LOCUS       NM_001291465            2122 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens TBC1 domain family member 3D (TBC1D3D), mRNA.
ACCESSION   NM_001291465 XM_003960695 XM_006722251
VERSION     NM_001291465.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2122)
  AUTHORS   Hodzic,D., Kong,C., Wainszelbaum,M.J., Charron,A.J., Su,X. and
            Stahl,P.D.
  TITLE     TBC1D3, a hominoid oncoprotein, is encoded by a cluster of
            paralogues located on chromosome 17q12
  JOURNAL   Genomics 88 (6), 731-736 (2006)
   PUBMED   16863688
REFERENCE   2  (bases 1 to 2122)
  AUTHORS   Zody,M.C., Garber,M., Adams,D.J., Sharpe,T., Harrow,J.,
            Lupski,J.R., Nicholson,C., Searle,S.M., Wilming,L., Young,S.K.,
            Abouelleil,A., Allen,N.R., Bi,W., Bloom,T., Borowsky,M.L.,
            Bugalter,B.E., Butler,J., Chang,J.L., Chen,C.K., Cook,A., Corum,B.,
            Cuomo,C.A., de Jong,P.J., DeCaprio,D., Dewar,K., FitzGerald,M.,
            Gilbert,J., Gibson,R., Gnerre,S., Goldstein,S., Grafham,D.V.,
            Grocock,R., Hafez,N., Hagopian,D.S., Hart,E., Norman,C.H.,
            Humphray,S., Jaffe,D.B., Jones,M., Kamal,M., Khodiyar,V.K.,
            LaButti,K., Laird,G., Lehoczky,J., Liu,X., Lokyitsang,T.,
            Loveland,J., Lui,A., Macdonald,P., Major,J.E., Matthews,L.,
            Mauceli,E., McCarroll,S.A., Mihalev,A.H., Mudge,J., Nguyen,C.,
            Nicol,R., O'Leary,S.B., Osoegawa,K., Schwartz,D.C., Shaw-Smith,C.,
            Stankiewicz,P., Steward,C., Swarbreck,D., Venkataraman,V.,
            Whittaker,C.A., Yang,X., Zimmer,A.R., Bradley,A., Hubbard,T.,
            Birren,B.W., Rogers,J., Lander,E.S. and Nusbaum,C.
  TITLE     DNA sequence of human chromosome 17 and analysis of rearrangement
            in the human lineage
  JOURNAL   Nature 440 (7087), 1045-1049 (2006)
   PUBMED   16625196
REFERENCE   3  (bases 1 to 2122)
  AUTHORS   Paulding,C.A., Ruvolo,M. and Haber,D.A.
  TITLE     The Tre2 (USP6) oncogene is a hominoid-specific gene
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2507-2511 (2003)
   PUBMED   12604796
REFERENCE   4  (bases 1 to 2122)
  AUTHORS   Pei,L., Peng,Y., Yang,Y., Ling,X.B., Van Eyndhoven,W.G.,
            Nguyen,K.C., Rubin,M., Hoey,T., Powers,S. and Li,J.
  TITLE     PRC17, a novel oncogene encoding a Rab GTPase-activating protein,
            is amplified in prostate cancer
  JOURNAL   Cancer Res 62 (19), 5420-5424 (2002)
   PUBMED   12359748
REFERENCE   5  (bases 1 to 2122)
  AUTHORS   Onno,M., Nakamura,T., Hillova,J. and Hill,M.
  TITLE     Identification of novel sequences in the repertoire of
            hypervariable TRE17 genes from immortalized nonmalignant and
            malignant human keratinocytes
  JOURNAL   Gene 131 (2), 209-215 (1993)
   PUBMED   8406013
REFERENCE   6  (bases 1 to 2122)
  AUTHORS   Onno,M., Nakamura,T., Mariage-Samson,R., Hillova,J. and Hill,M.
  TITLE     Human TRE17 oncogene is generated from a family of homologous
            polymorphic sequences by single-base changes
  JOURNAL   DNA Cell Biol 12 (2), 107-118 (1993)
   PUBMED   8471161
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC233968.3.
