LOCUS       NM_001123391            2077 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens TBC1 domain family member 3 (TBC1D3), mRNA.
ACCESSION   NM_001123391 XM_001134186
VERSION     NM_001123391.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2077)
  AUTHORS   Hou,Q.Q., Xiao,Q., Sun,X.Y., Ju,X.C. and Luo,Z.G.
  TITLE     TBC1D3 promotes neural progenitor proliferation by suppressing the
            histone methyltransferase G9a
  JOURNAL   Sci Adv 7 (3) (2021)
   PUBMED   33523893
  REMARK    GeneRIF: TBC1D3 promotes neural progenitor proliferation by
            suppressing the histone methyltransferase G9a.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2077)
  AUTHORS   Wang,B., Zhao,H., Zhao,L., Zhang,Y., Wan,Q., Shen,Y., Bu,X., Wan,M.
            and Shen,C.
  TITLE     Up-regulation of OLR1 expression by TBC1D3 through activation of
            TNFalpha/NF-kappaB pathway promotes the migration of human breast
            cancer cells
  JOURNAL   Cancer Lett 408, 60-70 (2017)
   PUBMED   28844714
  REMARK    GeneRIF: High TBC1B3 expression is associated with breast cancer.
REFERENCE   3  (bases 1 to 2077)
  AUTHORS   Zhao,H., Zhang,L., Zhang,Y., Zhao,L., Wan,Q., Wang,B., Bu,X.,
            Wan,M. and Shen,C.
  TITLE     Calmodulin promotes matrix metalloproteinase 9 production and cell
            migration by inhibiting the ubiquitination and degradation of
            TBC1D3 oncoprotein in human breast cancer cells
  JOURNAL   Oncotarget 8 (22), 36383-36398 (2017)
   PUBMED   28422741
  REMARK    GeneRIF: our work reveals a novel model by which CaM promotes cell
            migration through inhibiting the ubiquitination and degradation of
            TBC1D3.
REFERENCE   4  (bases 1 to 2077)
  AUTHORS   Ju,X.C., Hou,Q.Q., Sheng,A.L., Wu,K.Y., Zhou,Y., Jin,Y., Wen,T.,
            Yang,Z., Wang,X. and Luo,Z.G.
  TITLE     The hominoid-specific gene TBC1D3 promotes generation of basal
            neural progenitors and induces cortical folding in mice
  JOURNAL   Elife 5, e18197 (2016)
   PUBMED   27504805
  REMARK    GeneRIF: Here, the found that expression of TBC1D3 in ventricular
            cortical progenitors of mice via in utero electroporation caused
            delamination of ventricular radial glia cells (vRGs) and promoted
            generation of self-renewing basal progenitors with typical
            morphology of outer radial glia (oRG), which are most abundant in
            primates. Expression of TBC1D3, was often found to underlie
            cortical regions exhibiting folding.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2077)
  AUTHORS   He,Z., Tian,T., Guo,D., Wu,H., Chen,Y., Zhang,Y., Wan,Q., Zhao,H.,
            Wang,C., Shen,H., Zhao,L., Bu,X., Wan,M. and Shen,C.
  TITLE     Cytoplasmic retention of a nucleocytoplasmic protein TBC1D3 by
            microtubule network is required for enhanced EGFR signaling
  JOURNAL   PLoS One 9 (4), e94134 (2014)
   PUBMED   24714105
  REMARK    GeneRIF: these studies indicate a novel model by which the
            microtubule network regulates EGFR stability and signaling through
            tubulin dimer/oligomer interaction with the nucleocytoplasmic
            protein TBC1D3.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2077)
  AUTHORS   Paulding,C.A., Ruvolo,M. and Haber,D.A.
  TITLE     The Tre2 (USP6) oncogene is a hominoid-specific gene
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2507-2511 (2003)
   PUBMED   12604796
REFERENCE   7  (bases 1 to 2077)
  AUTHORS   Masuda-Robens,J.M., Kutney,S.N., Qi,H. and Chou,M.M.
