LOCUS       NM_001001417            2120 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens TBC1 domain family member 3B (TBC1D3B), mRNA.
ACCESSION   NM_001001417
VERSION     NM_001001417.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2120)
  AUTHORS   Hodzic,D., Kong,C., Wainszelbaum,M.J., Charron,A.J., Su,X. and
            Stahl,P.D.
  TITLE     TBC1D3, a hominoid oncoprotein, is encoded by a cluster of
            paralogues located on chromosome 17q12
  JOURNAL   Genomics 88 (6), 731-736 (2006)
   PUBMED   16863688
REFERENCE   2  (bases 1 to 2120)
  AUTHORS   Zody,M.C., Garber,M., Adams,D.J., Sharpe,T., Harrow,J.,
            Lupski,J.R., Nicholson,C., Searle,S.M., Wilming,L., Young,S.K.,
            Abouelleil,A., Allen,N.R., Bi,W., Bloom,T., Borowsky,M.L.,
            Bugalter,B.E., Butler,J., Chang,J.L., Chen,C.K., Cook,A., Corum,B.,
            Cuomo,C.A., de Jong,P.J., DeCaprio,D., Dewar,K., FitzGerald,M.,
            Gilbert,J., Gibson,R., Gnerre,S., Goldstein,S., Grafham,D.V.,
            Grocock,R., Hafez,N., Hagopian,D.S., Hart,E., Norman,C.H.,
            Humphray,S., Jaffe,D.B., Jones,M., Kamal,M., Khodiyar,V.K.,
            LaButti,K., Laird,G., Lehoczky,J., Liu,X., Lokyitsang,T.,
            Loveland,J., Lui,A., Macdonald,P., Major,J.E., Matthews,L.,
            Mauceli,E., McCarroll,S.A., Mihalev,A.H., Mudge,J., Nguyen,C.,
            Nicol,R., O'Leary,S.B., Osoegawa,K., Schwartz,D.C., Shaw-Smith,C.,
            Stankiewicz,P., Steward,C., Swarbreck,D., Venkataraman,V.,
            Whittaker,C.A., Yang,X., Zimmer,A.R., Bradley,A., Hubbard,T.,
            Birren,B.W., Rogers,J., Lander,E.S. and Nusbaum,C.
  TITLE     DNA sequence of human chromosome 17 and analysis of rearrangement
            in the human lineage
  JOURNAL   Nature 440 (7087), 1045-1049 (2006)
   PUBMED   16625196
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC243829.3.
            
            On Aug 13, 2020 this sequence version replaced NM_001001417.6.
            
            Summary: This gene encodes a protein that is similar to TBC1 domain
            family, member 3. This protein contains a TBC (Tre-2, Bub2p, and
            Cdc16p) domain, which is found in proteins involved in RAB GTPase
            signaling and vesicle trafficking. There are multiple copies of
            this gene located within a cluster of chemokine genes on chromosome
            17q. [provided by RefSeq, Apr 2009].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292257.1, AK225985.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000611257.5/ ENSP00000478473.1
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               AC243829.3         143715-143871       c
            158-230             AC243829.3         142214-142286       c
            231-316             AC243829.3         141966-142051       c
            317-356             AC243829.3         140643-140682       c
            357-437             AC243829.3         140080-140160       c
            438-545             AC243829.3         139529-139636       c
            546-655             AC243829.3         139090-139199       c
            656-704             AC243829.3         137790-137838       c
            705-825             AC243829.3         137126-137246       c
            826-920             AC243829.3         136315-136409       c
            921-986             AC243829.3         135865-135930       c
            987-1086            AC243829.3         135302-135401       c
            1087-1239           AC243829.3         134779-134931       c
            1240-2120           AC243829.3         132918-133798       c
FEATURES             Location/Qualifiers
