer: AATAAA"
     polyA_site      6500
                     /gene="TBC1D5"
                     /note="major polyA site"
ORIGIN      
        1 gccaccccct cccgccctgt tctctttcag gtcgggccgg gcccggccgc ttccgcgagc
       61 gccctgcaga ctgagggaga gagagagaaa gaggagggga ggaggaggag gattcaggga
      121 ataggagctg gggagccctt ctgcgccaca gtgatatcag tatcaagata aaagtttgga
      181 atgggagaaa aattctcaaa gcctgaaaga aaatctgtag ttacttttgg tgacgctgtc
      241 cagttcccac aatgtatcat tccttatctg aaactagaca tcctctgcag ccagaagaac
      301 aagaagtagg cattgacccc ttgtccagtt actctaacaa gtctggagga gattcaaata
      361 aaaatggaag aagaacaagt tctactttag actctgaagg gacttttaat tcctatagga
      421 aagaatggga agaactattt gtaaacaaca attacttggc aacaataagg cagaagggga
      481 ttaatgggca gctgagaagc agcaggttcc gcagcatttg ctggaagcta tttctttgtg
      541 ttcttcctca agacaaaagt caatggataa gtagaattga agaattaaga gcatggtata
      601 gcaacattaa agaaatacat attaccaacc cgaggaaggt tgttggccaa caagatttga
      661 tgatcaataa tcctctttca caggatgaag ggagtctttg gaacaaattc ttccaagata
      721 aagaacttcg atcaatgatt gaacaagatg tcaaaagaac gtttcctgaa atgcagtttt
      781 tccagcaaga aaatgtgaga aaaattctta cagatgttct tttctgttat gccagagaaa
      841 acgagcagtt gctttataaa cagggcatgc acgaactgtt agcacctata gtctttgtcc
      901 ttcactgtga ccaccaagct tttctacatg ccagtgagtc tgcacagccc agtgaggaaa
      961 tgaaaactgt cttgaaccct gagtatctgg aacatgatgc ctatgcagtg ttctcacaac
     1021 ttatggaaac tgctgaacct tggttttcaa cttttgagca tgatggtcag aaggggaaag
     1081 aaacactgat gactcccatt ccctttgcta gaccacaaga tttagggcca acaattgcta
     1141 ttgttactaa agtcaaccag atccaggatc atctactgaa gaagcatgat attgagcttt
     1201 acatgcactt gaacagacta gaaattgcac cacagatata tgggttaagg tgggtgcggc
     1261 tgctatttgg acgagagttc cccctgcagg accttctggt ggtctgggat gccttgtttg
     1321 cagacggcct cagcctgggt ttagtagatt atatcttcgt agccatgtta ctttacatcc
     1381 gagatgcttt gatctctagt aactaccaga cctgtctcgg ccttctgatg cattacccat
     1441 tcatcgggga tgtacactca ctgattctta aggctctgtt ccttagagat ccaaagagaa
     1501 atccaagacc agtgacttat caattccatc caaatttaga ttattacaaa gcacgaggag
     1561 cagacctcat gaataaaagc cggaccaatg ccaaaggtgc tcccctgaat ataaataagg
     1621 tctctaatag cctgattaat tttggaagaa agttgatttc cccagcaatg gctccaggca
     1681 gtgcaggtgg ccctgtacct ggaggcaaca gcagtagctc ctcctctgtt gtaattccta
     1741 ccaggacctc agcagaggcc ccaagccatc acttgcaaca gcaacagcag cagcagaggc
     1801 tgatgaaatc agaaagcatg cctgtgcaat tgaacaaagg cgatgtagtt acaggaagcg
     1861 atgctcaggt ttctgttcct gtccagactc taactgacct ccaagggcta agttctaaaa
     1921 acatcagttc atctccaagc gttgagagtt tgcctggagg aagagaattc actggctctc
     1981 caccttcatc tgctactaaa aaagattcct tttttagcaa catctcacgt tctcgctcac
     2041 acagcaaaac tatgggcaga aaagaatctg aagaagaatt agaagcccaa atttccttcc