  TITLE     The TRE17 oncogene encodes a component of a novel effector pathway
            for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling
  JOURNAL   Mol Cell Biol 23 (6), 2151-2161 (2003)
   PUBMED   12612085
REFERENCE   8  (bases 1 to 2077)
  AUTHORS   Pei,L., Peng,Y., Yang,Y., Ling,X.B., Van Eyndhoven,W.G.,
            Nguyen,K.C., Rubin,M., Hoey,T., Powers,S. and Li,J.
  TITLE     PRC17, a novel oncogene encoding a Rab GTPase-activating protein,
            is amplified in prostate cancer
  JOURNAL   Cancer Res 62 (19), 5420-5424 (2002)
   PUBMED   12359748
REFERENCE   9  (bases 1 to 2077)
  AUTHORS   Onno,M., Nakamura,T., Hillova,J. and Hill,M.
  TITLE     Identification of novel sequences in the repertoire of
            hypervariable TRE17 genes from immortalized nonmalignant and
            malignant human keratinocytes
  JOURNAL   Gene 131 (2), 209-215 (1993)
   PUBMED   8406013
REFERENCE   10 (bases 1 to 2077)
  AUTHORS   Onno,M., Nakamura,T., Mariage-Samson,R., Hillova,J. and Hill,M.
  TITLE     Human TRE17 oncogene is generated from a family of homologous
            polymorphic sequences by single-base changes
  JOURNAL   DNA Cell Biol 12 (2), 107-118 (1993)
   PUBMED   8471161
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC244154.3 and AC233968.3.
            
            On Nov 20, 2020 this sequence version replaced NM_001123391.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074968.178035.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000620215.3/ ENSP00000478683.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               AC244154.3         171953-172063       c
            112-184             AC244154.3         170466-170538       c
            185-270             AC244154.3         170218-170303       c
            271-310             AC244154.3         168895-168934       c
            311-391             AC244154.3         168332-168412       c
            392-499             AC244154.3         167781-167888       c
            500-609             AC244154.3         167342-167451       c
            610-658             AC244154.3         166040-166088       c
            659-779             AC244154.3         165376-165496       c
            780-874             AC244154.3         164568-164662       c
            875-940             AC244154.3         164118-164183       c
            941-1040            AC244154.3         163555-163654       c
            1041-1193           AC244154.3         163032-163184       c
            1194-1981           AC244154.3         161263-162050       c
            1982-2077           AC233968.3         1-96
FEATURES             Location/Qualifiers
     source          1..2077
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..2077
                     /gene="TBC1D3"
                     /gene_synonym="PRC17; TBC1D3A; TBC1D3C; TBC1D3D; TBC1D3F;
                     TBC1D3L"
                     /note="TBC1 domain family member 3"
                     /db_xref="GeneID:729873"
                     /db_xref="HGNC:HGNC:19031"
                     /db_xref="MIM:607741"
     exon            1..111
                     /gene="TBC1D3"
                     /gene_synonym="PRC17; TBC1D3A; TBC1D3C; TBC1D3D; TBC1D3F;
                     TBC1D3L"
                     /inference="alignment:Splign:2.1.0"
     exon            112..184
                     /gene="TBC1D3"
                     /gene_synonym="PRC17; TBC1D3A; TBC1D3C; TBC1D3D; TBC1D3F;