     source          1..2120
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..2120
                     /gene="TBC1D3B"
                     /gene_synonym="PRC17; TBC1D3I; TBC1D3L"
                     /note="TBC1 domain family member 3B"
                     /db_xref="GeneID:414059"
                     /db_xref="HGNC:HGNC:27011"
                     /db_xref="MIM:610144"
     exon            1..157
                     /gene="TBC1D3B"
                     /gene_synonym="PRC17; TBC1D3I; TBC1D3L"
                     /inference="alignment:Splign:2.1.0"
     exon            158..230
                     /gene="TBC1D3B"
                     /gene_synonym="PRC17; TBC1D3I; TBC1D3L"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..1808
                     /gene="TBC1D3B"
                     /gene_synonym="PRC17; TBC1D3I; TBC1D3L"
                     /note="Rab GTPase-activating protein PRC17 duplicate;
                     prostate cancer gene 17 duplicate; TBC1 domain family,
                     member 3I; TBC1 domain family member 3B/I; TBC1 domain
                     family, member 3-like"
                     /codon_start=1
                     /product="TBC1 domain family member 3B"
                     /protein_id="NP_001001417.6"
                     /db_xref="CCDS:CCDS42300.1"
                     /db_xref="GeneID:414059"
                     /db_xref="HGNC:HGNC:27011"
                     /db_xref="MIM:610144"
                     /translation="MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNN
                     NVDHLGIVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGM
                     PMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDISGTLRKHMFFR
                     DRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASER
                     HSLQGFHSPNGGTVQGLQDQQEHVVATSQSKTMGHQDKKDLCGQCSPLGCLIRILIDG
                     ISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWAR
                     DEDTVLKHLRASMKKLTRKQGDLPPPAKPEQGSSASRPVPASRGRKTLCKGDRQAPPG
                     PPARFPRPIWSASPPRAPRSSTPCPGGAVREDTYPVGTQGVPSPALAQGGPQGSWRFL
                     QWNSMPRLPTDLDVEGPWFRHYDFRQSCWVRAISQEDQLAPCWQAEHPAERVRSAFAA
                     PSTDSDQGTPFRARDEQQCAPTSGPCLCGLHLESSQFPPGF"
     exon            231..316
                     /gene="TBC1D3B"
                     /gene_synonym="PRC17; TBC1D3I; TBC1D3L"
                     /inference="alignment:Splign:2.1.0"
     exon            317..356
                     /gene="TBC1D3B"
                     /gene_synonym="PRC17; TBC1D3I; TBC1D3L"
                     /inference="alignment:Splign:2.1.0"
     exon            357..437
                     /gene="TBC1D3B"
                     /gene_synonym="PRC17; TBC1D3I; TBC1D3L"
                     /inference="alignment:Splign:2.1.0"
     exon            438..545
                     /gene="TBC1D3B"
                     /gene_synonym="PRC17; TBC1D3I; TBC1D3L"
                     /inference="alignment:Splign:2.1.0"
     exon            546..655
                     /gene="TBC1D3B"
                     /gene_synonym="PRC17; TBC1D3I; TBC1D3L"
                     /inference="alignment:Splign:2.1.0"
     exon            656..704
                     /gene="TBC1D3B"
                     /gene_synonym="PRC17; TBC1D3I; TBC1D3L"
                     /inference="alignment:Splign:2.1.0"
     exon            705..825
                     /gene="TBC1D3B"
                     /gene_synonym="PRC17; TBC1D3I; TBC1D3L"
                     /inference="alignment:Splign:2.1.0"
     exon            826..920
                     /gene="TBC1D3B"
                     /gene_synonym="PRC17; TBC1D3I; TBC1D3L"
                     /inference="alignment:Splign:2.1.0"
