LOCUS       NM_001291466            2082 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens TBC1 domain family member 3E (TBC1D3E), mRNA.
ACCESSION   NM_001291466 XM_006725389
VERSION     NM_001291466.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2082)
  AUTHORS   Sudmant,P.H., Kitzman,J.O., Antonacci,F., Alkan,C., Malig,M.,
            Tsalenko,A., Sampas,N., Bruhn,L., Shendure,J. and Eichler,E.E.
  CONSRTM   1000 Genomes Project
  TITLE     Diversity of human copy number variation and multicopy genes
  JOURNAL   Science 330 (6004), 641-646 (2010)
   PUBMED   21030649
REFERENCE   2  (bases 1 to 2082)
  AUTHORS   Hodzic,D., Kong,C., Wainszelbaum,M.J., Charron,A.J., Su,X. and
            Stahl,P.D.
  TITLE     TBC1D3, a hominoid oncoprotein, is encoded by a cluster of
            paralogues located on chromosome 17q12
  JOURNAL   Genomics 88 (6), 731-736 (2006)
   PUBMED   16863688
REFERENCE   3  (bases 1 to 2082)
  AUTHORS   Zody,M.C., Garber,M., Adams,D.J., Sharpe,T., Harrow,J.,
            Lupski,J.R., Nicholson,C., Searle,S.M., Wilming,L., Young,S.K.,
            Abouelleil,A., Allen,N.R., Bi,W., Bloom,T., Borowsky,M.L.,
            Bugalter,B.E., Butler,J., Chang,J.L., Chen,C.K., Cook,A., Corum,B.,
            Cuomo,C.A., de Jong,P.J., DeCaprio,D., Dewar,K., FitzGerald,M.,
            Gilbert,J., Gibson,R., Gnerre,S., Goldstein,S., Grafham,D.V.,
            Grocock,R., Hafez,N., Hagopian,D.S., Hart,E., Norman,C.H.,
            Humphray,S., Jaffe,D.B., Jones,M., Kamal,M., Khodiyar,V.K.,
            LaButti,K., Laird,G., Lehoczky,J., Liu,X., Lokyitsang,T.,
            Loveland,J., Lui,A., Macdonald,P., Major,J.E., Matthews,L.,
            Mauceli,E., McCarroll,S.A., Mihalev,A.H., Mudge,J., Nguyen,C.,
            Nicol,R., O'Leary,S.B., Osoegawa,K., Schwartz,D.C., Shaw-Smith,C.,
            Stankiewicz,P., Steward,C., Swarbreck,D., Venkataraman,V.,
            Whittaker,C.A., Yang,X., Zimmer,A.R., Bradley,A., Hubbard,T.,
            Birren,B.W., Rogers,J., Lander,E.S. and Nusbaum,C.
  TITLE     DNA sequence of human chromosome 17 and analysis of rearrangement
            in the human lineage
  JOURNAL   Nature 440 (7087), 1045-1049 (2006)
   PUBMED   16625196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC233968.3.
            
            On Aug 13, 2020 this sequence version replaced NM_001291466.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL136860.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151119, SAMEA2152798
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000621587.2/ ENSP00000483965.1
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               AC233968.3         53689-53804         c
            117-189             AC233968.3         52188-52260         c
            190-275             AC233968.3         51940-52025         c
            276-315             AC233968.3         50617-50656         c
            316-396             AC233968.3         50054-50134         c
            397-504             AC233968.3         49503-49610         c
            505-614             AC233968.3         49064-49173         c
            615-663             AC233968.3         47760-47808         c
            664-784             AC233968.3         47096-47216         c
            785-879             AC233968.3         46288-46382         c
            880-945             AC233968.3         45838-45903         c
            946-1045            AC233968.3         45275-45374         c
            1046-1198           AC233968.3         44752-44904         c
            1199-2082           AC233968.3         42887-43770         c
FEATURES             Location/Qualifiers
     source          1..2082
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..2082
                     /gene="TBC1D3E"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1DE3"
                     /note="TBC1 domain family member 3E"
                     /db_xref="GeneID:102723859"
                     /db_xref="HGNC:HGNC:27071"
                     /db_xref="MIM:610808"
     exon            1..116
                     /gene="TBC1D3E"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1DE3"
                     /inference="alignment:Splign:2.1.0"
     exon            117..189
                     /gene="TBC1D3E"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1DE3"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1767
                     /gene="TBC1D3E"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1DE3"
                     /note="TBC1 domain family member-like; TBC1 domain family
                     member 3; Prostate cancer gene 17 protein; Protein
                     TRE17-alpha; Rab GTPase-activating protein PRC17"
                     /codon_start=1
                     /product="TBC1 domain family member 3E"
                     /protein_id="NP_001278395.1"
                     /db_xref="CCDS:CCDS77009.1"
                     /db_xref="GeneID:102723859"
                     /db_xref="HGNC:HGNC:27071"
                     /db_xref="MIM:610808"
                     /translation="MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNN
                     NVDHLGIVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDQAYKGM
                     PMNIRGPMWSVLLNTEEMKLKNPGRYQIMKEKGKKSSEHIQRIDRDVSGTLRKHIFFR