                     TBC1D3L"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..1762
                     /gene="TBC1D3"
                     /gene_synonym="PRC17; TBC1D3A; TBC1D3C; TBC1D3D; TBC1D3F;
                     TBC1D3L"
                     /note="TBC1 domain family, member 3F; Rab
                     GTPase-activating protein PRC17; protein TRE17-alpha;
                     prostate cancer gene 17 protein; TBC1 domain family member
                     3L; TBC1 domain family member 3C"
                     /codon_start=1
                     /product="TBC1 domain family member 3"
                     /protein_id="NP_001116863.3"
                     /db_xref="CCDS:CCDS45658.1"
                     /db_xref="GeneID:729873"
                     /db_xref="HGNC:HGNC:19031"
                     /db_xref="MIM:607741"
                     /translation="MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNN
                     NVDHLGIVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGM
                     PMNIRGPMWSVLLNTEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDVSGTLRKHIFFR
                     DRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASER
                     HSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDG
                     ISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWAR
                     DEDTVLKHLRASMKKLTRKKGDLPPPAKPEQGSSASRPVPASRGGKTLCKGDRQAPPG
                     PPARFPRPIWSASPPRAPRSSTPCPGGAVREDTYPVGTQGVPSPALAQGGPQGSWRFL
                     QWNSMPRLPTDLDVEGPWFRHYDFRQSCWVRAISQEDQLAPCWQAEHPAERVRSAFAA
                     PSTDSDQGTPFRARDEQQCAPTSGPCLCGLHLESSQFPPGF"
     exon            185..270
                     /gene="TBC1D3"
                     /gene_synonym="PRC17; TBC1D3A; TBC1D3C; TBC1D3D; TBC1D3F;
                     TBC1D3L"
                     /inference="alignment:Splign:2.1.0"
     exon            271..310
                     /gene="TBC1D3"
                     /gene_synonym="PRC17; TBC1D3A; TBC1D3C; TBC1D3D; TBC1D3F;
                     TBC1D3L"
                     /inference="alignment:Splign:2.1.0"
     exon            311..391
                     /gene="TBC1D3"
                     /gene_synonym="PRC17; TBC1D3A; TBC1D3C; TBC1D3D; TBC1D3F;
                     TBC1D3L"
                     /inference="alignment:Splign:2.1.0"
     exon            392..499
                     /gene="TBC1D3"
                     /gene_synonym="PRC17; TBC1D3A; TBC1D3C; TBC1D3D; TBC1D3F;
                     TBC1D3L"
                     /inference="alignment:Splign:2.1.0"
     exon            500..609
                     /gene="TBC1D3"
                     /gene_synonym="PRC17; TBC1D3A; TBC1D3C; TBC1D3D; TBC1D3F;
                     TBC1D3L"
                     /inference="alignment:Splign:2.1.0"
     exon            610..658
                     /gene="TBC1D3"
                     /gene_synonym="PRC17; TBC1D3A; TBC1D3C; TBC1D3D; TBC1D3F;
                     TBC1D3L"
                     /inference="alignment:Splign:2.1.0"
     exon            659..779
                     /gene="TBC1D3"
                     /gene_synonym="PRC17; TBC1D3A; TBC1D3C; TBC1D3D; TBC1D3F;
                     TBC1D3L"
                     /inference="alignment:Splign:2.1.0"
     exon            780..874
                     /gene="TBC1D3"
                     /gene_synonym="PRC17; TBC1D3A; TBC1D3C; TBC1D3D; TBC1D3F;
                     TBC1D3L"
