LOCUS       NM_001001418            2105 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens TBC1 domain family member 3C (TBC1D3C), mRNA.
ACCESSION   NM_001001418 XM_001714094 XM_006725572 XM_011547460
VERSION     NM_001001418.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2105)
  AUTHORS   Luan,Y., Deng,Z., Zhu,Y., Dai,L., Yang,Y. and Xia,Z.
  TITLE     Decoupling actin assembly from microtubule disassembly by
            TBC1D3C-mediated direct GEF-H1 activation
  JOURNAL   Life Sci Alliance 8 (1), e202402585 (2024)
   PUBMED   39467635
  REMARK    GeneRIF: Decoupling actin assembly from microtubule disassembly by
            TBC1D3C-mediated direct GEF-H1 activation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2105)
  AUTHORS   Hodzic,D., Kong,C., Wainszelbaum,M.J., Charron,A.J., Su,X. and
            Stahl,P.D.
  TITLE     TBC1D3, a hominoid oncoprotein, is encoded by a cluster of
            paralogues located on chromosome 17q12
  JOURNAL   Genomics 88 (6), 731-736 (2006)
   PUBMED   16863688
REFERENCE   3  (bases 1 to 2105)
  AUTHORS   Paulding,C.A., Ruvolo,M. and Haber,D.A.
  TITLE     The Tre2 (USP6) oncogene is a hominoid-specific gene
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2507-2511 (2003)
   PUBMED   12604796
  REMARK    GeneRIF: The Tre2 (USP6) oncogene is derived from the chimeric
            fusion of two genes, USP32 (NY-REN-60), and TBC1D3.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC233968.3.
            
            On or before Mar 22, 2015 this sequence version replaced
            XM_011547460.1, XM_006725572.1, NM_001001418.5.
            
            Summary: This gene represents one of a cluster of related genes
            found on chromosome 17. The proteins encoded by this gene family
            contain a TBC (Tre-2, Bub2p, and Cdc16p) domain and may be involved
            in GTPase signaling and vesicle trafficking. [provided by RefSeq,
            Apr 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK313329.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000622206.2/ ENSP00000482345.1
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               AC233968.3         113121-113259
            140-212             AC233968.3         114688-114760
            213-298             AC233968.3         114923-115008
            299-338             AC233968.3         116292-116331
            339-419             AC233968.3         116814-116894
            420-527             AC233968.3         117338-117445
            528-637             AC233968.3         117775-117884
            638-686             AC233968.3         119140-119188
            687-807             AC233968.3         119732-119852
            808-902             AC233968.3         120566-120660
            903-968             AC233968.3         121046-121111
            969-1068            AC233968.3         121575-121674
            1069-1221           AC233968.3         122045-122197
            1222-2105           AC233968.3         123179-124062
FEATURES             Location/Qualifiers
     source          1..2105
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..2105
                     /gene="TBC1D3C"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1D3D"
                     /note="TBC1 domain family member 3C"
                     /db_xref="GeneID:414060"
                     /db_xref="HGNC:HGNC:24889"
                     /db_xref="MIM:610806"
     exon            1..139
                     /gene="TBC1D3C"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1D3D"
                     /inference="alignment:Splign:2.1.0"
     exon            140..212
                     /gene="TBC1D3C"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1D3D"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1790
                     /gene="TBC1D3C"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1D3D"
                     /note="Rab GTPase-activating protein PRC17; TBC1 domain
                     family member 3C/3D; TBC1 domain family member 3C-like
                     protein ENSP00000341742; Prostate cancer gene 17 protein;
                     Protein TRE17-alpha"
                     /codon_start=1
                     /product="TBC1 domain family member 3C"
                     /protein_id="NP_001001418.5"
                     /db_xref="CCDS:CCDS74045.1"
                     /db_xref="GeneID:414060"
                     /db_xref="HGNC:HGNC:24889"
                     /db_xref="MIM:610806"
                     /translation="MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNN
                     NVDHLGIVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGM
                     PMNIRGPMWSVLLNTEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDVSGTLRKHIFFR
                     DRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASER
                     HSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDG
                     ISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWAR
                     DEDTVLKHLRASMKKLTRKKGDLPPPAKPEQGSSASRPVPASRGGKTLCKGDRQAPPG
                     PPARFPRPIWSASPPRAPRSSTPCPGGAVREDTYPVGTQGVPSPALAQGGPQGSWRFL