     2101 ttcaagggca gttgaatgac ctggatgcca tgtgcaaata ctgtgcaaag gtgatggaca
     2161 ctcatcttgt aaatattcaa gatgtgatat tacaagaaaa tttggaaaaa gaagatcaaa
     2221 ttctggtttc cctggcagga ttaaaacaga tcaaagacat tctaaaaggt tccctgcgtt
     2281 ttaaccagag ccagctagag gccgaagaga acgaacagat caccattgcg gacaaccact
     2341 actgctccag cggccagggc cagggccgag gccaaggcca gagcgttcaa atgtcagggg
     2401 ccattaaaca ggcctcttca gaaacgccag ggtgcactga tagagggaat tccgatgact
     2461 tcatcctgat ttccaaagat gatgatggga gcagtgccag gggctccttc tccggccagg
     2521 cccagcctct tcgcaccctc agaagcacct ctgggaaaag ccaggcccca gtctgctccc
     2581 cactggtgtt ctcagatcca ctgatgggcc cagcctcagc ttcctccagc aaccccagct
     2641 ccagtcctga tgacgacagc agcaaggact ctggcttcac cattgtgagt cccctggaca
     2701 tctgaccaca gtgcccagtc ctgccccaca gggatctagc cacccttcag tggccccaag
     2761 gccagactga ggctcatcca gtggagaacc ttcttaaacc actgcttcct tcccggcatg
     2821 cattttgcat tggtccagcc ctttgaaacc ccttagagag aagcatatat ggccacaaag
     2881 cacagaggct taggtttgcc acatgcagac agggctttct gggcccttac ctaatcccca
     2941 cccgactctt gctctgagtt agagctgagt tacgtaccca gtatcacact cacagttaga
     3001 aaagaccgaa tcacaattta gaatcacttt tcctctgtcc ccttctcccc agctaagaat
     3061 gtgtggcacc tccatcagtt atacttagaa ggagcagaaa tagttatttt cgtatcttct
     3121 atccctcaaa gcatcagaca tgggaaaatt ggtttatacc aagaaagctt cctctgtgga
     3181 aatctgtctc agcctacttt attcctgcat tgggaagcca tatcgcagag ctaaatgcaa
     3241 tagaatgaac cagaactagt ggattccagg gctgggggaa aaaaaaaaag aaaaaacctc
     3301 attactgacc tctcaaagtt ataaggatct ctgcaaacag gatctaagct taggaataat
     3361 atttaggtgt gatatagtgt tagatttttt tgatgtatta aagaatgcat ctccaatcct
     3421 taggccatat caactttggc catcaatatc tctccttaaa caattatatt tcacctttta
     3481 gaatctttca tagccagaaa acaagattac tgtaagccag ttttagctgc actgatttca
     3541 aaagatataa gaatattact atccttcaaa tggaaaatgc gaccttgact ttatgggata
     3601 aacatctttc agacagtcag ttttctagtc aggtttctct ggtttcagag ctgtatatac
     3661 ctgtcaactg aggaataaag ggaaaaaccc aagttcattc ccacccaaag tcagaatccc
     3721 tcattggcct taaggtagca gtcataagac agagaattgg acctagagtc ccttctgtgg
     3781 ggaataagga tacctagaga acattccaca tgccaagagg atgcaggatt tctacacaac
     3841 cccttccctt cttggaagtc aagtgtaggt actgcagggc ctgtgctcag ctgtgaaccc
     3901 cgtatcctgg gccccactgc cgggaccggg tctgacatgc cagtgccttc ctgggctgag
     3961 cacagattag agactctccc ccttgtcagt cagcacctta ggaaaccatg atgggcacag
     4021 agcatcacat gagctgtttc tctccttaaa gaagatccct ggaaaggatg cttttcctct
     4081 cctttgcctg cgcaggaatt ctaacaggag tgggtgagga tggcagaggg acacagtgcc
     4141 tgtctcgcct ccatcaggga gagcagccat gccagggatg actagctctt tgagcctgtc
     4201 ctcagaggat ggcgaggcag ccgggcagtg gaggccttca tggtaacaaa tgaaagctca
     4261 gtatagagga acagacactg tttacgtccc tcccactgct aaccttatat atctctatag