                     DRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASER
                     HSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDG
                     ISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWAR
                     DEDTVLKHLRASMKKLTRKKGDLPPPAKPEQGSSASRPVPASRGGKTLCKGDRQAPPG
                     PPARFPRPIWSASPPRAPRSSTPCPGGAVREDTYPVGTQGVPSPALAQGGPQGSWRFL
                     QWNSMPRLPTDLDVEGPWFRHYDFRQSCWVRAISQEDQLAPCWQAEHPAERVRSAFAA
                     PSTDSDQGTPFRARDEQQCAPTSGPCLCGLHLESSQFPPGF"
     exon            190..275
                     /gene="TBC1D3E"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1DE3"
                     /inference="alignment:Splign:2.1.0"
     exon            276..315
                     /gene="TBC1D3E"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1DE3"
                     /inference="alignment:Splign:2.1.0"
     exon            316..396
                     /gene="TBC1D3E"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1DE3"
                     /inference="alignment:Splign:2.1.0"
     exon            397..504
                     /gene="TBC1D3E"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1DE3"
                     /inference="alignment:Splign:2.1.0"
     exon            505..614
                     /gene="TBC1D3E"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1DE3"
                     /inference="alignment:Splign:2.1.0"
     exon            615..663
                     /gene="TBC1D3E"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1DE3"
                     /inference="alignment:Splign:2.1.0"
     exon            664..784
                     /gene="TBC1D3E"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1DE3"
                     /inference="alignment:Splign:2.1.0"
     exon            785..879
                     /gene="TBC1D3E"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1DE3"
                     /inference="alignment:Splign:2.1.0"
     exon            880..945
                     /gene="TBC1D3E"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1DE3"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1045
                     /gene="TBC1D3E"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1DE3"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1198
                     /gene="TBC1D3E"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1DE3"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..2082
                     /gene="TBC1D3E"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1DE3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctcagtgg tctacagcag ttacacacag gcagtggtat ctgtgagcag ctctgtggac
       61 tcaaaggttt tctccctgag aggcatgacc caggccagct gattcatcag aatcaggatg
      121 gacgtggtag aggtcgcggg cagttggtgg gcacaagagc gagaggacat cattatgaaa
      181 tacgaaaagg gacaccgagc tgggctgcca gaggacaagg ggcctaagcc ttttcgaagc
      241 tacaacaaca acgtcgatca tttggggatt gtacatgaga cggagctgcc tcctctgact
      301 gcgcgggagg cgaagcaaat tcggcgggag atcagccgaa agagcaagtg ggtggatatg
      361 ctgggagact gggagaaata caaaagcagc agaaagctca tagatcaagc gtacaaggga
      421 atgcccatga acatccgggg cccgatgtgg tcagtcctcc tgaacactga ggaaatgaag
      481 ttgaaaaacc ccggaagata ccagatcatg aaggagaagg gcaagaagtc atctgagcac
      541 atccagcgca tcgaccggga cgtaagcggg acattaagga agcatatatt cttcagggat
      601 cgatacggaa ccaagcagcg ggaactactc cacatcctcc tggcatatga ggagtacaac
      661 ccggaggtgg gctactgcag ggacctgagc cacatcgccg ccttgttcct cctctatctt
      721 cctgaggagg atgcattctg ggcactggtg cagctgctgg ccagtgagag gcactccctg
      781 cagggatttc acagcccaaa tggcgggacc gtccaggggc tccaagacca acaggagcat
      841 gtggtagcca cgtcacaacc caagaccatg gggcatcagg acaagaaaga tctatgtggg
      901 cagtgttccc cgttaggctg cctcatccgg atattgattg acgggatctc tctcgggctc
      961 accctgcgcc tgtgggacgt gtatctggta gaaggcgaac aggcgctgat gccgataaca
     1021 agaatcgcct ttaaggttca gcagaagcgc ctcacgaaga cgtccaggtg tggcccgtgg
     1081 gcacgttttt gcaaccggtt cgttgatacc tgggccaggg atgaggacac tgtgctcaag
     1141 catcttaggg cctctatgaa gaaactaaca agaaagaagg gggacctgcc acccccagcc
     1201 aaacccgagc aagggtcgtc ggcatccagg cctgtgccgg cttcacgtgg cgggaagacc
     1261 ctctgcaagg gggacaggca ggcccctcca ggcccaccag cccggttccc gcggcccatt
     1321 tggtcagctt ccccgccacg ggcacctcgt tcttccacac cctgtcctgg tggggctgtc
     1381 cgggaagaca cctaccctgt gggcactcag ggtgtgccca gcccggccct ggctcaggga
     1441 ggacctcagg gttcctggag attcctgcag tggaactcca tgccccgcct cccaacggac
     1501 ctggacgtag agggcccttg gttccgccat tatgatttca gacagagctg ctgggtccgt
     1561 gccatatccc aggaggacca gctggccccc tgctggcagg ctgaacaccc tgcggagcgg
     1621 gtgagatcgg ctttcgctgc acccagcact gattccgacc agggcacccc cttcagagct
     1681 agggacgaac agcagtgtgc tcccacctca gggccttgcc tctgcggcct ccacttggaa
     1741 agttctcagt tccctccagg cttctagaag catctgggcc agggctcatg gctggataat
     1801 ttccctaggc ttaacaaccc aagcaagctt cgcatcctcg ttttattttt ggttaaactt
     1861 atgaaaatgt attaagaaag agtgcagctc gagagagatt cagagatgga acacaccaga
     1921 ccccagatca caaagccaac catgcccagc ccctcccagc acccccagcc ccacgaccat
     1981 cgttctgaat tctgacgaca ccgtgagcct gcctttgtac ttcaaactca tggaaggata
     2041 accaccttca tgttttgaaa taaatgtttc ctgttgaaat ga
//