                     QWNSMPRLPTDLDVEGPWFRHYDFRQSCWVRAISQEDQLAPCWQAEHPAERVRSAFAA
                     PSTDSDQGTPFRARDEQQCAPTSGPCLCGLHLESSQFPPGF"
     exon            213..298
                     /gene="TBC1D3C"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1D3D"
                     /inference="alignment:Splign:2.1.0"
     exon            299..338
                     /gene="TBC1D3C"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1D3D"
                     /inference="alignment:Splign:2.1.0"
     exon            339..419
                     /gene="TBC1D3C"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1D3D"
                     /inference="alignment:Splign:2.1.0"
     exon            420..527
                     /gene="TBC1D3C"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1D3D"
                     /inference="alignment:Splign:2.1.0"
     exon            528..637
                     /gene="TBC1D3C"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1D3D"
                     /inference="alignment:Splign:2.1.0"
     exon            638..686
                     /gene="TBC1D3C"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1D3D"
                     /inference="alignment:Splign:2.1.0"
     exon            687..807
                     /gene="TBC1D3C"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1D3D"
                     /inference="alignment:Splign:2.1.0"
     exon            808..902
                     /gene="TBC1D3C"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1D3D"
                     /inference="alignment:Splign:2.1.0"
     exon            903..968
                     /gene="TBC1D3C"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1D3D"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1068
                     /gene="TBC1D3C"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1D3D"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1221
                     /gene="TBC1D3C"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1D3D"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..2105
                     /gene="TBC1D3C"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1D3D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2082..2087
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBC1D3C"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1D3D"
     polyA_site      2105
                     /gene="TBC1D3C"
                     /gene_synonym="PRC17; TBC1D3; TBC1D3A; TBC1D3D"
ORIGIN      
        1 agcacctatc tgctctctgg tctgcctcag tggtctacag cagttacaca caggcagtgg
       61 tatctgtgag cagctctgtg gactcaaagg ttttctccct gagaggcacg acccaggcca
      121 gctgattcat cagaatcagg atggacgtgg tagaggtcgc gggcagttgg tgggcacaag
      181 agcgagagga catcattatg aaatacgaaa agggacaccg agctgggctg ccagaggaca
      241 aggggcctaa gccttttcga agctacaaca acaacgtcga tcatttgggg attgtacatg
      301 agacggagct gcctcctctg actgcgcggg aggcgaagca aattcggcgg gagatcagcc
      361 gaaagagcaa gtgggtggat atgctgggag actgggagaa atacaaaagc agcagaaagc
      421 tcatagatcg agcgtacaag ggaatgccca tgaacatccg gggcccgatg tggtcagtcc
      481 tcctgaacac tgaggaaatg aagttgaaaa accccggaag ataccagatc atgaaggaga
      541 agggcaagag gtcatctgag cacatccagc gcatcgaccg ggacgtaagc gggacattaa
      601 ggaagcatat attcttcagg gatcgatacg gaaccaagca gcgggaacta ctccacatcc
      661 tcctggcata tgaggagtac aacccggagg tgggctactg cagggacctg agccacatcg
      721 ccgccttgtt cctcctctat cttcctgagg aggatgcatt ctgggcactg gtgcagctgc
      781 tggccagtga gaggcactcc ctgcagggat ttcacagccc aaatggcggg accgtccagg
      841 ggctccaaga ccaacaggag catgtggtag ccacgtcaca acccaagacc atggggcatc
      901 aggacaagaa agatctatgt gggcagtgtt ccccgttagg ctgcctcatc cggatattga
      961 ttgacgggat ctctctcggg ctcaccctgc gcctgtggga cgtgtatctg gtagaaggcg
     1021 aacaggcgtt gatgccgata acaagaatcg cctttaaggt tcagcagaag cgcctcacga
     1081 agacgtccag gtgtggcccg tgggcacgtt tttgcaaccg gttcgttgat acctgggcca
     1141 gggatgagga cactgtgctc aagcatctta gggcctctat gaagaaacta acaagaaaga
     1201 agggggacct gccaccccca gccaaacccg agcaagggtc gtcggcatcc aggcctgtgc
     1261 cggcttcacg tggcgggaag accctctgca agggggacag gcaggcccct ccaggcccac
     1321 cagcccggtt cccgcggccc atttggtcag cttccccgcc acgggcacct cgttcttcca
     1381 caccctgtcc tggtggggct gtccgggaag acacctaccc tgtgggcact cagggtgtgc
     1441 ccagcccggc cctggctcag ggaggacctc agggttcctg gagattcctg cagtggaact
     1501 ccatgccccg cctcccaacg gacctggacg tagagggccc ttggttccgc cattatgatt
     1561 tcagacagag ctgctgggtc cgtgccatat cccaggagga ccagctggcc ccctgctggc
     1621 aggctgaaca ccctgcggag cgggtgagat cggctttcgc tgcacccagc actgattccg
     1681 accagggcac ccccttcaga gctagggacg aacagcagtg tgctcccacc tcagggcctt
     1741 gcctctgcgg cctccacttg gaaagttctc agttccctcc aggcttctag aagcatctgg
     1801 gccagggctc atggctggat aatttcccta ggcttaacaa cccaagcaag cttcgcatcc
     1861 tcgttttatt tttggttaaa cttatgaaaa tgtattaaga aagagtgcag ctcgagagag
     1921 attcagagat ggaacacacc agaccccaga tcacaaagcc aaccatgccc agcccctccc
     1981 agcaccccca gccccacgac catcgttctg aattctgacg acaccgtgag cctacctttg
     2041 tacttcaaac tcatggaagg ataaccacct tcatgttttg aaataaatgt ttcctgttga
     2101 aatga
//