            
            On Jul 22, 2021 this sequence version replaced NM_001291465.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR14372080.1278613.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1965299, SAMEA1968968 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000616101.5/ ENSP00000478426.1
            RefSeq Select criteria :: based on manual assertion
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               AC233968.3         177624-177779       c
            157-229             AC233968.3         176123-176195       c
            230-315             AC233968.3         175875-175960       c
            316-355             AC233968.3         174552-174591       c
            356-436             AC233968.3         173989-174069       c
            437-544             AC233968.3         173438-173545       c
            545-654             AC233968.3         172999-173108       c
            655-703             AC233968.3         171702-171750       c
            704-824             AC233968.3         171038-171158       c
            825-919             AC233968.3         170230-170324       c
            920-985             AC233968.3         169780-169845       c
            986-1085            AC233968.3         169217-169316       c
            1086-1238           AC233968.3         168694-168846       c
            1239-2122           AC233968.3         166847-167730       c
FEATURES             Location/Qualifiers
     source          1..2122
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..2122
                     /gene="TBC1D3D"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1D3H"
                     /note="TBC1 domain family member 3D"
                     /db_xref="GeneID:101060389"
                     /db_xref="HGNC:HGNC:28944"
                     /db_xref="MIM:610807"
     exon            1..156
                     /gene="TBC1D3D"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1D3H"
                     /inference="alignment:Splign:2.1.0"
     exon            157..229
                     /gene="TBC1D3D"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1D3H"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..1807
                     /gene="TBC1D3D"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1D3H"
                     /note="TBC1 domain family, member 3H; TRE17 alpha protein;
                     TBC1 domain family member 3; Prostate cancer gene 17
                     protein; Rab GTPase-activating protein PRC17"
                     /codon_start=1
                     /product="TBC1 domain family member 3D"
                     /protein_id="NP_001278394.1"
                     /db_xref="CCDS:CCDS74044.1"
                     /db_xref="GeneID:101060389"
                     /db_xref="HGNC:HGNC:28944"
                     /db_xref="MIM:610807"
                     /translation="MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNN
                     NVDHLGIVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGM
                     PMNIRGPMWSVLLNTEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDVSGTLRKHIFFR
                     DRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASER
                     HSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDG
                     ISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWAR
                     DEDTVLKHLRASMKKLTRKQGDLPPPAKPEQGSSASRPVPASRGGKTLCKGDRQAPPG
                     PPARFPRPIWSASPPRAPRSSTPCPGGAVREDTYPVGTQGVPSPALAQGGPQGSWRFL
                     QWNSMPRLPTDLDVEGPWFRHYDFRQSCWVRAISQEDQLAPCWQAEHPAERVRSAFAA
                     PSTDSDQGTPFRARDEQQCAPTSGPCLCGLHLESSQFPPGF"
     exon            230..315
                     /gene="TBC1D3D"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1D3H"
                     /inference="alignment:Splign:2.1.0"
     exon            316..355
                     /gene="TBC1D3D"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1D3H"
                     /inference="alignment:Splign:2.1.0"
     exon            356..436
                     /gene="TBC1D3D"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1D3H"
                     /inference="alignment:Splign:2.1.0"
     exon            437..544
                     /gene="TBC1D3D"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1D3H"
                     /inference="alignment:Splign:2.1.0"