     exon            921..986
                     /gene="TBC1D3B"
                     /gene_synonym="PRC17; TBC1D3I; TBC1D3L"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1086
                     /gene="TBC1D3B"
                     /gene_synonym="PRC17; TBC1D3I; TBC1D3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1239
                     /gene="TBC1D3B"
                     /gene_synonym="PRC17; TBC1D3I; TBC1D3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..2120
                     /gene="TBC1D3B"
                     /gene_synonym="PRC17; TBC1D3I; TBC1D3L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2100..2105
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBC1D3B"
                     /gene_synonym="PRC17; TBC1D3I; TBC1D3L"
                     /note="hexamer: AATAAA"
     polyA_site      2120
                     /gene="TBC1D3B"
                     /gene_synonym="PRC17; TBC1D3I; TBC1D3L"
                     /note="major polyA site"
ORIGIN      
        1 agaatgtcac tggtgcttag cacctatctg ctctctggcc tgcctcagtg gtctacagca
       61 gttacacaca ggcagtggta tctgtgagca gctctgtgga ctcaaaggtt ttctccctga
      121 gaggcatgac ccaggccagc tgattcatca gaatcaggat ggacgtggta gaggtcgcgg
      181 gtagttggtg ggcacaagag cgagaggaca tcattatgaa atacgaaaag ggacaccgag
      241 ctgggctgcc agaggacaag gggcctaagc cttttcgaag ctacaacaac aacgtcgatc
      301 atttggggat tgtacatgag acggagctgc ctcctctgac tgcgcgggag gcgaagcaaa
      361 ttcggcggga gatcagccga aagagcaagt gggtggatat gctgggagac tgggagaaat
      421 acaaaagcag cagaaagctc atagatcgag cgtacaaggg aatgcccatg aacatccggg
      481 gcccgatgtg gtcagtcctc ctgaacattg aggaaatgaa gttgaaaaac cccggaagat
      541 accagatcat gaaggagaag ggcaagaggt catctgagca catccagcgc atcgaccggg
      601 acataagcgg gacattaagg aagcatatgt tcttcaggga tcgatacgga accaagcagc
      661 gggaactact ccacatcctc ctggcatatg aggagtataa cccggaggtg ggctactgca
      721 gggacctgag ccacatcgcc gccttgttcc tcctctatct tcctgaggag gatgcattct
      781 gggcactggt gcagctgctg gccagtgaga ggcactccct gcagggattt cacagcccaa
      841 atggcgggac cgtccagggg ctccaagacc aacaggagca tgtggtagcc acgtcacaat
      901 ccaagaccat ggggcatcag gacaagaaag atctatgtgg gcagtgttcc ccgttaggct
      961 gcctcatccg gatattgatt gacgggatct ctctcgggct caccctgcgc ctgtgggacg
     1021 tgtatctggt agaaggcgaa caggcgttga tgccgataac aagaatcgcc tttaaggttc
     1081 agcagaagcg cctcacgaag acgtccaggt gtggcccgtg ggcacgtttt tgcaaccggt
     1141 tcgttgatac ctgggccagg gatgaggaca ctgtgctcaa gcatcttagg gcctctatga
     1201 agaaactaac aagaaagcag ggggacctgc cacccccagc caaacccgag caagggtcgt
     1261 cggcatccag gcctgtgccg gcttcacgtg gcaggaagac cctctgcaag ggggacaggc
     1321 aggcccctcc aggcccacca gcccggttcc cgcggcccat ttggtcagct tccccgccac
     1381 gggcacctcg ttcttccaca ccctgtcctg gtggggctgt ccgggaagac acctaccctg
     1441 tgggcactca gggtgtgccc agcccggccc tggctcaggg aggacctcag ggttcctgga
     1501 gattcctgca gtggaactcc atgccccgcc tcccaacgga cctggacgta gaggggcctt
     1561 ggttccgcca ttatgatttc agacagagct gctgggtccg tgccatatcc caggaggacc
     1621 agctggcccc ctgctggcag gctgaacacc ctgcggagcg ggtgagatcg gctttcgctg
     1681 cacccagcac tgattccgac cagggcaccc ccttcagagc tagggacgaa cagcagtgtg
     1741 ctcccacctc agggccttgc ctctgcggcc tccacttgga aagttctcag ttccctccag
     1801 gcttctagaa gcatctgggc cagggctcat ggctggataa tttccctagg cttaacaacc
     1861 caagcaagct tcgcgtcctc gttttatttt tggttaaact tatgaatatg tattaagaaa
     1921 gagtgcagct tgagagacat tcagagatgg aacacaccag accccagatc acaaagccaa
     1981 ccatgcccag cccctcccag caccccaagc cccacgacca tcgttctgaa ttctgacgac
     2041 accgtgagcc tgcctttgta ctttaaactc atggaaggat aactaccttc acgttttgaa
     2101 ataaatgttt cctgttgaaa
//
