LOCUS       NM_032258               2077 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens TBC1 domain family member 3F (TBC1D3F), mRNA.
ACCESSION   NM_032258 NM_001040282 XM_946371
VERSION     NM_032258.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2077)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2077)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2077)
  AUTHORS   Ishibashi,K., Kanno,E., Itoh,T. and Fukuda,M.
  TITLE     Identification and characterization of a novel Tre-2/Bub2/Cdc16
            (TBC) protein that possesses Rab3A-GAP activity
  JOURNAL   Genes Cells 14 (1), 41-52 (2009)
   PUBMED   19077034
REFERENCE   4  (bases 1 to 2077)
  AUTHORS   Hodzic,D., Kong,C., Wainszelbaum,M.J., Charron,A.J., Su,X. and
            Stahl,P.D.
  TITLE     TBC1D3, a hominoid oncoprotein, is encoded by a cluster of
            paralogues located on chromosome 17q12
  JOURNAL   Genomics 88 (6), 731-736 (2006)
   PUBMED   16863688
  REMARK    GeneRIF: We describe eight highly related TBC1D3 paralogues located
            on Chromosome 17q12 that display specific transcription patterns in
            human tissues, and that pattern is altered in several primary
            prostate tumors in comparison to healthy prostate tissues.
REFERENCE   5  (bases 1 to 2077)
  AUTHORS   Pei,L., Peng,Y., Yang,Y., Ling,X.B., Van Eyndhoven,W.G.,
            Nguyen,K.C., Rubin,M., Hoey,T., Powers,S. and Li,J.
  TITLE     PRC17, a novel oncogene encoding a Rab GTPase-activating protein,
            is amplified in prostate cancer
  JOURNAL   Cancer Res 62 (19), 5420-5424 (2002)
   PUBMED   12359748
  REMARK    GeneRIF: PRC17 is amplified in 15% of prostate cancers, it is
            highly overexpressed in approximately one-half of metastatic
            prostate tumors.
REFERENCE   6  (bases 1 to 2077)
  AUTHORS   Onno,M., Nakamura,T., Hillova,J. and Hill,M.
  TITLE     Identification of novel sequences in the repertoire of
            hypervariable TRE17 genes from immortalized nonmalignant and
            malignant human keratinocytes
  JOURNAL   Gene 131 (2), 209-215 (1993)
   PUBMED   8406013
REFERENCE   7  (bases 1 to 2077)
  AUTHORS   Onno,M., Nakamura,T., Mariage-Samson,R., Hillova,J. and Hill,M.
  TITLE     Human TRE17 oncogene is generated from a family of homologous
            polymorphic sequences by single-base changes
  JOURNAL   DNA Cell Biol 12 (2), 107-118 (1993)
   PUBMED   8471161
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC233698.3.
            
            On Nov 1, 2018 this sequence version replaced NM_032258.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               AC233698.3         126622-126732
            112-184             AC233698.3         128161-128233
            185-270             AC233698.3         128396-128481
            271-310             AC233698.3         129765-129804
            311-391             AC233698.3         130287-130367
            392-499             AC233698.3         130811-130918
            500-609             AC233698.3         131248-131357
            610-658             AC233698.3         132609-132657
            659-779             AC233698.3         133201-133321
            780-874             AC233698.3         134035-134129
            875-940             AC233698.3         134514-134579
            941-1040            AC233698.3         135043-135142
            1041-1193           AC233698.3         135513-135665
            1194-1596           AC233698.3         136647-137049
            1597-2077           AC233698.3         137051-137531
FEATURES             Location/Qualifiers
     source          1..2077
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..2077
                     /gene="TBC1D3F"
                     /gene_synonym="TBC1D3; TBC1D3G"
                     /note="TBC1 domain family member 3F"
                     /db_xref="GeneID:84218"
                     /db_xref="HGNC:HGNC:18257"
                     /db_xref="MIM:610809"
     exon            1..111
                     /gene="TBC1D3F"
                     /gene_synonym="TBC1D3; TBC1D3G"
                     /inference="alignment:Splign:2.1.0"
     exon            112..184
                     /gene="TBC1D3F"
                     /gene_synonym="TBC1D3; TBC1D3G"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..1762
                     /gene="TBC1D3F"
                     /gene_synonym="TBC1D3; TBC1D3G"
                     /note="TBC1 domain family member 3; prostate cancer gene
                     17 protein; protein TRE17-alpha; TBC1 domain family member
                     3G"
                     /codon_start=1
                     /product="TBC1 domain family member 3F"
                     /protein_id="NP_115634.3"
                     /db_xref="GeneID:84218"
                     /db_xref="HGNC:HGNC:18257"
                     /db_xref="MIM:610809"
                     /translation="MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNN
                     NVDHLGIVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGM
                     PMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDVSGTLRKHIFFR
                     DRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASER
                     HSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDG
                     ISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWAR
                     DEDTVLKHLRASMKKLTRKKGDVPPPAKPEQGSSASRPVPASRGGKTLCKGDRQAPPG
                     PPARFPRPIWSASPPRAPRSSTPCPGGAVREDTYPVGTQGVPSPALAQGGPQGSWRFL
                     QWNSMPRLPTDLDVEGPWFRHYDFRQSCWVRAISQEDQLAPCWQAEHPAERVRSAFAA
                     PSTDSDQGTPFRARDEQQCAPTSGPCLCGLHLESSQFPPGF"
     exon            185..270
                     /gene="TBC1D3F"
                     /gene_synonym="TBC1D3; TBC1D3G"
                     /inference="alignment:Splign:2.1.0"
     exon            271..310
                     /gene="TBC1D3F"
                     /gene_synonym="TBC1D3; TBC1D3G"
                     /inference="alignment:Splign:2.1.0"
     exon            311..391
                     /gene="TBC1D3F"
                     /gene_synonym="TBC1D3; TBC1D3G"
                     /inference="alignment:Splign:2.1.0"
     exon            392..499
                     /gene="TBC1D3F"
                     /gene_synonym="TBC1D3; TBC1D3G"
                     /inference="alignment:Splign:2.1.0"
     exon            500..609
                     /gene="TBC1D3F"
                     /gene_synonym="TBC1D3; TBC1D3G"
                     /inference="alignment:Splign:2.1.0"
     exon            610..658
                     /gene="TBC1D3F"
                     /gene_synonym="TBC1D3; TBC1D3G"
                     /inference="alignment:Splign:2.1.0"
     exon            659..779
                     /gene="TBC1D3F"
                     /gene_synonym="TBC1D3; TBC1D3G"
                     /inference="alignment:Splign:2.1.0"
     exon            780..874
                     /gene="TBC1D3F"
                     /gene_synonym="TBC1D3; TBC1D3G"
                     /inference="alignment:Splign:2.1.0"
     exon            875..940
                     /gene="TBC1D3F"
                     /gene_synonym="TBC1D3; TBC1D3G"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1040
                     /gene="TBC1D3F"
                     /gene_synonym="TBC1D3; TBC1D3G"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1193
                     /gene="TBC1D3F"
                     /gene_synonym="TBC1D3; TBC1D3G"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..2077
                     /gene="TBC1D3F"
                     /gene_synonym="TBC1D3; TBC1D3G"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtggtctac agcagttaca cacaggcagt ggtatctgtg agcagctctg tggactcaaa
       61 ggttttctcc ctgagaggca tgacccaggc cagctgattc atcagaatca ggatggacgt
      121 ggtagaggtc gcgggtagtt ggtgggcaca agagcgagag gacatcatta tgaaatacga
      181 aaagggacac cgagctgggc tgccagagga caaggggcct aagccttttc gaagctacaa
      241 caacaacgtc gatcatttgg ggattgtaca tgagacggag ctgcctcctc tgactgcgcg
      301 ggaggcgaag caaattcggc gggagatcag ccgaaagagc aagtgggtgg atatgctggg
      361 agactgggag aaatacaaaa gcagcagaaa gctcatagat cgagcgtaca agggaatgcc
      421 catgaacatc cggggcccga tgtggtcagt cctcctgaac attgaggaaa tgaagttgaa
      481 aaaccccgga agataccaga tcatgaagga gaagggcaag aggtcatctg agcacatcca
      541 gcgcatcgac cgggacgtaa gcgggacatt aaggaagcat atattcttca gggatcgata
      601 cggaaccaag cagcgggaac tactccacat cctcctggca tatgaggagt acaacccgga
      661 ggtgggctac tgcagggacc tgagccacat cgccgccttg ttcctcctct atcttcctga
      721 ggaggatgca ttctgggcac tggtgcagct gctggccagt gagaggcact ccctgcaggg
      781 atttcacagc ccaaatggcg ggaccgtcca ggggctccaa gaccaacagg agcatgtggt
      841 agccacgtca caacccaaga ccatggggca tcaggacaag aaagatctat gtgggcagtg
      901 ttccccgtta ggctgcctca tccggatatt gattgacggg atctctctcg ggctcaccct
      961 gcgcctgtgg gacgtgtatc tggtagaagg cgaacaggcg ttgatgccga taacaagaat
     1021 cgcctttaag gttcagcaga agcgcctcac gaagacgtcc aggtgtggcc cgtgggcacg
     1081 tttttgcaac cggttcgttg atacctgggc cagggatgag gacactgtgc tcaagcatct
     1141 tagggcctct atgaagaaac taacaagaaa gaagggggac gtgccacccc cagccaaacc
     1201 cgagcaaggg tcgtcggcat ccaggcctgt gccggcttca cgtggcggga agaccctctg
     1261 caagggggac agacaggccc ctccaggccc accagcccgg ttcccgcggc ccatttggtc
     1321 agcttccccg ccacgggcac ctcgttcttc cacaccctgt cctggtgggg ctgtccggga
     1381 agacacctac cctgtgggca ctcagggtgt gcccagcccg gccctggctc agggaggacc
     1441 tcagggttcc tggagattcc tgcagtggaa ctccatgccc cgcctcccaa ccgacctgga
     1501 cgtagagggc ccttggttcc gccattatga tttcagacag agctgctggg tccgtgccat
     1561 atcccaggag gaccagctgg ccccctgctg gcaggctgaa caccctgcgg agcgggtgag
     1621 atcggctttc gctgcaccca gcactgattc cgaccagggc acccccttca gagctaggga
     1681 cgaacagcag tgtgctccca cctcagggcc ttgcctctgc ggcctccact tggaaagttc
     1741 tcagttccct ccaggcttct agaagcatct gggccagggc tcatggctgg ataatttccc
     1801 taggcttaac aacccaagca agcttcgcat cctcgtttta tttttggtta aacttatgaa
     1861 aatgtattaa gaaagagtgc agctcgagag agattcagag atggaacaca ccagacccca
     1921 gatcacaaag ccaaccatgc ccagcccctc ccagcacccc cagccccacg accatcgttc
     1981 tgaattctga cgacaccgtg agcctgcctt tgtacttcaa actcatggaa ggataaccac
     2041 cttcatgttt tgaaataaat gtttcctgtt gaaatga
//