     exon            545..654
                     /gene="TBC1D3D"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1D3H"
                     /inference="alignment:Splign:2.1.0"
     exon            655..703
                     /gene="TBC1D3D"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1D3H"
                     /inference="alignment:Splign:2.1.0"
     exon            704..824
                     /gene="TBC1D3D"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1D3H"
                     /inference="alignment:Splign:2.1.0"
     exon            825..919
                     /gene="TBC1D3D"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1D3H"
                     /inference="alignment:Splign:2.1.0"
     exon            920..985
                     /gene="TBC1D3D"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1D3H"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1085
                     /gene="TBC1D3D"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1D3H"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1238
                     /gene="TBC1D3D"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1D3H"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..2122
                     /gene="TBC1D3D"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1D3H"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2099..2104
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBC1D3D"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1D3H"
                     /note="hexamer: AATAAA"
     polyA_site      2119
                     /gene="TBC1D3D"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1D3H"
                     /note="major polyA site"
ORIGIN      
        1 gaatgtcact ggtgcttagc acctatctgc tctctggtct gcctcagtgg tctacagcag
       61 ttacacacag gcagtggtat ctgtgagcag ctctgtggac tcaaaggttt tctccctgag
      121 aggcacgacc caggccagct gattcatcag aatcaggatg gacgtggtag aggtcgcggg
      181 cagttggtgg gcacaagagc gagaggacat cattatgaaa tacgaaaagg gacaccgagc
      241 tgggctgcca gaggacaagg ggcctaagcc ttttcgaagc tacaacaaca acgtcgatca
      301 tttggggatt gtacatgaga cggagctgcc tcctctgact gcgcgggagg cgaagcaaat
      361 tcggcgggag atcagccgaa agagcaagtg ggtggatatg ctgggagact gggagaaata
      421 caaaagcagc agaaagctca tagatcgagc gtacaaggga atgcccatga acatccgggg
      481 cccgatgtgg tcagtcctcc tgaacactga ggaaatgaag ttgaaaaacc ccggaagata
      541 ccagatcatg aaggagaagg gcaagaggtc atctgagcac atccagcgca tcgaccggga
      601 cgtaagcggg acattaagga agcatatatt cttcagggat cgatacggaa ccaagcagcg
      661 ggaactactc cacatcctcc tggcatatga ggagtataac ccggaggtgg gctactgcag
      721 ggacctgagc cacatcgccg ccttgttcct cctctatctt cctgaggagg atgcattctg
      781 ggcactggtg cagctgctgg ccagtgagag gcactccctg cagggatttc acagcccaaa
      841 tggcgggacc gtccaggggc tccaagacca acaggagcat gtggtagcca cgtcacaacc
      901 caagaccatg gggcatcagg acaagaaaga tctatgtggg cagtgttccc cgttaggctg
      961 cctcatccgg atattgattg acgggatctc tctcgggctc accctgcgcc tgtgggacgt
     1021 gtatctggta gaaggcgaac aggcgttgat gccgataaca agaatcgcct ttaaggttca
     1081 gcagaagcgc ctcacgaaga cgtccaggtg tggcccgtgg gcacgttttt gcaaccggtt
     1141 cgttgatacc tgggccaggg atgaggacac tgtgctcaag catcttaggg cctctatgaa
     1201 gaaactaaca agaaagcagg gggacctgcc acccccagcc aaacccgagc aagggtcgtc
     1261 ggcatccagg cctgtgccgg cttcacgtgg cgggaagacc ctctgcaagg gggacaggca
     1321 ggcccctcca ggcccaccag cccggttccc gcggcccatt tggtcagctt ccccgccacg
     1381 ggcacctcgt tcttccacac cctgtcctgg tggggctgtc cgggaagaca cctaccctgt
     1441 gggcactcag ggtgtgccca gcccggccct ggctcaggga ggacctcagg gttcctggag
     1501 attcctgcag tggaactcca tgccccgcct cccaacggac ctggacgtag agggcccttg
     1561 gttccgccat tatgatttca gacagagctg ctgggtccgt gccatatccc aggaggacca
     1621 gctggccccc tgctggcagg ctgaacaccc tgcggagcgg gtgagatcgg ctttcgctgc
     1681 acccagcact gattccgacc agggcacccc cttcagagct agggacgaac agcagtgtgc
     1741 tcccacctca gggccttgcc tctgcggcct ccacttggaa agttctcagt tccctccagg
     1801 cttctagaag catctgggcc agggctcatg gctggataat ttccctaggc ttaacaaccc
     1861 aagcaagctt cgcatcctcg ttttattttt ggttaaactt atgaaaatgt attaagaaag
     1921 agtgcagctc gagagagatt cagagatgga acacaccaga ccccagatca caaagccaac
     1981 catgcccggc ccctcccagc acccccagcc ccacgaccat cgttctgaat tctgacgaca
     2041 ccgtgagcct gcctttgtac ttcaaactca tggaaggata accaccttca tgttttgaaa
     2101 taaatgtttc ctgttgaaat ga
//