                     /inference="alignment:Splign:2.1.0"
     exon            875..940
                     /gene="TBC1D3"
                     /gene_synonym="PRC17; TBC1D3A; TBC1D3C; TBC1D3D; TBC1D3F;
                     TBC1D3L"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1040
                     /gene="TBC1D3"
                     /gene_synonym="PRC17; TBC1D3A; TBC1D3C; TBC1D3D; TBC1D3F;
                     TBC1D3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1193
                     /gene="TBC1D3"
                     /gene_synonym="PRC17; TBC1D3A; TBC1D3C; TBC1D3D; TBC1D3F;
                     TBC1D3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..2077
                     /gene="TBC1D3"
                     /gene_synonym="PRC17; TBC1D3A; TBC1D3C; TBC1D3D; TBC1D3F;
                     TBC1D3L"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtggtctac agcagttaca cacaggcagt ggtatctgtg agcagctctg tggactcaaa
       61 ggttttctcc ctgagaggca tgacccaggc cagctgattc atcagaatca ggatggacgt
      121 ggtagaggtc gcgggcagtt ggtgggcaca agagcgagag gacatcatta tgaaatacga
      181 aaagggacac cgagctgggc tgccagagga caaggggcct aagccttttc gaagctacaa
      241 caacaacgtc gatcatttgg ggattgtaca tgagacggag ctgcctcctc tgactgcgcg
      301 ggaggcgaag caaattcggc gggagatcag ccgaaagagc aagtgggtgg atatgctggg
      361 agactgggag aaatacaaaa gcagcagaaa gctcatagat cgagcgtaca agggaatgcc
      421 catgaacatc cggggcccga tgtggtcagt cctcctgaac actgaggaaa tgaagttgaa
      481 aaaccccgga agataccaga tcatgaagga gaagggcaag aggtcatctg agcacatcca
      541 gcgcatcgac cgggacgtaa gcgggacatt aaggaagcat atattcttca gggatcgata
      601 cggaaccaag cagcgggaac tactccacat cctcctggca tatgaggagt acaacccgga
      661 ggtgggctac tgcagggacc tgagccacat cgccgccttg ttcctcctct atcttcctga
      721 ggaggatgca ttctgggcac tggtgcagct gctggccagt gagaggcact ccctgcaggg
      781 atttcacagc ccaaatggcg ggaccgtcca ggggctccaa gaccaacagg agcatgtggt
      841 agccacgtca caacccaaga ccatggggca tcaggacaag aaagatctat gtgggcagtg
      901 ttccccgtta ggctgcctca tccggatatt gattgacggg atctctctcg ggctcaccct
      961 gcgcctgtgg gacgtgtatc tggtagaagg cgaacaggcg ttgatgccga taacaagaat
     1021 cgcctttaag gttcagcaga agcgcctcac gaagacgtcc aggtgtggcc cgtgggcacg
     1081 tttttgcaac cggttcgttg atacctgggc cagggatgag gacactgtgc tcaagcatct
     1141 tagggcctct atgaagaaac taacaagaaa gaagggggac ctgccacccc cagccaaacc
     1201 cgagcaaggg tcgtcggcat ccaggcctgt gccggcttca cgtggcggga agaccctctg
     1261 caagggggac aggcaggccc ctccaggccc accagcccgg ttcccgcggc ccatttggtc
     1321 agcttccccg ccacgggcac ctcgttcttc cacaccctgt cctggtgggg ctgtccggga
     1381 agacacctac cctgtgggca ctcagggtgt gcccagcccg gccctggctc agggaggacc
     1441 tcagggttcc tggagattcc tgcagtggaa ctccatgccc cgcctcccaa cggacctgga
     1501 cgtagagggc ccttggttcc gccattatga tttcaggcag agctgctggg tccgtgccat
     1561 atcccaggag gaccagctgg ccccctgctg gcaggctgaa caccctgcgg agcgggtgag
     1621 atcggctttc gctgcaccca gcactgattc cgaccagggc acccccttca gagctaggga
     1681 cgaacagcag tgtgctccca cctcagggcc ttgcctctgc ggcctccact tggaaagttc
     1741 tcagttccct ccaggcttct agaagcatct gggccagggc tcatggctgg ataatttccc
     1801 taggcttaac aacccaagca agcttcgcat cctcgtttta tttttggtta aacttatgaa
     1861 aatgtattaa gaaagagtgc agctcgagag agattcagag atggaacaca ccagacccca
     1921 gatcacaaag ccaaccatgc ccagcccctc ccagcacccc cagccccacg accatcgttc
     1981 tgaattctga cgacaccgtg agcctgcctt tgtacttcaa actcatggaa ggataaccac
     2041 cttcatgttt tgaaataaat gtttcctgtt gaaatga
//