     4321 acaaatgtga taatgacatg atttcccacc tgccctccaa gaaaatggtg actcactctc
     4381 aagtcagcta ctgtagagag ggttctaatt ggttctgcaa tttgctctta aactctagca
     4441 gggaactctc ctcttaccac atcagcatgt aaggtgaata ataactggtt ttgccagaca
     4501 gcaggttgtc tgaccttcaa ccactgggca attgcctggc agatgcacac agtagctccc
     4561 tggcttctgg ctctgagtgt tcctctcagc acctctgagt aagctgctgc caagcacata
     4621 tccctatgac aacactttgt aaaagccgcg gggcccccat acagcgagtg accttgcaac
     4681 tgtgcagggt tgccattggt cactttctca ccttgggaag gtgtcagtgt tttcagttct
     4741 aaggtaagag gtgtagagct gttcccacca gggctctggg acagactgga aaggaccaca
     4801 gacctggcca tccctgggca gcagggccag tgtcacctgc tgacctctag tatttccttt
     4861 gccctagagc tagagtcatg atagctgagg gtcactcgcc ctgcaagagt cactaggcac
     4921 ccaccatgcc aataaggctc tccgctggct ccctgcagtt ggctgggtgt ttaatagtca
     4981 ctgaaaactc ccagccctgc tgcacactag aggcaggtcc tctcggtcct ctccatcctg
     5041 tgcttctgtg gcccccagca agctcaccac ctccttggag gagagagaca tacaaggaca
     5101 gtgggtcatg ggtagtacca gcctcaaatt cccacaggct catactcaga caattgtatt
     5161 actgccttat gttttttaag tgttttttta aattcttcat agttgagtat tatttgcaat
     5221 tttattagtt acagtgctat taaagaatat gtgctccttt ttattatatt atcagatact
     5281 tatgtttaat tgtacatttt ttaaatcctg aatatattgt gttttgttaa caaatgtaat
     5341 cagtggaacc cttcttacgt tttgattatt agcagttaaa tacattttgt atacatgaag
     5401 cttagattaa ttcccatcat catcatctcc tgtttttata tgtgtcccta tgtgtttcat
     5461 gcattcctct ttgatcagat tggaatttga gttaaaattt agctttgtac attacgtgtg
     5521 agagttacag actagcaagt ctaattactt tgccttacct tgagtgtatg ccacagggtc
     5581 agataacaca ttaaacattt agttacactg gattactctt ccaaagctga cctcctgcta
     5641 atgttcagag gtaactgcaa tccggaaaga aataatatca ctgcagaaag aatgtgactc
     5701 taaaaataaa ccaggacctc cctgtgattt gccttgcctg cagatgacca gttgactctt
     5761 gtgctgtcag ccctggggtt gctaaggaag ctgcttcagg gagttggggg ttagttgccc
     5821 gctctcaaca ggaatgcctc ctctactttg tcagagatgc tgaacaaata tcaaactctg
     5881 tggcagtcat gctggcctcc taagaataac ctgtgagtca gagttgatgc acattatttt
     5941 tgtttttatt ttattttttt aaggaactgc tccaagggtt cattatagaa caggagtgtg
     6001 tacggaggac ttaggtcccc acatagagtg gccgttctgt ggcggctcca accaattcca
     6061 tccctccttt cctgcggaca cacacctggc ccctggcccc tgccctgtgt gtctggagga
     6121 ggggcactgg ggaggctgtg gagcagagag aagaggccgg atacattgag gatggcacct
     6181 ggcaagccag gcttccttct caaaggccag actgctttct cagtgttact tactaaagct
     6241 ctctttttat actgttaaaa agatatataa agttcgtata aacaggcttg agaccacttt
     6301 gatgtaaaag ctgtcatagt agtttttctc acagtggcac aattcatttg attgatggaa
     6361 tattcagtga cgccatgtat gccctatcgc ttttttctca tccatcttta tgctataact
     6421 catactgatt taagaaatga tttctccttt tggcaaagcg accccattca atatggttat
     6481 aataaaagac taatgtcaaa
//
